PITPNB

Functionⁱ

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

GO - Molecular functionⁱ

phosphatidylcholine binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224
phosphatidylcholine transporter activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224
phosphatidylinositol binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224
phosphatidylinositol transporter activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid metabolic process
Source: ProtInc
Non-traceable author statementⁱ
- 8541325
nucleus organization
Source: BHF-UCL
Traceable author statementⁱ
- 22822086
phospholipid transport
Source: BHF-UCL
Inferred from direct assayⁱ
- 16274224
retrograde vesicle-mediated transport, Golgi to ER
Source: BHF-UCL
Traceable author statementⁱ
- 22822086

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport
Ligand	Lipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483196 PI and PC transport between ER and Golgi membranes

Reactomeⁱ

R-HSA-1483196 PI and PC transport between ER and Golgi membranes

Chemistry databases

SwissLipidsⁱ	SLP:000000416

SwissLipidsⁱ

SLP:000000416

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phosphatidylinositol transfer protein beta isoform Short name: PI-TP-beta Short name: PtdIns transfer protein beta Short name: PtdInsTP beta
Gene namesⁱ	Name:PITPNB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180957.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9002 PITPNB
MIMⁱ	606876 gene
neXtProtⁱ	NX_P48739

Keywords - Cellular componentⁱ

Cytoplasm, Golgi apparatus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000180957
PharmGKBⁱ	PA33336

Polymorphism and mutation databases

DMDMⁱ	1346772

DMDMⁱ

1346772

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191643	1 – 271	Phosphatidylinositol transfer protein beta isoformAdd BLAST		271

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	215	N6-acetyllysineCombined sources		1
Modified residueⁱ	262	PhosphoserineBy similarity		1

Post-translational modificationⁱ

Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.By similarity

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P48739
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P48739
PaxDbⁱ	P48739
PeptideAtlas More...PeptideAtlasⁱ	P48739
PRIDEⁱ	P48739
ProteomicsDBⁱ	55934 55935 [P48739-2]

PTM databases

iPTMnetⁱ	P48739
PhosphoSitePlusⁱ	P48739

Expressionⁱ

Tissue specificityⁱ

Widely expressed in various tissues including brain.

Gene expression databases

Bgeeⁱ	ENSG00000180957 Expressed in 241 organ(s), highest expression level in gingival epithelium
CleanExⁱ	HS_PITPNB
ExpressionAtlasⁱ	P48739 baseline and differential
Genevisibleⁱ	P48739 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000528

HPAⁱ

HPA000528

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	117261, 26 interactors
IntActⁱ	P48739, 5 interactors
Molecular INTeraction database More...MINTⁱ	P48739
STRINGⁱ	9606.ENSP00000334738

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P48739
SMRⁱ	P48739
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3668 Eukaryota COG5083 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119216
HOGENOMⁱ	HOG000006717
HOVERGENⁱ	HBG058915
InParanoidⁱ	P48739
OMAⁱ	AIHEEAW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CQQ
PhylomeDBⁱ	P48739
TreeFamⁱ	TF313279

Family and domain databases

Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR001666 PI_transfer IPR023393 START-like_dom_sf
PANTHERⁱ	PTHR10658 PTHR10658, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02121 IP_trans, 1 hit
PRINTSⁱ	PR00391 PITRANSFER

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P48739-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK 
        60         70         80         90        100
DGEKGQYTHK IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN 
       110        120        130        140        150
EYMKDDFFIK IETWHKPDLG TLENVHGLDP NTWKTVEIVH IDIADRSQVE 
       160        170        180        190        200
PADYKADEDP ALFQSVKTKR GPLGPNWKKE LANSPDCPQM CAYKLVTIKF 
       210        220        230        240        250
KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM EDIRRMEDET 
       260        270 
QKELETMRKR GSVRGTSAAD V

Length:271

Mass (Da):31,540

Last modified:January 23, 2007 - v2

Checksum:ⁱAC5333FBC0F6CA06

GO

Isoform 2 (identifier: P48739-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
257-271: MRKRGSVRGTSAADV → LRNQGQVRGTSAASDE

« Hide

        10         20         30         40         50
MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK 
        60         70         80         90        100
DGEKGQYTHK IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN 
       110        120        130        140        150
EYMKDDFFIK IETWHKPDLG TLENVHGLDP NTWKTVEIVH IDIADRSQVE 
       160        170        180        190        200
PADYKADEDP ALFQSVKTKR GPLGPNWKKE LANSPDCPQM CAYKLVTIKF 
       210        220        230        240        250
KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM EDIRRMEDET 
       260        270 
QKELETLRNQ GQVRGTSAAS DE

Show »

Length:272

Mass (Da):31,638

Checksum:ⁱ05142EA9F80BA7CB

GO

Isoform 3 (identifier: P48739-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-7: MVLIKEF → MGDLLMEKC

« Hide

        10         20         30         40         50
MGDLLMEKCR VVLPCSVQEY QVGQLYSVAE ASKNETGGGE GIEVLKNEPY 
        60         70         80         90        100
EKDGEKGQYT HKIYHLKSKV PAFVRMIAPE GSLVFHEKAW NAYPYCRTIV 
       110        120        130        140        150
TNEYMKDDFF IKIETWHKPD LGTLENVHGL DPNTWKTVEI VHIDIADRSQ 
       160        170        180        190        200
VEPADYKADE DPALFQSVKT KRGPLGPNWK KELANSPDCP QMCAYKLVTI 
       210        220        230        240        250
KFKWWGLQSK VENFIQKQEK RIFTNFHRQL FCWIDKWIDL TMEDIRRMED 
       260        270 
ETQKELETMR KRGSVRGTSA ADV

Show »

Length:273

Mass (Da):31,700

Checksum:ⁱ547F67C88E573741

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MSW4	A0A0A0MSW4_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein beta isoform	PITPNB	271	Annotation score:
B3KYB6	B3KYB6_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein beta isoform	PITPNB	120	Annotation score:
B3KYB7	B3KYB7_HUMAN	Phosphatidylinositol transfer prote... Phosphatidylinositol transfer protein beta isoform	PITPNB	167	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055132	1 – 7	MVLIKEF → MGDLLMEKC in isoform 3. 1 Publication		7
Alternative sequenceⁱVSP_012762	257 – 271	MRKRG…SAADV → LRNQGQVRGTSAASDE in isoform 2. 1 PublicationAdd BLAST		15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D30037 mRNA Translation: BAA06277.1 CR456541 mRNA Translation: CAG30427.1 AK302367 mRNA Translation: BAH13686.1 AL031591 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW59743.1 BC018704 mRNA Translation: AAH18704.1 BC031427 mRNA Translation: AAH31427.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13842.1 [P48739-1] CCDS63432.1 [P48739-3] CCDS63433.1 [P48739-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001271206.1, NM_001284277.1 [P48739-2] NP_001271207.1, NM_001284278.1 [P48739-3] NP_036531.1, NM_012399.4 [P48739-1]
UniGeneⁱ	Hs.705323

Genome annotation databases

Ensemblⁱ	ENST00000320996; ENSP00000321266; ENSG00000180957 [P48739-2] ENST00000335272; ENSP00000334738; ENSG00000180957 [P48739-1] ENST00000634017; ENSP00000487693; ENSG00000180957 [P48739-3]
GeneIDⁱ	23760
KEGGⁱ	hsa:23760
UCSC genome browser More...UCSCⁱ	uc003adk.5 human [P48739-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P48739	Phosphatidylinositol transfer protein, beta		PANTR		283	UniRef100_P48739
PITPNB isoform 1		PONAB		271
Phosphatidylinositol transfer protein beta isoform		MACMU		271
Uncharacterized protein		AOTNA		271
PITPNB isoform 1		PANTR		271
P48739-2	PITPNB isoform 2		PANTR		272	UniRef100_A0A2I3T5X8
Uncharacterized protein		MACMU		272
Uncharacterized protein		COLAP		272
PITPNB isoform 2		PONAB		272
Uncharacterized protein		RHIRO		272
+7
P48739-3	PITPNB isoform 4		PANTR		273	UniRef100_A0A2I3SR29
Uncharacterized protein		MACMU		273
PITPNB isoform 4		PONAB		273
Uncharacterized protein		CERAT		273
Uncharacterized protein		PAPAN		273
+3

Protein	Similar proteins		Species	Score	Length	Source
P48739	Phosphatidylinositol transfer protein beta isoform		BOVIN		271	UniRef90_P48739
Phosphatidylinositol transfer protein beta isoform		MOUSE		271
Phosphatidylinositol transfer protein beta isoform	)	RAT		271
Phosphatidylinositol transfer protein, beta		PANTR		283
PITPNB isoform 1		PONAB		271
+156
P48739-2	Phosphatidylinositol transfer protein beta isoform		PONAB		272	UniRef90_Q5R6F0
Phosphatidylinositol transfer protein beta		ANAPL		276
Phosphatidylinositol transfer protein beta		MELGA		273
phosphatidylinositol transfer protein beta isoform isoform X1		DELLE		272
phosphatidylinositol transfer protein beta isoform isoform X1		LIPVE		272
+87

Protein	Similar proteins		Species	Score	Length	Source
P48739	Phosphatidylinositol transfer protein beta isoform	)	RAT		271	UniRef50_P48739
Phosphatidylinositol transfer protein beta isoform		MOUSE		271
Phosphatidylinositol transfer protein beta isoform		BOVIN		271
Phosphatidylinositol transfer protein beta isoform		PONAB		272
Phosphatidylinositol transfer protein, beta		PANTR		283
+385

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D30037 mRNA Translation: BAA06277.1 CR456541 mRNA Translation: CAG30427.1 AK302367 mRNA Translation: BAH13686.1 AL031591 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW59743.1 BC018704 mRNA Translation: AAH18704.1 BC031427 mRNA Translation: AAH31427.1
CCDSⁱ	CCDS13842.1 [P48739-1] CCDS63432.1 [P48739-3] CCDS63433.1 [P48739-2]
RefSeqⁱ	NP_001271206.1, NM_001284277.1 [P48739-2] NP_001271207.1, NM_001284278.1 [P48739-3] NP_036531.1, NM_012399.4 [P48739-1]
UniGeneⁱ	Hs.705323

3D structure databases

ProteinModelPortalⁱ	P48739
SMRⁱ	P48739
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117261, 26 interactors
IntActⁱ	P48739, 5 interactors
MINTⁱ	P48739
STRINGⁱ	9606.ENSP00000334738

Chemistry databases

SwissLipidsⁱ	SLP:000000416

SwissLipidsⁱ

SLP:000000416

PTM databases

iPTMnetⁱ	P48739
PhosphoSitePlusⁱ	P48739

Polymorphism and mutation databases

DMDMⁱ	1346772

DMDMⁱ

1346772

Proteomic databases

EPDⁱ	P48739
MaxQBⁱ	P48739
PaxDbⁱ	P48739
PeptideAtlasⁱ	P48739
PRIDEⁱ	P48739
ProteomicsDBⁱ	55934 55935 [P48739-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23760
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000320996; ENSP00000321266; ENSG00000180957 [P48739-2] ENST00000335272; ENSP00000334738; ENSG00000180957 [P48739-1] ENST00000634017; ENSP00000487693; ENSG00000180957 [P48739-3]
GeneIDⁱ	23760
KEGGⁱ	hsa:23760
UCSCⁱ	uc003adk.5 human [P48739-1]

Organism-specific databases

CTDⁱ	23760
EuPathDBⁱ	HostDB:ENSG00000180957.17
GeneCardsⁱ	PITPNB
HGNCⁱ	HGNC:9002 PITPNB
HPAⁱ	HPA000528
MIMⁱ	606876 gene
neXtProtⁱ	NX_P48739
OpenTargetsⁱ	ENSG00000180957
PharmGKBⁱ	PA33336
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3668 Eukaryota COG5083 LUCA
GeneTreeⁱ	ENSGT00760000119216
HOGENOMⁱ	HOG000006717
HOVERGENⁱ	HBG058915
InParanoidⁱ	P48739
OMAⁱ	AIHEEAW
OrthoDBⁱ	EOG091G0CQQ
PhylomeDBⁱ	P48739
TreeFamⁱ	TF313279

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1483196 PI and PC transport between ER and Golgi membranes

Reactomeⁱ

R-HSA-1483196 PI and PC transport between ER and Golgi membranes

Miscellaneous databases

ChiTaRSⁱ	PITPNB human
GeneWikiⁱ	PITPNB
GenomeRNAiⁱ	23760
Protein Ontology More...PROⁱ	PR:P48739
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180957 Expressed in 241 organ(s), highest expression level in gingival epithelium
CleanExⁱ	HS_PITPNB
ExpressionAtlasⁱ	P48739 baseline and differential
Genevisibleⁱ	P48739 HS

Family and domain databases

Gene3Dⁱ	3.30.530.20, 1 hit
InterProⁱ	View protein in InterPro IPR001666 PI_transfer IPR023393 START-like_dom_sf
PANTHERⁱ	PTHR10658 PTHR10658, 1 hit
Pfamⁱ	View protein in Pfam PF02121 IP_trans, 1 hit
PRINTSⁱ	PR00391 PITRANSFER
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PIPNB_HUMAN
Accessionⁱ	P48739Primary (citable) accession number: P48739 Secondary accession number(s): B3KYB8, B7Z7Q0, Q8N5W1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM

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UniProtKB - P48739 (PIPNB_HUMAN)

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Phosphatidylinositol transfer protein beta isoform

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Other locations

Endoplasmic reticulum

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ