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Protein

Gastric inhibitory polypeptide

Gene

Gip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
R-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide
Short name:
GIP
Alternative name(s):
Glucose-dependent insulinotropic polypeptide
Gene namesi
Name:Gip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107504 Gip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PropeptideiPRO_000001121722 – 42Add BLAST21
PeptideiPRO_000001121844 – 85Gastric inhibitory polypeptideAdd BLAST42
PropeptideiPRO_000001121987 – 144Add BLAST58

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP48756
PeptideAtlasiP48756
PRIDEiP48756

PTM databases

PhosphoSitePlusiP48756

Expressioni

Gene expression databases

BgeeiENSMUSG00000014351 Expressed in 62 organ(s), highest expression level in jejunum
CleanExiMM_GIP
GenevisibleiP48756 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099445

Structurei

3D structure databases

ProteinModelPortaliP48756
SMRiP48756
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucagon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JC1A Eukaryota
ENOG4111BXQ LUCA
GeneTreeiENSGT00390000005121
HOGENOMiHOG000112725
HOVERGENiHBG005839
InParanoidiP48756
KOiK05258
OMAiMDKIHQQ
OrthoDBiEOG091G153X
TreeFamiTF332333

Family and domain databases

InterProiView protein in InterPro
IPR039078 GIP
IPR000532 Glucagon_GIP_secretin_VIP
PANTHERiPTHR15211 PTHR15211, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48756-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVALKTCSLL LVLLFLAVGL GEKEEVEFRS HAKFAGPRPR GPRYAEGTFI
60 70 80 90 100
SDYSIAMDKI RQQDFVNWLL AQRGKKSDWK HNITQREARA LVLAGQSQGK
110 120 130 140
EDKEAQESSL PKSLSDDDVL RDLLIQELLA WMVDQTELCR LRSQ
Length:144
Mass (Da):16,389
Last modified:October 3, 2012 - v2
Checksum:i36E618665D4DA8C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136T → A in AAC52731 (PubMed:8764827).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34295 mRNA Translation: AAC52731.1
AK008308 mRNA Translation: BAB25592.1
AL603682 Genomic DNA Translation: CAM18267.1
CH466556 Genomic DNA Translation: EDL16005.1
CCDSiCCDS25287.1
PIRiS71426
RefSeqiNP_032145.2, NM_008119.2
XP_006532287.1, XM_006532224.3
XP_006532288.1, XM_006532225.3
UniGeneiMm.248452

Genome annotation databases

EnsembliENSMUST00000103156; ENSMUSP00000099445; ENSMUSG00000014351
ENSMUST00000103157; ENSMUSP00000099446; ENSMUSG00000014351
GeneIDi14607
KEGGimmu:14607
UCSCiuc007lba.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34295 mRNA Translation: AAC52731.1
AK008308 mRNA Translation: BAB25592.1
AL603682 Genomic DNA Translation: CAM18267.1
CH466556 Genomic DNA Translation: EDL16005.1
CCDSiCCDS25287.1
PIRiS71426
RefSeqiNP_032145.2, NM_008119.2
XP_006532287.1, XM_006532224.3
XP_006532288.1, XM_006532225.3
UniGeneiMm.248452

3D structure databases

ProteinModelPortaliP48756
SMRiP48756
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099445

PTM databases

PhosphoSitePlusiP48756

Proteomic databases

PaxDbiP48756
PeptideAtlasiP48756
PRIDEiP48756

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103156; ENSMUSP00000099445; ENSMUSG00000014351
ENSMUST00000103157; ENSMUSP00000099446; ENSMUSG00000014351
GeneIDi14607
KEGGimmu:14607
UCSCiuc007lba.1 mouse

Organism-specific databases

CTDi2695
MGIiMGI:107504 Gip

Phylogenomic databases

eggNOGiENOG410JC1A Eukaryota
ENOG4111BXQ LUCA
GeneTreeiENSGT00390000005121
HOGENOMiHOG000112725
HOVERGENiHBG005839
InParanoidiP48756
KOiK05258
OMAiMDKIHQQ
OrthoDBiEOG091G153X
TreeFamiTF332333

Enzyme and pathway databases

ReactomeiR-MMU-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
R-MMU-418555 G alpha (s) signalling events
R-MMU-420092 Glucagon-type ligand receptors

Miscellaneous databases

PROiPR:P48756
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014351 Expressed in 62 organ(s), highest expression level in jejunum
CleanExiMM_GIP
GenevisibleiP48756 MM

Family and domain databases

InterProiView protein in InterPro
IPR039078 GIP
IPR000532 Glucagon_GIP_secretin_VIP
PANTHERiPTHR15211 PTHR15211, 1 hit
PfamiView protein in Pfam
PF00123 Hormone_2, 1 hit
SMARTiView protein in SMART
SM00070 GLUCA, 1 hit
PROSITEiView protein in PROSITE
PS00260 GLUCAGON, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGIP_MOUSE
AccessioniPrimary (citable) accession number: P48756
Secondary accession number(s): Q9D887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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