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Protein

Phosphatidylinositol transfer protein beta isoform

Gene

PITPNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

GO - Molecular functioni

GO - Biological processi

  • lipid metabolic process Source: ProtInc
  • nucleus organization Source: BHF-UCL
  • phospholipid transport Source: BHF-UCL
  • retrograde vesicle-mediated transport, Golgi to ER Source: BHF-UCL

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-1483196 PI and PC transport between ER and Golgi membranes

Chemistry databases

SwissLipidsiSLP:000000416

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol transfer protein beta isoform
Short name:
PI-TP-beta
Short name:
PtdIns transfer protein beta
Short name:
PtdInsTP beta
Gene namesi
Name:PITPNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000180957.17
HGNCiHGNC:9002 PITPNB
MIMi606876 gene
neXtProtiNX_P48739

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180957
PharmGKBiPA33336

Polymorphism and mutation databases

DMDMi1346772

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916431 – 271Phosphatidylinositol transfer protein beta isoformAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215N6-acetyllysineCombined sources1
Modified residuei262PhosphoserineBy similarity1

Post-translational modificationi

Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP48739
MaxQBiP48739
PaxDbiP48739
PeptideAtlasiP48739
PRIDEiP48739
ProteomicsDBi55934
55935 [P48739-2]

PTM databases

iPTMnetiP48739
PhosphoSitePlusiP48739

Expressioni

Tissue specificityi

Widely expressed in various tissues including brain.

Gene expression databases

BgeeiENSG00000180957 Expressed in 241 organ(s), highest expression level in gingival epithelium
CleanExiHS_PITPNB
ExpressionAtlasiP48739 baseline and differential
GenevisibleiP48739 HS

Organism-specific databases

HPAiHPA000528

Interactioni

Protein-protein interaction databases

BioGridi117261, 26 interactors
IntActiP48739, 5 interactors
MINTiP48739
STRINGi9606.ENSP00000334738

Structurei

3D structure databases

ProteinModelPortaliP48739
SMRiP48739
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3668 Eukaryota
COG5083 LUCA
GeneTreeiENSGT00760000119216
HOGENOMiHOG000006717
HOVERGENiHBG058915
InParanoidiP48739
OMAiAIHEEAW
OrthoDBiEOG091G0CQQ
PhylomeDBiP48739
TreeFamiTF313279

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR001666 PI_transfer
IPR023393 START-like_dom_sf
PANTHERiPTHR10658 PTHR10658, 1 hit
PfamiView protein in Pfam
PF02121 IP_trans, 1 hit
PRINTSiPR00391 PITRANSFER

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P48739-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLIKEFRVV LPCSVQEYQV GQLYSVAEAS KNETGGGEGI EVLKNEPYEK
60 70 80 90 100
DGEKGQYTHK IYHLKSKVPA FVRMIAPEGS LVFHEKAWNA YPYCRTIVTN
110 120 130 140 150
EYMKDDFFIK IETWHKPDLG TLENVHGLDP NTWKTVEIVH IDIADRSQVE
160 170 180 190 200
PADYKADEDP ALFQSVKTKR GPLGPNWKKE LANSPDCPQM CAYKLVTIKF
210 220 230 240 250
KWWGLQSKVE NFIQKQEKRI FTNFHRQLFC WIDKWIDLTM EDIRRMEDET
260 270
QKELETMRKR GSVRGTSAAD V
Length:271
Mass (Da):31,540
Last modified:January 23, 2007 - v2
Checksum:iAC5333FBC0F6CA06
GO
Isoform 2 (identifier: P48739-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-271: MRKRGSVRGTSAADV → LRNQGQVRGTSAASDE

Show »
Length:272
Mass (Da):31,638
Checksum:i05142EA9F80BA7CB
GO
Isoform 3 (identifier: P48739-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MVLIKEF → MGDLLMEKC

Show »
Length:273
Mass (Da):31,700
Checksum:i547F67C88E573741
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSW4A0A0A0MSW4_HUMAN
Phosphatidylinositol transfer prote...
PITPNB
271Annotation score:
B3KYB6B3KYB6_HUMAN
Phosphatidylinositol transfer prote...
PITPNB
120Annotation score:
B3KYB7B3KYB7_HUMAN
Phosphatidylinositol transfer prote...
PITPNB
167Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551321 – 7MVLIKEF → MGDLLMEKC in isoform 3. 1 Publication7
Alternative sequenceiVSP_012762257 – 271MRKRG…SAADV → LRNQGQVRGTSAASDE in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30037 mRNA Translation: BAA06277.1
CR456541 mRNA Translation: CAG30427.1
AK302367 mRNA Translation: BAH13686.1
AL031591 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59743.1
BC018704 mRNA Translation: AAH18704.1
BC031427 mRNA Translation: AAH31427.1
CCDSiCCDS13842.1 [P48739-1]
CCDS63432.1 [P48739-3]
CCDS63433.1 [P48739-2]
RefSeqiNP_001271206.1, NM_001284277.1 [P48739-2]
NP_001271207.1, NM_001284278.1 [P48739-3]
NP_036531.1, NM_012399.4 [P48739-1]
UniGeneiHs.705323

Genome annotation databases

EnsembliENST00000320996; ENSP00000321266; ENSG00000180957 [P48739-2]
ENST00000335272; ENSP00000334738; ENSG00000180957 [P48739-1]
ENST00000634017; ENSP00000487693; ENSG00000180957 [P48739-3]
GeneIDi23760
KEGGihsa:23760
UCSCiuc003adk.5 human [P48739-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30037 mRNA Translation: BAA06277.1
CR456541 mRNA Translation: CAG30427.1
AK302367 mRNA Translation: BAH13686.1
AL031591 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59743.1
BC018704 mRNA Translation: AAH18704.1
BC031427 mRNA Translation: AAH31427.1
CCDSiCCDS13842.1 [P48739-1]
CCDS63432.1 [P48739-3]
CCDS63433.1 [P48739-2]
RefSeqiNP_001271206.1, NM_001284277.1 [P48739-2]
NP_001271207.1, NM_001284278.1 [P48739-3]
NP_036531.1, NM_012399.4 [P48739-1]
UniGeneiHs.705323

3D structure databases

ProteinModelPortaliP48739
SMRiP48739
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117261, 26 interactors
IntActiP48739, 5 interactors
MINTiP48739
STRINGi9606.ENSP00000334738

Chemistry databases

SwissLipidsiSLP:000000416

PTM databases

iPTMnetiP48739
PhosphoSitePlusiP48739

Polymorphism and mutation databases

DMDMi1346772

Proteomic databases

EPDiP48739
MaxQBiP48739
PaxDbiP48739
PeptideAtlasiP48739
PRIDEiP48739
ProteomicsDBi55934
55935 [P48739-2]

Protocols and materials databases

DNASUi23760
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320996; ENSP00000321266; ENSG00000180957 [P48739-2]
ENST00000335272; ENSP00000334738; ENSG00000180957 [P48739-1]
ENST00000634017; ENSP00000487693; ENSG00000180957 [P48739-3]
GeneIDi23760
KEGGihsa:23760
UCSCiuc003adk.5 human [P48739-1]

Organism-specific databases

CTDi23760
EuPathDBiHostDB:ENSG00000180957.17
GeneCardsiPITPNB
HGNCiHGNC:9002 PITPNB
HPAiHPA000528
MIMi606876 gene
neXtProtiNX_P48739
OpenTargetsiENSG00000180957
PharmGKBiPA33336
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3668 Eukaryota
COG5083 LUCA
GeneTreeiENSGT00760000119216
HOGENOMiHOG000006717
HOVERGENiHBG058915
InParanoidiP48739
OMAiAIHEEAW
OrthoDBiEOG091G0CQQ
PhylomeDBiP48739
TreeFamiTF313279

Enzyme and pathway databases

ReactomeiR-HSA-1483196 PI and PC transport between ER and Golgi membranes

Miscellaneous databases

ChiTaRSiPITPNB human
GeneWikiiPITPNB
GenomeRNAii23760
PROiPR:P48739
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180957 Expressed in 241 organ(s), highest expression level in gingival epithelium
CleanExiHS_PITPNB
ExpressionAtlasiP48739 baseline and differential
GenevisibleiP48739 HS

Family and domain databases

Gene3Di3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR001666 PI_transfer
IPR023393 START-like_dom_sf
PANTHERiPTHR10658 PTHR10658, 1 hit
PfamiView protein in Pfam
PF02121 IP_trans, 1 hit
PRINTSiPR00391 PITRANSFER
ProtoNetiSearch...

Entry informationi

Entry nameiPIPNB_HUMAN
AccessioniPrimary (citable) accession number: P48739
Secondary accession number(s): B3KYB8, B7Z7Q0, Q8N5W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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