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UniProtKB - P48730 (KC1D_HUMAN)

Entry version 212 (07 Apr 2021)
Sequence version 2 (27 Jan 2003)
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Protein

Casein kinase I isoform delta

Gene

CSNK1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.17 Publications

Miscellaneous

May be involved in Alzheimer disease by phosphorylating MAPT/TAU.1 Publication

Caution

Was shown to phosphorylate and activate DCK in vitro but probably not in vivo.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261), N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CKI-7), 4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-diaryl-isoxazoles and -imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670).10 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Maximal velocity nearly identical for the reactions with alpha-casein and PER2 peptide.
  1. KM=36.5 µM for alpha-casein1 Publication
  2. KM=635.8 µM for PER2 peptide1 Publication
  3. KM=180.6 µM for ATP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei38ATPPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei128Proton acceptorPROSITE-ProRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi15 – 23ATPPROSITE-ProRule annotation9

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Serine/threonine-protein kinase, Transferase
    Biological processBiological rhythms, Wnt signaling pathway
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...    BRENDAi    		2.7.11.1, 2681

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		P48730

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-204005, COPII-mediated vesicle transport
    R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
    R-HSA-380259, Loss of Nlp from mitotic centrosomes
    R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
    R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
    R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
    R-HSA-400253, Circadian Clock
    R-HSA-5620912, Anchoring of the basal body to the plasma membrane
    R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
    R-HSA-8854518, AURKA Activation by TPX2

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		P48730

    SignaLink: a signaling pathway resource with multi-layered regulatory networks

    More...    SignaLinki    		P48730

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		P48730

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Casein kinase I isoform delta (EC:2.7.11.1)
    Short name:
    CKI-delta
    Short name:
    CKId
    Alternative name(s):
    Tau-protein kinase CSNK1D (EC:2.7.11.26)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CSNK1D
    Synonyms:HCKID
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:2452, CSNK1D

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		600864, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_P48730

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...    VEuPathDBi    		HostDB:ENSG00000141551.14

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Advanced sleep phase syndrome, familial, 2 (FASPS2)2 Publications
    The disease is caused by variants affecting the gene represented in this entry.
    Disease descriptionA disorder characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02907544T → A in FASPS2; strongly reduces kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894561EnsemblClinVar.1
    Natural variantiVAR_06980146H → R in FASPS2; strongly reduces kinase activity. 1 PublicationCorresponds to variant dbSNP:rs397514693EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38K → M: Impaired kinase activity and abnormal subcellular localization with exclusive accumulation to the nucleus. 1 Publication1
    Mutagenesisi176T → I: Impaired kinase activity and abnormal subcellular localization with exclusive accumulation to the nucleus. 1 Publication1

    Keywords - Diseasei

    Disease variant

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		1453

    MalaCards human disease database

    More...    MalaCardsi    		CSNK1D
    MIMi615224, phenotype

    Open Targets

    More...    OpenTargetsi    		ENSG00000141551

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...    Orphaneti    		164736, Familial advanced sleep-phase syndrome

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA26952

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		P48730, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL2828

    DrugCentral

    More...    DrugCentrali    		P48730

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		1997

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		CSNK1D

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		27923980

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001928331 – 415Casein kinase I isoform deltaAdd BLAST415

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei328PhosphoserineCombined sources1
    Modified residuei331PhosphoserineCombined sources1
    Modified residuei370PhosphoserineBy similarity1
    Modified residuei375Omega-N-methylarginineBy similarity1
    Modified residuei382PhosphoserineCombined sources1
    Modified residuei383PhosphoserineCombined sources1
    Modified residuei384PhosphoserineCombined sources1
    Modified residuei407PhosphoserineCombined sources1
    Modified residuei411PhosphoserineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		P48730

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		P48730

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		P48730

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		P48730

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		P48730

    PeptideAtlas

    More...    PeptideAtlasi    		P48730

    PRoteomics IDEntifications database

    More...    PRIDEi    		P48730

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		55930 [P48730-1]
    55931 [P48730-2]

    Consortium for Top Down Proteomics

    More...    TopDownProteomicsi    		P48730-1 [P48730-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		P48730

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		P48730

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.2 Publications

    <p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Highly present in extravillous trophoblast cells, which are present at the placenta implantation site and invade the decidua and decidual vessels.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000141551, Expressed in adenohypophysis and 238 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		P48730, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		P48730, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000141551, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer (PubMed:22168824, PubMed:23106386).

    Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity).

    Interacts with DNMT1 and MAP1A (By similarity).

    Interacts directly with PER1 and PER2 which may lead to their degradation (PubMed:11165242).

    Interacts with MAPT/TAU (PubMed:14761950).

    Interacts with SNAPIN (By similarity).

    Interacts with DBNDD2 (PubMed:16618118).

    Interacts with AIB1/NCOA3 and ESR1 (PubMed:19339517).

    Interacts with AKAP9/AKAP450; this interaction promotes centrosomal subcellular location (PubMed:12270714). Binds to tubulins in mitotic cells upon DNA damage (PubMed:10826492).

    Interacts with GJA1 (PubMed:12270943).

    Interacts with DDX3X; this interaction enhances CSNK1D kinase activity in vitro, but it is unclear whether this interaction is physiologically relevant (PubMed:29222110).

    By similarity10 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    P48730
    With#Exp.IntAct
    APP [P05067]3EBI-751621,EBI-77613
    CCDC14 - isoform 3 [Q49A88-3]3EBI-751621,EBI-12105646
    DRICH1 [Q6PGQ1]3EBI-751621,EBI-10253641
    DVL3 [Q92997]4EBI-751621,EBI-739789
    EVI5 [O60447]3EBI-751621,EBI-852291
    IKZF4 [Q9H2S9]3EBI-751621,EBI-1640423
    LURAP1 [Q96LR2]4EBI-751621,EBI-741355
    LZTS2 [Q9BRK4]3EBI-751621,EBI-741037
    MDM2 [Q00987]6EBI-751621,EBI-389668
    PAK5 [Q9P286]3EBI-751621,EBI-741896
    PER2 [O15055]4EBI-751621,EBI-1054296
    TRIM3 [O75382]3EBI-751621,EBI-2129889
    TRIM9 [Q9C026]3EBI-751621,EBI-720828
    ZBTB8A [Q96BR9]3EBI-751621,EBI-742740
    ZNF618 [Q5T7W0]3EBI-751621,EBI-6255994
    Dvl2 [Q60838] from Mus musculus.2EBI-751621,EBI-641940
    Isoform 2 [P48730-2]
    With#Exp.IntAct
    APP [P05067]3EBI-9087876,EBI-77613
    APPBP2 [Q92624]3EBI-9087876,EBI-743771
    BCAN [Q96GW7]3EBI-9087876,EBI-2690445
    CALHM1 [Q8IU99]3EBI-9087876,EBI-1790341
    CAV1 [Q03135]3EBI-9087876,EBI-603614
    CBX5 [P45973]3EBI-9087876,EBI-78219
    CRH [P06850]3EBI-9087876,EBI-3870390
    DR1 [Q01658]3EBI-9087876,EBI-750300
    ERP44 [Q9BS26]3EBI-9087876,EBI-541644
    FUS [P35637]3EBI-9087876,EBI-400434
    GJA1 [P17302]3EBI-9087876,EBI-1103439
    GORASP2 [Q9H8Y8]3EBI-9087876,EBI-739467
    GRK2 [P25098]3EBI-9087876,EBI-3904795
    GTF2B [Q00403]3EBI-9087876,EBI-389564
    GTF3C3 [Q9Y5Q9]3EBI-9087876,EBI-1054873
    HTT [P42858]15EBI-9087876,EBI-466029
    LRP8 - isoform 3 [Q14114-3]3EBI-9087876,EBI-25832196
    LRRK2 [Q5S007]3EBI-9087876,EBI-5323863
    MAPK14 [Q16539]3EBI-9087876,EBI-73946
    MARK4 [Q96L34]3EBI-9087876,EBI-302319
    NF2 - isoform 4 [P35240-4]3EBI-9087876,EBI-1014514
    PAXIP1 [Q6ZW49]3EBI-9087876,EBI-743225
    PLPP1 [O14494]3EBI-9087876,EBI-2865290
    PMP22 [D3DTS7]3EBI-9087876,EBI-25882629
    PRKACA [P17612]3EBI-9087876,EBI-476586
    PSAP [P07602]3EBI-9087876,EBI-716699
    RAD23A [P54725]3EBI-9087876,EBI-746453
    S100B [P04271]3EBI-9087876,EBI-458391
    SCARB1 [Q8WTV0]3EBI-9087876,EBI-78657
    SERPINH1 [P50454]3EBI-9087876,EBI-350723
    SIAH1 - isoform 2 [Q8IUQ4-2]3EBI-9087876,EBI-11522811
    SMAD3 [P84022]3EBI-9087876,EBI-347161
    SNCA [P37840]3EBI-9087876,EBI-985879
    SOD1 [P00441]3EBI-9087876,EBI-990792
    SPTLC1 [Q6NUL7]3EBI-9087876,EBI-25912847
    TARDBP [Q13148]6EBI-9087876,EBI-372899
    TGFBR2 [P37173]3EBI-9087876,EBI-296151
    TMPRSS4 [Q9NRS4]3EBI-9087876,EBI-10313040
    UTP14A [Q9BVJ6]3EBI-9087876,EBI-473284
    VPS29 - isoform 2 [Q9UBQ0-2]3EBI-9087876,EBI-11141397
    ZDHHC17 [Q8IUH5]3EBI-9087876,EBI-524753

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		107837, 133 interactors

    Database of interacting proteins

    More...    DIPi    		DIP-39735N

    Protein interaction database and analysis system

    More...    IntActi    		P48730, 122 interactors

    Molecular INTeraction database

    More...    MINTi    		P48730

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000324464

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		P48730

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		P48730, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1415
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		P48730

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST269

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni278 – 364Centrosomal localization signal (CLS)Add BLAST87
    Regioni317 – 342AutoinhibitoryBy similarityAdd BLAST26

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1164, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000153536

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_019279_2_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		P48730

    Database of Orthologous Groups

    More...    OrthoDBi    		1097975at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		P48730

    TreeFam database of animal gene trees

    More...    TreeFami    		TF300544

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR011009, Kinase-like_dom_sf
    IPR000719, Prot_kinase_dom
    IPR017441, Protein_kinase_ATP_BS
    IPR008271, Ser/Thr_kinase_AS

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00069, Pkinase, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...    SMARTi    		View protein in SMART
    SM00220, S_TKc, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF56112, SSF56112, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00107, PROTEIN_KINASE_ATP, 1 hit
    PS50011, PROTEIN_KINASE_DOM, 1 hit
    PS00108, PROTEIN_KINASE_ST, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P48730-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH 
            60         70         80         90        100
    IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF 
           110        120        130        140        150
    SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF 
           160        170        180        190        200
    GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG 
           210        220        230        240        250
    YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT 
           260        270        280        290        300
    YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA 
           310        320        330        340        350
    ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS 
           360        370        380        390        400
    HTANTSPRPV SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI 
           410 
    PGRVASSGLQ SVVHR
    Length:415
    Mass (Da):47,330
    Last modified:January 27, 2003 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB97F1717A52466D2
    GO
    Isoform 2 (identifier: P48730-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         400-415: IPGRVASSGLQSVVHR → NSIPFEHHGK

    Show »
    Length:409
    Mass (Da):46,832
    Checksum:i970B55B1AF6B56DD
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    H7BYT1H7BYT1_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    		427Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QQI9J3QQI9_HUMAN
    Non-specific serine/threonine prote...
    CSNK1D
    		187Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y2N6H0Y2N6_HUMAN
    Non-specific serine/threonine prote...
    CSNK1D
    		120Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B4DLF1B4DLF1_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    		126Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3KRM8J3KRM8_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    		64Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3KRS6J3KRS6_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    		56Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QS70J3QS70_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    		43Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QQU8J3QQU8_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    		20Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti330A → D in AAC50807 (PubMed:8786104).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02907544T → A in FASPS2; strongly reduces kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894561EnsemblClinVar.1
    Natural variantiVAR_06980146H → R in FASPS2; strongly reduces kinase activity. 1 PublicationCorresponds to variant dbSNP:rs397514693EnsemblClinVar.1
    Natural variantiVAR_03645197S → C in breast cancer samples; infiltrating ductal carcinoma; somatic mutation. 2 Publications1
    Natural variantiVAR_042081401P → A1 PublicationCorresponds to variant dbSNP:rs56124628Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010253400 – 415IPGRV…SVVHR → NSIPFEHHGK in isoform 2. 2 PublicationsAdd BLAST16

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		U29171 mRNA Translation: AAC50807.1
    U31285 mRNA Translation: AAC50808.1
    AB091044 mRNA Translation: BAC10903.1
    AK291758 mRNA Translation: BAF84447.1
    EF015900 Genomic DNA Translation: ABM64211.1
    BC003558 mRNA Translation: AAH03558.1
    BC015775 mRNA Translation: AAH15775.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS11805.1 [P48730-1]
    CCDS11806.1 [P48730-2]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		G01876

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001884.2, NM_001893.4 [P48730-1]
    NP_620693.1, NM_139062.2 [P48730-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000314028; ENSP00000324464; ENSG00000141551 [P48730-1]
    ENST00000392334; ENSP00000376146; ENSG00000141551 [P48730-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		1453

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:1453

    UCSC genome browser

    More...    UCSCi    		uc002kei.4, human [P48730-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		U29171 mRNA Translation: AAC50807.1
    U31285 mRNA Translation: AAC50808.1
    AB091044 mRNA Translation: BAC10903.1
    AK291758 mRNA Translation: BAF84447.1
    EF015900 Genomic DNA Translation: ABM64211.1
    BC003558 mRNA Translation: AAH03558.1
    BC015775 mRNA Translation: AAH15775.1
    CCDSiCCDS11805.1 [P48730-1]
    CCDS11806.1 [P48730-2]
    PIRiG01876
    RefSeqiNP_001884.2, NM_001893.4 [P48730-1]
    NP_620693.1, NM_139062.2 [P48730-2]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3UYSX-ray2.30A/B/C/D1-294[»]
    3UYTX-ray2.00A/B/C/D1-294[»]
    3UZPX-ray1.94A/B1-294[»]
    4HGTX-ray1.80A/B1-294[»]
    4HNFX-ray2.07A/B1-294[»]
    4KB8X-ray1.95A/B/C/D3-317[»]
    4KBAX-ray1.98A/B/C/D3-317[»]
    4KBCX-ray1.98A/B1-317[»]
    4KBKX-ray2.10A/B/C/D3-317[»]
    4TN6X-ray2.41A/B1-301[»]
    4TW9X-ray2.40A/B1-295[»]
    4TWCX-ray1.70A/B1-295[»]
    5IH4X-ray1.90A1-294[»]
    5IH5X-ray2.25A1-294[»]
    5IH6X-ray2.30A1-294[»]
    5MQVX-ray2.15A/B/C/D/E/F1-294[»]
    5OKTX-ray2.13A/B/C/D1-294[»]
    5W4WX-ray1.99A/B/C/D3-317[»]
    6F1WX-ray1.86A/B1-294[»]
    6F26X-ray1.83A/B1-294[»]
    6GZMX-ray1.59A/B1-295[»]
    6HMPX-ray2.04A/B1-294[»]
    6HMRX-ray1.78A/B1-294[»]
    6PXNX-ray1.55A/B1-415[»]
    6PXOX-ray2.00A/B1-294[»]
    6PXPX-ray2.35A/B1-294[»]
    6RCGX-ray1.40A1-294[»]
    6RCHX-ray1.45A/B1-294[»]
    6RU6X-ray2.05A/B1-294[»]
    6RU7X-ray2.08A/B1-294[»]
    6RU8X-ray1.92A/B/C/D1-294[»]
    SMRiP48730
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi107837, 133 interactors
    DIPiDIP-39735N
    IntActiP48730, 122 interactors
    MINTiP48730
    STRINGi9606.ENSP00000324464

    Chemistry databases

    BindingDBiP48730
    ChEMBLiCHEMBL2828
    DrugCentraliP48730
    GuidetoPHARMACOLOGYi1997

    PTM databases

    iPTMnetiP48730
    PhosphoSitePlusiP48730

    Genetic variation databases

    BioMutaiCSNK1D
    DMDMi27923980

    Proteomic databases

    EPDiP48730
    jPOSTiP48730
    MassIVEiP48730
    MaxQBiP48730
    PaxDbiP48730
    PeptideAtlasiP48730
    PRIDEiP48730
    ProteomicsDBi55930 [P48730-1]
    55931 [P48730-2]
    TopDownProteomicsiP48730-1 [P48730-1]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		4210, 362 antibodies

    The DNASU plasmid repository

    More...    DNASUi    		1453

    Genome annotation databases

    EnsembliENST00000314028; ENSP00000324464; ENSG00000141551 [P48730-1]
    ENST00000392334; ENSP00000376146; ENSG00000141551 [P48730-2]
    GeneIDi1453
    KEGGihsa:1453
    UCSCiuc002kei.4, human [P48730-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		1453
    DisGeNETi1453

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		CSNK1D
    HGNCiHGNC:2452, CSNK1D
    HPAiENSG00000141551, Low tissue specificity
    MalaCardsiCSNK1D
    MIMi600864, gene
    615224, phenotype
    neXtProtiNX_P48730
    OpenTargetsiENSG00000141551
    Orphaneti164736, Familial advanced sleep-phase syndrome
    PharmGKBiPA26952
    VEuPathDBiHostDB:ENSG00000141551.14

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1164, Eukaryota
    GeneTreeiENSGT00940000153536
    HOGENOMiCLU_019279_2_2_1
    InParanoidiP48730
    OrthoDBi1097975at2759
    PhylomeDBiP48730
    TreeFamiTF300544

    Enzyme and pathway databases

    BRENDAi2.7.11.1, 2681
    PathwayCommonsiP48730
    ReactomeiR-HSA-204005, COPII-mediated vesicle transport
    R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
    R-HSA-380259, Loss of Nlp from mitotic centrosomes
    R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
    R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
    R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
    R-HSA-400253, Circadian Clock
    R-HSA-5620912, Anchoring of the basal body to the plasma membrane
    R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
    R-HSA-8854518, AURKA Activation by TPX2
    SABIO-RKiP48730
    SignaLinkiP48730
    SIGNORiP48730

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		1453, 16 hits in 1027 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		CSNK1D, human

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		CSNK1D

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		1453
    PharosiP48730, Tchem

    Protein Ontology

    More...    PROi    		PR:P48730
    RNActiP48730, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000141551, Expressed in adenohypophysis and 238 other tissues
    ExpressionAtlasiP48730, baseline and differential
    GenevisibleiP48730, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR011009, Kinase-like_dom_sf
    IPR000719, Prot_kinase_dom
    IPR017441, Protein_kinase_ATP_BS
    IPR008271, Ser/Thr_kinase_AS
    PfamiView protein in Pfam
    PF00069, Pkinase, 1 hit
    SMARTiView protein in SMART
    SM00220, S_TKc, 1 hit
    SUPFAMiSSF56112, SSF56112, 1 hit
    PROSITEiView protein in PROSITE
    PS00107, PROTEIN_KINASE_ATP, 1 hit
    PS50011, PROTEIN_KINASE_DOM, 1 hit
    PS00108, PROTEIN_KINASE_ST, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKC1D_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48730
    Secondary accession number(s): A2I2P2, Q96KZ6, Q9BTN5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 27, 2003
    Last modified: April 7, 2021
    This is version 212 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with genetic variants
      List of human entries with genetic variants
    4. Human variants curated from literature reports
      Index of human variants curated from literature reports
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families
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