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UniProtKB - P48725 (PCNT_MOUSE)

Entry version 143 (02 Dec 2020)
Sequence version 2 (20 Apr 2010)
Previous versions | rss
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Protein

Pericentrin

Gene

Pcnt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259, Loss of Nlp from mitotic centrosomes
R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320, Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912, Anchoring of the basal body to the plasma membrane
R-MMU-8854518, AURKA Activation by TPX2
R-MMU-9646399, Aggrephagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pericentrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pcnt
Synonyms:Pcnt2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:102722, Pcnt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000582581 – 2898PericentrinAdd BLAST2898

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei44PhosphoserineBy similarity1
Modified residuei1022PhosphoserineBy similarity1
Modified residuei1437PhosphoserineCombined sources1
Modified residuei1828PhosphoserineBy similarity1
Modified residuei1859PhosphoserineCombined sources1
Modified residuei1860PhosphoserineCombined sources1
Modified residuei1959PhosphoserineBy similarity1
Modified residuei1987PhosphoserineBy similarity1
Modified residuei2128PhosphoserineBy similarity1
Modified residuei2865PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved during mitotis which leads to removal of CDK5RAP2 from the centrosome and promotes centriole disengagement and subsequent centriole separation. The C-terminal fragment is rapidly degraded following cleavage.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P48725

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P48725

MaxQB - The MaxQuant DataBase

More...MaxQBi		P48725

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P48725

PeptideAtlas

More...PeptideAtlasi		P48725

PRoteomics IDEntifications database

More...PRIDEi		P48725

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P48725

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P48725

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart and lung (at protein level). Expressed in kidney, thymus, liver, brain, muscle, testis, spleen, lung and heart.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo at 17 dpc (at protein level). Expressed in embryos at 7, 11, 15 and 17 dpc. Strongly expressed in brain tissues at early stages of development.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DISC1 and PCM1. Binds calmodulin.

Interacts with CEP131 (By similarity).

Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of PCNT and CDK5RAP2 (PubMed:20471352).

Interacts with CHD3 (PubMed:17626165).

Interacts with CHD4; the interaction regulates centrosome integrity (PubMed:17626165).

Interacts with NEK2 (By similarity).

Interacts with CCDC13 (By similarity).

Interacts with CEP68 (By similarity).

Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		202052, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P48725

Protein interaction database and analysis system

More...IntActi		P48725, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000001179

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P48725, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1801 – 1822Interaction with CDK5RAP21 PublicationAdd BLAST22
Regioni2545 – 2810Interaction with NEK2By similarityAdd BLAST266
Regioni2758 – 2771Calmodulin-bindingBy similarityAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili127 – 343Sequence analysisAdd BLAST217
Coiled coili382 – 434Sequence analysisAdd BLAST53
Coiled coili468 – 527Sequence analysisAdd BLAST60
Coiled coili611 – 696Sequence analysisAdd BLAST86
Coiled coili727 – 787Sequence analysisAdd BLAST61
Coiled coili872 – 939Sequence analysisAdd BLAST68
Coiled coili1069 – 1383Sequence analysisAdd BLAST315
Coiled coili1429 – 1482Sequence analysisAdd BLAST54
Coiled coili1529 – 1593Sequence analysisAdd BLAST65
Coiled coili2211 – 2403Sequence analysisAdd BLAST193
Coiled coili2429 – 2590Sequence analysisAdd BLAST162

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of a coiled-coil central region flanked by non-helical N- and C-terminals.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QV16, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P48725

Database of Orthologous Groups

More...OrthoDBi		8180at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P48725

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028745, AKAP9/Pericentrin
IPR019528, PACT_domain

The PANTHER Classification System

More...PANTHERi		PTHR44981, PTHR44981, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10495, PACT_coil_coil, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P48725-1) [UniParc]FASTAAdd to basket
Also known as: Pericentrin B, Pericentrin-360

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDEQEQRRR KVEAGRAKLA NFRQRKTKGD CPNSKKKTAK RKGSAVHASV 
        60         70         80         90        100
QEEGSVATPN SELPQGGAVF ESPSCSNTLE GTRGASAAQE QEDCELDVTD 
       110        120        130        140        150
LQGQQQTQPP PPQTAHSLEL EALRLSLNNM HTAQLELTQA NLQKEKETAL 
       160        170        180        190        200
TELREMLNGR RAQELALLQS RQQCELELLR EQHAREKEEM ALRSGQEAAE 
       210        220        230        240        250
LKEKLRSEME KNAQTIETLK QDWESERELC LENLRQELSL KHQSEMEGLQ 
       260        270        280        290        300
SQFQKELSEQ KVELEKIFQA KHEAEVSLKN LEAQHQAAIK KLQEDLQSEH 
       310        320        330        340        350
CQYLQDLEQK FREKEKAKEL ELETLQASYE DLKAQSQEEI RLLWSQLESM 
       360        370        380        390        400
KTNREELNGS WDPVLAQASH LEELEHLRSG FAQQQQQERA QHESELEHLR 
       410        420        430        440        450
VYFEKKLKDA EKTYQEDLTV FQQRLQEARE DSLESTEISS SCVLPEETSG 
       460        470        480        490        500
REGKEPPDPL DLQLGQPKVQ ESLVEDCQVK LSKAEEKIQQ MKEEFQKKEA 
       510        520        530        540        550
EWELSREELK REAEERLASM FLELREKAES EKLSIISRFE HRESSMRHLQ 
       560        570        580        590        600
DQQAAQILDL ERSLMEQQGH LRQLEQELTR DDLLPCSQCG QEPAMAQEEK 
       610        620        630        640        650
NGALLREKED CALQLLMAQN RFLEERKEIM EKFAKEQDAF LRDAQEKHNH 
       660        670        680        690        700
ELQLLQQGHQ QQLLALRMEL ETKHRSELTE QLASSESRRQ ALLETHVAEL 
       710        720        730        740        750
QVKHNAEISA LEKRHLSNLD ELESCYVADV QTIRDEHQQA LELLRAELEE 
       760        770        780        790        800
QLQKKESCHR EMLTQELENL KRQHAEELQS VRDSLRMEMS AQHIENGKGP 
       810        820        830        840        850
AADLQGAHQQ DPAMALHNEG HLLVEDGDAV LRSVDAEGLL HQAGPQELGD 
       860        870        880        890        900
AHTVEMQKSQ AELAKPQELQ ASQDQVAQVR DKVFLLNREL EECRAELEQL 
       910        920        930        940        950
QQRRERENQE GTTLICMLRA DLELAQGEGK ALRDALRRLL DLFGDTLKAA 
       960        970        980        990       1000
VTLKSRISER AGLLLDHEDA ADTSDARLAA AALGDMWSDE GLLEIDRTLP 
      1010       1020       1030       1040       1050
EGAETSSVCE ISSHVCESFF ISPENTLDCE QPIRRVYQSL STAVEGLLEM 
      1060       1070       1080       1090       1100
ALDSSKQLEE ARQLHRCVER EFRHRNEEMA QAMQKQQELL ERLREESAAK 
      1110       1120       1130       1140       1150
DRLALELHTA KGLLEGFKVE KVDLQEALGK KEESEQQLIL ELEDLRKQLQ 
      1160       1170       1180       1190       1200
QAARELLTLK EEKSVLWNQK ETLTNEAKER EAALQEEVES LTRVQWESRK 
      1210       1220       1230       1240       1250
QSEKDRATLL SQMRVLESEL EDQLVQHRGC AQLAEEVATL KQQLAALDKH 
      1260       1270       1280       1290       1300
LRSQRQFMDD QAAEREHERE EFQQEIQRLE GQLRQAARPR PPGPRDSQCV 
      1310       1320       1330       1340       1350
QLDEEVELLQ EKLREKLDGF NELVIKKDFA DQQLLIQEEE IKRLEETNAS 
      1360       1370       1380       1390       1400
IQRQMVQLQE ELEKQKKSME ELKEKEILKQ ENMGDLLLTT VSRSGLDEAG 
      1410       1420       1430       1440       1450
CPMLPQGSSS RGPEAQPDVT ERALLQHENE VVHRRNSEID ELKSLIENLQ 
      1460       1470       1480       1490       1500
ENQRQLQKDK AEEIEQLHEV IEKLQSELSL MGPKVHEVSD PQAGSLHSEL 
      1510       1520       1530       1540       1550
ACLRGEGLGG QALRSELQAA QAAKEVFGQL LANQAHGHSQ ALEALQQRLQ 
      1560       1570       1580       1590       1600
DAEEVAARHL AELEHCVALR EAEVEAMASQ IQEFAATLKA KEAIIEQRDL 
      1610       1620       1630       1640       1650
EIDAVNKWKV SHSLELEAIL LALAHFRHAL EQQTCATPDE PPELRQLRVQ 
      1660       1670       1680       1690       1700
CARLSHQLQV LYRPFLKCRM QLDQHQPHVA SIGCANPCAD DELEQEGVSN 
      1710       1720       1730       1740       1750
RLALAPHSLA AQAKEELEDC PLGKANLMAQ VRQLQEELDH RVHSVASRDT 
      1760       1770       1780       1790       1800
NSETCKLQQP NLSENGPRNH CCNGEESKPS PPDDVLNIAK TTWDVIDIIK 
      1810       1820       1830       1840       1850
NQDLLVQVEM PDFPTQEKLT SQGGPFSSQA SGHSGSLLPE EAAEPQQDPV 
      1860       1870       1880       1890       1900
RALDLSSWSS PEVVRKDPSL EPQHSLPLTP GVGTVSLHSV DISPDWTDPL 
      1910       1920       1930       1940       1950
LQADVSGLLC YPGKSASGQA PLWAVAPSAG KHHAERTATE KDVEDFIVTS 
      1960       1970       1980       1990       2000
FDSQELLTSP SHELARRSDG SRKSDGPDIA MMLTLGSEGS ETPTTDLVAA 
      2010       2020       2030       2040       2050
AAAAVPFSRR FVQSPGAMKE KEIHAKQMKA LLQMVFDESH QILALSESQD 
      2060       2070       2080       2090       2100
PSSALNKGEP RDPLDGFPRD SQALSEVTTD KGEKESLETH LTWSEELLRA 
      2110       2120       2130       2140       2150
IQEVFAREQE KAELQPRPYG SNLGDYNSLV QRLEKVIQEQ GDPQKVQDHL 
      2160       2170       2180       2190       2200
CLSDRSSLLA EIQALRAQLR MTHLQNQEKL QQLCAALTST EARGSQREHQ 
      2210       2220       2230       2240       2250
LRRQVELLAY KVEQEKCIAN ELQKTLSKEQ ETASDVRKRL VVEQNAVQDL 
      2260       2270       2280       2290       2300
KSELHACKQE NTSLLESLDK VQQEVLRLRA VLDGKEKELK VVLEELESER 
      2310       2320       2330       2340       2350
GKGQALQAQQ EEQQLRYLQR EGQSSRALEE LKLSLEKQLA QNNQLCVALK 
      2360       2370       2380       2390       2400
HERAAKDNLQ KELQIEASRC EALLAQEKGQ LSELQKSLEA ERSRSLELSE 
      2410       2420       2430       2440       2450
ALQHERLLTE QLSRNSQEAC ARQETQVQHA LLRKLKAEKT RALELEAMLE 
      2460       2470       2480       2490       2500
KVQKQAAHTQ QQLEAQAQER CVELRREKER ELEIQRQRDE HKIEQLQRLV 
      2510       2520       2530       2540       2550
RELRWKEEVS GGNGPCRGSP GRGSLERDQF QEQQQELEKI RQQLLCAAGL 
      2560       2570       2580       2590       2600
LTSFTNHTVD RTIKDWTSSN EKAVSSLMRT LEELKSELSM PTSFQKKMTA 
      2610       2620       2630       2640       2650
ELQVQLMNEL LSDNDALTKA VGMATREKAE LCRTVSRLEK TLKHHTQKGC 
      2660       2670       2680       2690       2700
VLNRQSKSSL KQDGTDLQSS LRHSDPEWHS QTTSGDTNTC NIKMEKLYLH 
      2710       2720       2730       2740       2750
YLRAESFRKA LIYQKKYLLL LIGGFQDSEQ ETLSMIAHLG VFPSKADKKI 
      2760       2770       2780       2790       2800
TMSRPFTKFR TAVRVVIAVL RLRFLVKKWQ EVDRKGALVH PKSTRHGHRT 
      2810       2820       2830       2840       2850
SQRQRSPSGP RASLPTRDTS SGPTKASRHS PRSAAAGSPG KERSTSTPSS 
      2860       2870       2880       2890 
RLERSLTASQ DPEHSLTEYI HHLEMIQQRL GGLPPDSTQK SCHQKIKQ
Length:2,898
Mass (Da):329,465
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50E66D93F7E4E283
GO
Isoform 2 (identifier: P48725-2) [UniParc]FASTAAdd to basket
Also known as: Pericentrin S, Pericentrin-255

The sequence of this isoform differs from the canonical sequence as follows:
     1-916: Missing.

Show »
Length:1,982
Mass (Da):223,682
Checksum:i2781F4B76DB80818
GO
Isoform 3 (identifier: P48725-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2044-2050: ALSESQD → GNSRLLF
     2501-2898: Missing.

Show »
Length:2,500
Mass (Da):284,589
Checksum:iF17397506865AAAE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VPV0F8VPV0_MOUSE
Pericentrin
Pcnt
2,916Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P737A0A1W2P737_MOUSE
Pericentrin
Pcnt
2,898Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P8A6A0A1W2P8A6_MOUSE
Pericentrin
Pcnt
156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA17886 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti652Missing in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti662Missing in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti896 – 897EL → DV in AAA17886 (PubMed:8124707).Curated2
Sequence conflicti960R → G in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti982A → P in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti1022S → R in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti1150Q → E in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti1266 – 1267EH → DD in AAA17886 (PubMed:8124707).Curated2
Sequence conflicti1533N → D in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti1548R → G in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti1726N → G in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti1736E → Q in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti1772C → S in AAA17886 (PubMed:8124707).Curated1
Sequence conflicti2040H → L in AAA17886 (PubMed:8124707).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0389271 – 916Missing in isoform 2. 1 PublicationAdd BLAST916
Alternative sequenceiVSP_0389282044 – 2050ALSESQD → GNSRLLF in isoform 3. 1 Publication7
Alternative sequenceiVSP_0389292501 – 2898Missing in isoform 3. 1 PublicationAdd BLAST398

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U05823 mRNA Translation: AAA17886.1 Sequence problems.
AB207233 mRNA Translation: BAF36559.1
AB207234 mRNA Translation: BAF36560.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS88027.1 [P48725-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A53188

NCBI Reference Sequences

More...RefSeqi		NP_001269921.1, NM_001282992.1
NP_032813.3, NM_008787.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		18541

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:18541

UCSC genome browser

More...UCSCi		uc007fuj.1, mouse [P48725-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05823 mRNA Translation: AAA17886.1 Sequence problems.
AB207233 mRNA Translation: BAF36559.1
AB207234 mRNA Translation: BAF36560.1
CCDSiCCDS88027.1 [P48725-1]
PIRiA53188
RefSeqiNP_001269921.1, NM_001282992.1
NP_032813.3, NM_008787.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi202052, 7 interactors
CORUMiP48725
IntActiP48725, 3 interactors
STRINGi10090.ENSMUSP00000001179

PTM databases

iPTMnetiP48725
PhosphoSitePlusiP48725

Proteomic databases

EPDiP48725
jPOSTiP48725
MaxQBiP48725
PaxDbiP48725
PeptideAtlasiP48725
PRIDEiP48725

Genome annotation databases

GeneIDi18541
KEGGimmu:18541
UCSCiuc007fuj.1, mouse [P48725-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5116
MGIiMGI:102722, Pcnt

Phylogenomic databases

eggNOGiENOG502QV16, Eukaryota
InParanoidiP48725
OrthoDBi8180at2759
PhylomeDBiP48725

Enzyme and pathway databases

ReactomeiR-MMU-2565942, Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259, Loss of Nlp from mitotic centrosomes
R-MMU-380270, Recruitment of mitotic centrosome proteins and complexes
R-MMU-380284, Loss of proteins required for interphase microtubule organization from the centrosome
R-MMU-380320, Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912, Anchoring of the basal body to the plasma membrane
R-MMU-8854518, AURKA Activation by TPX2
R-MMU-9646399, Aggrephagy

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		18541, 4 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Pcnt, mouse

Protein Ontology

More...PROi		PR:P48725
RNActiP48725, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

InterProiView protein in InterPro
IPR028745, AKAP9/Pericentrin
IPR019528, PACT_domain
PANTHERiPTHR44981, PTHR44981, 2 hits
PfamiView protein in Pfam
PF10495, PACT_coil_coil, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCNT_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48725
Secondary accession number(s): A0JBT0, A0JBT1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 20, 2010
Last modified: December 2, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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