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Entry version 214 (29 Sep 2021)
Sequence version 2 (27 Jan 2003)
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Protein

Casein kinase I isoform delta

Gene

CSNK1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

17 Publications

Miscellaneous

May be involved in Alzheimer disease by phosphorylating MAPT/TAU.1 Publication

Caution

Was shown to phosphorylate and activate DCK in vitro but probably not in vivo.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261), N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CKI-7), 4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-diaryl-isoxazoles and -imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670).10 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Maximal velocity nearly identical for the reactions with alpha-casein and PER2 peptide.
  1. KM=36.5 µM for alpha-casein1 Publication
  2. KM=635.8 µM for PER2 peptide1 Publication
  3. KM=180.6 µM for ATP1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei38ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei128Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi15 – 23ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processBiological rhythms, Wnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.11.1, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P48730

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-204005, COPII-mediated vesicle transport
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-400253, Circadian Clock
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-8854518, AURKA Activation by TPX2

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P48730

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P48730

SIGNOR Signaling Network Open Resource

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SIGNORi
P48730

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Casein kinase I isoform delta (EC:2.7.11.1)
Short name:
CKI-delta
Short name:
CKId
Alternative name(s):
Tau-protein kinase CSNK1D (EC:2.7.11.26)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSNK1D
Synonyms:HCKID
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:2452, CSNK1D

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600864, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P48730

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000141551

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Advanced sleep phase syndrome, familial, 2 (FASPS2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02907544T → A in FASPS2; strongly reduces kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894561EnsemblClinVar.1
Natural variantiVAR_06980146H → R in FASPS2; strongly reduces kinase activity. 1 PublicationCorresponds to variant dbSNP:rs397514693EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38K → M: Impaired kinase activity and abnormal subcellular localization with exclusive accumulation to the nucleus. 1 Publication1
Mutagenesisi176T → I: Impaired kinase activity and abnormal subcellular localization with exclusive accumulation to the nucleus. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

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DisGeNETi
1453

MalaCards human disease database

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MalaCardsi
CSNK1D
MIMi615224, phenotype

Open Targets

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OpenTargetsi
ENSG00000141551

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
164736, Familial advanced sleep-phase syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26952

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P48730, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2828

DrugCentral

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DrugCentrali
P48730

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1997

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CSNK1D

Domain mapping of disease mutations (DMDM)

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DMDMi
27923980

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001928331 – 415Casein kinase I isoform deltaAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei328PhosphoserineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei370PhosphoserineBy similarity1
Modified residuei375Omega-N-methylarginineBy similarity1
Modified residuei382PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P48730

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P48730

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P48730

MaxQB - The MaxQuant DataBase

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MaxQBi
P48730

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P48730

PeptideAtlas

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PeptideAtlasi
P48730

PRoteomics IDEntifications database

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PRIDEi
P48730

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
55930 [P48730-1]
55931 [P48730-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P48730-1 [P48730-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P48730

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P48730

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly present in extravillous trophoblast cells, which are present at the placenta implantation site and invade the decidua and decidual vessels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000141551, Expressed in adenohypophysis and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P48730, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P48730, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000141551, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:22168824, PubMed:23106386).

Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity).

Interacts with DNMT1 and MAP1A (By similarity).

Interacts directly with PER1 and PER2 which may lead to their degradation (PubMed:11165242).

Interacts with MAPT/TAU (PubMed:14761950).

Interacts with SNAPIN (By similarity).

Interacts with DBNDD2 (PubMed:16618118).

Interacts with AIB1/NCOA3 and ESR1 (PubMed:19339517).

Interacts with AKAP9/AKAP450; this interaction promotes centrosomal subcellular location (PubMed:12270714). Binds to tubulins in mitotic cells upon DNA damage (PubMed:10826492).

Interacts with GJA1 (PubMed:12270943).

Interacts with DDX3X; this interaction enhances CSNK1D kinase activity in vitro, but it is unclear whether this interaction is physiologically relevant (PubMed:29222110).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P48730
With#Exp.IntAct
APP [P05067]3EBI-751621,EBI-77613
CCDC14 - isoform 3 [Q49A88-3]3EBI-751621,EBI-12105646
DRICH1 [Q6PGQ1]3EBI-751621,EBI-10253641
DVL3 [Q92997]4EBI-751621,EBI-739789
EVI5 [O60447]3EBI-751621,EBI-852291
IKZF4 [Q9H2S9]3EBI-751621,EBI-1640423
LURAP1 [Q96LR2]4EBI-751621,EBI-741355
LZTS2 [Q9BRK4]3EBI-751621,EBI-741037
MDM2 [Q00987]6EBI-751621,EBI-389668
PAK5 [Q9P286]3EBI-751621,EBI-741896
PER2 [O15055]4EBI-751621,EBI-1054296
TRIM3 [O75382]3EBI-751621,EBI-2129889
TRIM9 [Q9C026]3EBI-751621,EBI-720828
ZBTB8A [Q96BR9]3EBI-751621,EBI-742740
ZNF618 [Q5T7W0]3EBI-751621,EBI-6255994
Dvl2 [Q60838] from Mus musculus.2EBI-751621,EBI-641940
Isoform 2 [P48730-2]
With#Exp.IntAct
APP [P05067]3EBI-9087876,EBI-77613
APPBP2 [Q92624]3EBI-9087876,EBI-743771
BCAN [Q96GW7]3EBI-9087876,EBI-2690445
CALHM1 [Q8IU99]3EBI-9087876,EBI-1790341
CAV1 [Q03135]3EBI-9087876,EBI-603614
CBX5 [P45973]3EBI-9087876,EBI-78219
CRH [P06850]3EBI-9087876,EBI-3870390
DR1 [Q01658]3EBI-9087876,EBI-750300
ERP44 [Q9BS26]3EBI-9087876,EBI-541644
FUS [P35637]3EBI-9087876,EBI-400434
GJA1 [P17302]3EBI-9087876,EBI-1103439
GORASP2 [Q9H8Y8]3EBI-9087876,EBI-739467
GRK2 [P25098]3EBI-9087876,EBI-3904795
GTF2B [Q00403]3EBI-9087876,EBI-389564
GTF3C3 [Q9Y5Q9]3EBI-9087876,EBI-1054873
HTT [P42858]15EBI-9087876,EBI-466029
LRP8 - isoform 3 [Q14114-3]3EBI-9087876,EBI-25832196
LRRK2 [Q5S007]3EBI-9087876,EBI-5323863
MAPK14 [Q16539]3EBI-9087876,EBI-73946
MARK4 [Q96L34]3EBI-9087876,EBI-302319
NF2 - isoform 4 [P35240-4]3EBI-9087876,EBI-1014514
PAXIP1 [Q6ZW49]3EBI-9087876,EBI-743225
PLPP1 [O14494]3EBI-9087876,EBI-2865290
PMP22 [D3DTS7]3EBI-9087876,EBI-25882629
PRKACA [P17612]3EBI-9087876,EBI-476586
PSAP [P07602]3EBI-9087876,EBI-716699
RAD23A [P54725]3EBI-9087876,EBI-746453
S100B [P04271]3EBI-9087876,EBI-458391
SCARB1 [Q8WTV0]3EBI-9087876,EBI-78657
SERPINH1 [P50454]3EBI-9087876,EBI-350723
SIAH1 - isoform 2 [Q8IUQ4-2]3EBI-9087876,EBI-11522811
SMAD3 [P84022]3EBI-9087876,EBI-347161
SNCA [P37840]3EBI-9087876,EBI-985879
SOD1 [P00441]3EBI-9087876,EBI-990792
SPTLC1 [Q6NUL7]3EBI-9087876,EBI-25912847
TARDBP [Q13148]6EBI-9087876,EBI-372899
TGFBR2 [P37173]3EBI-9087876,EBI-296151
TMPRSS4 [Q9NRS4]3EBI-9087876,EBI-10313040
UTP14A [Q9BVJ6]3EBI-9087876,EBI-473284
VPS29 - isoform 2 [Q9UBQ0-2]3EBI-9087876,EBI-11141397
ZDHHC17 [Q8IUH5]3EBI-9087876,EBI-524753

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107837, 182 interactors

Database of interacting proteins

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DIPi
DIP-39735N

Protein interaction database and analysis system

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IntActi
P48730, 123 interactors

Molecular INTeraction database

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MINTi
P48730

STRING: functional protein association networks

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STRINGi
9606.ENSP00000324464

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P48730

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P48730, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P48730

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni278 – 364Centrosomal localization signal (CLS)Add BLAST87
Regioni301 – 415DisorderedSequence analysisAdd BLAST115
Regioni317 – 342AutoinhibitoryBy similarityAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi301 – 320Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi342 – 359Polar residuesSequence analysisAdd BLAST18
Compositional biasi380 – 415Polar residuesSequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1164, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153536

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019279_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48730

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYFCRGS

Database of Orthologous Groups

More...
OrthoDBi
1097975at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48730

TreeFam database of animal gene trees

More...
TreeFami
TF300544

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P48730-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH
60 70 80 90 100
IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF
110 120 130 140 150
SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF
160 170 180 190 200
GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG
210 220 230 240 250
YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT
260 270 280 290 300
YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
310 320 330 340 350
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS
360 370 380 390 400
HTANTSPRPV SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI
410
PGRVASSGLQ SVVHR
Length:415
Mass (Da):47,330
Last modified:January 27, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB97F1717A52466D2
GO
Isoform 2 (identifier: P48730-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-415: IPGRVASSGLQSVVHR → NSIPFEHHGK

Show »
Length:409
Mass (Da):46,832
Checksum:i970B55B1AF6B56DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYT1H7BYT1_HUMAN
Casein kinase I isoform delta
CSNK1D
427Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQI9J3QQI9_HUMAN
Non-specific serine/threonine prote...
CSNK1D
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2N6H0Y2N6_HUMAN
Non-specific serine/threonine prote...
CSNK1D
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DLF1B4DLF1_HUMAN
Casein kinase I isoform delta
CSNK1D
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRM8J3KRM8_HUMAN
Casein kinase I isoform delta
CSNK1D
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRS6J3KRS6_HUMAN
Casein kinase I isoform delta
CSNK1D
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS70J3QS70_HUMAN
Casein kinase I isoform delta
CSNK1D
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQU8J3QQU8_HUMAN
Casein kinase I isoform delta
CSNK1D
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti330A → D in AAC50807 (PubMed:8786104).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02907544T → A in FASPS2; strongly reduces kinase activity. 2 PublicationsCorresponds to variant dbSNP:rs104894561EnsemblClinVar.1
Natural variantiVAR_06980146H → R in FASPS2; strongly reduces kinase activity. 1 PublicationCorresponds to variant dbSNP:rs397514693EnsemblClinVar.1
Natural variantiVAR_03645197S → C in breast cancer samples; infiltrating ductal carcinoma; somatic mutation. 2 Publications1
Natural variantiVAR_042081401P → A1 PublicationCorresponds to variant dbSNP:rs56124628Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010253400 – 415IPGRV…SVVHR → NSIPFEHHGK in isoform 2. 2 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U29171 mRNA Translation: AAC50807.1
U31285 mRNA Translation: AAC50808.1
AB091044 mRNA Translation: BAC10903.1
AK291758 mRNA Translation: BAF84447.1
EF015900 Genomic DNA Translation: ABM64211.1
BC003558 mRNA Translation: AAH03558.1
BC015775 mRNA Translation: AAH15775.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11805.1 [P48730-1]
CCDS11806.1 [P48730-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
G01876

NCBI Reference Sequences

More...
RefSeqi
NP_001884.2, NM_001893.4 [P48730-1]
NP_620693.1, NM_139062.2 [P48730-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314028; ENSP00000324464; ENSG00000141551 [P48730-1]
ENST00000392334; ENSP00000376146; ENSG00000141551 [P48730-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1453

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1453

UCSC genome browser

More...
UCSCi
uc002kei.4, human [P48730-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29171 mRNA Translation: AAC50807.1
U31285 mRNA Translation: AAC50808.1
AB091044 mRNA Translation: BAC10903.1
AK291758 mRNA Translation: BAF84447.1
EF015900 Genomic DNA Translation: ABM64211.1
BC003558 mRNA Translation: AAH03558.1
BC015775 mRNA Translation: AAH15775.1
CCDSiCCDS11805.1 [P48730-1]
CCDS11806.1 [P48730-2]
PIRiG01876
RefSeqiNP_001884.2, NM_001893.4 [P48730-1]
NP_620693.1, NM_139062.2 [P48730-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UYSX-ray2.30A/B/C/D1-294[»]
3UYTX-ray2.00A/B/C/D1-294[»]
3UZPX-ray1.94A/B1-294[»]
4HGTX-ray1.80A/B1-294[»]
4HNFX-ray2.07A/B1-294[»]
4KB8X-ray1.95A/B/C/D3-317[»]
4KBAX-ray1.98A/B/C/D3-317[»]
4KBCX-ray1.98A/B1-317[»]
4KBKX-ray2.10A/B/C/D3-317[»]
4TN6X-ray2.41A/B1-301[»]
4TW9X-ray2.40A/B1-295[»]
4TWCX-ray1.70A/B1-295[»]
5IH4X-ray1.90A1-294[»]
5IH5X-ray2.25A1-294[»]
5IH6X-ray2.30A1-294[»]
5MQVX-ray2.15A/B/C/D/E/F1-294[»]
5OKTX-ray2.13A/B/C/D1-294[»]
5W4WX-ray1.99A/B/C/D3-317[»]
6F1WX-ray1.86A/B1-294[»]
6F26X-ray1.83A/B1-294[»]
6GZMX-ray1.59A/B1-295[»]
6HMPX-ray2.04A/B1-294[»]
6HMRX-ray1.78A/B1-294[»]
6PXNX-ray1.55A/B1-415[»]
6PXOX-ray2.00A/B1-294[»]
6PXPX-ray2.35A/B1-294[»]
6RCGX-ray1.40A1-294[»]
6RCHX-ray1.45A/B1-294[»]
6RU6X-ray2.05A/B1-294[»]
6RU7X-ray2.08A/B1-294[»]
6RU8X-ray1.92A/B/C/D1-294[»]
SMRiP48730
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107837, 182 interactors
DIPiDIP-39735N
IntActiP48730, 123 interactors
MINTiP48730
STRINGi9606.ENSP00000324464

Chemistry databases

BindingDBiP48730
ChEMBLiCHEMBL2828
DrugCentraliP48730
GuidetoPHARMACOLOGYi1997

PTM databases

iPTMnetiP48730
PhosphoSitePlusiP48730

Genetic variation databases

BioMutaiCSNK1D
DMDMi27923980

Proteomic databases

EPDiP48730
jPOSTiP48730
MassIVEiP48730
MaxQBiP48730
PaxDbiP48730
PeptideAtlasiP48730
PRIDEiP48730
ProteomicsDBi55930 [P48730-1]
55931 [P48730-2]
TopDownProteomicsiP48730-1 [P48730-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4210, 370 antibodies

The DNASU plasmid repository

More...
DNASUi
1453

Genome annotation databases

EnsembliENST00000314028; ENSP00000324464; ENSG00000141551 [P48730-1]
ENST00000392334; ENSP00000376146; ENSG00000141551 [P48730-2]
GeneIDi1453
KEGGihsa:1453
UCSCiuc002kei.4, human [P48730-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1453
DisGeNETi1453

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CSNK1D
HGNCiHGNC:2452, CSNK1D
HPAiENSG00000141551, Low tissue specificity
MalaCardsiCSNK1D
MIMi600864, gene
615224, phenotype
neXtProtiNX_P48730
OpenTargetsiENSG00000141551
Orphaneti164736, Familial advanced sleep-phase syndrome
PharmGKBiPA26952
VEuPathDBiHostDB:ENSG00000141551

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1164, Eukaryota
GeneTreeiENSGT00940000153536
HOGENOMiCLU_019279_2_2_1
InParanoidiP48730
OMAiIYFCRGS
OrthoDBi1097975at2759
PhylomeDBiP48730
TreeFamiTF300544

Enzyme and pathway databases

BRENDAi2.7.11.1, 2681
PathwayCommonsiP48730
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259, Loss of Nlp from mitotic centrosomes
R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320, Recruitment of NuMA to mitotic centrosomes
R-HSA-400253, Circadian Clock
R-HSA-5620912, Anchoring of the basal body to the plasma membrane
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-8854518, AURKA Activation by TPX2
SABIO-RKiP48730
SignaLinkiP48730
SIGNORiP48730

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
1453, 16 hits in 1051 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSNK1D, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CSNK1D

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1453
PharosiP48730, Tchem

Protein Ontology

More...
PROi
PR:P48730
RNActiP48730, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000141551, Expressed in adenohypophysis and 239 other tissues
ExpressionAtlasiP48730, baseline and differential
GenevisibleiP48730, HS

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKC1D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48730
Secondary accession number(s): A2I2P2, Q96KZ6, Q9BTN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 27, 2003
Last modified: September 29, 2021
This is version 214 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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