UniProtKB - P48746 (B3A2_RABIT)
Protein
Anion exchange protein 2
Gene
SLC4A2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Plasma membrane anion exchange protein of wide distribution.
GO - Molecular functioni
- anion:anion antiporter activity Source: UniProtKB-KW
- inorganic anion exchanger activity Source: InterPro
Keywordsi
Biological process | Anion exchange, Antiport, Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Anion exchange protein 2Short name: AE 2 Short name: Anion exchanger 2 Alternative name(s): Band 3-related protein Short name: B3RP Solute carrier family 4 member 2 |
Gene namesi | Name:SLC4A2 Synonyms:AE2 |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Other locations
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 703 | CytoplasmicSequence analysisAdd BLAST | 703 | |
Transmembranei | 704 – 727 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 733 – 770 | HelicalSequence analysisAdd BLAST | 38 | |
Transmembranei | 790 – 812 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 822 – 843 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 844 – 896 | ExtracellularSequence analysisAdd BLAST | 53 | |
Transmembranei | 897 – 914 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 915 – 929 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 930 – 950 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 984 – 1006 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1032 – 1053 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 1087 – 1132 | HelicalSequence analysisAdd BLAST | 46 | |
Transmembranei | 1159 – 1195 | HelicalSequence analysisAdd BLAST | 37 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079217 | 1 – 1237 | Anion exchange protein 2Add BLAST | 1237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 113 | PhosphoserineBy similarity | 1 | |
Modified residuei | 144 | PhosphoserineBy similarity | 1 | |
Modified residuei | 170 | PhosphoserineBy similarity | 1 | |
Modified residuei | 172 | PhosphoserineBy similarity | 1 | |
Modified residuei | 239 | PhosphoserineBy similarity | 1 | |
Modified residuei | 253 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 270 | N6-methyllysineBy similarity | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 855 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 864 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 878 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 1169 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, Methylation, Palmitate, PhosphoproteinProteomic databases
PRIDEi | P48746 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 704 – 1237 | Membrane (anion exchange)Add BLAST | 534 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 5 – 316 | Pro-richAdd BLAST | 312 | |
Compositional biasi | 74 – 88 | His-richAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | P48746 |
OrthoDBi | 265068at2759 |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002978, Anion_exchange_2 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF14, PTHR11453:SF14, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01188, ANIONEXHNGR2 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P48746-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSAPRRPAS GADSFRTPEP ESLGPGTPGF PEQEEDELHR TLGVERFEEI
60 70 80 90 100
LQEAGSRGGE EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ
110 120 130 140 150
GPGRKPRRRP GASPTGATPT IEEGEEDEEE ANEAEGARAP TEPSPASTPS
160 170 180 190 200
SVQFFLQEDE GAERKAERTS PSPPTLLPHQ EAAPWATEGA QTGVPVEEVA
210 220 230 240 250
VVASGTAGGD NGGASGRPLT KAQPGHRSYN LQERRRIGSM TGAEQALLPR
260 270 280 290 300
VPTDESEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSAQSSREGR
310 320 330 340 350
EPGPTPRSRP RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE
360 370 380 390 400
EETERWGKPH VASLSFRSLL ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ
410 420 430 440 450
MVISDQIKAE DRANVLRALL LKHSHPSDEK DFSFPRNISA GSLGSLLGHH
460 470 480 490 500
HGQGAESDPH VTEPLIGGIP ETRLDVERER DVPPSAPPAG ITRSKSKHEL
510 520 530 540 550
KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR
560 570 580 590 600
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA
610 620 630 640 650
FLDCSVVLPP SEVQGEELLR SVAHFQRQML KKREEQGRLL PPGLGLEPKS
660 670 680 690 700
AQDKALLQMV EAAGAAEDDP LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL
710 720 730 740 750
DPQCVAAVIF IYFAALSPAI TFGGLLGEKT QDLIGVSELI MSTALQGVIF
760 770 780 790 800
CLLGAQPLLV IGFSGPLLVF EEAFFTFCSS NQLEYLVGRV WIGFWLVLLA
810 820 830 840 850
LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLI KIFQEHPLHG
860 870 880 890 900
CSVSNSSETD SSENATWAGA GSTLGPANRS SAGQAGQGRP RGQPNTALLS
910 920 930 940 950
LVLMAGTFFI AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI
960 970 980 990 1000
EDTYTQKLSV PSGFSVTAPD KRGWVINPLG EKSPFPVWMM VASLLPAILV
1010 1020 1030 1040 1050
FILIFMETQI TTLIISKKER MLQKGSGFHL DLLLIVAMGG ICALFGLPWL
1060 1070 1080 1090 1100
AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL LVALLVGLSI
1110 1120 1130 1140 1150
VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY
1160 1170 1180 1190 1200
VKKVRTLRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL
1210 1220 1230
TRIFTEREMK CLDANEAEPV FDEREGVDEY NEMPMPV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S45791 mRNA Translation: AAB23488.1 |
PIRi | A56764 |
RefSeqi | NP_001075788.1, NM_001082319.1 |
Genome annotation databases
GeneIDi | 100009159 |
KEGGi | ocu:100009159 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S45791 mRNA Translation: AAB23488.1 |
PIRi | A56764 |
RefSeqi | NP_001075788.1, NM_001082319.1 |
3D structure databases
SMRi | P48746 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P48746 |
Genome annotation databases
GeneIDi | 100009159 |
KEGGi | ocu:100009159 |
Organism-specific databases
CTDi | 6522 |
Phylogenomic databases
InParanoidi | P48746 |
OrthoDBi | 265068at2759 |
Family and domain databases
Gene3Di | 3.40.930.10, 1 hit |
InterProi | View protein in InterPro IPR001717, Anion_exchange IPR002978, Anion_exchange_2 IPR018241, Anion_exchange_CS IPR013769, Band3_cytoplasmic_dom IPR011531, HCO3_transpt_C IPR003020, HCO3_transpt_euk IPR016152, PTrfase/Anion_transptr |
PANTHERi | PTHR11453, PTHR11453, 1 hit PTHR11453:SF14, PTHR11453:SF14, 1 hit |
Pfami | View protein in Pfam PF07565, Band_3_cyto, 1 hit PF00955, HCO3_cotransp, 1 hit |
PRINTSi | PR00165, ANIONEXCHNGR PR01188, ANIONEXHNGR2 PR01231, HCO3TRNSPORT |
SUPFAMi | SSF55804, SSF55804, 1 hit |
TIGRFAMsi | TIGR00834, ae, 1 hit |
PROSITEi | View protein in PROSITE PS00219, ANION_EXCHANGER_1, 1 hit PS00220, ANION_EXCHANGER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B3A2_RABIT | |
Accessioni | P48746Primary (citable) accession number: P48746 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families