UniProtKB - P48735 (IDHP_HUMAN)
Protein
Isocitrate dehydrogenase [NADP], mitochondrial
Gene
IDH2
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
Catalytic activityi
- EC:1.1.1.42
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 117 | SubstrateBy similarity | 1 | |
Binding sitei | 122 | NADPBy similarity | 1 | |
Binding sitei | 149 | SubstrateBy similarity | 1 | |
Binding sitei | 172 | SubstrateBy similarity | 1 | |
Sitei | 179 | Critical for catalysisBy similarity | 1 | |
Sitei | 251 | Critical for catalysisBy similarity | 1 | |
Metal bindingi | 291 | Magnesium or manganeseBy similarity | 1 | |
Binding sitei | 299 | NADPBy similarity | 1 | |
Metal bindingi | 314 | Magnesium or manganeseBy similarity | 1 | |
Binding sitei | 367 | NADP; via amide nitrogen and carbonyl oxygenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 115 – 117 | NADPBy similarity | 3 | |
Nucleotide bindingi | 349 – 354 | NADPBy similarity | 6 |
GO - Molecular functioni
- isocitrate dehydrogenase (NADP+) activity Source: CACAO
- magnesium ion binding Source: UniProtKB
- NAD binding Source: InterPro
GO - Biological processi
- 2-oxoglutarate metabolic process Source: UniProtKB
- carbohydrate metabolic process Source: ProtInc
- glyoxylate cycle Source: UniProtKB-KW
- isocitrate metabolic process Source: UniProtKB
- NADP biosynthetic process Source: Ensembl
- NADP metabolic process Source: GO_Central
- negative regulation of glial cell migration Source: Ensembl
- negative regulation of glial cell proliferation Source: Ensembl
- negative regulation of matrix metallopeptidase secretion Source: Ensembl
- tricarboxylic acid cycle Source: Reactome
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Glyoxylate bypass, Tricarboxylic acid cycle |
Ligand | Magnesium, Manganese, Metal-binding, NADP |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00021-MONOMER |
BRENDAi | 1.1.1.42, 2681 |
PathwayCommonsi | P48735 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-71403, Citric acid cycle (TCA cycle) |
SABIO-RKi | P48735 |
SIGNORi | P48735 |
Names & Taxonomyi
Protein namesi | Recommended name: Isocitrate dehydrogenase [NADP], mitochondrial (EC:1.1.1.42)Short name: IDH Alternative name(s): ICD-M IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase |
Gene namesi | Name:IDH2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5383, IDH2 |
MIMi | 147650, gene |
neXtProti | NX_P48735 |
VEuPathDBi | HostDB:ENSG00000182054.9 |
Subcellular locationi
Mitochondrion
Cytosol
- cytosol Source: Ensembl
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrial matrix Source: Reactome
- mitochondrion Source: HPA
Peroxisome
- peroxisome Source: Ensembl
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
D-2-hydroxyglutaric aciduria 2 (D2HGA2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both a mild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onset epileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosis is based on the presence of an excess of D-2-hydroxyglutaric acid in the urine.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065174 | 140 | R → G in D2HGA2. 1 PublicationCorresponds to variant dbSNP:rs267606870Ensembl. | 1 | |
Natural variantiVAR_065175 | 140 | R → Q in D2HGA2. 1 PublicationCorresponds to variant dbSNP:rs121913502Ensembl. | 1 |
Glioma (GLM)2 Publications
The gene represented in this entry is involved in disease pathogenesis.
Disease descriptionGliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073181 | 158 | P → L in GLM; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_073182 | 162 | P → S in GLM; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_073183 | 172 | R → G in GLM; somatic mutation; reduces enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs1057519906Ensembl. | 1 | |
Natural variantiVAR_073184 | 172 | R → K in GLM; somatic mutation; reduces enzymatic activity. 2 PublicationsCorresponds to variant dbSNP:rs121913503Ensembl. | 1 | |
Natural variantiVAR_073185 | 172 | R → M in GLM; somatic mutation; reduces enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs121913503Ensembl. | 1 |
enetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 413 | K → A: 44-fold loss in activity. 1 Publication | 1 | |
Mutagenesisi | 413 | K → Q: 20-fold decrease in Vmax. 1 Publication | 1 | |
Mutagenesisi | 413 | K → R: No appreciable difference in Km for isocitrate and NADP. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 3418 |
MalaCardsi | IDH2 |
MIMi | 137800, phenotype 613657, phenotype |
OpenTargetsi | ENSG00000182054 |
Orphaneti | 251589, Anaplastic astrocytoma 251663, Anaplastic oligoastrocytoma 251630, Anaplastic oligodendroglioma 79315, D-2-hydroxyglutaric aciduria 251601, Fibrillary astrocytoma 251604, Gemistocytic astrocytoma 163634, Maffucci syndrome 251656, Oligoastrocytoma 251627, Oligodendroglioma 296, Ollier disease 251598, Protoplasmic astrocytoma |
PharmGKBi | PA29631 |
Miscellaneous databases
Pharosi | P48735, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3991501 |
DrugBanki | DB13874, Enasidenib DB01727, Isocitric Acid |
DrugCentrali | P48735 |
Genetic variation databases
BioMutai | IDH2 |
DMDMi | 20141568 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 39 | MitochondrionBy similarityAdd BLAST | 39 | |
ChainiPRO_0000014420 | 40 – 452 | Isocitrate dehydrogenase [NADP], mitochondrialAdd BLAST | 413 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 45 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 48 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 67 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 69 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 80 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 80 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 106 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 106 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 155 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 166 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 166 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 180 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 180 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 193 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 193 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 199 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 256 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 256 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 263 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 272 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 275 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 280 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 282 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 282 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 384 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 384 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 400 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 413 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 442 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3.1 Publication
Keywords - PTMi
AcetylationProteomic databases
CPTACi | CPTAC-221 CPTAC-222 |
EPDi | P48735 |
jPOSTi | P48735 |
MassIVEi | P48735 |
MaxQBi | P48735 |
PaxDbi | P48735 |
PeptideAtlasi | P48735 |
PRIDEi | P48735 |
ProteomicsDBi | 4054 55932 [P48735-1] |
2D gel databases
OGPi | P48735 |
UCD-2DPAGEi | P48735 |
PTM databases
CarbonylDBi | P48735 |
iPTMneti | P48735 |
MetOSitei | P48735 |
PhosphoSitePlusi | P48735 |
SwissPalmi | P48735 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182054, Expressed in muscle of leg and 247 other tissues |
ExpressionAtlasi | P48735, baseline and differential |
Genevisiblei | P48735, HS |
Organism-specific databases
HPAi | ENSG00000182054, Tissue enhanced (heart muscle, skeletal muscle) |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
BioGRIDi | 109644, 97 interactors |
CORUMi | P48735 |
DIPi | DIP-61416N |
IntActi | P48735, 22 interactors |
MINTi | P48735 |
STRINGi | 9606.ENSP00000331897 |
Chemistry databases
BindingDBi | P48735 |
Miscellaneous databases
RNActi | P48735, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P48735 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 134 – 140 | Substrate bindingBy similarity | 7 |
Sequence similaritiesi
Belongs to the isocitrate and isopropylmalate dehydrogenases family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1526, Eukaryota |
GeneTreei | ENSGT00390000012547 |
HOGENOMi | CLU_023296_1_1_1 |
InParanoidi | P48735 |
OMAi | EATLKYG |
OrthoDBi | 1029485at2759 |
PhylomeDBi | P48735 |
TreeFami | TF300428 |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004790, Isocitrate_DH_NADP IPR024084, IsoPropMal-DH-like_dom |
PANTHERi | PTHR11822, PTHR11822, 1 hit |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
PIRSFi | PIRSF000108, IDH_NADP, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00127, nadp_idh_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P48735-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGYLRVVRS LCRASGSRPA WAPAALTAPT SQEQPRRHYA DKRIKVAKPV
60 70 80 90 100
VEMDGDEMTR IIWQFIKEKL ILPHVDIQLK YFDLGLPNRD QTDDQVTIDS
110 120 130 140 150
ALATQKYSVA VKCATITPDE ARVEEFKLKK MWKSPNGTIR NILGGTVFRE
160 170 180 190 200
PIICKNIPRL VPGWTKPITI GRHAHGDQYK ATDFVADRAG TFKMVFTPKD
210 220 230 240 250
GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI QKKWPLYMST
260 270 280 290 300
KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS
310 320 330 340 350
SGGFVWACKN YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT
360 370 380 390 400
VTRHYREHQK GRPTSTNPIA SIFAWTRGLE HRGKLDGNQD LIRFAQMLEK
410 420 430 440 450
VCVETVESGA MTKDLAGCIH GLSNVKLNEH FLNTTDFLDT IKSNLDRALG
RQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YL11 | H0YL11_HUMAN | IDP | IDH2 | 312 | Annotation score: | ||
H0YLL5 | H0YLL5_HUMAN | Isocitrate dehydrogenase [NADP], mi... | IDH2 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | Q → H in CAA49208 (Ref. 1) Curated | 1 | |
Sequence conflicti | 435 | T → M in CAA49208 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065174 | 140 | R → G in D2HGA2. 1 PublicationCorresponds to variant dbSNP:rs267606870Ensembl. | 1 | |
Natural variantiVAR_065175 | 140 | R → Q in D2HGA2. 1 PublicationCorresponds to variant dbSNP:rs121913502Ensembl. | 1 | |
Natural variantiVAR_073181 | 158 | P → L in GLM; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_073182 | 162 | P → S in GLM; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_073183 | 172 | R → G in GLM; somatic mutation; reduces enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs1057519906Ensembl. | 1 | |
Natural variantiVAR_073184 | 172 | R → K in GLM; somatic mutation; reduces enzymatic activity. 2 PublicationsCorresponds to variant dbSNP:rs121913503Ensembl. | 1 | |
Natural variantiVAR_073185 | 172 | R → M in GLM; somatic mutation; reduces enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs121913503Ensembl. | 1 | |
Natural variantiVAR_076512 | 172 | R → S Found in patients with cartilagenous tumors. 1 PublicationCorresponds to variant dbSNP:rs1057519736Ensembl. | 1 | |
Natural variantiVAR_076513 | 172 | R → T Found in patients with cartilagenous tumors. 1 Publication | 1 | |
Natural variantiVAR_076514 | 172 | R → W Found in patients with cartilagenous tumors. 1 PublicationCorresponds to variant dbSNP:rs1057519906Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056278 | 1 – 52 | Missing in isoform 2. 1 PublicationAdd BLAST | 52 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69433 mRNA Translation: CAA49208.1 AK294148 mRNA Translation: BAG57473.1 AK312627 mRNA Translation: BAG35513.1 AK316388 mRNA Translation: BAH14759.1 AC087284 Genomic DNA No translation available. AC092769 Genomic DNA No translation available. CH471101 Genomic DNA Translation: EAX02082.1 BC009244 mRNA Translation: AAH09244.1 BC071828 mRNA Translation: AAH71828.1 |
CCDSi | CCDS10359.1 [P48735-1] CCDS76792.1 [P48735-2] |
PIRi | S57499 |
RefSeqi | NP_001276839.1, NM_001289910.1 [P48735-2] NP_001277043.1, NM_001290114.1 NP_002159.2, NM_002168.3 [P48735-1] |
Genome annotation databases
Ensembli | ENST00000330062; ENSP00000331897; ENSG00000182054 [P48735-1] ENST00000540499; ENSP00000446147; ENSG00000182054 [P48735-2] |
GeneIDi | 3418 |
KEGGi | hsa:3418 |
UCSCi | uc002box.4, human [P48735-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69433 mRNA Translation: CAA49208.1 AK294148 mRNA Translation: BAG57473.1 AK312627 mRNA Translation: BAG35513.1 AK316388 mRNA Translation: BAH14759.1 AC087284 Genomic DNA No translation available. AC092769 Genomic DNA No translation available. CH471101 Genomic DNA Translation: EAX02082.1 BC009244 mRNA Translation: AAH09244.1 BC071828 mRNA Translation: AAH71828.1 |
CCDSi | CCDS10359.1 [P48735-1] CCDS76792.1 [P48735-2] |
PIRi | S57499 |
RefSeqi | NP_001276839.1, NM_001289910.1 [P48735-2] NP_001277043.1, NM_001290114.1 NP_002159.2, NM_002168.3 [P48735-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4JA8 | X-ray | 1.55 | A/B | 41-452 | [»] | |
5GIS | X-ray | 1.93 | C | 165-180 | [»] | |
5I95 | X-ray | 1.54 | A | 40-452 | [»] | |
5I96 | X-ray | 1.55 | A/B | 1-452 | [»] | |
5SVN | X-ray | 2.10 | A/B | 40-452 | [»] | |
5SVO | X-ray | 1.87 | A/B | 40-452 | [»] | |
6ADI | X-ray | 1.97 | A/B | 41-452 | [»] | |
6VFZ | X-ray | 1.99 | A/B | 1-452 | [»] | |
SMRi | P48735 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109644, 97 interactors |
CORUMi | P48735 |
DIPi | DIP-61416N |
IntActi | P48735, 22 interactors |
MINTi | P48735 |
STRINGi | 9606.ENSP00000331897 |
Chemistry databases
BindingDBi | P48735 |
ChEMBLi | CHEMBL3991501 |
DrugBanki | DB13874, Enasidenib DB01727, Isocitric Acid |
DrugCentrali | P48735 |
PTM databases
CarbonylDBi | P48735 |
iPTMneti | P48735 |
MetOSitei | P48735 |
PhosphoSitePlusi | P48735 |
SwissPalmi | P48735 |
Genetic variation databases
BioMutai | IDH2 |
DMDMi | 20141568 |
2D gel databases
OGPi | P48735 |
UCD-2DPAGEi | P48735 |
Proteomic databases
CPTACi | CPTAC-221 CPTAC-222 |
EPDi | P48735 |
jPOSTi | P48735 |
MassIVEi | P48735 |
MaxQBi | P48735 |
PaxDbi | P48735 |
PeptideAtlasi | P48735 |
PRIDEi | P48735 |
ProteomicsDBi | 4054 55932 [P48735-1] |
Protocols and materials databases
ABCDi | P48735, 1 sequenced antibody |
Antibodypediai | 15858, 439 antibodies |
DNASUi | 3418 |
Genome annotation databases
Ensembli | ENST00000330062; ENSP00000331897; ENSG00000182054 [P48735-1] ENST00000540499; ENSP00000446147; ENSG00000182054 [P48735-2] |
GeneIDi | 3418 |
KEGGi | hsa:3418 |
UCSCi | uc002box.4, human [P48735-1] |
Organism-specific databases
CTDi | 3418 |
DisGeNETi | 3418 |
GeneCardsi | IDH2 |
HGNCi | HGNC:5383, IDH2 |
HPAi | ENSG00000182054, Tissue enhanced (heart muscle, skeletal muscle) |
MalaCardsi | IDH2 |
MIMi | 137800, phenotype 147650, gene 613657, phenotype |
neXtProti | NX_P48735 |
OpenTargetsi | ENSG00000182054 |
Orphaneti | 251589, Anaplastic astrocytoma 251663, Anaplastic oligoastrocytoma 251630, Anaplastic oligodendroglioma 79315, D-2-hydroxyglutaric aciduria 251601, Fibrillary astrocytoma 251604, Gemistocytic astrocytoma 163634, Maffucci syndrome 251656, Oligoastrocytoma 251627, Oligodendroglioma 296, Ollier disease 251598, Protoplasmic astrocytoma |
PharmGKBi | PA29631 |
VEuPathDBi | HostDB:ENSG00000182054.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1526, Eukaryota |
GeneTreei | ENSGT00390000012547 |
HOGENOMi | CLU_023296_1_1_1 |
InParanoidi | P48735 |
OMAi | EATLKYG |
OrthoDBi | 1029485at2759 |
PhylomeDBi | P48735 |
TreeFami | TF300428 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00021-MONOMER |
BRENDAi | 1.1.1.42, 2681 |
PathwayCommonsi | P48735 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-71403, Citric acid cycle (TCA cycle) |
SABIO-RKi | P48735 |
SIGNORi | P48735 |
Miscellaneous databases
BioGRID-ORCSi | 3418, 6 hits in 875 CRISPR screens |
ChiTaRSi | IDH2, human |
GeneWikii | IDH2 |
GenomeRNAii | 3418 |
Pharosi | P48735, Tclin |
PROi | PR:P48735 |
RNActi | P48735, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182054, Expressed in muscle of leg and 247 other tissues |
ExpressionAtlasi | P48735, baseline and differential |
Genevisiblei | P48735, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019818, IsoCit/isopropylmalate_DH_CS IPR004790, Isocitrate_DH_NADP IPR024084, IsoPropMal-DH-like_dom |
PANTHERi | PTHR11822, PTHR11822, 1 hit |
Pfami | View protein in Pfam PF00180, Iso_dh, 1 hit |
PIRSFi | PIRSF000108, IDH_NADP, 1 hit |
SMARTi | View protein in SMART SM01329, Iso_dh, 1 hit |
TIGRFAMsi | TIGR00127, nadp_idh_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00470, IDH_IMDH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IDHP_HUMAN | |
Accessioni | P48735Primary (citable) accession number: P48735 Secondary accession number(s): B2R6L6, B4DFL2, Q96GT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | April 3, 2002 | |
Last modified: | February 10, 2021 | |
This is version 204 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families