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Protein

Cytochrome c oxidase subunit 7A2, mitochondrial

Gene

Cox7a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-liver/heart
Short name:
Cytochrome c oxidase subunit VIIa-L
Gene namesi
Name:Cox7a2
Synonyms:Cox7a3, Cox7al
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1316715 Cox7a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionBy similarityAdd BLAST23
ChainiPRO_000000614624 – 83Cytochrome c oxidase subunit 7A2, mitochondrialAdd BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP48771
MaxQBiP48771
PaxDbiP48771
PeptideAtlasiP48771
PRIDEiP48771
TopDownProteomicsiP48771

PTM databases

iPTMnetiP48771
PhosphoSitePlusiP48771

Expressioni

Gene expression databases

BgeeiENSMUSG00000032330
CleanExiMM_COX7A2
GenevisibleiP48771 MM

Interactioni

Subunit structurei

Interacts with PET100.By similarity

Protein-protein interaction databases

BioGridi198847, 2 interactors
CORUMiP48771
IntActiP48771, 3 interactors
MINTiP48771
STRINGi10090.ENSMUSP00000034881

Structurei

3D structure databases

ProteinModelPortaliP48771
SMRiP48771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IZJ9 Eukaryota
ENOG41124EQ LUCA
GeneTreeiENSGT00400000022054
HOGENOMiHOG000264231
HOVERGENiHBG051095
InParanoidiP48771
KOiK02270
OMAiHFENKVP
OrthoDBiEOG091G12UD
PhylomeDBiP48771
TreeFamiTF105067

Family and domain databases

CDDicd00928 Cyt_c_Oxidase_VIIa, 1 hit
Gene3Di4.10.91.10, 1 hit
InterProiView protein in InterPro
IPR039297 COX7a
IPR036539 Cyt_c_oxidase_su7a_sf
IPR003177 Cytc_oxidase_su7a_met
PANTHERiPTHR10510 PTHR10510, 1 hit
PfamiView protein in Pfam
PF02238 COX7a, 1 hit
SUPFAMiSSF81419 SSF81419, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRNLLALRQ IAQRTISTTS RRHFENKVPE KQKLFQEDNG MPVHLKGGAS
60 70 80
DALLYRATMA LTLGGTAYAI YLLAMAAFPK KQN
Length:83
Mass (Da):9,291
Last modified:December 1, 2000 - v2
Checksum:i06A3766E23ED69ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10Q → K in CAA41396 (PubMed:1659684).Curated1
Sequence conflicti51D → N in CAA41396 (PubMed:1659684).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58486 mRNA Translation: CAA41396.1
AF037371 mRNA Translation: AAB92615.1
AK007875 mRNA Translation: BAB25324.1
AK011269 mRNA Translation: BAB27507.1
AK019210 mRNA Translation: BAB31602.1
AK153173 mRNA Translation: BAE31778.1
BC010979 mRNA Translation: AAH10979.1
CCDSiCCDS23366.1
PIRiI48286
RefSeqiNP_034075.2, NM_009945.3
UniGeneiMm.152627

Genome annotation databases

EnsembliENSMUST00000034881; ENSMUSP00000034881; ENSMUSG00000032330
GeneIDi12866
KEGGimmu:12866
UCSCiuc009quv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCX7A2_MOUSE
AccessioniPrimary (citable) accession number: P48771
Secondary accession number(s): O54969, Q545J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: July 18, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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