RFX-like DNA-binding protein RFX1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: SGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor."
    Huang M., Zhou Z., Elledge S.J.
    Cell 94:595-605(1998) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: SGDInferred from high throughput direct assayⁱ
  • "A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters."
    Badis G., Chan E.T., van Bakel H., Pena-Castillo L., Tillo D., Tsui K., Carlson C.D., Gossett A.J., Hasinoff M.J., Warren C.L., Gebbia M., Talukder S., Yang A., Mnaimneh S., Terterov D., Coburn D., Li Yeo A., Yeo Z.X.

    , Clarke N.D., Lieb J.D., Ansari A.Z., Nislow C., Hughes T.R.
    Mol. Cell 32:878-887(2008) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• negative regulation of transcription by RNA polymerase II Source: SGDInferred from direct assayⁱ
  • "The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor."
    Huang M., Zhou Z., Elledge S.J.
    Cell 94:595-605(1998) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Molecular genetic analysis of the yeast repressor Rfx1/Crt1 reveals a novel two-step regulatory mechanism."
    Zhang Z., Reese J.C.
    Mol. Cell. Biol. 25:7399-7411(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MVIFKERKPT ENLFTRKIPA KYFIFSPSFL SVHYFEFYLP MSGDNNIEPT 
        60         70         80         90        100
SRGSNDNSNG PSNGSSVNSN RYSLNAPKYS SQPPPASHTY LPPMSVNIPP 
       110        120        130        140        150
IASKSSSIYS LLHQSSPRPE TPNPILPPLI GSGPGSHKPS PTPTQPPAQP 
       160        170        180        190        200
ATQRQPATYS VYPASISLNR SNSSAYPLSF KSEETLNNNP PTAAKRTNTF 
       210        220        230        240        250
PSIPSSTKKQ KTSQEKRISS ISRRNTQEII AKQIAENNKS KTIEEYAQIV 
       260        270        280        290        300
KHAEIKVLSM DSQNTSKAAL QLAEQNRERE RQVFALLWLM KNCKSQHDSY 
       310        320        330        340        350
VPRGKIFAQY ASSCSQNNLK PLSQASLGKL IRTVFPDLTT RRLGMRGQSK 
       360        370        380        390        400
YHYCGLKLTV NESGSVSLNN NNASLSLVHN NDPISPLSSP SPSSPSPQVP 
       410        420        430        440        450
NVSSPFSLNR KSLSRTGSPV KQSSNDNPNE PELESQHPNE TEANKLDSLP 
       460        470        480        490        500
PAANNPTGTL SSDELTFTHD LIEKVFNCND KLSDNYNTQI LSNTEHPLLT 
       510        520        530        540        550
SYKLDFPKIP AGVLPTDTDS DVISSLESLY HIHCNSVYEC IKFLKSDNIS 
       560        570        580        590        600
NALFFSNSNS ISPTMFNLFI SEPLIDWVTK CDLITYTGLI KFFSQFIIHS 
       610        620        630        640        650
NEISDSIIQK LESMIKLLPE QINKAVLELP KALVQRKLSI INNFTKLVKK 
       660        670        680        690        700
LIKLLKFILN FLKSFPIFKS GMNNDWKNIV NLDDILEMMI NEDDTNSETN 
       710        720        730        740        750
TIMQHLQGFC QVFVTKFLNS SMSVSNDPSV SIECKSLNEM IKDFCSFISL 
       760        770        780        790        800
QSKFSCLKLI DCSTRFRNAI IGDISLKSNE NLLSWLFLNN VMGQLLNYCF 
       810 
EVMKFVNGLK V                                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Yeast chromosome XII
   Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
3. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD