UniProtKB - P48730 (KC1D_HUMAN)
Casein kinase I isoform delta
CSNK1D
Functioni
Miscellaneous
Caution
Catalytic activityi
Activity regulationi
Kineticsi
- KM=36.5 µM for alpha-casein1 Publication
- KM=635.8 µM for PER2 peptide1 Publication
- KM=180.6 µM for ATP1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 38 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 128 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 15 – 23 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cadherin binding Source: BHF-UCL
- protein kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: ParkinsonsUK-UCL
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
- tau-protein kinase activity Source: UniProtKB-EC
GO - Biological processi
- ciliary basal body-plasma membrane docking Source: Reactome
- circadian regulation of gene expression Source: UniProtKB
- COPII vesicle coating Source: Reactome
- G2/M transition of mitotic cell cycle Source: Reactome
- Golgi organization Source: SYSCILIA_CCNET
- microtubule nucleation Source: SYSCILIA_CCNET
- non-motile cilium assembly Source: SYSCILIA_CCNET
- peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
- positive regulation of non-canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- positive regulation of protein phosphorylation Source: BHF-UCL
- positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
- protein localization to centrosome Source: SYSCILIA_CCNET
- protein localization to cilium Source: SYSCILIA_CCNET
- protein localization to Golgi apparatus Source: SYSCILIA_CCNET
- protein phosphorylation Source: UniProtKB
- regulation of circadian rhythm Source: UniProtKB
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
- spindle assembly Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Biological rhythms, Wnt signaling pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | P48730 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-400253, Circadian Clock R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-8854518, AURKA Activation by TPX2 |
SABIO-RKi | P48730 |
SignaLinki | P48730 |
SIGNORi | P48730 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CSNK1D Synonyms:HCKID |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2452, CSNK1D |
MIMi | 600864, gene |
neXtProti | NX_P48730 |
VEuPathDBi | HostDB:ENSG00000141551.14 |
Subcellular locationi
Golgi apparatus
Cytoskeleton
- centrosome 1 Publication
- spindle
Nucleus
Plasma membrane
Other locations
Note: Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.
Cytoskeleton
- centrosome Source: UniProtKB
- ciliary basal body Source: GO_Central
- spindle Source: UniProtKB
- spindle microtubule Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: GOC
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Advanced sleep phase syndrome, familial, 2 (FASPS2)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029075 | 44 | T → A in FASPS2; strongly reduces kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894561EnsemblClinVar. | 1 | |
Natural variantiVAR_069801 | 46 | H → R in FASPS2; strongly reduces kinase activity. 1 PublicationCorresponds to variant dbSNP:rs397514693EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 | K → M: Impaired kinase activity and abnormal subcellular localization with exclusive accumulation to the nucleus. 1 Publication | 1 | |
Mutagenesisi | 176 | T → I: Impaired kinase activity and abnormal subcellular localization with exclusive accumulation to the nucleus. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1453 |
MalaCardsi | CSNK1D |
MIMi | 615224, phenotype |
OpenTargetsi | ENSG00000141551 |
Orphaneti | 164736, Familial advanced sleep-phase syndrome |
PharmGKBi | PA26952 |
Miscellaneous databases
Pharosi | P48730, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2828 |
DrugCentrali | P48730 |
GuidetoPHARMACOLOGYi | 1997 |
Genetic variation databases
BioMutai | CSNK1D |
DMDMi | 27923980 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000192833 | 1 – 415 | Casein kinase I isoform deltaAdd BLAST | 415 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 328 | PhosphoserineCombined sources | 1 | |
Modified residuei | 331 | PhosphoserineCombined sources | 1 | |
Modified residuei | 370 | PhosphoserineBy similarity | 1 | |
Modified residuei | 375 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 382 | PhosphoserineCombined sources | 1 | |
Modified residuei | 383 | PhosphoserineCombined sources | 1 | |
Modified residuei | 384 | PhosphoserineCombined sources | 1 | |
Modified residuei | 407 | PhosphoserineCombined sources | 1 | |
Modified residuei | 411 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | P48730 |
jPOSTi | P48730 |
MassIVEi | P48730 |
MaxQBi | P48730 |
PaxDbi | P48730 |
PeptideAtlasi | P48730 |
PRIDEi | P48730 |
ProteomicsDBi | 55930 [P48730-1] 55931 [P48730-2] |
TopDownProteomicsi | P48730-1 [P48730-1] |
PTM databases
iPTMneti | P48730 |
PhosphoSitePlusi | P48730 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSG00000141551, Expressed in adenohypophysis and 238 other tissues |
ExpressionAtlasi | P48730, baseline and differential |
Genevisiblei | P48730, HS |
Organism-specific databases
HPAi | ENSG00000141551, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (PubMed:22168824, PubMed:23106386).
Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity).
Interacts with DNMT1 and MAP1A (By similarity).
Interacts directly with PER1 and PER2 which may lead to their degradation (PubMed:11165242).
Interacts with MAPT/TAU (PubMed:14761950).
Interacts with SNAPIN (By similarity).
Interacts with DBNDD2 (PubMed:16618118).
Interacts with AIB1/NCOA3 and ESR1 (PubMed:19339517).
Interacts with AKAP9/AKAP450; this interaction promotes centrosomal subcellular location (PubMed:12270714). Binds to tubulins in mitotic cells upon DNA damage (PubMed:10826492).
Interacts with GJA1 (PubMed:12270943).
Interacts with DDX3X; this interaction enhances CSNK1D kinase activity in vitro, but it is unclear whether this interaction is physiologically relevant (PubMed:29222110).
By similarity10 PublicationsBinary interactionsi
P48730
Isoform 2 [P48730-2]
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107837, 123 interactors |
DIPi | DIP-39735N |
IntActi | P48730, 121 interactors |
MINTi | P48730 |
STRINGi | 9606.ENSP00000324464 |
Chemistry databases
BindingDBi | P48730 |
Miscellaneous databases
RNActi | P48730, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P48730 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 277 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 269 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 278 – 364 | Centrosomal localization signal (CLS)Add BLAST | 87 | |
Regioni | 317 – 342 | AutoinhibitoryBy similarityAdd BLAST | 26 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1164, Eukaryota |
GeneTreei | ENSGT00940000153536 |
HOGENOMi | CLU_019279_2_2_1 |
InParanoidi | P48730 |
OrthoDBi | 1097975at2759 |
PhylomeDBi | P48730 |
TreeFami | TF300544 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH
60 70 80 90 100
IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF
110 120 130 140 150
SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF
160 170 180 190 200
GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG
210 220 230 240 250
YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT
260 270 280 290 300
YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
310 320 330 340 350
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS
360 370 380 390 400
HTANTSPRPV SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI
410
PGRVASSGLQ SVVHR
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BYT1 | H7BYT1_HUMAN | Casein kinase I isoform delta | CSNK1D | 427 | Annotation score: | ||
J3QQI9 | J3QQI9_HUMAN | Non-specific serine/threonine prote... | CSNK1D | 187 | Annotation score: | ||
H0Y2N6 | H0Y2N6_HUMAN | Non-specific serine/threonine prote... | CSNK1D | 120 | Annotation score: | ||
J3KRM8 | J3KRM8_HUMAN | Casein kinase I isoform delta | CSNK1D | 64 | Annotation score: | ||
B4DLF1 | B4DLF1_HUMAN | Casein kinase I isoform delta | CSNK1D | 126 | Annotation score: | ||
J3KRS6 | J3KRS6_HUMAN | Casein kinase I isoform delta | CSNK1D | 56 | Annotation score: | ||
J3QS70 | J3QS70_HUMAN | Casein kinase I isoform delta | CSNK1D | 43 | Annotation score: | ||
J3QQU8 | J3QQU8_HUMAN | Casein kinase I isoform delta | CSNK1D | 20 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 330 | A → D in AAC50807 (PubMed:8786104).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029075 | 44 | T → A in FASPS2; strongly reduces kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894561EnsemblClinVar. | 1 | |
Natural variantiVAR_069801 | 46 | H → R in FASPS2; strongly reduces kinase activity. 1 PublicationCorresponds to variant dbSNP:rs397514693EnsemblClinVar. | 1 | |
Natural variantiVAR_036451 | 97 | S → C in breast cancer samples; infiltrating ductal carcinoma; somatic mutation. 2 Publications | 1 | |
Natural variantiVAR_042081 | 401 | P → A1 PublicationCorresponds to variant dbSNP:rs56124628Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010253 | 400 – 415 | IPGRV…SVVHR → NSIPFEHHGK in isoform 2. 2 PublicationsAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29171 mRNA Translation: AAC50807.1 U31285 mRNA Translation: AAC50808.1 AB091044 mRNA Translation: BAC10903.1 AK291758 mRNA Translation: BAF84447.1 EF015900 Genomic DNA Translation: ABM64211.1 BC003558 mRNA Translation: AAH03558.1 BC015775 mRNA Translation: AAH15775.1 |
CCDSi | CCDS11805.1 [P48730-1] CCDS11806.1 [P48730-2] |
PIRi | G01876 |
RefSeqi | NP_001884.2, NM_001893.4 [P48730-1] NP_620693.1, NM_139062.2 [P48730-2] |
Genome annotation databases
Ensembli | ENST00000314028; ENSP00000324464; ENSG00000141551 [P48730-1] ENST00000392334; ENSP00000376146; ENSG00000141551 [P48730-2] |
GeneIDi | 1453 |
KEGGi | hsa:1453 |
UCSCi | uc002kei.4, human [P48730-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29171 mRNA Translation: AAC50807.1 U31285 mRNA Translation: AAC50808.1 AB091044 mRNA Translation: BAC10903.1 AK291758 mRNA Translation: BAF84447.1 EF015900 Genomic DNA Translation: ABM64211.1 BC003558 mRNA Translation: AAH03558.1 BC015775 mRNA Translation: AAH15775.1 |
CCDSi | CCDS11805.1 [P48730-1] CCDS11806.1 [P48730-2] |
PIRi | G01876 |
RefSeqi | NP_001884.2, NM_001893.4 [P48730-1] NP_620693.1, NM_139062.2 [P48730-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3UYS | X-ray | 2.30 | A/B/C/D | 1-294 | [»] | |
3UYT | X-ray | 2.00 | A/B/C/D | 1-294 | [»] | |
3UZP | X-ray | 1.94 | A/B | 1-294 | [»] | |
4HGT | X-ray | 1.80 | A/B | 1-294 | [»] | |
4HNF | X-ray | 2.07 | A/B | 1-294 | [»] | |
4KB8 | X-ray | 1.95 | A/B/C/D | 3-317 | [»] | |
4KBA | X-ray | 1.98 | A/B/C/D | 3-317 | [»] | |
4KBC | X-ray | 1.98 | A/B | 1-317 | [»] | |
4KBK | X-ray | 2.10 | A/B/C/D | 3-317 | [»] | |
4TN6 | X-ray | 2.41 | A/B | 1-301 | [»] | |
4TW9 | X-ray | 2.40 | A/B | 1-295 | [»] | |
4TWC | X-ray | 1.70 | A/B | 1-295 | [»] | |
5IH4 | X-ray | 1.90 | A | 1-294 | [»] | |
5IH5 | X-ray | 2.25 | A | 1-294 | [»] | |
5IH6 | X-ray | 2.30 | A | 1-294 | [»] | |
5MQV | X-ray | 2.15 | A/B/C/D/E/F | 1-294 | [»] | |
5OKT | X-ray | 2.13 | A/B/C/D | 1-294 | [»] | |
5W4W | X-ray | 1.99 | A/B/C/D | 3-317 | [»] | |
6F1W | X-ray | 1.86 | A/B | 1-294 | [»] | |
6F26 | X-ray | 1.83 | A/B | 1-294 | [»] | |
6GZM | X-ray | 1.59 | A/B | 1-295 | [»] | |
6HMP | X-ray | 2.04 | A/B | 1-294 | [»] | |
6HMR | X-ray | 1.78 | A/B | 1-294 | [»] | |
6PXN | X-ray | 1.55 | A/B | 1-415 | [»] | |
6PXO | X-ray | 2.00 | A/B | 1-294 | [»] | |
6PXP | X-ray | 2.35 | A/B | 1-294 | [»] | |
6RCG | X-ray | 1.40 | A | 1-294 | [»] | |
6RCH | X-ray | 1.45 | A/B | 1-294 | [»] | |
6RU6 | X-ray | 2.05 | A/B | 1-294 | [»] | |
6RU7 | X-ray | 2.08 | A/B | 1-294 | [»] | |
6RU8 | X-ray | 1.92 | A/B/C/D | 1-294 | [»] | |
SMRi | P48730 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107837, 123 interactors |
DIPi | DIP-39735N |
IntActi | P48730, 121 interactors |
MINTi | P48730 |
STRINGi | 9606.ENSP00000324464 |
Chemistry databases
BindingDBi | P48730 |
ChEMBLi | CHEMBL2828 |
DrugCentrali | P48730 |
GuidetoPHARMACOLOGYi | 1997 |
PTM databases
iPTMneti | P48730 |
PhosphoSitePlusi | P48730 |
Genetic variation databases
BioMutai | CSNK1D |
DMDMi | 27923980 |
Proteomic databases
EPDi | P48730 |
jPOSTi | P48730 |
MassIVEi | P48730 |
MaxQBi | P48730 |
PaxDbi | P48730 |
PeptideAtlasi | P48730 |
PRIDEi | P48730 |
ProteomicsDBi | 55930 [P48730-1] 55931 [P48730-2] |
TopDownProteomicsi | P48730-1 [P48730-1] |
Protocols and materials databases
Antibodypediai | 4210, 353 antibodies |
DNASUi | 1453 |
Genome annotation databases
Ensembli | ENST00000314028; ENSP00000324464; ENSG00000141551 [P48730-1] ENST00000392334; ENSP00000376146; ENSG00000141551 [P48730-2] |
GeneIDi | 1453 |
KEGGi | hsa:1453 |
UCSCi | uc002kei.4, human [P48730-1] |
Organism-specific databases
CTDi | 1453 |
DisGeNETi | 1453 |
GeneCardsi | CSNK1D |
HGNCi | HGNC:2452, CSNK1D |
HPAi | ENSG00000141551, Low tissue specificity |
MalaCardsi | CSNK1D |
MIMi | 600864, gene 615224, phenotype |
neXtProti | NX_P48730 |
OpenTargetsi | ENSG00000141551 |
Orphaneti | 164736, Familial advanced sleep-phase syndrome |
PharmGKBi | PA26952 |
VEuPathDBi | HostDB:ENSG00000141551.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1164, Eukaryota |
GeneTreei | ENSGT00940000153536 |
HOGENOMi | CLU_019279_2_2_1 |
InParanoidi | P48730 |
OrthoDBi | 1097975at2759 |
PhylomeDBi | P48730 |
TreeFami | TF300544 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | P48730 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-400253, Circadian Clock R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-8854518, AURKA Activation by TPX2 |
SABIO-RKi | P48730 |
SignaLinki | P48730 |
SIGNORi | P48730 |
Miscellaneous databases
BioGRID-ORCSi | 1453, 11 hits in 905 CRISPR screens |
ChiTaRSi | CSNK1D, human |
GeneWikii | CSNK1D |
GenomeRNAii | 1453 |
Pharosi | P48730, Tchem |
PROi | PR:P48730 |
RNActi | P48730, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141551, Expressed in adenohypophysis and 238 other tissues |
ExpressionAtlasi | P48730, baseline and differential |
Genevisiblei | P48730, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KC1D_HUMAN | |
Accessioni | P48730Primary (citable) accession number: P48730 Secondary accession number(s): A2I2P2, Q96KZ6, Q9BTN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | January 27, 2003 | |
Last modified: | February 10, 2021 | |
This is version 211 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index