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Protein

Gastrin

Gene

Gast

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

GO - Molecular functioni

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: MGI
  • response to food Source: GO_Central
  • signal transduction Source: MGI

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-881907 Gastrin-CREB signalling pathway via PKC and MAPK

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin
Cleaved into the following 3 chains:
Gastrin-71
Short name:
G71
Alternative name(s):
Gastrin-34
Short name:
G34
Gene namesi
Name:Gast
Synonyms:Gas
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104768 Gast

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PeptideiPRO_000001064022 – 92Gastrin-71Add BLAST71
PeptideiPRO_000001064159 – 92Big gastrinAdd BLAST34
PeptideiPRO_000001064276 – 92GastrinAdd BLAST17
PropeptideiPRO_000001064396 – 101By similarity6

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87SulfotyrosineBy similarity1
Modified residuei92Phenylalanine amideBy similarity1
Modified residuei96PhosphoserineBy similarity1

Post-translational modificationi

Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins and between tissues (By similarity).By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP48757
PRIDEiP48757

PTM databases

PhosphoSitePlusiP48757

Expressioni

Tissue specificityi

Abundantly expressed in the stomach and duodenum. Low levels in brain, ovary and pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000017165 Expressed in 62 organ(s), highest expression level in pyloric antrum
CleanExiMM_GAST
GenevisibleiP48757 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017309

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ZA Eukaryota
ENOG4111D7Y LUCA
GeneTreeiENSGT00390000014792
HOGENOMiHOG000073533
HOVERGENiHBG097593
InParanoidiP48757
KOiK13768
OMAiKKQGPWM
OrthoDBiEOG091G147Z
TreeFamiTF336994

Family and domain databases

InterProiView protein in InterPro
IPR039236 GAST
IPR001651 Gastrin/CCK
IPR013152 Gastrin/cholecystokinin_CS
PANTHERiPTHR19309 PTHR19309, 1 hit
PfamiView protein in Pfam
PF00918 Gastrin, 1 hit
PROSITEiView protein in PROSITE
PS00259 GASTRIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48757-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRLCVYMLV LVLALATFSE ASWKPRSQLQ DASSGPGTNE DLEQRQFNKL
60 70 80 90 100
GSASHHRRQL GPQGPQHFIA DLSKKQRPRM EEEEEAYGWM DFGRRSAEED

Q
Length:101
Mass (Da):11,590
Last modified:October 3, 2012 - v2
Checksum:i41DE15814DBFB68E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45R → G in AAB06947 (PubMed:7492958).Curated1
Sequence conflicti62P → L in AAB97872 (PubMed:7488110).Curated1
Sequence conflicti62P → L in AAB06947 (PubMed:7492958).Curated1
Sequence conflicti62P → L in CAA64385 (PubMed:8647266).Curated1
Sequence conflicti62P → L in CAA64386 (PubMed:8647266).Curated1
Sequence conflicti76Q → E in AAB97872 (PubMed:7488110).Curated1
Sequence conflicti76Q → E in AAB06947 (PubMed:7492958).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34293 Genomic DNA Translation: AAB97872.1
U58136 Genomic DNA Translation: AAB06947.1
X94760 Genomic DNA Translation: CAA64386.1
X94758 mRNA Translation: CAA64385.1
AK008062 mRNA Translation: BAB25437.1
AK008159 mRNA Translation: BAB25501.1
AK008313 mRNA Translation: BAB25596.1
AK008420 mRNA Translation: BAB25658.1
AK008494 mRNA Translation: BAB25699.1
AK008649 mRNA Translation: BAB25807.1
AL590968 Genomic DNA Translation: CAM23027.1
CCDSiCCDS25418.1
PIRiS68861
RefSeqiNP_034387.3, NM_010257.4
UniGeneiMm.4767

Genome annotation databases

EnsembliENSMUST00000017309; ENSMUSP00000017309; ENSMUSG00000017165
GeneIDi14459
KEGGimmu:14459
UCSCiuc007lkw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34293 Genomic DNA Translation: AAB97872.1
U58136 Genomic DNA Translation: AAB06947.1
X94760 Genomic DNA Translation: CAA64386.1
X94758 mRNA Translation: CAA64385.1
AK008062 mRNA Translation: BAB25437.1
AK008159 mRNA Translation: BAB25501.1
AK008313 mRNA Translation: BAB25596.1
AK008420 mRNA Translation: BAB25658.1
AK008494 mRNA Translation: BAB25699.1
AK008649 mRNA Translation: BAB25807.1
AL590968 Genomic DNA Translation: CAM23027.1
CCDSiCCDS25418.1
PIRiS68861
RefSeqiNP_034387.3, NM_010257.4
UniGeneiMm.4767

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017309

PTM databases

PhosphoSitePlusiP48757

Proteomic databases

PaxDbiP48757
PRIDEiP48757

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017309; ENSMUSP00000017309; ENSMUSG00000017165
GeneIDi14459
KEGGimmu:14459
UCSCiuc007lkw.2 mouse

Organism-specific databases

CTDi2520
MGIiMGI:104768 Gast

Phylogenomic databases

eggNOGiENOG410J1ZA Eukaryota
ENOG4111D7Y LUCA
GeneTreeiENSGT00390000014792
HOGENOMiHOG000073533
HOVERGENiHBG097593
InParanoidiP48757
KOiK13768
OMAiKKQGPWM
OrthoDBiEOG091G147Z
TreeFamiTF336994

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-881907 Gastrin-CREB signalling pathway via PKC and MAPK

Miscellaneous databases

PROiPR:P48757
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017165 Expressed in 62 organ(s), highest expression level in pyloric antrum
CleanExiMM_GAST
GenevisibleiP48757 MM

Family and domain databases

InterProiView protein in InterPro
IPR039236 GAST
IPR001651 Gastrin/CCK
IPR013152 Gastrin/cholecystokinin_CS
PANTHERiPTHR19309 PTHR19309, 1 hit
PfamiView protein in Pfam
PF00918 Gastrin, 1 hit
PROSITEiView protein in PROSITE
PS00259 GASTRIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGAST_MOUSE
AccessioniPrimary (citable) accession number: P48757
Secondary accession number(s): P70334, Q64295, Q9CPR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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