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Entry version 125 (11 Dec 2019)
Sequence version 2 (14 Oct 2008)
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Protein

Light-mediated development protein DET1

Gene

DET1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of light signal transduction machinery. Involved in repression of photomorphogenesis in darkness by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes (E2s). Involved in repression of deetiolation in the developing seedling. Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis-promoting factors such as HY5, HYH and LAF1. Involved in the repression of blue light responsive promoter in chloroplasts. May be required to stabilize the CDD complex. Its association with histone tail suggests a role in remodeling of chromatin (PubMed:9681024, PubMed:15342494). Required for the regulation of histone H2B monoubiquitination (H2Bub) over most genes by controlling the stability of the deubiquitination module (DUB module) (PubMed:30192741).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPhytochrome signaling pathway, Ubl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Light-mediated development protein DET1
Alternative name(s):
Protein DEETIOLATED 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DET1
Ordered Locus Names:At4g10180
ORF Names:F28M11.100, T9A4.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT4G10180

The Arabidopsis Information Resource

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TAIRi
locus:2005505 AT4G10180

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001290281 – 543Light-mediated development protein DET1Add BLAST543

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48732

PRoteomics IDEntifications database

More...
PRIDEi
P48732

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P48732 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P48732 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CDD complex, at least composed of COP10, DET1 and DDB1A (PubMed:15342494, PubMed:24563205).

Interacts with DDB1A (PubMed:12225661).

Interacts with non-acetylated N-terminal tail of histone H2B in a nucleosome context (PubMed:12225670).

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
11908, 24 interactors

Protein interaction database and analysis system

More...
IntActi
P48732, 2 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT4G10180.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P48732

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi421 – 436Nuclear localization signalSequence analysisAdd BLAST16
Motifi492 – 510Nuclear localization signalSequence analysisAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DET1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2558 Eukaryota
ENOG410XSK5 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007709

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48732

KEGG Orthology (KO)

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KOi
K10571

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITPCLTI

Database of Orthologous Groups

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OrthoDBi
603320at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48732

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR019138 De-etiolated_protein_1_Det1

The PANTHER Classification System

More...
PANTHERi
PTHR13374 PTHR13374, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09737 Det1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48208 SSF48208, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P48732-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFTSGNVTAR VFERQIRTPP PGASVNRARH FYENLVPSYT LYDVESPDHC
60 70 80 90 100
FRKFTEDGLF LISFSRNHQE LIVYRPSWLT YSTTDDSTTT LPPLPRRASK
110 120 130 140 150
FDSFFTQLYS VNLASSNELI CKDFFLYHQT RRFGLFATST AQIHDSSSPS
160 170 180 190 200
NDAVPGVPSI DKITFVLLRL DDGVVLDERV FLHDFVNLAH NMGVFLYDDL
210 220 230 240 250
LAILSLRYQR IHLLQIRDSG HLVDARAIGY FCREDDELFL NSSSQAMMSQ
260 270 280 290 300
DKSKQQSLSG SKEDDTGENG LRHSLSQPSG SNSFLSGVKQ RLLSFIFREI
310 320 330 340 350
WNEESDNVMR VQSLKKKFYF HFQDYVDLII WKVQFLDRQH LLIKFGSVDG
360 370 380 390 400
GVTRSADHHP AFFAVYNMET TDIVAFYQNS AEDLYQLFEQ FSDHFTVSSS
410 420 430 440 450
TPFMNFVTSH SNNVYALEQL KYTKNKSNSF SQFVKKMLLS LPFSCQSQSP
460 470 480 490 500
SPYFDQSLFR FDEKLISAAD RHRQSSDNPI KFISRRQPQT LKFKIKPGPE
510 520 530 540
CGTADGRSKK ICSFLFHPHL PLAISIQQTL FMPPSVVNIH FRR
Length:543
Mass (Da):62,492
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD38354984D5F646A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4JLM2F4JLM2_ARATH
RmlC-like cupins superfamily protei...
At4g10290, T9A4.13
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB59299 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC62814 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB39770 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78141 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L33695 Genomic DNA Translation: AAB59299.1 Sequence problems.
AF096373 Genomic DNA Translation: AAC62814.1 Sequence problems.
AL049487 Genomic DNA Translation: CAB39770.1 Sequence problems.
AL161516 Genomic DNA Translation: CAB78141.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82852.1
BT015348 mRNA Translation: AAU05471.1
BT020454 mRNA Translation: AAW30032.1

Protein sequence database of the Protein Information Resource

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PIRi
A54841

NCBI Reference Sequences

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RefSeqi
NP_192756.2, NM_117086.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G10180.1; AT4G10180.1; AT4G10180

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
826609

Gramene; a comparative resource for plants

More...
Gramenei
AT4G10180.1; AT4G10180.1; AT4G10180

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G10180

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33695 Genomic DNA Translation: AAB59299.1 Sequence problems.
AF096373 Genomic DNA Translation: AAC62814.1 Sequence problems.
AL049487 Genomic DNA Translation: CAB39770.1 Sequence problems.
AL161516 Genomic DNA Translation: CAB78141.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE82852.1
BT015348 mRNA Translation: AAU05471.1
BT020454 mRNA Translation: AAW30032.1
PIRiA54841
RefSeqiNP_192756.2, NM_117086.4

3D structure databases

SMRiP48732
ModBaseiSearch...

Protein-protein interaction databases

BioGridi11908, 24 interactors
IntActiP48732, 2 interactors
STRINGi3702.AT4G10180.1

Proteomic databases

PaxDbiP48732
PRIDEiP48732

Genome annotation databases

EnsemblPlantsiAT4G10180.1; AT4G10180.1; AT4G10180
GeneIDi826609
GrameneiAT4G10180.1; AT4G10180.1; AT4G10180
KEGGiath:AT4G10180

Organism-specific databases

AraportiAT4G10180
TAIRilocus:2005505 AT4G10180

Phylogenomic databases

eggNOGiKOG2558 Eukaryota
ENOG410XSK5 LUCA
HOGENOMiHOG000007709
InParanoidiP48732
KOiK10571
OMAiITPCLTI
OrthoDBi603320at2759
PhylomeDBiP48732

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P48732

Gene expression databases

ExpressionAtlasiP48732 baseline and differential
GenevisibleiP48732 AT

Family and domain databases

InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR019138 De-etiolated_protein_1_Det1
PANTHERiPTHR13374 PTHR13374, 1 hit
PfamiView protein in Pfam
PF09737 Det1, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDET1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48732
Secondary accession number(s): Q66GQ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 14, 2008
Last modified: December 11, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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