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UniProtKB - P48723 (HSP13_HUMAN)

Entry version 177 (07 Apr 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Heat shock 70 kDa protein 13

Gene

HSPA13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has peptide-independent ATPase activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P48723

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3371453, Regulation of HSF1-mediated heat shock response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heat shock 70 kDa protein 13
Alternative name(s):
Microsomal stress-70 protein ATPase core
Stress-70 protein chaperone microsome-associated 60 kDa protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSPA13
Synonyms:STCH
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11375, HSPA13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601100, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P48723

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000155304.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6782

Open Targets

More...OpenTargetsi		ENSG00000155304

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162391697

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P48723, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB09130, Copper

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HSPA13

Domain mapping of disease mutations (DMDM)

More...DMDMi		1351125

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001355823 – 471Heat shock 70 kDa protein 13Add BLAST449

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P48723

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P48723

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P48723

MaxQB - The MaxQuant DataBase

More...MaxQBi		P48723

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P48723

PeptideAtlas

More...PeptideAtlasi		P48723

PRoteomics IDEntifications database

More...PRIDEi		P48723

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55924

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P48723

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00299299

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1294, 5 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P48723, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P48723

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P48723

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Constitutively expressed in all tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155304, Expressed in ventricular zone and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P48723, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P48723, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000155304, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds UBQLN2.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112659, 24 interactors

Protein interaction database and analysis system

More...IntActi		P48723, 18 interactors

Molecular INTeraction database

More...MINTi		P48723

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000285667

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P48723, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P48723

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0101, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00890000139503

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005965_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P48723

Identification of Orthologs from Complete Genome Data

More...OMAi		LRKTNFN

Database of Orthologous Groups

More...OrthoDBi		288077at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P48723

TreeFam database of animal gene trees

More...TreeFami		TF105047

Family and domain databases

Conserved Domains Database

More...CDDi		cd10237, HSPA13-like_NBD, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043129, ATPase_NBD
IPR018181, Heat_shock_70_CS
IPR013126, Hsp_70_fam
IPR042048, HSPA13

The PANTHER Classification System

More...PANTHERi		PTHR19375, PTHR19375, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00012, HSP70, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53067, SSF53067, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00297, HSP70_1, 1 hit
PS00329, HSP70_2, 1 hit
PS01036, HSP70_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P48723-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAREMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP 
        60         70         80         90        100
GTGKVKVIPD ENGHISIPSM VSFTDNDVYV GYESVELADS NPQNTIYDAK 
       110        120        130        140        150
RFIGKIFTAE ELEAEIGRYP FKVLNKNGMV EFSVTSNETI TVSPEYVGSR 
       160        170        180        190        200
LLLKLKEMAE AYLGMPVANA VISVPAEFDL KQRNSTIEAA NLAGLKILRV 
       210        220        230        240        250
INEPTAAAMA YGLHKADVFH VLVIDLGGGT LDVSLLNKQG GMFLTRAMSG 
       260        270        280        290        300
NNKLGGQDFN QRLLQYLYKQ IYQTYGFVPS RKEEIHRLRQ AVEMVKLNLT 
       310        320        330        340        350
LHQSAQLSVL LTVEEQDRKE PHSSDTELPK DKLSSADDHR VNSGFGRGLS 
       360        370        380        390        400
DKKSGESQVL FETEISRKLF DTLNEDLFQK ILVPIQQVLK EGHLEKTEID 
       410        420        430        440        450
EVVLVGGSTR IPRIRQVIQE FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS 
       460        470 
WPLQVSALEI PNKHLQKTNF N
Length:471
Mass (Da):51,927
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC78028E7CB0D03F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti450S → F in AAH36370 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U04735 mRNA Translation: AAA16954.1
AF130249 Genomic DNA Translation: AAD21091.1
AK312396 mRNA Translation: BAG35313.1
AL163206 Genomic DNA Translation: CAB90390.1
CH471079 Genomic DNA Translation: EAX10056.1
BC036370 mRNA Translation: AAH36370.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13567.1

Protein sequence database of the Protein Information Resource

More...PIRi		S42631

NCBI Reference Sequences

More...RefSeqi		NP_008879.3, NM_006948.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000285667; ENSP00000285667; ENSG00000155304

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6782

UCSC genome browser

More...UCSCi		uc002yjt.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04735 mRNA Translation: AAA16954.1
AF130249 Genomic DNA Translation: AAD21091.1
AK312396 mRNA Translation: BAG35313.1
AL163206 Genomic DNA Translation: CAB90390.1
CH471079 Genomic DNA Translation: EAX10056.1
BC036370 mRNA Translation: AAH36370.1
CCDSiCCDS13567.1
PIRiS42631
RefSeqiNP_008879.3, NM_006948.4

3D structure databases

SMRiP48723
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112659, 24 interactors
IntActiP48723, 18 interactors
MINTiP48723
STRINGi9606.ENSP00000285667

Chemistry databases

DrugBankiDB09130, Copper

PTM databases

GlyConnecti1294, 5 N-Linked glycans (2 sites)
GlyGeniP48723, 2 sites
iPTMnetiP48723
PhosphoSitePlusiP48723

Genetic variation databases

BioMutaiHSPA13
DMDMi1351125

2D gel databases

REPRODUCTION-2DPAGEiIPI00299299

Proteomic databases

EPDiP48723
jPOSTiP48723
MassIVEiP48723
MaxQBiP48723
PaxDbiP48723
PeptideAtlasiP48723
PRIDEiP48723
ProteomicsDBi55924
TopDownProteomicsiP48723

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2522, 189 antibodies

The DNASU plasmid repository

More...DNASUi		6782

Genome annotation databases

EnsembliENST00000285667; ENSP00000285667; ENSG00000155304
GeneIDi6782
KEGGihsa:6782
UCSCiuc002yjt.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6782
DisGeNETi6782

GeneCards: human genes, protein and diseases

More...GeneCardsi		HSPA13
HGNCiHGNC:11375, HSPA13
HPAiENSG00000155304, Low tissue specificity
MIMi601100, gene
neXtProtiNX_P48723
OpenTargetsiENSG00000155304
PharmGKBiPA162391697
VEuPathDBiHostDB:ENSG00000155304.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0101, Eukaryota
GeneTreeiENSGT00890000139503
HOGENOMiCLU_005965_0_3_1
InParanoidiP48723
OMAiLRKTNFN
OrthoDBi288077at2759
PhylomeDBiP48723
TreeFamiTF105047

Enzyme and pathway databases

PathwayCommonsiP48723
ReactomeiR-HSA-3371453, Regulation of HSF1-mediated heat shock response

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6782, 110 hits in 997 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HSPA13, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		STCH

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6782
PharosiP48723, Tbio

Protein Ontology

More...PROi		PR:P48723
RNActiP48723, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000155304, Expressed in ventricular zone and 243 other tissues
ExpressionAtlasiP48723, baseline and differential
GenevisibleiP48723, HS

Family and domain databases

CDDicd10237, HSPA13-like_NBD, 1 hit
InterProiView protein in InterPro
IPR043129, ATPase_NBD
IPR018181, Heat_shock_70_CS
IPR013126, Hsp_70_fam
IPR042048, HSPA13
PANTHERiPTHR19375, PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012, HSP70, 2 hits
SUPFAMiSSF53067, SSF53067, 2 hits
PROSITEiView protein in PROSITE
PS00297, HSP70_1, 1 hit
PS00329, HSP70_2, 1 hit
PS01036, HSP70_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHSP13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48723
Secondary accession number(s): B2R616, Q8NE40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 7, 2021
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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