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UniProtKB - P48764 (SL9A3_HUMAN)

Entry version 177 (23 Feb 2022)
Sequence version 2 (24 Nov 2009)
Previous versions | rss
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Protein

Sodium/hydrogen exchanger 3

Gene

SLC9A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773).

Plays an important role in signal transduction.

1 Publication

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P48764

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-425986, Sodium/Proton exchangers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P48764

SIGNOR Signaling Network Open Resource

More...SIGNORi		P48764

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.36.1.15, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 3Curated
Alternative name(s):
Na(+)/H(+) exchanger 31 Publication
Short name:
NHE-31 Publication
Solute carrier family 9 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC9A3Imported
Synonyms:NHE31 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11073, SLC9A3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182307, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P48764

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000066230

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei13 – 24Name=A/M1Sequence analysisAdd BLAST12
Topological domaini25 – 54CytoplasmicSequence analysisAdd BLAST30
Intramembranei55 – 73Name=B/M2Sequence analysisAdd BLAST19
Topological domaini74 – 79CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei80 – 99Helical; Name=C/M3Sequence analysisAdd BLAST20
Topological domaini100 – 112ExtracellularSequence analysisAdd BLAST13
Transmembranei113 – 133Helical; Name=D/M4Sequence analysisAdd BLAST21
Topological domaini134 – 139CytoplasmicSequence analysis6
Transmembranei140 – 160Helical; Name=E/M5Sequence analysisAdd BLAST21
Topological domaini161 – 180ExtracellularSequence analysisAdd BLAST20
Transmembranei181 – 202Helical; Name=F/M5ASequence analysisAdd BLAST22
Topological domaini203 – 210CytoplasmicSequence analysis8
Transmembranei211 – 232Helical; Name=G/M5BSequence analysisAdd BLAST22
Topological domaini233 – 252ExtracellularSequence analysisAdd BLAST20
Transmembranei253 – 274Helical; Name=H/M6Sequence analysisAdd BLAST22
Topological domaini275 – 290CytoplasmicSequence analysisAdd BLAST16
Transmembranei291 – 309Helical; Name=I/M7Sequence analysisAdd BLAST19
Topological domaini310 – 340ExtracellularSequence analysisAdd BLAST31
Transmembranei341 – 362Helical; Name=J/M8Sequence analysisAdd BLAST22
Topological domaini363 – 369CytoplasmicSequence analysis7
Transmembranei370 – 390Helical; Name=K/M9Sequence analysisAdd BLAST21
Topological domaini391 – 405ExtracellularSequence analysisAdd BLAST15
Intramembranei406 – 426Name=LSequence analysisAdd BLAST21
Topological domaini427 – 435ExtracellularSequence analysis9
Transmembranei436 – 456Helical; Name=M/M10Sequence analysisAdd BLAST21
Topological domaini457 – 834CytoplasmicSequence analysisAdd BLAST378

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diarrhea 8, secretory sodium, congenital (DIAR8)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by watery secretory diarrhea with prenatal onset, prominent abdominal distension after birth due to dilated fluid-filled loops of intestine, elevated fecal sodium concentrations and low urinary sodium concentrations.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076419127A → T in DIAR8; unknown pathological significance; does not affect cell membrane localization; reduces weakly Na(+)/H(+) exchange activity. 1 PublicationCorresponds to variant dbSNP:rs1047334552Ensembl.1
Natural variantiVAR_076420269A → T in DIAR8; decreases cell membrane expression; reduces Na(+)/H(+) exchange activity. 1 PublicationCorresponds to variant dbSNP:rs869312807EnsemblClinVar.1
Natural variantiVAR_076421311A → V in DIAR8; decreases cell membrane expression; reduces strongly Na(+)/H(+) exchange activity. 1 PublicationCorresponds to variant dbSNP:rs869312806EnsemblClinVar.1
Natural variantiVAR_076422382R → Q in DIAR8; decreases cell membrane localization; reduces strongly Na(+)/H(+) exchange activity. 1 PublicationCorresponds to variant dbSNP:rs766076524EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		6550

MalaCards human disease database

More...MalaCardsi		SLC9A3
MIMi616868, phenotype

Open Targets

More...OpenTargetsi		ENSG00000066230

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		103908, Congenital sodium diarrhea
586, Cystic fibrosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA316

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P48764, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3273

Drug and drug target database

More...DrugBanki		DB11761, Tenapanor

DrugCentral

More...DrugCentrali		P48764

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC9A3

Domain mapping of disease mutations (DMDM)

More...DMDMi		269849652

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523561 – 834Sodium/hydrogen exchanger 3Add BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei555PhosphoserineBy similarity1
Modified residuei563PhosphoserineBy similarity1
Modified residuei592PhosphoserineBy similarity1
Modified residuei607PhosphoserineBy similarity1
Modified residuei663Phosphoserine; by SGK1By similarity1
Modified residuei810PhosphoserineBy similarity1
Modified residuei813PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P48764

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P48764

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P48764

PeptideAtlas

More...PeptideAtlasi		P48764

PRoteomics IDEntifications database

More...PRIDEi		P48764

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20040
55946 [P48764-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P48764, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P48764

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P48764

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000066230, Expressed in cortex of kidney and 109 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P48764, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P48764, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000066230, Tissue enhanced (gallbladder, intestine, kidney, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds SLC9A3R1 and SLC9A3R2.

Interacts with CHP1, CHP2 and SHANK2.

Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity).

Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels.

Interacts with AHCYL1; the interaction is required for SLC9A3 activity (PubMed:18829453, PubMed:20584908).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112440, 14 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P48764

Protein interaction database and analysis system

More...IntActi		P48764, 1 interactor

Molecular INTeraction database

More...MINTi		P48764

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000264938

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P48764

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P48764, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P48764

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni590 – 667Interaction with PDZD3By similarityAdd BLAST78
Regioni679 – 728DisorderedSequence analysisAdd BLAST50
Regioni814 – 834DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1966, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158616

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005912_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P48764

Identification of Orthologs from Complete Genome Data

More...OMAi		MVQLELI

Database of Orthologous Groups

More...OrthoDBi		389547at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P48764

TreeFam database of animal gene trees

More...TreeFami		TF317212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR018410, Na/H_exchanger_3/5
IPR004709, NaH_exchanger

The PANTHER Classification System

More...PANTHERi		PTHR10110, PTHR10110, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01084, NAHEXCHNGR
PR01087, NAHEXCHNGR3

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00840, b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P48764-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWGLGARGPD RGLLLALALG GLARAGGVEV EPGGAHGESG GFQVVTFEWA 
        60         70         80         90        100
HVQDPYVIAL WILVASLAKI GFHLSHKVTS VVPESALLIV LGLVLGGIVW 
       110        120        130        140        150
AADHIASFTL TPTVFFFYLL PPIVLDAGYF MPNRLFFGNL GTILLYAVVG 
       160        170        180        190        200
TVWNAATTGL SLYGVFLSGL MGDLQIGLLD FLLFGSLMAA VDPVAVLAVF 
       210        220        230        240        250
EEVHVNEVLF IIVFGESLLN DAVTVVLYNV FESFVALGGD NVTGVDCVKG 
       260        270        280        290        300
IVSFFVVSLG GTLVGVVFAF LLSLVTRFTK HVRIIEPGFV FIISYLSYLT 
       310        320        330        340        350
SEMLSLSAIL AITFCGICCQ KYVKANISEQ SATTVRYTMK MLASSAETII 
       360        370        380        390        400
FMFLGISAVN PFIWTWNTAF VLLTLVFISV YRAIGVVLQT WLLNRYRMVQ 
       410        420        430        440        450
LEPIDQVVLS YGGLRGAVAF ALVVLLDGDK VKEKNLFVST TIIVVFFTVI 
       460        470        480        490        500
FQGLTIKPLV QWLKVKRSEH REPRLNEKLH GRAFDHILSA IEDISGQIGH 
       510        520        530        540        550
NYLRDKWSHF DRKFLSRVLM RRSAQKSRDR ILNVFHELNL KDAISYVAEG 
       560        570        580        590        600
ERRGSLAFIR SPSTDNVVNV DFTPRSSTVE ASVSYLLREN VSAVCLDMQS 
       610        620        630        640        650
LEQRRRSIRD AEDMVTHHTL QQYLYKPRQE YKHLYSRHEL TPTEDEKQDR 
       660        670        680        690        700
EIFHRTMRKR LESFKSTKLG LNQNKKAAKL YKRERAQKRR NSSIPNGKLP 
       710        720        730        740        750
MESPAQNFTI KEKDLELSDT EEPPNYDEEM SGGIEFLASV TKDTASDSPA 
       760        770        780        790        800
GIDNPVFSPD EALDRSLLAR LPPWLSPGET VVPSQRARTQ IPYSPGTFCR 
       810        820        830 
LMPFRLSSKS VDSFLQADGP EERPPAALPE STHM
Length:834
Mass (Da):92,855
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E7CE3267F6E86F7
GO
Isoform 2 (identifier: P48764-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     452-460: Missing.

Show »
Length:825
Mass (Da):91,904
Checksum:iAEFBDB9089FC18C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y780A0A2R8Y780_HUMAN
Sodium/hydrogen exchanger
SLC9A3
889Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQZ3A0A0G2JQZ3_HUMAN
Sodium/hydrogen exchanger 3
SLC9A3
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076419127A → T in DIAR8; unknown pathological significance; does not affect cell membrane localization; reduces weakly Na(+)/H(+) exchange activity. 1 PublicationCorresponds to variant dbSNP:rs1047334552Ensembl.1
Natural variantiVAR_076420269A → T in DIAR8; decreases cell membrane expression; reduces Na(+)/H(+) exchange activity. 1 PublicationCorresponds to variant dbSNP:rs869312807EnsemblClinVar.1
Natural variantiVAR_076421311A → V in DIAR8; decreases cell membrane expression; reduces strongly Na(+)/H(+) exchange activity. 1 PublicationCorresponds to variant dbSNP:rs869312806EnsemblClinVar.1
Natural variantiVAR_076422382R → Q in DIAR8; decreases cell membrane localization; reduces strongly Na(+)/H(+) exchange activity. 1 PublicationCorresponds to variant dbSNP:rs766076524EnsemblClinVar.1
Natural variantiVAR_060593799C → R2 PublicationsCorresponds to variant dbSNP:rs2247114Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053989452 – 460Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U28043 mRNA Translation: AAB48990.1
AC010442 Genomic DNA No translation available.
AC106772 Genomic DNA No translation available.
BC101669 mRNA Translation: AAI01670.1
BC101671 mRNA Translation: AAI01672.1
BC143328 mRNA Translation: AAI43329.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3855.1 [P48764-1]
CCDS64116.1 [P48764-2]

Protein sequence database of the Protein Information Resource

More...PIRi		B40205

NCBI Reference Sequences

More...RefSeqi		NP_001271280.1, NM_001284351.2 [P48764-2]
NP_004165.2, NM_004174.3 [P48764-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264938; ENSP00000264938; ENSG00000066230
ENST00000514375; ENSP00000422983; ENSG00000066230 [P48764-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6550

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6550

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000264938.8; ENSP00000264938.3; NM_004174.4; NP_004165.2

UCSC genome browser

More...UCSCi		uc003jbe.3, human [P48764-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28043 mRNA Translation: AAB48990.1
AC010442 Genomic DNA No translation available.
AC106772 Genomic DNA No translation available.
BC101669 mRNA Translation: AAI01670.1
BC101671 mRNA Translation: AAI01672.1
BC143328 mRNA Translation: AAI43329.1
CCDSiCCDS3855.1 [P48764-1]
CCDS64116.1 [P48764-2]
PIRiB40205
RefSeqiNP_001271280.1, NM_001284351.2 [P48764-2]
NP_004165.2, NM_004174.3 [P48764-1]

3D structure databases

SMRiP48764
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112440, 14 interactors
CORUMiP48764
IntActiP48764, 1 interactor
MINTiP48764
STRINGi9606.ENSP00000264938

Chemistry databases

BindingDBiP48764
ChEMBLiCHEMBL3273
DrugBankiDB11761, Tenapanor
DrugCentraliP48764

Protein family/group databases

TCDBi2.A.36.1.15, the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

GlyGeniP48764, 2 sites
iPTMnetiP48764
PhosphoSitePlusiP48764

Genetic variation databases

BioMutaiSLC9A3
DMDMi269849652

Proteomic databases

jPOSTiP48764
MassIVEiP48764
PaxDbiP48764
PeptideAtlasiP48764
PRIDEiP48764
ProteomicsDBi20040
55946 [P48764-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22241, 317 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		6550

Genome annotation databases

EnsembliENST00000264938; ENSP00000264938; ENSG00000066230
ENST00000514375; ENSP00000422983; ENSG00000066230 [P48764-2]
GeneIDi6550
KEGGihsa:6550
MANE-SelectiENST00000264938.8; ENSP00000264938.3; NM_004174.4; NP_004165.2
UCSCiuc003jbe.3, human [P48764-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6550
DisGeNETi6550

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC9A3
HGNCiHGNC:11073, SLC9A3
HPAiENSG00000066230, Tissue enhanced (gallbladder, intestine, kidney, stomach)
MalaCardsiSLC9A3
MIMi182307, gene
616868, phenotype
neXtProtiNX_P48764
OpenTargetsiENSG00000066230
Orphaneti103908, Congenital sodium diarrhea
586, Cystic fibrosis
PharmGKBiPA316
VEuPathDBiHostDB:ENSG00000066230

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1966, Eukaryota
GeneTreeiENSGT00940000158616
HOGENOMiCLU_005912_4_2_1
InParanoidiP48764
OMAiMVQLELI
OrthoDBi389547at2759
PhylomeDBiP48764
TreeFamiTF317212

Enzyme and pathway databases

PathwayCommonsiP48764
ReactomeiR-HSA-425986, Sodium/Proton exchangers
SignaLinkiP48764
SIGNORiP48764

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6550, 12 hits in 1036 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Sodium%E2%80%93hydrogen_antiporter_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6550
PharosiP48764, Tclin

Protein Ontology

More...PROi		PR:P48764
RNActiP48764, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000066230, Expressed in cortex of kidney and 109 other tissues
ExpressionAtlasiP48764, baseline and differential
GenevisibleiP48764, HS

Family and domain databases

InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR018410, Na/H_exchanger_3/5
IPR004709, NaH_exchanger
PANTHERiPTHR10110, PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PRINTSiPR01084, NAHEXCHNGR
PR01087, NAHEXCHNGR3
TIGRFAMsiTIGR00840, b_cpa1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48764
Secondary accession number(s): B7ZKR2, E9PF67, Q3MIW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 24, 2009
Last modified: February 23, 2022
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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