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Entry version 188 (10 Apr 2019)
Sequence version 3 (16 Dec 2008)
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Protein

Mannan-binding lectin serine protease 1

Gene

MASP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343).2 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by SERPING1 and A2M.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.10 mM for Ac-Gly-Lys-OMe (at 30 degrees Celsius)2 Publications
  2. KM=310 µM for Bz-Arg-OEt (at 30 degrees Celsius)2 Publications
  3. KM=4.8 µM for C2 (at 37 degrees Celsius)2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi68Calcium 11
    Metal bindingi76Calcium 11
    Metal bindingi121Calcium 11
    Metal bindingi123Calcium 1; via carbonyl oxygen1
    Metal bindingi139Calcium 21
    Metal bindingi140Calcium 2; via carbonyl oxygen1
    Metal bindingi142Calcium 21
    Metal bindingi159Calcium 21
    Metal bindingi160Calcium 2; via carbonyl oxygen1
    Metal bindingi163Calcium 2; via carbonyl oxygen1
    Metal bindingi235Calcium 31
    Metal bindingi245Calcium 31
    Metal bindingi282Calcium 31
    Metal bindingi284Calcium 3; via carbonyl oxygen1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei490Charge relay systemBy similarity1
    Active sitei552Charge relay systemBy similarity1
    Active sitei646Charge relay systemBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease, Serine protease
    Biological processComplement activation lectin pathway, Immunity, Innate immunity
    LigandCalcium, Metal-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.21.B7 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-166662 Lectin pathway of complement activation
    R-HSA-166663 Initial triggering of complement
    R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface
    R-HSA-3000480 Scavenging by Class A Receptors

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P48740

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    S01.132

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Mannan-binding lectin serine protease 1 (EC:3.4.21.-)
    Alternative name(s):
    Complement factor MASP-3
    Complement-activating component of Ra-reactive factor
    Mannose-binding lectin-associated serine protease 1
    Short name:
    MASP-1
    Mannose-binding protein-associated serine protease
    Ra-reactive factor serine protease p100
    Short name:
    RaRF
    Serine protease 5
    Cleaved into the following 2 chains:
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:MASP1
    Synonyms:CRARF, CRARF1, PRSS5
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000127241.16

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:6901 MASP1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    600521 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P48740

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    3MC syndrome 1 (3MC1)3 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of 3MC syndrome, an autosomal recessive disorder characterized by facial dysmorphism, craniosynostosis, learning disability, and genital, limb and vesicorenal anomalies. Facial features include hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes.
    See also OMIM:257920
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0788143 – 699Missing in 3MC1. 1 PublicationAdd BLAST697

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi68E → A or Q: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi77Y → A: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi99E → A: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi121D → A or N: Loss of interaction with FNC2 and FCN3 and partial loss of interaction with MBL2. 1 Publication1
    Mutagenesisi122F → A: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi123S → A: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi125E → A: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi237H → A: Loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi239E → A: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi244Y → A: Loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi262E → A: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi274S → A: Partial loss of interaction with FCN2 and FCN3. No effect on interaction with MBL2. 1 Publication1
    Mutagenesisi283N → A: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi286E → A: Partial loss of interaction with FCN2, FCN3 and MBL2. 1 Publication1
    Mutagenesisi646S → A: No autoproteolytic processing. 1 Publication1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    5648

    MalaCards human disease database

    More...
    MalaCardsi
    MASP1
    MIMi257920 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000127241

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    293843 3MC syndrome

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA30644

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    MASP1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    218512135

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 191 PublicationAdd BLAST19
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002759220 – 699Mannan-binding lectin serine protease 1Add BLAST680
    ChainiPRO_000002759320 – 448Mannan-binding lectin serine protease 1 heavy chainAdd BLAST429
    ChainiPRO_0000027594449 – 699Mannan-binding lectin serine protease 1 light chainAdd BLAST251

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi49N-linked (GlcNAc...) asparagine2 Publications1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi73 ↔ 911 Publication
    Disulfide bondi143 ↔ 1571 Publication
    Disulfide bondi153 ↔ 1661 Publication
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei159(3R)-3-hydroxyasparagineSequence analysis1
    Disulfide bondi168 ↔ 1811 Publication
    Glycosylationi178N-linked (GlcNAc...) (complex) asparagine3 Publications1
    Disulfide bondi185 ↔ 2121 Publication
    Disulfide bondi242 ↔ 2601 Publication
    Disulfide bondi301 ↔ 349By similarity
    Disulfide bondi329 ↔ 362By similarity
    Disulfide bondi367 ↔ 414By similarity
    Glycosylationi385N-linked (GlcNAc...) (complex) asparagine2 Publications1
    Disulfide bondi397 ↔ 432By similarity
    Glycosylationi407N-linked (GlcNAc...) asparagine2 Publications1
    Disulfide bondi436 ↔ 572Interchain (between heavy and light chains)PROSITE-ProRule annotation
    Disulfide bondi475 ↔ 491By similarity
    Disulfide bondi614 ↔ 631By similarity
    Disulfide bondi642 ↔ 672By similarity

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity
    N-glycosylated. Some N-linked glycan are of the complex-type (By similarity).By similarity
    Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. Isoform 1 but not isoform 2 is activated through autoproteolytic processing.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei448 – 449Cleavage; by autolysis1 Publication2

    Keywords - PTMi

    Autocatalytic cleavage, Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P48740

    PeptideAtlas

    More...
    PeptideAtlasi
    P48740

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P48740

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    55936
    55937 [P48740-2]
    55938 [P48740-3]
    55939 [P48740-4]

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    P48740-3 [P48740-3]

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1488

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P48740

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P48740

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Protein of the plasma which is primarily expressed by liver.4 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000127241 Expressed in 161 organ(s), highest expression level in ectocervix

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P48740 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P48740 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA001617
    HPA009641

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer. Interacts with the oligomeric lectins MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1. Interacts with COLEC11; probably triggers the lectin pathway of complement (PubMed:20956340).9 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    MBL2P112263EBI-16138717,EBI-5325353

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    111629, 21 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-61382N

    Protein interaction database and analysis system

    More...
    IntActi
    P48740, 18 interactors

    Molecular INTeraction database

    More...
    MINTi
    P48740

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1699
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3DEMX-ray2.30A/B20-297[»]
    3GOVX-ray2.55A298-448[»]
    B449-699[»]
    4AQBX-ray4.20A20-363[»]
    4DJZX-ray3.20A/C298-448[»]
    B/D449-699[»]
    4IGDX-ray2.50A298-699[»]
    4IW4X-ray3.20E/F625-696[»]
    4KKDX-ray2.60A/B298-696[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P48740

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P48740

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P48740

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 138CUB 1PROSITE-ProRule annotationAdd BLAST119
    Domaini139 – 182EGF-like; calcium-bindingAdd BLAST44
    Domaini185 – 297CUB 2PROSITE-ProRule annotationAdd BLAST113
    Domaini299 – 364Sushi 1PROSITE-ProRule annotationAdd BLAST66
    Domaini365 – 434Sushi 2PROSITE-ProRule annotationAdd BLAST70
    Domaini449 – 696Peptidase S1PROSITE-ProRule annotationAdd BLAST248

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 278Interaction with FCN2Add BLAST259
    Regioni20 – 184HomodimerizationBy similarityAdd BLAST165
    Regioni20 – 184Interaction with MBL2Add BLAST165

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Sushi

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000183084

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG000559

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P48740

    KEGG Orthology (KO)

    More...
    KOi
    K03992

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DLSQRWV

    Database of Orthologous Groups

    More...
    OrthoDBi
    156878at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P48740

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF330373

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00033 CCP, 2 hits
    cd00041 CUB, 2 hits
    cd00190 Tryp_SPc, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.120.290, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000859 CUB_dom
    IPR001881 EGF-like_Ca-bd_dom
    IPR013032 EGF-like_CS
    IPR018097 EGF_Ca-bd_CS
    IPR009003 Peptidase_S1_PA
    IPR001314 Peptidase_S1A
    IPR035914 Sperma_CUB_dom_sf
    IPR035976 Sushi/SCR/CCP_sf
    IPR000436 Sushi_SCR_CCP_dom
    IPR001254 Trypsin_dom
    IPR018114 TRYPSIN_HIS
    IPR033116 TRYPSIN_SER

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00431 CUB, 2 hits
    PF00084 Sushi, 2 hits
    PF00089 Trypsin, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00722 CHYMOTRYPSIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00032 CCP, 2 hits
    SM00042 CUB, 2 hits
    SM00179 EGF_CA, 1 hit
    SM00020 Tryp_SPc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF49854 SSF49854, 2 hits
    SSF50494 SSF50494, 1 hit
    SSF57535 SSF57535, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00010 ASX_HYDROXYL, 1 hit
    PS01180 CUB, 2 hits
    PS01186 EGF_2, 1 hit
    PS01187 EGF_CA, 1 hit
    PS50923 SUSHI, 2 hits
    PS50240 TRYPSIN_DOM, 1 hit
    PS00134 TRYPSIN_HIS, 1 hit
    PS00135 TRYPSIN_SER, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P48740-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MRWLLLYYAL CFSLSKASAH TVELNNMFGQ IQSPGYPDSY PSDSEVTWNI
    60 70 80 90 100
    TVPDGFRIKL YFMHFNLESS YLCEYDYVKV ETEDQVLATF CGRETTDTEQ
    110 120 130 140 150
    TPGQEVVLSP GSFMSITFRS DFSNEERFTG FDAHYMAVDV DECKEREDEE
    160 170 180 190 200
    LSCDHYCHNY IGGYYCSCRF GYILHTDNRT CRVECSDNLF TQRTGVITSP
    210 220 230 240 250
    DFPNPYPKSS ECLYTIELEE GFMVNLQFED IFDIEDHPEV PCPYDYIKIK
    260 270 280 290 300
    VGPKVLGPFC GEKAPEPIST QSHSVLILFH SDNSGENRGW RLSYRAAGNE
    310 320 330 340 350
    CPELQPPVHG KIEPSQAKYF FKDQVLVSCD TGYKVLKDNV EMDTFQIECL
    360 370 380 390 400
    KDGTWSNKIP TCKIVDCRAP GELEHGLITF STRNNLTTYK SEIKYSCQEP
    410 420 430 440 450
    YYKMLNNNTG IYTCSAQGVW MNKVLGRSLP TCLPVCGLPK FSRKLMARIF
    460 470 480 490 500
    NGRPAQKGTT PWIAMLSHLN GQPFCGGSLL GSSWIVTAAH CLHQSLDPED
    510 520 530 540 550
    PTLRDSDLLS PSDFKIILGK HWRLRSDENE QHLGVKHTTL HPQYDPNTFE
    560 570 580 590 600
    NDVALVELLE SPVLNAFVMP ICLPEGPQQE GAMVIVSGWG KQFLQRFPET
    610 620 630 640 650
    LMEIEIPIVD HSTCQKAYAP LKKKVTRDMI CAGEKEGGKD ACAGDSGGPM
    660 670 680 690
    VTLNRERGQW YLVGTVSWGD DCGKKDRYGV YSYIHHNKDW IQRVTGVRN
    Length:699
    Mass (Da):79,247
    Last modified:December 16, 2008 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B37C7FB9F51FD1D
    GO
    Isoform 2 (identifier: P48740-2) [UniParc]FASTAAdd to basket
    Also known as: MASP-3

    The sequence of this isoform differs from the canonical sequence as follows:
         435-435: V → ECGQPSRSLP...QSVVEPQVER
         436-699: Missing.

    Note: Contains a N-linked (GlcNAc...) asparagine at position 533 (PubMed:16335952). Contains a N-linked (GlcNAc...) asparagine at position 599 (PubMed:16335952).3 Publications
    Show »
    Length:728
    Mass (Da):81,860
    Checksum:i09B5297A6C14283A
    GO
    Isoform 3 (identifier: P48740-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         364-380: IVDCRAPGELEHGLITF → KNEIDLESELKSEQVTE
         381-699: Missing.

    Show »
    Length:380
    Mass (Da):43,640
    Checksum:iDDED114311A62714
    GO
    Isoform 4 (identifier: P48740-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-113: Missing.
         435-435: V → ECGQPSRSLP...QSVVEPQVER
         436-699: Missing.

    Show »
    Length:615
    Mass (Da):68,918
    Checksum:iEEE63886709340FA
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F8W876F8W876_HUMAN
    Mannan-binding lectin serine protea...
    MASP1
    354Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JMA2C9JMA2_HUMAN
    Mannan-binding lectin serine protea...
    MASP1
    204Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9J1C7C9J1C7_HUMAN
    Mannan-binding lectin serine protea...
    MASP1
    118Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JLU5C9JLU5_HUMAN
    Mannan-binding lectin serine protea...
    MASP1
    55Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAH39724 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2R → K in BAF84375 (PubMed:14702039).Curated1
    Sequence conflicti89T → A in CAH18409 (PubMed:17974005).Curated1
    Sequence conflicti232F → L in BAF84375 (PubMed:14702039).Curated1
    Sequence conflicti235E → Q in BAA05928 (PubMed:8018603).Curated1
    Sequence conflicti235E → Q in BAA34864 (PubMed:8921412).Curated1
    Sequence conflicti285G → A in BAA05928 (PubMed:8018603).Curated1
    Sequence conflicti285G → A in BAA34864 (PubMed:8921412).Curated1
    Sequence conflicti285G → A in BAA89206 (PubMed:10475605).Curated1
    Sequence conflicti392E → G in BAF83846 (PubMed:14702039).Curated1
    Sequence conflicti499E → G in BAA05928 (PubMed:8018603).Curated1
    Sequence conflicti499E → K in BAA04477 (PubMed:8240317).Curated1
    Sequence conflicti499E → K in BAA89206 (PubMed:10475605).Curated1
    Sequence conflicti527D → A in BAA34864 (PubMed:8921412).Curated1
    Sequence conflicti543Q → K in BAA04477 (PubMed:8240317).Curated1
    Sequence conflicti552D → V in BAA34864 (PubMed:8921412).Curated1
    Sequence conflicti643A → S in BAA04477 (PubMed:8240317).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_0788143 – 699Missing in 3MC1. 1 PublicationAdd BLAST697
    Natural variantiVAR_05183121T → I. Corresponds to variant dbSNP:rs1062049Ensembl.1
    Natural variantiVAR_051832568V → A. Corresponds to variant dbSNP:rs13322090Ensembl.1
    Natural variantiVAR_051833679G → R. Corresponds to variant dbSNP:rs3774266Ensembl.1
    Isoform 2 (identifier: P48740-2)
    Natural varianti484G → E in 3MC1) (PubMed:26419238. 3 Publications1
    Natural varianti497H → Y in 3MC1) (PubMed:21258343. 3 Publications1
    Natural varianti553D → N in 3MC1) (PubMed:26419238. 3 Publications1
    Natural varianti630C → R in 3MC1) (PubMed:21258343. 3 Publications1
    Natural varianti663D → Y in 3MC1) (PubMed:26419238. 3 Publications1
    Natural varianti666G → E in 3MC1) (PubMed:21258343. 3 Publications1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0368091 – 113Missing in isoform 4. 1 PublicationAdd BLAST113
    Alternative sequenceiVSP_036810364 – 380IVDCR…GLITF → KNEIDLESELKSEQVTE in isoform 3. 2 PublicationsAdd BLAST17
    Alternative sequenceiVSP_036811381 – 699Missing in isoform 3. 2 PublicationsAdd BLAST319
    Alternative sequenceiVSP_036812435V → ECGQPSRSLPSLVKRIIGGR NAEPGLFPWQALIVVEDTSR VPNDKWFGSGALLSASWILT AAHVLRSQRRDTTVIPVSKE HVTVYLGLHDVRDKSGAVNS SAARVVLHPDFNIQNYNHDI ALVQLQEPVPLGPHVMPVCL PRLEPEGPAPHMLGLVAGWG ISNPNVTVDEIISSGTRTLS DVLQYVKLPVVPHAECKTSY ESRSGNYSVTENMFCAGYYE GGKDTCLGDSGGAFVIFDDL SQRWVVQGLVSWGGPEECGS KQVYGVYTKVSNYVDWVWEQ MGLPQSVVEPQVER in isoform 2 and isoform 4. 3 Publications1
    Alternative sequenceiVSP_036813436 – 699Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST264

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    D17525 mRNA Translation: BAA04477.1
    D28593 mRNA Translation: BAA05928.1
    D61695 Genomic DNA Translation: BAA34864.1
    AB007617 Genomic DNA Translation: BAA89206.1
    AF284421 mRNA Translation: AAK84071.1
    AK291157 mRNA Translation: BAF83846.1
    AK291686 mRNA Translation: BAF84375.1
    AK304334 mRNA Translation: BAG65179.1
    CR749615 mRNA Translation: CAH18409.1
    AC007920 Genomic DNA No translation available.
    CH471052 Genomic DNA Translation: EAW78153.1
    BC039724 mRNA Translation: AAH39724.1 Different initiation.
    BC106945 mRNA Translation: AAI06946.1
    BC106946 mRNA Translation: AAI06947.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS33907.1 [P48740-1]
    CCDS33908.1 [P48740-2]
    CCDS33909.1 [P48740-3]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    I54763

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001027019.1, NM_001031849.2 [P48740-3]
    NP_001870.3, NM_001879.5 [P48740-1]
    NP_624302.1, NM_139125.3 [P48740-2]
    XP_016862361.1, XM_017006872.1 [P48740-4]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.89983

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000169293; ENSP00000169293; ENSG00000127241 [P48740-3]
    ENST00000296280; ENSP00000296280; ENSG00000127241 [P48740-2]
    ENST00000337774; ENSP00000336792; ENSG00000127241 [P48740-1]
    ENST00000392472; ENSP00000376264; ENSG00000127241 [P48740-4]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5648

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:5648

    UCSC genome browser

    More...
    UCSCi
    uc003frh.3 human [P48740-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D17525 mRNA Translation: BAA04477.1
    D28593 mRNA Translation: BAA05928.1
    D61695 Genomic DNA Translation: BAA34864.1
    AB007617 Genomic DNA Translation: BAA89206.1
    AF284421 mRNA Translation: AAK84071.1
    AK291157 mRNA Translation: BAF83846.1
    AK291686 mRNA Translation: BAF84375.1
    AK304334 mRNA Translation: BAG65179.1
    CR749615 mRNA Translation: CAH18409.1
    AC007920 Genomic DNA No translation available.
    CH471052 Genomic DNA Translation: EAW78153.1
    BC039724 mRNA Translation: AAH39724.1 Different initiation.
    BC106945 mRNA Translation: AAI06946.1
    BC106946 mRNA Translation: AAI06947.1
    CCDSiCCDS33907.1 [P48740-1]
    CCDS33908.1 [P48740-2]
    CCDS33909.1 [P48740-3]
    PIRiI54763
    RefSeqiNP_001027019.1, NM_001031849.2 [P48740-3]
    NP_001870.3, NM_001879.5 [P48740-1]
    NP_624302.1, NM_139125.3 [P48740-2]
    XP_016862361.1, XM_017006872.1 [P48740-4]
    UniGeneiHs.89983

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3DEMX-ray2.30A/B20-297[»]
    3GOVX-ray2.55A298-448[»]
    B449-699[»]
    4AQBX-ray4.20A20-363[»]
    4DJZX-ray3.20A/C298-448[»]
    B/D449-699[»]
    4IGDX-ray2.50A298-699[»]
    4IW4X-ray3.20E/F625-696[»]
    4KKDX-ray2.60A/B298-696[»]
    ProteinModelPortaliP48740
    SMRiP48740
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi111629, 21 interactors
    DIPiDIP-61382N
    IntActiP48740, 18 interactors
    MINTiP48740

    Protein family/group databases

    MEROPSiS01.132

    PTM databases

    GlyConnecti1488
    iPTMnetiP48740
    PhosphoSitePlusiP48740

    Polymorphism and mutation databases

    BioMutaiMASP1
    DMDMi218512135

    Proteomic databases

    jPOSTiP48740
    PeptideAtlasiP48740
    PRIDEiP48740
    ProteomicsDBi55936
    55937 [P48740-2]
    55938 [P48740-3]
    55939 [P48740-4]
    TopDownProteomicsiP48740-3 [P48740-3]

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000169293; ENSP00000169293; ENSG00000127241 [P48740-3]
    ENST00000296280; ENSP00000296280; ENSG00000127241 [P48740-2]
    ENST00000337774; ENSP00000336792; ENSG00000127241 [P48740-1]
    ENST00000392472; ENSP00000376264; ENSG00000127241 [P48740-4]
    GeneIDi5648
    KEGGihsa:5648
    UCSCiuc003frh.3 human [P48740-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5648
    DisGeNETi5648
    EuPathDBiHostDB:ENSG00000127241.16

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    MASP1
    HGNCiHGNC:6901 MASP1
    HPAiHPA001617
    HPA009641
    MalaCardsiMASP1
    MIMi257920 phenotype
    600521 gene
    neXtProtiNX_P48740
    OpenTargetsiENSG00000127241
    Orphaneti293843 3MC syndrome
    PharmGKBiPA30644

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    GeneTreeiENSGT00950000183084
    HOVERGENiHBG000559
    InParanoidiP48740
    KOiK03992
    OMAiDLSQRWV
    OrthoDBi156878at2759
    PhylomeDBiP48740
    TreeFamiTF330373

    Enzyme and pathway databases

    BRENDAi3.4.21.B7 2681
    ReactomeiR-HSA-166662 Lectin pathway of complement activation
    R-HSA-166663 Initial triggering of complement
    R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface
    R-HSA-3000480 Scavenging by Class A Receptors
    SABIO-RKiP48740

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    MASP1 human
    EvolutionaryTraceiP48740

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    MASP1_(protein)

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    5648

    Protein Ontology

    More...
    PROi
    PR:P48740

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000127241 Expressed in 161 organ(s), highest expression level in ectocervix
    ExpressionAtlasiP48740 baseline and differential
    GenevisibleiP48740 HS

    Family and domain databases

    CDDicd00033 CCP, 2 hits
    cd00041 CUB, 2 hits
    cd00190 Tryp_SPc, 1 hit
    Gene3Di2.60.120.290, 2 hits
    InterProiView protein in InterPro
    IPR000859 CUB_dom
    IPR001881 EGF-like_Ca-bd_dom
    IPR013032 EGF-like_CS
    IPR018097 EGF_Ca-bd_CS
    IPR009003 Peptidase_S1_PA
    IPR001314 Peptidase_S1A
    IPR035914 Sperma_CUB_dom_sf
    IPR035976 Sushi/SCR/CCP_sf
    IPR000436 Sushi_SCR_CCP_dom
    IPR001254 Trypsin_dom
    IPR018114 TRYPSIN_HIS
    IPR033116 TRYPSIN_SER
    PfamiView protein in Pfam
    PF00431 CUB, 2 hits
    PF00084 Sushi, 2 hits
    PF00089 Trypsin, 1 hit
    PRINTSiPR00722 CHYMOTRYPSIN
    SMARTiView protein in SMART
    SM00032 CCP, 2 hits
    SM00042 CUB, 2 hits
    SM00179 EGF_CA, 1 hit
    SM00020 Tryp_SPc, 1 hit
    SUPFAMiSSF49854 SSF49854, 2 hits
    SSF50494 SSF50494, 1 hit
    SSF57535 SSF57535, 2 hits
    PROSITEiView protein in PROSITE
    PS00010 ASX_HYDROXYL, 1 hit
    PS01180 CUB, 2 hits
    PS01186 EGF_2, 1 hit
    PS01187 EGF_CA, 1 hit
    PS50923 SUSHI, 2 hits
    PS50240 TRYPSIN_DOM, 1 hit
    PS00134 TRYPSIN_HIS, 1 hit
    PS00135 TRYPSIN_SER, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMASP1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48740
    Secondary accession number(s): A8K542
    , A8K6M1, B4E2L7, O95570, Q68D21, Q8IUV8, Q96RS4, Q9UF09
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: December 16, 2008
    Last modified: April 10, 2019
    This is version 188 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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