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Protein

Sodium/hydrogen exchanger 2

Gene

Slc9a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated
PubMed:8595899 sequence was originally thought to originate from human.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • potassium:proton antiporter activity Source: GO_Central
  • sodium:proton antiporter activity Source: RGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-425986 Sodium/Proton exchangers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 2
Alternative name(s):
H7
Na(+)/H(+) exchanger 2
Short name:
NHE-2
Solute carrier family 9 member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc9a2
Synonyms:Nhe2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Rat genome database

More...
RGDi
3719 Slc9a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei14 – 34Name=A/M1Sequence analysisAdd BLAST21
Topological domaini35 – 80CytoplasmicSequence analysisAdd BLAST46
Intramembranei81 – 101Name=B/M2Sequence analysisAdd BLAST21
Topological domaini102 – 107CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei108 – 128Helical; Name=C/M3Sequence analysisAdd BLAST21
Topological domaini129 – 139ExtracellularSequence analysisAdd BLAST11
Transmembranei140 – 160Helical; Name=D/M4Sequence analysisAdd BLAST21
Topological domaini161 – 169CytoplasmicSequence analysis9
Transmembranei170 – 190Helical; Name=E/M5Sequence analysisAdd BLAST21
Topological domaini191 – 209ExtracellularSequence analysisAdd BLAST19
Transmembranei210 – 230Helical; Name=F/M5ASequence analysisAdd BLAST21
Topological domaini231 – 237CytoplasmicSequence analysis7
Transmembranei238 – 258Helical; Name=G/M5BSequence analysisAdd BLAST21
Topological domaini259 – 278ExtracellularSequence analysisAdd BLAST20
Transmembranei279 – 299Helical; Name=H/M6Sequence analysisAdd BLAST21
Topological domaini300 – 308CytoplasmicSequence analysis9
Transmembranei309 – 329Helical; Name=I/M7Sequence analysisAdd BLAST21
Topological domaini330 – 361ExtracellularSequence analysisAdd BLAST32
Transmembranei362 – 382Helical; Name=J/M8Sequence analysisAdd BLAST21
Topological domaini383 – 392CytoplasmicSequence analysis10
Transmembranei393 – 413Helical; Name=K/M9Sequence analysisAdd BLAST21
Topological domaini414 – 430ExtracellularSequence analysisAdd BLAST17
Intramembranei431 – 451Name=LSequence analysisAdd BLAST21
Topological domaini452 – 459ExtracellularSequence analysis8
Transmembranei460 – 480Helical; Name=M13Sequence analysisAdd BLAST21
Topological domaini481 – 813CytoplasmicSequence analysisAdd BLAST333

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3886122

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523541 – 813Sodium/hydrogen exchanger 2Add BLAST813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated (Possible).

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48763

PRoteomics IDEntifications database

More...
PRIDEi
P48763

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48763

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48763

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly in small intestine, colon, and stomach, with much lower levels in skeletal muscle, kidney, brain, testis, uterus, heart and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000015567 Expressed in 7 organ(s), highest expression level in colon

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P48763 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHP1 and CHP2.1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P48763, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000021270

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P48763

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P48763

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1966 Eukaryota
COG0025 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156807

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247044

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052615

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48763

KEGG Orthology (KO)

More...
KOi
K14722

Identification of Orthologs from Complete Genome Data

More...
OMAi
AYKMEWK

Database of Orthologous Groups

More...
OrthoDBi
316731at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48763

TreeFam database of animal gene trees

More...
TreeFami
TF317212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR001953 Na/H_exchanger_2
IPR004709 NaH_exchanger
IPR032103 NHE_CaM-bd

The PANTHER Classification System

More...
PANTHERi
PTHR10110 PTHR10110, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF16644 NEXCaM_BD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01084 NAHEXCHNGR
PR01086 NAHEXCHNGR2

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00840 b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: P48763-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPSGTAHRM RAPLSWLLLL LLSLQVAVPA GALAETLLDA PGARGASSNP
60 70 80 90 100
PSPASVVAPG TTPFEESRLP VFTLDYPHVQ IPFEITLWIL LASLAKIGFH
110 120 130 140 150
LYHKLPTIVP ESCLLIMVGL LLGGIIFGVD EKSPPAMKTD VFFLYLLPPI
160 170 180 190 200
VLDAGYFMPT RPFFENLGTI FWYAVVGTLW NSIGIGLSLF GICQIEAFGL
210 220 230 240 250
SDITLLQNLL FGSLISAVDP VAVLAVFENI HVNEQLYILV FGESLLNDAV
260 270 280 290 300
TVVLYNLFKS FCQMKTIQTV DVFAGIANFF VVGIGGVLIG ILLGFIAAFT
310 320 330 340 350
TRFTHNIRVI EPLFVFLYSY LSYITAEMFH LSGIMAITAC AMTMNKYVEE
360 370 380 390 400
NVSQKSYTTI KYFMKMLSSV SETLIFIFMG VSTVGKNHEW NWAFVCFTLA
410 420 430 440 450
FCLIWRALGV FVLTQVINWF RTIPLTFKDQ FIIAYGGLRG AICFALVFLL
460 470 480 490 500
PATVFPRKKL FITAAIVVIF FTVFILGITI RPLVEFLDVK RSNKKQQAVS
510 520 530 540 550
EEIHCRFFDH VKTGIEDVCG HWGHNFWRDK FKKFDDKYLR KLLIRENQPK
560 570 580 590 600
SSIVSLYKKL EIKHAIEMAE TGMISTVPSF ASLNDCREEK IRKLTPGEMD
610 620 630 640 650
EIREILSRNL YQIRQRTLSY NRHNLTADTS ERQAKEILIR RRHSLRESLR
660 670 680 690 700
KDNSLNRERR ASTSTSRYLS LPKNTKLPEK LQKKNKVSNA DGNSSDSDMD
710 720 730 740 750
GTTVLNLQPR ARRFLPDQFS KKASPAYKME WKNEVDVGSA RAPPSVTPAP
760 770 780 790 800
RSKEGGTQTP GVLRQPLLSK DQRFGRGRED SLTEDVPPKP PPRLVRRASE
810
PGNRKGRLGN EKP
Length:813
Mass (Da):91,403
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29727267D7085845
GO
Isoform Short (identifier: P48763-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Show »
Length:697
Mass (Da):79,063
Checksum:iDD5C1A503CAE9ACE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti504H → HW in AAB36180 (PubMed:8595899).Curated1
Sequence conflicti610 – 616LYQIRQR → SLSNPPA in AAB36180 (PubMed:8595899).Curated7
Sequence conflicti742A → P in AAB36180 (PubMed:8595899).Curated1
Sequence conflicti786V → G in AAA75406 (PubMed:7683411).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0033941 – 116Missing in isoform Short. 2 PublicationsAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L11236 mRNA Translation: AAA72350.1
L11004 mRNA Translation: AAA75406.1
S81591 mRNA Translation: AAB36180.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A46748
A57644

NCBI Reference Sequences

More...
RefSeqi
NP_001106806.1, NM_001113335.1 [P48763-1]
NP_036785.2, NM_012653.2 [P48763-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.11047

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000021270; ENSRNOP00000021270; ENSRNOG00000015567 [P48763-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:24783

UCSC genome browser

More...
UCSCi
RGD:3719 rat [P48763-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11236 mRNA Translation: AAA72350.1
L11004 mRNA Translation: AAA75406.1
S81591 mRNA Translation: AAB36180.1
PIRiA46748
A57644
RefSeqiNP_001106806.1, NM_001113335.1 [P48763-1]
NP_036785.2, NM_012653.2 [P48763-2]
UniGeneiRn.11047

3D structure databases

ProteinModelPortaliP48763
SMRiP48763
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP48763, 2 interactors
STRINGi10116.ENSRNOP00000021270

Chemistry databases

ChEMBLiCHEMBL3886122

PTM databases

iPTMnetiP48763
PhosphoSitePlusiP48763

Proteomic databases

PaxDbiP48763
PRIDEiP48763

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021270; ENSRNOP00000021270; ENSRNOG00000015567 [P48763-1]
GeneIDi24783
KEGGirno:24783
UCSCiRGD:3719 rat [P48763-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6549
RGDi3719 Slc9a2

Phylogenomic databases

eggNOGiKOG1966 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00940000156807
HOGENOMiHOG000247044
HOVERGENiHBG052615
InParanoidiP48763
KOiK14722
OMAiAYKMEWK
OrthoDBi316731at2759
PhylomeDBiP48763
TreeFamiTF317212

Enzyme and pathway databases

ReactomeiR-RNO-425986 Sodium/Proton exchangers

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P48763

Gene expression databases

BgeeiENSRNOG00000015567 Expressed in 7 organ(s), highest expression level in colon
GenevisibleiP48763 RN

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR001953 Na/H_exchanger_2
IPR004709 NaH_exchanger
IPR032103 NHE_CaM-bd
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PF16644 NEXCaM_BD, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01086 NAHEXCHNGR2
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A2_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48763
Secondary accession number(s): Q16434
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 16, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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