UniProtKB - P48744 (NDP_MOUSE)
Norrin
Ndp
Functioni
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
2 PublicationsGO - Molecular functioni
- cytokine activity Source: BHF-UCL
- frizzled binding Source: BHF-UCL
- protein homodimerization activity Source: MGI
GO - Biological processi
- decidualization Source: Ensembl
- extracellular matrix-cell signaling Source: BHF-UCL
- Norrin signaling pathway Source: BHF-UCL
- placenta development Source: MGI
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- retina vasculature morphogenesis in camera-type eye Source: MGI
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: NorrinAlternative name(s): Norrie disease protein homolog |
Gene namesi | Name:Ndp Synonyms:Ndph |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102570, Ndp |
VEuPathDBi | HostDB:ENSMUSG00000040138 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: MGI
Other locations
- cell surface Source: MGI
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000021796 | 25 – 131 | NorrinAdd BLAST | 107 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 37 ↔ 94 | By similarity | ||
Disulfide bondi | 53 ↔ 108 | By similarity | ||
Disulfide bondi | 63 ↔ 124 | By similarity | ||
Disulfide bondi | 67 ↔ 126 | By similarity | ||
Disulfide bondi | 91 | Interchain (with C-93)By similarity | ||
Disulfide bondi | 93 | Interchain (with C-91)By similarity | ||
Disulfide bondi | 129 | InterchainBy similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P48744 |
PRIDEi | P48744 |
ProteomicsDBi | 252866 |
PTM databases
PhosphoSitePlusi | P48744 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000040138, Expressed in brain and 119 other tissues |
Genevisiblei | P48744, MM |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (By similarity).
Component of a complex, at least composed of TSPAN12, FZD4, LRP5/6 and norrin (NDP). Binds FZD4 with high affinity.
Interacts with LRP6 (via Beta-propellers 1 and 2).
By similarity2 PublicationsGO - Molecular functioni
- cytokine activity Source: BHF-UCL
- frizzled binding Source: BHF-UCL
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 201713, 1 interactor |
STRINGi | 10090.ENSMUSP00000046692 |
Miscellaneous databases
RNActi | P48744, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 130 | CTCKPROSITE-ProRule annotationAdd BLAST | 94 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1216, Eukaryota |
GeneTreei | ENSGT01040000241190 |
HOGENOMi | CLU_153977_0_0_1 |
InParanoidi | P48744 |
OMAi | DPGRCMR |
OrthoDBi | 1589857at2759 |
PhylomeDBi | P48744 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR029034, Cystine-knot_cytokine IPR006208, Glyco_hormone_CN IPR003064, Norrie_dis |
PANTHERi | PTHR28611, PTHR28611, 1 hit |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit |
PRINTSi | PR01304, NORRIEDSEASE |
SMARTi | View protein in SMART SM00041, CT, 1 hit |
PROSITEi | View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MRNHVLAASI SMLSLLAIMG DTDSKTDSSF LMDSQRCMRH HYVDSISHPL
60 70 80 90 100
YKCSSKMVLL ARCEGHCSQA SRSEPLVSFS TVLKQPFRSS CHCCRPQTSK
110 120 130
LKALRLRCSG GMRLTATYRY ILSCHCEECS S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92397 mRNA Translation: CAA63134.1 X83794 Genomic DNA Translation: CAA58725.1 AL732321 Genomic DNA No translation available. BC090623 mRNA Translation: AAH90623.1 |
CCDSi | CCDS30034.1 |
PIRi | S55380 |
RefSeqi | NP_035013.1, NM_010883.3 |
Genome annotation databases
Ensembli | ENSMUST00000040134; ENSMUSP00000046692; ENSMUSG00000040138 |
GeneIDi | 17986 |
KEGGi | mmu:17986 |
UCSCi | uc009ssc.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92397 mRNA Translation: CAA63134.1 X83794 Genomic DNA Translation: CAA58725.1 AL732321 Genomic DNA No translation available. BC090623 mRNA Translation: AAH90623.1 |
CCDSi | CCDS30034.1 |
PIRi | S55380 |
RefSeqi | NP_035013.1, NM_010883.3 |
3D structure databases
AlphaFoldDBi | P48744 |
SMRi | P48744 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201713, 1 interactor |
STRINGi | 10090.ENSMUSP00000046692 |
Chemistry databases
ChEMBLi | CHEMBL2176820 |
PTM databases
PhosphoSitePlusi | P48744 |
Proteomic databases
PaxDbi | P48744 |
PRIDEi | P48744 |
ProteomicsDBi | 252866 |
Protocols and materials databases
Antibodypediai | 514, 180 antibodies from 31 providers |
DNASUi | 17986 |
Genome annotation databases
Ensembli | ENSMUST00000040134; ENSMUSP00000046692; ENSMUSG00000040138 |
GeneIDi | 17986 |
KEGGi | mmu:17986 |
UCSCi | uc009ssc.1, mouse |
Organism-specific databases
CTDi | 4693 |
MGIi | MGI:102570, Ndp |
VEuPathDBi | HostDB:ENSMUSG00000040138 |
Phylogenomic databases
eggNOGi | KOG1216, Eukaryota |
GeneTreei | ENSGT01040000241190 |
HOGENOMi | CLU_153977_0_0_1 |
InParanoidi | P48744 |
OMAi | DPGRCMR |
OrthoDBi | 1589857at2759 |
PhylomeDBi | P48744 |
Miscellaneous databases
BioGRID-ORCSi | 17986, 3 hits in 73 CRISPR screens |
PROi | PR:P48744 |
RNActi | P48744, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040138, Expressed in brain and 119 other tissues |
Genevisiblei | P48744, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR029034, Cystine-knot_cytokine IPR006208, Glyco_hormone_CN IPR003064, Norrie_dis |
PANTHERi | PTHR28611, PTHR28611, 1 hit |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit |
PRINTSi | PR01304, NORRIEDSEASE |
SMARTi | View protein in SMART SM00041, CT, 1 hit |
PROSITEi | View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NDP_MOUSE | |
Accessioni | P48744Primary (citable) accession number: P48744 Secondary accession number(s): Q5CZY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot