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UniProtKB - P48743 (RFX1_YEAST)
Protein
RFX-like DNA-binding protein RFX1
Gene
RFX1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 377 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 285 – 360 | RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST | 76 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: SGD
- sequence-specific DNA binding Source: SGD
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: RFX-like DNA-binding protein RFX1 |
Gene namesi | Name:RFX1 Synonyms:CRT1 Ordered Locus Names:YLR176C ORF Names:L9470.18 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004166, RFX1 |
VEuPathDBi | FungiDB:YLR176C |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215295 | 1 – 811 | RFX-like DNA-binding protein RFX1Add BLAST | 811 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 173 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P48743 |
PaxDbi | P48743 |
PRIDEi | P48743 |
PTM databases
iPTMneti | P48743 |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 31447, 176 interactors |
DIPi | DIP-6790N |
IntActi | P48743, 18 interactors |
MINTi | P48743 |
STRINGi | 4932.YLR176C |
Miscellaneous databases
RNActi | P48743, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 48 – 92 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 111 – 156 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 181 – 222 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 377 – 461 | DisorderedSequence analysisAdd BLAST | 85 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 48 – 85 | Polar residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 181 – 209 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 400 – 432 | Polar residuesSequence analysisAdd BLAST | 33 |
Sequence similaritiesi
Belongs to the RFX family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3712, Eukaryota |
GeneTreei | ENSGT00980000198574 |
HOGENOMi | CLU_011526_2_0_1 |
InParanoidi | P48743 |
OMAi | AQYASSC |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003150, DNA-bd_RFX IPR039779, RFX-like IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12619, PTHR12619, 1 hit |
Pfami | View protein in Pfam PF02257, RFX_DNA_binding, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51526, RFX_DBD, 1 hit |
i Sequence
Sequence statusi: Complete.
P48743-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVIFKERKPT ENLFTRKIPA KYFIFSPSFL SVHYFEFYLP MSGDNNIEPT
60 70 80 90 100
SRGSNDNSNG PSNGSSVNSN RYSLNAPKYS SQPPPASHTY LPPMSVNIPP
110 120 130 140 150
IASKSSSIYS LLHQSSPRPE TPNPILPPLI GSGPGSHKPS PTPTQPPAQP
160 170 180 190 200
ATQRQPATYS VYPASISLNR SNSSAYPLSF KSEETLNNNP PTAAKRTNTF
210 220 230 240 250
PSIPSSTKKQ KTSQEKRISS ISRRNTQEII AKQIAENNKS KTIEEYAQIV
260 270 280 290 300
KHAEIKVLSM DSQNTSKAAL QLAEQNRERE RQVFALLWLM KNCKSQHDSY
310 320 330 340 350
VPRGKIFAQY ASSCSQNNLK PLSQASLGKL IRTVFPDLTT RRLGMRGQSK
360 370 380 390 400
YHYCGLKLTV NESGSVSLNN NNASLSLVHN NDPISPLSSP SPSSPSPQVP
410 420 430 440 450
NVSSPFSLNR KSLSRTGSPV KQSSNDNPNE PELESQHPNE TEANKLDSLP
460 470 480 490 500
PAANNPTGTL SSDELTFTHD LIEKVFNCND KLSDNYNTQI LSNTEHPLLT
510 520 530 540 550
SYKLDFPKIP AGVLPTDTDS DVISSLESLY HIHCNSVYEC IKFLKSDNIS
560 570 580 590 600
NALFFSNSNS ISPTMFNLFI SEPLIDWVTK CDLITYTGLI KFFSQFIIHS
610 620 630 640 650
NEISDSIIQK LESMIKLLPE QINKAVLELP KALVQRKLSI INNFTKLVKK
660 670 680 690 700
LIKLLKFILN FLKSFPIFKS GMNNDWKNIV NLDDILEMMI NEDDTNSETN
710 720 730 740 750
TIMQHLQGFC QVFVTKFLNS SMSVSNDPSV SIECKSLNEM IKDFCSFISL
760 770 780 790 800
QSKFSCLKLI DCSTRFRNAI IGDISLKSNE NLLSWLFLNN VMGQLLNYCF
810
EVMKFVNGLK V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17246 Genomic DNA Translation: AAB67470.1 BK006945 Genomic DNA Translation: DAA09496.1 |
PIRi | S51421 |
RefSeqi | NP_013277.1, NM_001182063.1 |
Genome annotation databases
EnsemblFungii | YLR176C_mRNA; YLR176C; YLR176C |
GeneIDi | 850873 |
KEGGi | sce:YLR176C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U17246 Genomic DNA Translation: AAB67470.1 BK006945 Genomic DNA Translation: DAA09496.1 |
PIRi | S51421 |
RefSeqi | NP_013277.1, NM_001182063.1 |
3D structure databases
AlphaFoldDBi | P48743 |
SMRi | P48743 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31447, 176 interactors |
DIPi | DIP-6790N |
IntActi | P48743, 18 interactors |
MINTi | P48743 |
STRINGi | 4932.YLR176C |
PTM databases
iPTMneti | P48743 |
Proteomic databases
MaxQBi | P48743 |
PaxDbi | P48743 |
PRIDEi | P48743 |
Genome annotation databases
EnsemblFungii | YLR176C_mRNA; YLR176C; YLR176C |
GeneIDi | 850873 |
KEGGi | sce:YLR176C |
Organism-specific databases
SGDi | S000004166, RFX1 |
VEuPathDBi | FungiDB:YLR176C |
Phylogenomic databases
eggNOGi | KOG3712, Eukaryota |
GeneTreei | ENSGT00980000198574 |
HOGENOMi | CLU_011526_2_0_1 |
InParanoidi | P48743 |
OMAi | AQYASSC |
Miscellaneous databases
PROi | PR:P48743 |
RNActi | P48743, protein |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR003150, DNA-bd_RFX IPR039779, RFX-like IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12619, PTHR12619, 1 hit |
Pfami | View protein in Pfam PF02257, RFX_DNA_binding, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51526, RFX_DBD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RFX1_YEAST | |
Accessioni | P48743Primary (citable) accession number: P48743 Secondary accession number(s): D6VYI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - SIMILARITY comments
Index of protein domains and families