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Protein

Fibroblast growth factor 5

Gene

Fgf5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: InterPro
  • growth factor activity Source: RGD
  • nerve growth factor receptor binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-RNO-109704 PI3K Cascade
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-190372 FGFR3c ligand binding and activation
R-RNO-190373 FGFR1c ligand binding and activation
R-RNO-190375 FGFR2c ligand binding and activation
R-RNO-5654219 Phospholipase C-mediated cascade: FGFR1
R-RNO-5654221 Phospholipase C-mediated cascade, FGFR2
R-RNO-5654227 Phospholipase C-mediated cascade, FGFR3
R-RNO-5654687 Downstream signaling of activated FGFR1
R-RNO-5654688 SHC-mediated cascade:FGFR1
R-RNO-5654689 PI-3K cascade:FGFR1
R-RNO-5654693 FRS-mediated FGFR1 signaling
R-RNO-5654695 PI-3K cascade:FGFR2
R-RNO-5654699 SHC-mediated cascade:FGFR2
R-RNO-5654700 FRS-mediated FGFR2 signaling
R-RNO-5654704 SHC-mediated cascade:FGFR3
R-RNO-5654706 FRS-mediated FGFR3 signaling
R-RNO-5654710 PI-3K cascade:FGFR3
R-RNO-5654712 FRS-mediated FGFR4 signaling
R-RNO-5654726 Negative regulation of FGFR1 signaling
R-RNO-5654727 Negative regulation of FGFR2 signaling
R-RNO-5654732 Negative regulation of FGFR3 signaling
R-RNO-5658623 FGFRL1 modulation of FGFR1 signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 5
Short name:
FGF-5
Alternative name(s):
Heparin-binding growth factor 5
Short name:
HBGF-5
Gene namesi
Name:Fgf5
Synonyms:Fgf-5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi620129 Fgf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000896018 – 266Fibroblast growth factor 5Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP48807
PRIDEiP48807

Expressioni

Gene expression databases

BgeeiENSRNOG00000022631
ExpressionAtlasiP48807 baseline and differential

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: InterPro
  • growth factor activity Source: RGD
  • nerve growth factor receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029046

Structurei

3D structure databases

ProteinModelPortaliP48807
SMRiP48807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi54 – 59Poly-Ser6

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP48807
KOiK04358
PhylomeDBiP48807

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028240 FGF5
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF23 PTHR11486:SF23, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P48807-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSLLFLIF CSHLILSAPA QGEKRLTPEG QPAPPRNPGD SSGSRGRSSA
60 70 80 90 100
TFASSSASSP VAASPGSQGS GSEHSSFQWS PSGRRTGSLY CRVGIGFHLQ
110 120 130 140 150
IYPDGKVNGS HEASVLSILE IFAVSQGIVG IRGVFSNKFL AMSKKGKLHA
160 170 180 190 200
SAKFTDDCKF RERFQENSYN TYASAIHRTE KTGREWYVAL NKRGKAKRGC
210 220 230 240 250
SPRVKPQHVS THFLPRFKQS EQPELSFTVT VPEKKKPPRP WKPKVPLSPS
260
RRSPSPVKYR LKFRFG
Length:266
Mass (Da):29,264
Last modified:February 1, 1996 - v1
Checksum:i95B0A0CA7C0A200C
GO
Isoform Short (identifier: P48807-2) [UniParc]FASTAAdd to basket
Also known as: FGF-5S

The sequence of this isoform differs from the canonical sequence as follows:
     118-121: ILEI → QIYR
     122-266: Missing.

Note: Seems to have an antagonistic effect compared to that of the isoform Long.
Show »
Length:121
Mass (Da):12,636
Checksum:i9B3FFD9BEC363EC4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001522118 – 121ILEI → QIYR in isoform Short. 1 Publication4
Alternative sequenceiVSP_001523122 – 266Missing in isoform Short. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64085 mRNA Translation: BAA10966.1
D64086 mRNA Translation: BAA10967.1
PIRiS68144
S68145
RefSeqiNP_071547.1, NM_022211.1 [P48807-1]
XP_006250763.1, XM_006250701.3 [P48807-2]
UniGeneiRn.44445

Genome annotation databases

EnsembliENSRNOT00000077861; ENSRNOP00000074979; ENSRNOG00000022631 [P48807-2]
GeneIDi60662
KEGGirno:60662
UCSCiRGD:620129 rat [P48807-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFGF5_RAT
AccessioniPrimary (citable) accession number: P48807
Secondary accession number(s): Q63402
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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