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Protein

Putative heat shock 70 kDa protein 7

Gene

HSPA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Putative heat shock 70 kDa protein 7
Alternative name(s):
Heat shock 70 kDa protein B
Gene namesi
Name:HSPA7
Synonyms:HSP70B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5240 HSPA7
MIMi140556 gene
neXtProtiNX_P48741

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi3311

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000782671 – 367Putative heat shock 70 kDa protein 7Add BLAST367

Proteomic databases

EPDiP48741
MaxQBiP48741
PeptideAtlasiP48741
PRIDEiP48741
ProteomicsDBi55940

PTM databases

iPTMnetiP48741
PhosphoSitePlusiP48741
SwissPalmiP48741

Expressioni

Organism-specific databases

HPAiHPA052504

Interactioni

Protein-protein interaction databases

IntActiP48741, 12 interactors

Structurei

3D structure databases

ProteinModelPortaliP48741
SMRiP48741
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
HOVERGENiHBG051845
InParanoidiP48741
PhylomeDBiP48741

Family and domain databases

InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE
60 70 80 90 100
RLVGDAAKSQ AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG
110 120 130 140 150
GKPKVRVCYR GEDKTFYPEE ISSMVLSKMK ETAEAYLGQP VKHAVITVPT
160 170 180 190 200
YFSNSQRQAT KDAGAIAGLK VLPIINEATA AAIAYGLDRR GAGKRNVLIF
210 220 230 240 250
DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV NHFMEEFRRK
260 270 280 290 300
HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT
310 320 330 340 350
RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE
360
VAAGLLQRQG AEQEHQP
Length:367
Mass (Da):40,244
Last modified:September 11, 2007 - v2
Checksum:i060DFA210A29A5D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59S → N in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti95Q → K in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti99E → G in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti127S → T in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti191G → R in AAA52696 (PubMed:3927293).Curated1
Sequence conflicti213S → T in AAA52696 (PubMed:3927293).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451067 Genomic DNA No translation available.
M11236 Genomic DNA Translation: AAA52696.1
PIRiA25773
UniGeneiHs.662180
Hs.690634

Similar proteinsi

Entry informationi

Entry nameiHSP77_HUMAN
AccessioniPrimary (citable) accession number: P48741
Secondary accession number(s): P19790
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 11, 2007
Last modified: June 20, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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