Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heterogeneous nuclear ribonucleoprotein 27C

Gene

Hrb27C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a component of ribonucleosomes. Could be needed to organize a concentration gradient of a dorsalizing morphogen (Dm) originating in the germinal vesicle.

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: FlyBase
  • mRNA 5'-UTR binding Source: FlyBase
  • mRNA binding Source: FlyBase
  • single-stranded DNA binding Source: FlyBase

GO - Biological processi

  • axon guidance Source: FlyBase
  • border follicle cell migration Source: FlyBase
  • negative regulation of oskar mRNA translation Source: FlyBase
  • pole plasm oskar mRNA localization Source: FlyBase
  • positive regulation of translation Source: FlyBase
  • regulation of mRNA splicing, via spliceosome Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein 27C
Short name:
Hrb27-C
Alternative name(s):
HRP48.1
hnRNP 48
Gene namesi
Name:Hrb27C
Synonyms:hrp48, Rbp7
ORF Names:CG10377
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0004838 Hrb27C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817481 – 421Heterogeneous nuclear ribonucleoprotein 27CAdd BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177Phosphoserine1 Publication1
Modified residuei366Phosphoserine1 Publication1
Modified residuei368Phosphoserine1 Publication1
Modified residuei370Phosphoserine1 Publication1
Modified residuei372Phosphotyrosine1 Publication1
Modified residuei379Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48809
PRIDEiP48809

PTM databases

iPTMnetiP48809

Expressioni

Gene expression databases

BgeeiFBgn0004838
ExpressionAtlasiP48809 baseline and differential
GenevisibleiP48809 DM

Interactioni

Protein-protein interaction databases

BioGridi60119, 29 interactors
IntActiP48809, 18 interactors
STRINGi7227.FBpp0297875

Structurei

3D structure databases

ProteinModelPortaliP48809
SMRiP48809
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 88RRM 1PROSITE-ProRule annotationAdd BLAST82
Domaini96 – 173RRM 2PROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4205 Eukaryota
ENOG410YA8Z LUCA
GeneTreeiENSGT00900000140835
InParanoidiP48809
KOiK14411
OMAiALENGPH
OrthoDBiEOG091G1CPI
PhylomeDBiP48809

Family and domain databases

CDDicd12574 RRM1_DAZAP1, 1 hit
cd12327 RRM2_DAZAP1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034134 DAZAP1_RRM1
IPR034131 DAZAP1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

P48809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDERGKLF VGGLSWETTQ ENLSRYFCRF GDIIDCVVMK NNESGRSRGF
60 70 80 90 100
GFVTFADPTN VNHVLQNGPH TLDGRTIDPK PCNPRTLQKP KKGGGYKVFL
110 120 130 140 150
GGLPSNVTET DLRTFFNRYG KVTEVVIMYD QEKKKSRGFG FLSFEEESSV
160 170 180 190 200
EHVTNERYIN LNGKQVEIKK AEPRDGSGGQ NSNNSTVGGA YGKLGNECSH
210 220 230 240 250
WGPHHAPINM MQGQNGQMGG PPLNMPIGAP NMMPGYQGWG TSPQQQQYGY
260 270 280 290 300
GNSGPGSYQG WGAPPGPQGP PPQWSNYAGP QQTQGYGGYD MYNSTSTGAP
310 320 330 340 350
SGPSGGGSWN SWNMPPNSAG PTGAPGAGAG TATDMYSRAQ AWATGGPSTT
360 370 380 390 400
GPVGGMPRTG PGNSASKSGS EYDYGGYGSG YDYDYSNYVK QEGASNYGAG
410 420
PRSAYGNDSS TQPPYATSQA V
Length:421
Mass (Da):44,770
Last modified:September 27, 2005 - v2
Checksum:iD59DD2A647CE23F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262 – 297Missing in CAA44505 (PubMed:1730754).CuratedAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62639 mRNA Translation: CAA44505.1
DQ062784 mRNA Translation: AAY56657.1
AE014134 Genomic DNA Translation: AAF52456.1
AE014134 Genomic DNA Translation: AAF52457.1
AE014134 Genomic DNA Translation: AAN10605.1
AY069699 mRNA Translation: AAL39844.1
AY128430 mRNA Translation: AAM75023.1
S51720 mRNA Translation: AAB24628.1
PIRiD41732
RefSeqiNP_001162897.1, NM_001169426.2
NP_001162898.1, NM_001169427.2
NP_001245917.1, NM_001258988.2
NP_001245918.1, NM_001258989.2
NP_001245919.1, NM_001258990.2
NP_476869.1, NM_057521.6
NP_723228.1, NM_164720.4
NP_723229.1, NM_164721.3
UniGeneiDm.1997

Genome annotation databases

EnsemblMetazoaiFBtr0079346; FBpp0078974; FBgn0004838
FBtr0079347; FBpp0078975; FBgn0004838
FBtr0079348; FBpp0078976; FBgn0004838
FBtr0301403; FBpp0290617; FBgn0004838
FBtr0301404; FBpp0290618; FBgn0004838
FBtr0307030; FBpp0297873; FBgn0004838
FBtr0307031; FBpp0297874; FBgn0004838
FBtr0307032; FBpp0297875; FBgn0004838
GeneIDi33968
KEGGidme:Dmel_CG10377
UCSCiCG10377-RB d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiRB27C_DROME
AccessioniPrimary (citable) accession number: P48809
Secondary accession number(s): A4V0B8
, Q7JPT5, Q9TY67, Q9VM68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2005
Last modified: July 18, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health