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Protein

Complement component C9

Gene

C9

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.By similarity

GO - Biological processi

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Protein family/group databases

TCDBi1.C.39.3.5 the membrane attack complex/perforin (macpf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C9
Gene namesi
Name:C9
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei314 – 330Beta strandedSequence analysisAdd BLAST17
Transmembranei335 – 354Beta strandedSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Membrane attack complex, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002360122 – 547Complement component C9Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 78By similarity
Disulfide bondi54 ↔ 57By similarity
Disulfide bondi88 ↔ 94By similarity
Disulfide bondi101 ↔ 112By similarity
Disulfide bondi107 ↔ 125By similarity
Disulfide bondi119 ↔ 134By similarity
Disulfide bondi142 ↔ 181By similarity
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi380 ↔ 404By similarity
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi510 ↔ 526By similarity
Disulfide bondi513 ↔ 528By similarity
Disulfide bondi530 ↔ 539By similarity

Post-translational modificationi

Thrombin cleaves factor C9 to produce C9a and C9b.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48770
PRIDEiP48770

Interactioni

Subunit structurei

Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target membranes.By similarity

Protein-protein interaction databases

STRINGi9796.ENSECAP00000006188

Structurei

3D structure databases

ProteinModelPortaliP48770
SMRiP48770
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 95TSP type-1PROSITE-ProRule annotationAdd BLAST54
Domaini99 – 136LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Domaini138 – 509MACPFPROSITE-ProRule annotationAdd BLAST372
Domaini510 – 540EGF-likeAdd BLAST31

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG410IH3C Eukaryota
ENOG410XT9A LUCA
HOGENOMiHOG000111869
HOVERGENiHBG106792
InParanoidiP48770
KOiK04000

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR037567 Complement_C9
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001862 MAC_perforin
IPR020864 MACPF
IPR020863 MACPF_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR19325:SF362 PTHR19325:SF362, 1 hit
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF01823 MACPF, 1 hit
PRINTSiPR00764 COMPLEMENTC9
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00457 MACPF, 1 hit
SM00209 TSP1, 1 hit
SUPFAMiSSF57184 SSF57184, 2 hits
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS00279 MACPF_1, 1 hit
PS51412 MACPF_2, 1 hit
PS50092 TSP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48770-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGRTFAFA ICILEVSVLT AGPTPNYAPE PEQQSGTPLP IDCRMSSWSE
60 70 80 90 100
WSECDPCLRQ MFRSRSIEVF GQFNGQRCVD AVGDRRQCVP TEACEEVEDD
110 120 130 140 150
CGNDFQCGTG RCIKKRLLCN GDNDCGDFSD EDDCENDPRP PCRERVVEES
160 170 180 190 200
ELARTAGYGI NILGMDPLST PFDNEYYNGL CDRVRDGNTL TYYRKPWNLA
210 220 230 240 250
SLAYETKADK NFRIEHYEQQ IQAFRSVIEE RRSHFNADFT LKFTPTEAKK
260 270 280 290 300
CKQEPEESCN GTDSSENRIF RFAYSKNETY QLFLSYSSKK EKMFLHVKGV
310 320 330 340 350
IQLGKFVMRS RDVVLTTTFL DDIKALPTAY EKGEYIAFLE TYGTHYSSSG
360 370 380 390 400
SLGGLYELIY VLDKASMDQK GVELRDIQRC LGFNLDLSLK DKYEVTAKID
410 420 430 440 450
KNDCLKRNEK EIVNIMDGSL IDDVISLIRG GTRKYAFELK EKLLKGAKTV
460 470 480 490 500
NVTDFVNWAS SLNDAPVLIS QRLSPIYNLI PVKMKDAHQK KQNLERAIED
510 520 530 540
YINEFSVRKC HPCQNGGTVI QIDGQCLCSC PIAFEGIACE TGKKKIS
Length:547
Mass (Da):62,014
Last modified:February 1, 1996 - v1
Checksum:i75E5FE961DE873B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19381 mRNA Translation: AAB16820.1
RefSeqiNP_001075419.1, NM_001081950.1
UniGeneiEca.13069

Genome annotation databases

GeneIDi100034183
KEGGiecb:100034183

Similar proteinsi

Entry informationi

Entry nameiCO9_HORSE
AccessioniPrimary (citable) accession number: P48770
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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