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Protein

Granulocyte-macrophage colony-stimulating factor

Gene

Csf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-RNO-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte-macrophage colony-stimulating factor
Short name:
GM-CSF
Alternative name(s):
Colony-stimulating factor
Short name:
CSF
Gene namesi
Name:Csf2
Synonyms:Csfgm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621065 Csf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
ChainiPRO_000014483318 – 144Granulocyte-macrophage colony-stimulating factorAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22O-linked (GalNAc...) serineBy similarity1
Glycosylationi27O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi71 ↔ 113By similarity
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 138By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48750

PTM databases

PhosphoSitePlusiP48750

Expressioni

Gene expression databases

BgeeiENSRNOG00000026805 Expressed in 5 organ(s), highest expression level in lung
GenevisibleiP48750 RN

Interactioni

Subunit structurei

Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034235

Structurei

3D structure databases

SMRiP48750
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GM-CSF family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBQ7 Eukaryota
ENOG411164J LUCA
GeneTreeiENSGT00390000013425
HOGENOMiHOG000037940
HOVERGENiHBG000532
InParanoidiP48750
KOiK05427
OMAiMWLQNLL
OrthoDBiEOG091G0XFL
PhylomeDBiP48750
TreeFamiTF338611

Family and domain databases

CDDicd00040 CSF2, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000773 GM_colony-stim-fac
PANTHERiPTHR10059 PTHR10059, 1 hit
PfamiView protein in Pfam
PF01109 GM_CSF, 1 hit
PRINTSiPR00693 GMCSFACTOR
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007349 GM_colony-stim-fac, 1 hit
SMARTiView protein in SMART
SM00040 CSF2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00702 GM_CSF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLQNLLFLG IVVYSFSAPT RSPNPVTRPW KHVDAIKEAL SLLNDMRALE
60 70 80 90 100
NEKNEDVDII SNEFSIQRPT CVQTRLKLYK QGLRGNLTKL NGALTMIASH
110 120 130 140
YQTNCPPTPE TDCEIEVTTF EDFIKNLKGF LFDIPFDCWK PVQK
Length:144
Mass (Da):16,562
Last modified:November 25, 2008 - v2
Checksum:i7385E93CC40836B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03075230 Genomic DNA No translation available.
U00620 mRNA Translation: AAA18281.1
PIRiI46269
RefSeqiNP_446304.1, NM_053852.1
UniGeneiRn.44285

Genome annotation databases

EnsembliENSRNOT00000032333; ENSRNOP00000034235; ENSRNOG00000026805
GeneIDi116630
KEGGirno:116630
UCSCiRGD:621065 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03075230 Genomic DNA No translation available.
U00620 mRNA Translation: AAA18281.1
PIRiI46269
RefSeqiNP_446304.1, NM_053852.1
UniGeneiRn.44285

3D structure databases

SMRiP48750
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034235

PTM databases

PhosphoSitePlusiP48750

Proteomic databases

PaxDbiP48750

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032333; ENSRNOP00000034235; ENSRNOG00000026805
GeneIDi116630
KEGGirno:116630
UCSCiRGD:621065 rat

Organism-specific databases

CTDi1437
RGDi621065 Csf2

Phylogenomic databases

eggNOGiENOG410JBQ7 Eukaryota
ENOG411164J LUCA
GeneTreeiENSGT00390000013425
HOGENOMiHOG000037940
HOVERGENiHBG000532
InParanoidiP48750
KOiK05427
OMAiMWLQNLL
OrthoDBiEOG091G0XFL
PhylomeDBiP48750
TreeFamiTF338611

Enzyme and pathway databases

ReactomeiR-RNO-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-912526 Interleukin receptor SHC signaling

Miscellaneous databases

PROiPR:P48750

Gene expression databases

BgeeiENSRNOG00000026805 Expressed in 5 organ(s), highest expression level in lung
GenevisibleiP48750 RN

Family and domain databases

CDDicd00040 CSF2, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000773 GM_colony-stim-fac
PANTHERiPTHR10059 PTHR10059, 1 hit
PfamiView protein in Pfam
PF01109 GM_CSF, 1 hit
PRINTSiPR00693 GMCSFACTOR
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007349 GM_colony-stim-fac, 1 hit
SMARTiView protein in SMART
SM00040 CSF2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00702 GM_CSF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSF2_RAT
AccessioniPrimary (citable) accession number: P48750
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2008
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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