UniProtKB - P48750 (CSF2_RAT)
Protein
Granulocyte-macrophage colony-stimulating factor
Gene
Csf2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.By similarity
GO - Molecular functioni
- cytokine activity Source: RGD
- granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: RGD
- cellular response to lipopolysaccharide Source: RGD
- dendritic cell differentiation Source: RGD
- embryonic placenta development Source: RGD
- epithelial cell proliferation Source: RGD
- epithelial fluid transport Source: RGD
- histamine secretion Source: RGD
- immune response Source: InterPro
- macrophage activation Source: RGD
- macrophage differentiation Source: RGD
- monocyte differentiation Source: RGD
- myeloid cell differentiation Source: GO_Central
- myeloid dendritic cell differentiation Source: RGD
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- neutrophil differentiation Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of interleukin-23 production Source: RGD
- positive regulation of macrophage derived foam cell differentiation Source: RGD
- positive regulation of macrophage differentiation Source: RGD
- positive regulation of podosome assembly Source: RGD
- positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
- regulation of cell population proliferation Source: RGD
- regulation of circadian sleep/wake cycle, sleep Source: RGD
- regulation of gene expression Source: RGD
- response to fluid shear stress Source: RGD
- response to silicon dioxide Source: RGD
Keywordsi
Molecular function | Cytokine, Growth factor |
Enzyme and pathway databases
Reactomei | R-RNO-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-RNO-5673001, RAF/MAP kinase cascade R-RNO-912526, Interleukin receptor SHC signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Granulocyte-macrophage colony-stimulating factorShort name: GM-CSF Alternative name(s): Colony-stimulating factor Short name: CSF |
Gene namesi | Name:Csf2 Synonyms:Csfgm |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621065, Csf2 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: RGD
Other locations
- intracellular membrane-bounded organelle Source: Ensembl
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | By similarityAdd BLAST | 17 | |
ChainiPRO_0000144833 | 18 – 144 | Granulocyte-macrophage colony-stimulating factorAdd BLAST | 127 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 22 | O-linked (GalNAc...) serineBy similarity | 1 | |
Glycosylationi | 27 | O-linked (GalNAc...) threonineBy similarity | 1 | |
Disulfide bondi | 71 ↔ 113 | By similarity | ||
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 105 ↔ 138 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P48750 |
PRIDEi | P48750 |
PTM databases
GlyGeni | P48750, 3 sites |
PhosphoSitePlusi | P48750 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000026805, Expressed in lung and 13 other tissues |
Genevisiblei | P48750, RN |
Interactioni
Subunit structurei
Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).
By similarityGO - Molecular functioni
- cytokine activity Source: RGD
- granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000034235 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GM-CSF family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TDUI, Eukaryota |
GeneTreei | ENSGT00390000013425 |
HOGENOMi | CLU_152286_0_0_1 |
InParanoidi | P48750 |
OMAi | VTRPWKH |
OrthoDBi | 1412355at2759 |
PhylomeDBi | P48750 |
TreeFami | TF338611 |
Family and domain databases
CDDi | cd00040, CSF2, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000773, GM_colony-stim-fac |
PANTHERi | PTHR10059, PTHR10059, 1 hit |
Pfami | View protein in Pfam PF01109, GM_CSF, 1 hit |
PRINTSi | PR00693, GMCSFACTOR |
SMARTi | View protein in SMART SM00040, CSF2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00702, GM_CSF, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P48750-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWLQNLLFLG IVVYSFSAPT RSPNPVTRPW KHVDAIKEAL SLLNDMRALE
60 70 80 90 100
NEKNEDVDII SNEFSIQRPT CVQTRLKLYK QGLRGNLTKL NGALTMIASH
110 120 130 140
YQTNCPPTPE TDCEIEVTTF EDFIKNLKGF LFDIPFDCWK PVQK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03075230 Genomic DNA No translation available. U00620 mRNA Translation: AAA18281.1 |
PIRi | I46269 |
RefSeqi | NP_446304.1, NM_053852.1 |
Genome annotation databases
Ensembli | ENSRNOT00000032333; ENSRNOP00000034235; ENSRNOG00000026805 |
GeneIDi | 116630 |
KEGGi | rno:116630 |
UCSCi | RGD:621065, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03075230 Genomic DNA No translation available. U00620 mRNA Translation: AAA18281.1 |
PIRi | I46269 |
RefSeqi | NP_446304.1, NM_053852.1 |
3D structure databases
SMRi | P48750 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000034235 |
PTM databases
GlyGeni | P48750, 3 sites |
PhosphoSitePlusi | P48750 |
Proteomic databases
PaxDbi | P48750 |
PRIDEi | P48750 |
Genome annotation databases
Ensembli | ENSRNOT00000032333; ENSRNOP00000034235; ENSRNOG00000026805 |
GeneIDi | 116630 |
KEGGi | rno:116630 |
UCSCi | RGD:621065, rat |
Organism-specific databases
CTDi | 1437 |
RGDi | 621065, Csf2 |
Phylogenomic databases
eggNOGi | ENOG502TDUI, Eukaryota |
GeneTreei | ENSGT00390000013425 |
HOGENOMi | CLU_152286_0_0_1 |
InParanoidi | P48750 |
OMAi | VTRPWKH |
OrthoDBi | 1412355at2759 |
PhylomeDBi | P48750 |
TreeFami | TF338611 |
Enzyme and pathway databases
Reactomei | R-RNO-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-RNO-5673001, RAF/MAP kinase cascade R-RNO-912526, Interleukin receptor SHC signaling |
Miscellaneous databases
PROi | PR:P48750 |
Gene expression databases
Bgeei | ENSRNOG00000026805, Expressed in lung and 13 other tissues |
Genevisiblei | P48750, RN |
Family and domain databases
CDDi | cd00040, CSF2, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000773, GM_colony-stim-fac |
PANTHERi | PTHR10059, PTHR10059, 1 hit |
Pfami | View protein in Pfam PF01109, GM_CSF, 1 hit |
PRINTSi | PR00693, GMCSFACTOR |
SMARTi | View protein in SMART SM00040, CSF2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00702, GM_CSF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CSF2_RAT | |
Accessioni | P48750Primary (citable) accession number: P48750 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | November 25, 2008 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families