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Protein

Anion exchange protein 3

Gene

SLC4A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl-/HCO3- exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl-.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAnion exchange, Antiport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-425381 Bicarbonate transporters
SIGNORiP48751

Protein family/group databases

TCDBi2.A.31.1.3 the anion exchanger (ae) family

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 3
Short name:
AE 3
Short name:
Anion exchanger 3
Alternative name(s):
CAE3/BAE3
Cardiac/brain band 3-like protein
Neuronal band 3-like protein
Solute carrier family 4 member 3
Gene namesi
Name:SLC4A3
Synonyms:AE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000114923.16
HGNCiHGNC:11029 SLC4A3
MIMi106195 gene
neXtProtiNX_P48751

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 708CytoplasmicAdd BLAST708
Transmembranei709 – 731HelicalSequence analysisAdd BLAST23
Transmembranei737 – 774HelicalSequence analysisAdd BLAST38
Transmembranei794 – 816HelicalSequence analysisAdd BLAST23
Transmembranei826 – 847HelicalSequence analysisAdd BLAST22
Transmembranei893 – 910HelicalSequence analysisAdd BLAST18
Topological domaini911 – 925CytoplasmicSequence analysisAdd BLAST15
Transmembranei926 – 946HelicalSequence analysisAdd BLAST21
Transmembranei980 – 1002HelicalSequence analysisAdd BLAST23
Transmembranei1028 – 1049HelicalSequence analysisAdd BLAST22
Transmembranei1083 – 1128HelicalSequence analysisAdd BLAST46
Transmembranei1155 – 1191HelicalSequence analysisAdd BLAST37

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6508
OpenTargetsiENSG00000114923
PharmGKBiPA35897

Polymorphism and mutation databases

BioMutaiSLC4A3
DMDMi308153414

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792191 – 1232Anion exchange protein 3Add BLAST1232

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineBy similarity1
Modified residuei170PhosphoserineBy similarity1
Modified residuei175PhosphoserineBy similarity1
Modified residuei198PhosphoserineBy similarity1
Modified residuei295Omega-N-methylarginineBy similarity1
Lipidationi1165S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP48751
PaxDbiP48751
PeptideAtlasiP48751
PRIDEiP48751
ProteomicsDBi55943
55944 [P48751-2]
55945 [P48751-3]

PTM databases

iPTMnetiP48751
PhosphoSitePlusiP48751

Expressioni

Tissue specificityi

Both BAE3 and CAE3 are expressed in failing ventricle.

Gene expression databases

BgeeiENSG00000114923
CleanExiHS_SLC4A3
ExpressionAtlasiP48751 baseline and differential
GenevisibleiP48751 HS

Organism-specific databases

HPAiHPA063498

Interactioni

Protein-protein interaction databases

BioGridi112399, 1 interactor
STRINGi9606.ENSP00000273063

Structurei

3D structure databases

ProteinModelPortaliP48751
SMRiP48751
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni709 – 1232Membrane (anion exchange)Add BLAST524

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 149Poly-GluAdd BLAST14
Compositional biasi152 – 161Pro-rich10
Compositional biasi202 – 207Poly-Ser6
Compositional biasi308 – 313Poly-Lys6
Compositional biasi442 – 445Poly-Ser4
Compositional biasi1184 – 1187Poly-Leu4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00760000119021
HOGENOMiHOG000280683
HOVERGENiHBG004326
InParanoidiP48751
KOiK13856
OMAiPAPLWPH
OrthoDBiEOG091G01FT
PhylomeDBiP48751
TreeFamiTF313630

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR001717 Anion_exchange
IPR002979 Anion_exchange_3
IPR018241 Anion_exchange_CS
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PTHR11453:SF15 PTHR11453:SF15, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 2 hits
PRINTSiPR00165 ANIONEXCHNGR
PR01189 ANIONEXHNGR3
PR01231 HCO3TRNSPORT
SUPFAMiSSF55804 SSF55804, 2 hits
TIGRFAMsiTIGR00834 ae, 1 hit
PROSITEiView protein in PROSITE
PS00219 ANION_EXCHANGER_1, 1 hit
PS00220 ANION_EXCHANGER_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform BAE3 (identifier: P48751-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL
60 70 80 90 100
ISKPPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP
110 120 130 140 150
TSARHTRRKR KKEKTSAPPS EGTPPIQEEG GAGVDEEEEE EEEEEGESEA
160 170 180 190 200
EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG RAAVTKPLPS VGPHTDKSPQ
210 220 230 240 250
HSSSSPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA LGNPGGPEQQ
260 270 280 290 300
VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG
310 320 330 340 350
LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED
360 370 380 390 400
VEEETERWGK PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV
410 420 430 440 450
ETMIVSDQIR PEDRASVLRT LLLKHSHPND DKDSGFFPRN PSSSSMNSVL
460 470 480 490 500
GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP HDPDAKEKPL HMPGGDGHRG
510 520 530 540 550
KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV LLESVLEVPV
560 570 580 590 600
PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA
610 620 630 640 650
ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG
660 670 680 690 700
GYTAPGKELS LELGGSEATP EDDPLLRTGS VFGGLVRDVR RRYPHYPSDL
710 720 730 740 750
RDALHSQCVA AVLFIYFAAL SPAITFGGLL GEKTEGLMGV SELIVSTAVL
760 770 780 790 800
GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK FCRAQDLEYL TGRVWVGLWL
810 820 830 840 850
VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF YKLYKVFTEH
860 870 880 890 900
PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQP NTALLSLILM
910 920 930 940 950
LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY
960 970 980 990 1000
TQKLTVPTGL SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI
1010 1020 1030 1040 1050
FMETQITALI VSQKARRLLK GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT
1060 1070 1080 1090 1100
VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE QRVTGVLIAS LVGLSIVMGA
1110 1120 1130 1140 1150
VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH HPEQPYVTKV
1160 1170 1180 1190 1200
KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF
1210 1220 1230
QDRELQALDS EDAEPNFDED GQDEYNELHM PV
Length:1,232
Mass (Da):135,791
Last modified:October 5, 2010 - v2
Checksum:iBA0B360E9D30030A
GO
Isoform CAE3 (identifier: P48751-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-296: Missing.
     297-299: SPS → MPA

Show »
Length:936
Mass (Da):103,737
Checksum:i0C028134284DD31B
GO
Isoform 3 (identifier: P48751-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-203: S → SRPCSELRDGDGTTDLALSSPRLLCCLP

Show »
Length:1,259
Mass (Da):138,662
Checksum:iC175EF6C771E31A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118P → S in AAI46657 (PubMed:15489334).Curated1
Sequence conflicti243N → S in AAI71760 (PubMed:15489334).Curated1
Sequence conflicti250Q → H in AAI46657 (PubMed:15489334).Curated1
Sequence conflicti304I → V in AAB05850 (Ref. 2) Curated1
Sequence conflicti343R → P in AAB05850 (Ref. 2) Curated1
Sequence conflicti466P → S in AAB05850 (Ref. 2) Curated1
Sequence conflicti590Q → K in AAN34939 (Ref. 3) Curated1
Sequence conflicti608S → G in AAB05850 (Ref. 2) Curated1
Sequence conflicti702D → A in AAB05850 (Ref. 2) Curated1
Sequence conflicti812 – 813GS → FI in AAB05850 (Ref. 2) Curated2
Sequence conflicti822F → L in AAB05850 (Ref. 2) Curated1
Sequence conflicti850H → R in AAN34939 (Ref. 3) Curated1
Sequence conflicti860 – 863Missing in AAB05850 (Ref. 2) Curated4
Sequence conflicti875S → C in AAB05850 (Ref. 2) Curated1
Sequence conflicti885 – 887SPR → GPE in AAB05850 (Ref. 2) Curated3
Sequence conflicti899L → P in AAB05850 (Ref. 2) Curated1
Sequence conflicti953K → N in BAF82663 (PubMed:14702039).Curated1
Sequence conflicti983P → L in AAI71760 (PubMed:15489334).Curated1
Sequence conflicti1052R → H in BAF82663 (PubMed:14702039).Curated1
Sequence conflicti1054V → I in AAN34939 (Ref. 3) Curated1
Sequence conflicti1096I → M in AAB05850 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059081157H → P5 PublicationsCorresponds to variant dbSNP:rs597306Ensembl.1
Natural variantiVAR_055536226S → L. Corresponds to variant dbSNP:rs36068948Ensembl.1
Natural variantiVAR_059082867D → A4 PublicationsCorresponds to variant dbSNP:rs635311Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0004621 – 296Missing in isoform CAE3. 1 PublicationAdd BLAST296
Alternative sequenceiVSP_038184203S → SRPCSELRDGDGTTDLALSS PRLLCCLP in isoform 3. 1 Publication1
Alternative sequenceiVSP_000463297 – 299SPS → MPA in isoform CAE3. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05596 mRNA Translation: AAA50748.1
L27213 mRNA Translation: AAB05850.1
AY142112 mRNA Translation: AAN34939.1
AK289974 mRNA Translation: BAF82663.1
AC009955 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70778.1
BC136384 mRNA Translation: AAI36385.1
BC146656 mRNA Translation: AAI46657.1
BC171760 mRNA Translation: AAI71760.1
CCDSiCCDS2445.1 [P48751-1]
CCDS2446.1 [P48751-3]
PIRiI38496
RefSeqiNP_001313488.1, NM_001326559.1
NP_005061.2, NM_005070.3
NP_963868.2, NM_201574.2
XP_005246846.1, XM_005246789.4 [P48751-3]
UniGeneiHs.1176
Hs.684906

Genome annotation databases

EnsembliENST00000273063; ENSP00000273063; ENSG00000114923 [P48751-3]
ENST00000317151; ENSP00000314006; ENSG00000114923 [P48751-1]
ENST00000358055; ENSP00000350756; ENSG00000114923 [P48751-1]
ENST00000373760; ENSP00000362865; ENSG00000114923 [P48751-1]
GeneIDi6508
KEGGihsa:6508
UCSCiuc002vmo.5 human [P48751-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiB3A3_HUMAN
AccessioniPrimary (citable) accession number: P48751
Secondary accession number(s): A6H8L2
, A8K1Q9, B7ZVX6, B9EGD1, Q6YIQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 5, 2010
Last modified: June 20, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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