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Protein

Tryptophan 2,3-dioxygenase

Gene

Tdo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.UniRule annotation

Catalytic activityi

L-tryptophan + O2 = N-formyl-L-kynurenine.UniRule annotation

Cofactori

hemeUniRule annotationNote: Binds 1 heme group per subunit.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 1 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (Tdo2), Indoleamine 2,3-dioxygenase 2 (Ido2), Tryptophan 2,3-dioxygenase (Tdo2), Tryptophan 2,3-dioxygenase (Tdo2)
  2. Kynurenine formamidase (Afmid)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei144SubstrateUniRule annotation1
Metal bindingi328Iron (heme axial ligand)UniRule annotation1
Binding sitei342SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processTryptophan catabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.11.11 3474
ReactomeiR-MMU-71240 Tryptophan catabolism
UniPathwayiUPA00333; UER00453

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan 2,3-dioxygenaseUniRule annotation (EC:1.13.11.11UniRule annotation)
Short name:
TDOUniRule annotation
Alternative name(s):
Tryptamin 2,3-dioxygenaseUniRule annotation
Tryptophan oxygenaseUniRule annotation
Short name:
TOUniRule annotation
Short name:
TRPOUniRule annotation
Tryptophan pyrrolaseUniRule annotation
TryptophanaseUniRule annotation
Gene namesi
Name:Tdo2UniRule annotation
Synonyms:Tdo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1928486 Tdo2

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075307
GuidetoPHARMACOLOGYi2887

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724001 – 406Tryptophan 2,3-dioxygenaseAdd BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48776
PRIDEiP48776

PTM databases

iPTMnetiP48776
PhosphoSitePlusiP48776
SwissPalmiP48776

Expressioni

Gene expression databases

BgeeiENSMUSG00000028011
CleanExiMM_TDO2
ExpressionAtlasiP48776 baseline and differential
GenevisibleiP48776 MM

Interactioni

Subunit structurei

Homotetramer. Dimer of dimers.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029645

Chemistry databases

BindingDBiP48776

Structurei

3D structure databases

ProteinModelPortaliP48776
SMRiP48776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 76Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the tryptophan 2,3-dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3906 Eukaryota
COG3483 LUCA
GeneTreeiENSGT00390000008593
HOGENOMiHOG000221584
HOVERGENiHBG003043
InParanoidiP48776
KOiK00453
OMAiYWDLYQL
OrthoDBiEOG091G080K
PhylomeDBiP48776
TreeFamiTF105827

Family and domain databases

HAMAPiMF_01972 T23O, 1 hit
InterProiView protein in InterPro
IPR037217 Trp/Indoleamine_2_3_dOase-like
IPR004981 Trp_2_3_dOase
PANTHERiPTHR10138 PTHR10138, 1 hit
PfamiView protein in Pfam
PF03301 Trp_dioxygenase, 1 hit
SUPFAMiSSF140959 SSF140959, 2 hits

Sequencei

Sequence statusi: Complete.

P48776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGCPFAGNS VGYTLKNVSM EDNEEDRAQT GVNRASKGGL IYGNYLQLEK
60 70 80 90 100
ILNAQELQSE VKGNKIHDEH LFIITHQAYE LWFKQILWEL DSVREIFQNG
110 120 130 140 150
HVRDERNMLK VIARMHRVVV IFKLLVQQFS VLETMTALDF NDFREYLSPA
160 170 180 190 200
SGFQSLQFRL LENKIGVLQS LRVPYNRKHY RDNFGGDYNE LLLKSEQEQT
210 220 230 240 250
LLQLVEAWLE RTPGLEPNGF NFWGKFEKNI LKGLEEEFLR IQAKTDSEEK
260 270 280 290 300
EEQMAEFRKQ KEVLLCLFDE KRHDYLLSKG ERRLSYRALQ GALMIYFYRE
310 320 330 340 350
EPRFQVPFQL LTSLMDIDTL MTKWRYNHVC MVHRMLGTKA GTGGSSGYHY
360 370 380 390 400
LRSTVSDRYK VFVDLFNLST YLVPRHWVPK MNPIIHKFLY TAEYSDSSYF

SSDESD
Length:406
Mass (Da):47,756
Last modified:January 20, 2009 - v2
Checksum:i201835A021BE7A24
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18V → L in AAB60491 (Ref. 1) Curated1
Sequence conflicti229N → K in AAB60491 (Ref. 1) Curated1
Sequence conflicti240R → K in AAB60491 (Ref. 1) Curated1
Sequence conflicti245T → K in AAB60491 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24493 mRNA Translation: AAB60491.1
AC159260 Genomic DNA No translation available.
CCDSiCCDS17427.1
RefSeqiNP_064295.2, NM_019911.2
UniGeneiMm.258622

Genome annotation databases

EnsembliENSMUST00000029645; ENSMUSP00000029645; ENSMUSG00000028011
GeneIDi56720
KEGGimmu:56720
UCSCiuc008poo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiT23O_MOUSE
AccessioniPrimary (citable) accession number: P48776
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 20, 2009
Last modified: June 20, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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