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Protein

Casein kinase I isoform delta

Gene

CSNK1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.17 Publications

Miscellaneous

May be involved in Alzheimer disease by phosphorylating MAPT/TAU.1 Publication

Caution

Was shown to phosphorylate and activate DCK in vitro but probably not in vivo.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [tau protein] = ADP + [tau protein] phosphate.

Activity regulationi

Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261), N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CKI-7), 4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-diaryl-isoxazoles and -imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670).10 Publications

Kineticsi

Maximal velocity nearly identical for the reactions with alpha-casein and PER2 peptide.
  1. KM=36.5 µM for alpha-casein1 Publication
  2. KM=635.8 µM for PER2 peptide1 Publication
  3. KM=180.6 µM for ATP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei38ATPPROSITE-ProRule annotation1
    Active sitei128Proton acceptorPROSITE-ProRule annotation1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi15 – 23ATPPROSITE-ProRule annotation9

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionKinase, Serine/threonine-protein kinase, Transferase
    Biological processBiological rhythms, Wnt signaling pathway
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1 2681
    ReactomeiR-HSA-204005 COPII-mediated vesicle transport
    R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
    R-HSA-380259 Loss of Nlp from mitotic centrosomes
    R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
    R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
    R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
    R-HSA-400253 Circadian Clock
    R-HSA-5620912 Anchoring of the basal body to the plasma membrane
    R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
    R-HSA-8854518 AURKA Activation by TPX2
    SABIO-RKiP48730
    SignaLinkiP48730
    SIGNORiP48730

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Casein kinase I isoform delta (EC:2.7.11.1)
    Short name:
    CKI-delta
    Short name:
    CKId
    Alternative name(s):
    Tau-protein kinase CSNK1D (EC:2.7.11.26)
    Gene namesi
    Name:CSNK1D
    Synonyms:HCKID
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 17

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000141551.14
    HGNCiHGNC:2452 CSNK1D
    MIMi600864 gene
    neXtProtiNX_P48730

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Advanced sleep phase syndrome, familial, 2 (FASPS2)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA disorder characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
    See also OMIM:615224
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02907544T → A in FASPS2; strongly reduces kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894561EnsemblClinVar.1
    Natural variantiVAR_06980146H → R in FASPS2; strongly reduces kinase activity. 1 PublicationCorresponds to variant dbSNP:rs397514693EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi38K → M: Impaired kinase activity and abnormal subcellular localization with exclusive accumulation to the nucleus. 1 Publication1
    Mutagenesisi176T → I: Impaired kinase activity and abnormal subcellular localization with exclusive accumulation to the nucleus. 1 Publication1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNETi1453
    MalaCardsiCSNK1D
    MIMi615224 phenotype
    OpenTargetsiENSG00000141551
    Orphaneti164736 Familial advanced sleep-phase syndrome
    PharmGKBiPA26952

    Chemistry databases

    ChEMBLiCHEMBL2828
    GuidetoPHARMACOLOGYi1997

    Polymorphism and mutation databases

    BioMutaiCSNK1D
    DMDMi27923980

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001928331 – 415Casein kinase I isoform deltaAdd BLAST415

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei328PhosphoserineCombined sources1
    Modified residuei331PhosphoserineCombined sources1
    Modified residuei370PhosphoserineBy similarity1
    Modified residuei375Omega-N-methylarginineBy similarity1
    Modified residuei382PhosphoserineCombined sources1
    Modified residuei383PhosphoserineCombined sources1
    Modified residuei384PhosphoserineCombined sources1
    Modified residuei407PhosphoserineCombined sources1
    Modified residuei411PhosphoserineCombined sources1

    Post-translational modificationi

    Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    EPDiP48730
    MaxQBiP48730
    PaxDbiP48730
    PeptideAtlasiP48730
    PRIDEiP48730
    ProteomicsDBi55930
    55931 [P48730-2]
    TopDownProteomicsiP48730-1 [P48730-1]

    PTM databases

    iPTMnetiP48730
    PhosphoSitePlusiP48730

    Expressioni

    Tissue specificityi

    Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.2 Publications

    Developmental stagei

    Highly present in extravillous trophoblast cells, which are present at the placenta implantation site and invade the decidua and decidual vessels.1 Publication

    Gene expression databases

    BgeeiENSG00000141551 Expressed in 227 organ(s), highest expression level in adenohypophysis
    CleanExiHS_CSNK1D
    ExpressionAtlasiP48730 baseline and differential
    GenevisibleiP48730 HS

    Organism-specific databases

    HPAiCAB015410

    Interactioni

    Subunit structurei

    Binds to DNMT1 and MAP1A (By similarity). Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation. Interacts with MAPT/TAU, SNAPIN, DBNDD2, AIB1/NCOA3 and ESR1. AKAP9/AKAP450 binding promotes centrosomal subcellular location. Binds to tubulins in mitotic cells upon DNA damage.By similarity9 Publications

    Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi107837, 97 interactors
    DIPiDIP-39735N
    IntActiP48730, 45 interactors
    MINTiP48730
    STRINGi9606.ENSP00000324464

    Chemistry databases

    BindingDBiP48730

    Structurei

    Secondary structure

    1415
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliP48730
    SMRiP48730
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini9 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST269

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni278 – 364Centrosomal localization signal (CLS)Add BLAST87
    Regioni317 – 342AutoinhibitoryBy similarityAdd BLAST26

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG1164 Eukaryota
    ENOG410XPGP LUCA
    GeneTreeiENSGT00930000150814
    HOGENOMiHOG000182055
    HOVERGENiHBG000176
    InParanoidiP48730
    KOiK08959
    PhylomeDBiP48730
    TreeFamiTF300544

    Family and domain databases

    InterProiView protein in InterPro
    IPR011009 Kinase-like_dom_sf
    IPR000719 Prot_kinase_dom
    IPR017441 Protein_kinase_ATP_BS
    IPR008271 Ser/Thr_kinase_AS
    PfamiView protein in Pfam
    PF00069 Pkinase, 1 hit
    SMARTiView protein in SMART
    SM00220 S_TKc, 1 hit
    SUPFAMiSSF56112 SSF56112, 1 hit
    PROSITEiView protein in PROSITE
    PS00107 PROTEIN_KINASE_ATP, 1 hit
    PS50011 PROTEIN_KINASE_DOM, 1 hit
    PS00108 PROTEIN_KINASE_ST, 1 hit

    Sequences (2+)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P48730-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH
    60 70 80 90 100
    IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF
    110 120 130 140 150
    SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF
    160 170 180 190 200
    GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG
    210 220 230 240 250
    YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT
    260 270 280 290 300
    YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
    310 320 330 340 350
    ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS
    360 370 380 390 400
    HTANTSPRPV SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI
    410
    PGRVASSGLQ SVVHR
    Length:415
    Mass (Da):47,330
    Last modified:January 27, 2003 - v2
    Checksum:iB97F1717A52466D2
    GO
    Isoform 2 (identifier: P48730-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         400-415: IPGRVASSGLQSVVHR → NSIPFEHHGK

    Show »
    Length:409
    Mass (Da):46,832
    Checksum:i970B55B1AF6B56DD
    GO

    Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H7BYT1H7BYT1_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    427Annotation score:
    B4DLF1B4DLF1_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    126Annotation score:
    J3QQI9J3QQI9_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    187Annotation score:
    H0Y2N6H0Y2N6_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    120Annotation score:
    J3KRM8J3KRM8_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    64Annotation score:
    J3KRS6J3KRS6_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    56Annotation score:
    J3QS70J3QS70_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    43Annotation score:
    J3QQU8J3QQU8_HUMAN
    Casein kinase I isoform delta
    CSNK1D
    20Annotation score:

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti330A → D in AAC50807 (PubMed:8786104).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02907544T → A in FASPS2; strongly reduces kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894561EnsemblClinVar.1
    Natural variantiVAR_06980146H → R in FASPS2; strongly reduces kinase activity. 1 PublicationCorresponds to variant dbSNP:rs397514693EnsemblClinVar.1
    Natural variantiVAR_03645197S → C in breast cancer samples; infiltrating ductal carcinoma; somatic mutation. 2 Publications1
    Natural variantiVAR_042081401P → A1 PublicationCorresponds to variant dbSNP:rs56124628Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_010253400 – 415IPGRV…SVVHR → NSIPFEHHGK in isoform 2. 2 PublicationsAdd BLAST16

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U29171 mRNA Translation: AAC50807.1
    U31285 mRNA Translation: AAC50808.1
    AB091044 mRNA Translation: BAC10903.1
    AK291758 mRNA Translation: BAF84447.1
    EF015900 Genomic DNA Translation: ABM64211.1
    BC003558 mRNA Translation: AAH03558.1
    BC015775 mRNA Translation: AAH15775.1
    CCDSiCCDS11805.1 [P48730-1]
    CCDS11806.1 [P48730-2]
    PIRiG01876
    RefSeqiNP_001884.2, NM_001893.4 [P48730-1]
    NP_620693.1, NM_139062.2 [P48730-2]
    UniGeneiHs.631725

    Genome annotation databases

    EnsembliENST00000314028; ENSP00000324464; ENSG00000141551 [P48730-1]
    ENST00000392334; ENSP00000376146; ENSG00000141551 [P48730-2]
    GeneIDi1453
    KEGGihsa:1453
    UCSCiuc002kei.4 human [P48730-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U29171 mRNA Translation: AAC50807.1
    U31285 mRNA Translation: AAC50808.1
    AB091044 mRNA Translation: BAC10903.1
    AK291758 mRNA Translation: BAF84447.1
    EF015900 Genomic DNA Translation: ABM64211.1
    BC003558 mRNA Translation: AAH03558.1
    BC015775 mRNA Translation: AAH15775.1
    CCDSiCCDS11805.1 [P48730-1]
    CCDS11806.1 [P48730-2]
    PIRiG01876
    RefSeqiNP_001884.2, NM_001893.4 [P48730-1]
    NP_620693.1, NM_139062.2 [P48730-2]
    UniGeneiHs.631725

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3UYSX-ray2.30A/B/C/D1-294[»]
    3UYTX-ray2.00A/B/C/D1-294[»]
    3UZPX-ray1.94A/B1-294[»]
    4HGTX-ray1.80A/B1-294[»]
    4HNFX-ray2.07A/B1-294[»]
    4KB8X-ray1.95A/B/C/D3-317[»]
    4KBAX-ray1.98A/B/C/D3-317[»]
    4KBCX-ray1.98A/B1-317[»]
    4KBKX-ray2.10A/B/C/D3-317[»]
    4TN6X-ray2.41A/B1-301[»]
    4TW9X-ray2.40A/B1-295[»]
    4TWCX-ray1.70A/B1-295[»]
    5IH4X-ray1.90A1-294[»]
    5IH5X-ray2.25A1-294[»]
    5IH6X-ray2.30A1-294[»]
    5MQVX-ray2.15A/B/C/D/E/F1-294[»]
    5OKTX-ray2.13A/B/C/D1-294[»]
    5W4WX-ray1.99A/B/C/D3-317[»]
    6GZMX-ray1.59A/B1-295[»]
    ProteinModelPortaliP48730
    SMRiP48730
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi107837, 97 interactors
    DIPiDIP-39735N
    IntActiP48730, 45 interactors
    MINTiP48730
    STRINGi9606.ENSP00000324464

    Chemistry databases

    BindingDBiP48730
    ChEMBLiCHEMBL2828
    GuidetoPHARMACOLOGYi1997

    PTM databases

    iPTMnetiP48730
    PhosphoSitePlusiP48730

    Polymorphism and mutation databases

    BioMutaiCSNK1D
    DMDMi27923980

    Proteomic databases

    EPDiP48730
    MaxQBiP48730
    PaxDbiP48730
    PeptideAtlasiP48730
    PRIDEiP48730
    ProteomicsDBi55930
    55931 [P48730-2]
    TopDownProteomicsiP48730-1 [P48730-1]

    Protocols and materials databases

    DNASUi1453
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000314028; ENSP00000324464; ENSG00000141551 [P48730-1]
    ENST00000392334; ENSP00000376146; ENSG00000141551 [P48730-2]
    GeneIDi1453
    KEGGihsa:1453
    UCSCiuc002kei.4 human [P48730-1]

    Organism-specific databases

    CTDi1453
    DisGeNETi1453
    EuPathDBiHostDB:ENSG00000141551.14
    GeneCardsiCSNK1D
    HGNCiHGNC:2452 CSNK1D
    HPAiCAB015410
    MalaCardsiCSNK1D
    MIMi600864 gene
    615224 phenotype
    neXtProtiNX_P48730
    OpenTargetsiENSG00000141551
    Orphaneti164736 Familial advanced sleep-phase syndrome
    PharmGKBiPA26952
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG1164 Eukaryota
    ENOG410XPGP LUCA
    GeneTreeiENSGT00930000150814
    HOGENOMiHOG000182055
    HOVERGENiHBG000176
    InParanoidiP48730
    KOiK08959
    PhylomeDBiP48730
    TreeFamiTF300544

    Enzyme and pathway databases

    BRENDAi2.7.11.1 2681
    ReactomeiR-HSA-204005 COPII-mediated vesicle transport
    R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
    R-HSA-380259 Loss of Nlp from mitotic centrosomes
    R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
    R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
    R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
    R-HSA-400253 Circadian Clock
    R-HSA-5620912 Anchoring of the basal body to the plasma membrane
    R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
    R-HSA-8854518 AURKA Activation by TPX2
    SABIO-RKiP48730
    SignaLinkiP48730
    SIGNORiP48730

    Miscellaneous databases

    ChiTaRSiCSNK1D human
    GeneWikiiCSNK1D
    GenomeRNAii1453
    PROiPR:P48730
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000141551 Expressed in 227 organ(s), highest expression level in adenohypophysis
    CleanExiHS_CSNK1D
    ExpressionAtlasiP48730 baseline and differential
    GenevisibleiP48730 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR011009 Kinase-like_dom_sf
    IPR000719 Prot_kinase_dom
    IPR017441 Protein_kinase_ATP_BS
    IPR008271 Ser/Thr_kinase_AS
    PfamiView protein in Pfam
    PF00069 Pkinase, 1 hit
    SMARTiView protein in SMART
    SM00220 S_TKc, 1 hit
    SUPFAMiSSF56112 SSF56112, 1 hit
    PROSITEiView protein in PROSITE
    PS00107 PROTEIN_KINASE_ATP, 1 hit
    PS50011 PROTEIN_KINASE_DOM, 1 hit
    PS00108 PROTEIN_KINASE_ST, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiKC1D_HUMAN
    AccessioniPrimary (citable) accession number: P48730
    Secondary accession number(s): A2I2P2, Q96KZ6, Q9BTN5
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 27, 2003
    Last modified: November 7, 2018
    This is version 193 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
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