Csf2

Functionⁱ

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.By similarity

GO - Molecular functionⁱ

cytokine activity
Source: RGD
Inferred from direct assayⁱ
- 8535150
granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
growth factor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
cellular response to lipopolysaccharide
Source: RGD
Inferred from expression patternⁱ
- 18387647
dendritic cell differentiation
Source: RGD
Inferred from direct assayⁱ
- 20628067
- 8535150
epithelial cell proliferation
Source: RGD
Traceable author statementⁱ
- 14504066
epithelial fluid transport
Source: RGD
Inferred from direct assayⁱ
- 14504066
histamine secretion
Source: RGD
Inferred from direct assayⁱ
- 9685678
immune response Source: InterPro
macrophage activation
Source: RGD
Inferred from mutant phenotypeⁱ
- 21326109
myeloid dendritic cell differentiation Source: Ensembl
negative regulation of cytolysis Source: Ensembl
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of interleukin-23 production Source: Ensembl
positive regulation of macrophage derived foam cell differentiation Source: Ensembl
positive regulation of macrophage differentiation
Source: RGD
Traceable author statementⁱ
- 14504066
positive regulation of podosome assembly Source: Ensembl
positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
regulation of circadian sleep/wake cycle, sleep
Source: RGD
Inferred from mutant phenotypeⁱ
- 12047622
response to fluid shear stress
Source: RGD
Inferred from expression patternⁱ
- 15010288
response to silicon dioxide
Source: RGD
Inferred from expression patternⁱ
- 21505002

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Growth factor

Molecular function

Cytokine, Growth factor

Enzyme and pathway databases

Reactomeⁱ	R-RNO-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling R-RNO-5673001 RAF/MAP kinase cascade R-RNO-912526 Interleukin receptor SHC signaling

Reactomeⁱ

R-RNO-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-912526 Interleukin receptor SHC signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Granulocyte-macrophage colony-stimulating factor Short name: GM-CSF Alternative name(s): Colony-stimulating factor Short name: CSF
Gene namesⁱ	Name:Csf2 Synonyms:Csfgm
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	621065 Csf2

RGDⁱ

621065 Csf2

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	By similarityAdd BLAST		17
ChainⁱPRO_0000144833	18 – 144	Granulocyte-macrophage colony-stimulating factorAdd BLAST		127

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	22	O-linked (GalNAc...) serineBy similarity	1
Glycosylationⁱ	27	O-linked (GalNAc...) threonineBy similarity	1
Disulfide bondⁱ	71 ↔ 113	By similarity
Glycosylationⁱ	86	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	105 ↔ 138	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P48750

PaxDbⁱ

P48750

PTM databases

PhosphoSitePlusⁱ	P48750

PhosphoSitePlusⁱ

P48750

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000026805 Expressed in 5 organ(s), highest expression level in lung
Genevisibleⁱ	P48750 RN

Interactionⁱ

Subunit structureⁱ

Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).By similarity

GO - Molecular functionⁱ

cytokine activity
Source: RGD
Inferred from direct assayⁱ
- 8535150
granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
growth factor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000034235

STRINGⁱ

10116.ENSRNOP00000034235

Structureⁱ

3D structure databases

SMRⁱ	P48750
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GM-CSF family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410JBQ7 Eukaryota ENOG411164J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013425
HOGENOMⁱ	HOG000037940
HOVERGENⁱ	HBG000532
InParanoidⁱ	P48750
KEGG Orthology (KO) More...KOⁱ	K05427
OMAⁱ	MWLQNLL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XFL
PhylomeDBⁱ	P48750
TreeFamⁱ	TF338611

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00040 CSF2, 1 hit
InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000773 GM_colony-stim-fac
PANTHERⁱ	PTHR10059 PTHR10059, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01109 GM_CSF, 1 hit
PRINTSⁱ	PR00693 GMCSFACTOR
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD007349 GM_colony-stim-fac, 1 hit
SMARTⁱ	View protein in SMART SM00040 CSF2, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00702 GM_CSF, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P48750-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWLQNLLFLG IVVYSFSAPT RSPNPVTRPW KHVDAIKEAL SLLNDMRALE 
        60         70         80         90        100
NEKNEDVDII SNEFSIQRPT CVQTRLKLYK QGLRGNLTKL NGALTMIASH 
       110        120        130        140 
YQTNCPPTPE TDCEIEVTTF EDFIKNLKGF LFDIPFDCWK PVQK

Length:144

Mass (Da):16,562

Last modified:November 25, 2008 - v2

Checksum:ⁱ7385E93CC40836B1

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR03075230 Genomic DNA No translation available. U00620 mRNA Translation: AAA18281.1
PIRⁱ	I46269
NCBI Reference Sequences More...RefSeqⁱ	NP_446304.1, NM_053852.1
UniGeneⁱ	Rn.44285

Genome annotation databases

Ensemblⁱ	ENSRNOT00000032333; ENSRNOP00000034235; ENSRNOG00000026805
GeneIDⁱ	116630
KEGGⁱ	rno:116630
UCSC genome browser More...UCSCⁱ	RGD:621065 rat

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P48750	Granulocyte-macrophage colony-stimulating factor		MOUSE		141	UniRef50_P01587
Uncharacterized protein		ICTTR		138
Granulocyte-macrophage colony stimulating factor		MARMO		138
Colony stimulating factor 2 (Fragment)		MUSPF		134
Granulocyte-macrophage colony-stimulating factor (Fragment)		NEOVI		157
+33

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR03075230 Genomic DNA No translation available. U00620 mRNA Translation: AAA18281.1
PIRⁱ	I46269
RefSeqⁱ	NP_446304.1, NM_053852.1
UniGeneⁱ	Rn.44285

3D structure databases

SMRⁱ	P48750
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000034235

STRINGⁱ

10116.ENSRNOP00000034235

PTM databases

PhosphoSitePlusⁱ	P48750

PhosphoSitePlusⁱ

P48750

Proteomic databases

PaxDbⁱ	P48750

PaxDbⁱ

P48750

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000032333; ENSRNOP00000034235; ENSRNOG00000026805
GeneIDⁱ	116630
KEGGⁱ	rno:116630
UCSCⁱ	RGD:621065 rat

Organism-specific databases

CTDⁱ	1437
RGDⁱ	621065 Csf2

Phylogenomic databases

eggNOGⁱ	ENOG410JBQ7 Eukaryota ENOG411164J LUCA
GeneTreeⁱ	ENSGT00390000013425
HOGENOMⁱ	HOG000037940
HOVERGENⁱ	HBG000532
InParanoidⁱ	P48750
KOⁱ	K05427
OMAⁱ	MWLQNLL
OrthoDBⁱ	EOG091G0XFL
PhylomeDBⁱ	P48750
TreeFamⁱ	TF338611

Enzyme and pathway databases

Reactomeⁱ	R-RNO-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling R-RNO-5673001 RAF/MAP kinase cascade R-RNO-912526 Interleukin receptor SHC signaling

Reactomeⁱ

R-RNO-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-912526 Interleukin receptor SHC signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P48750

PROⁱ

PR:P48750

Gene expression databases

Bgeeⁱ	ENSRNOG00000026805 Expressed in 5 organ(s), highest expression level in lung
Genevisibleⁱ	P48750 RN

Family and domain databases

CDDⁱ	cd00040 CSF2, 1 hit
InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000773 GM_colony-stim-fac
PANTHERⁱ	PTHR10059 PTHR10059, 1 hit
Pfamⁱ	View protein in Pfam PF01109 GM_CSF, 1 hit
PRINTSⁱ	PR00693 GMCSFACTOR
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD007349 GM_colony-stim-fac, 1 hit
SMARTⁱ	View protein in SMART SM00040 CSF2, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00702 GM_CSF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSF2_RAT
Accessionⁱ	P48750Primary (citable) accession number: P48750
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	November 25, 2008
	Last modified:	September 12, 2018
	This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P48750 (CSF2_RAT)

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Granulocyte-macrophage colony-stimulating factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ