UniProtKB - P48723 (HSP13_HUMAN)
Protein
Heat shock 70 kDa protein 13
Gene
HSPA13
Organism
Homo sapiens (Human)
Status
Functioni
Has peptide-independent ATPase activity.
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: GO_Central
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- protein folding chaperone Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- cellular response to unfolded protein Source: GO_Central
- chaperone cofactor-dependent protein refolding Source: GO_Central
- protein refolding Source: GO_Central
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P48723 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock 70 kDa protein 13Alternative name(s): Microsomal stress-70 protein ATPase core Stress-70 protein chaperone microsome-associated 60 kDa protein |
Gene namesi | Name:HSPA13 Synonyms:STCH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11375, HSPA13 |
MIMi | 601100, gene |
neXtProti | NX_P48723 |
VEuPathDBi | HostDB:ENSG00000155304.5 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrion Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: ProtInc
Keywords - Cellular componenti
Endoplasmic reticulum, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 6782 |
OpenTargetsi | ENSG00000155304 |
PharmGKBi | PA162391697 |
Miscellaneous databases
Pharosi | P48723, Tbio |
Chemistry databases
DrugBanki | DB09130, Copper |
Genetic variation databases
BioMutai | HSPA13 |
DMDMi | 1351125 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000013558 | 23 – 471 | Heat shock 70 kDa protein 13Add BLAST | 449 |
Proteomic databases
EPDi | P48723 |
jPOSTi | P48723 |
MassIVEi | P48723 |
MaxQBi | P48723 |
PaxDbi | P48723 |
PeptideAtlasi | P48723 |
PRIDEi | P48723 |
ProteomicsDBi | 55924 |
TopDownProteomicsi | P48723 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00299299 |
PTM databases
GlyConnecti | 1294, 5 N-Linked glycans (2 sites) |
GlyGeni | P48723, 2 sites |
iPTMneti | P48723 |
PhosphoSitePlusi | P48723 |
Expressioni
Tissue specificityi
Constitutively expressed in all tissues.
Gene expression databases
Bgeei | ENSG00000155304, Expressed in ventricular zone and 243 other tissues |
ExpressionAtlasi | P48723, baseline and differential |
Genevisiblei | P48723, HS |
Organism-specific databases
HPAi | ENSG00000155304, Low tissue specificity |
Interactioni
Subunit structurei
Binds UBQLN2.
Binary interactionsi
Hide detailsP48723
GO - Molecular functioni
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112659, 24 interactors |
IntActi | P48723, 18 interactors |
MINTi | P48723 |
STRINGi | 9606.ENSP00000285667 |
Miscellaneous databases
RNActi | P48723, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00890000139503 |
HOGENOMi | CLU_005965_0_3_1 |
InParanoidi | P48723 |
OMAi | LRKTNFN |
OrthoDBi | 288077at2759 |
PhylomeDBi | P48723 |
TreeFami | TF105047 |
Family and domain databases
CDDi | cd10237, HSPA13-like_NBD, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR013126, Hsp_70_fam IPR042048, HSPA13 |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 2 hits |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P48723-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAREMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP
60 70 80 90 100
GTGKVKVIPD ENGHISIPSM VSFTDNDVYV GYESVELADS NPQNTIYDAK
110 120 130 140 150
RFIGKIFTAE ELEAEIGRYP FKVLNKNGMV EFSVTSNETI TVSPEYVGSR
160 170 180 190 200
LLLKLKEMAE AYLGMPVANA VISVPAEFDL KQRNSTIEAA NLAGLKILRV
210 220 230 240 250
INEPTAAAMA YGLHKADVFH VLVIDLGGGT LDVSLLNKQG GMFLTRAMSG
260 270 280 290 300
NNKLGGQDFN QRLLQYLYKQ IYQTYGFVPS RKEEIHRLRQ AVEMVKLNLT
310 320 330 340 350
LHQSAQLSVL LTVEEQDRKE PHSSDTELPK DKLSSADDHR VNSGFGRGLS
360 370 380 390 400
DKKSGESQVL FETEISRKLF DTLNEDLFQK ILVPIQQVLK EGHLEKTEID
410 420 430 440 450
EVVLVGGSTR IPRIRQVIQE FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS
460 470
WPLQVSALEI PNKHLQKTNF N
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 450 | S → F in AAH36370 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04735 mRNA Translation: AAA16954.1 AF130249 Genomic DNA Translation: AAD21091.1 AK312396 mRNA Translation: BAG35313.1 AL163206 Genomic DNA Translation: CAB90390.1 CH471079 Genomic DNA Translation: EAX10056.1 BC036370 mRNA Translation: AAH36370.1 |
CCDSi | CCDS13567.1 |
PIRi | S42631 |
RefSeqi | NP_008879.3, NM_006948.4 |
Genome annotation databases
Ensembli | ENST00000285667; ENSP00000285667; ENSG00000155304 |
GeneIDi | 6782 |
KEGGi | hsa:6782 |
UCSCi | uc002yjt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U04735 mRNA Translation: AAA16954.1 AF130249 Genomic DNA Translation: AAD21091.1 AK312396 mRNA Translation: BAG35313.1 AL163206 Genomic DNA Translation: CAB90390.1 CH471079 Genomic DNA Translation: EAX10056.1 BC036370 mRNA Translation: AAH36370.1 |
CCDSi | CCDS13567.1 |
PIRi | S42631 |
RefSeqi | NP_008879.3, NM_006948.4 |
3D structure databases
SMRi | P48723 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112659, 24 interactors |
IntActi | P48723, 18 interactors |
MINTi | P48723 |
STRINGi | 9606.ENSP00000285667 |
Chemistry databases
DrugBanki | DB09130, Copper |
PTM databases
GlyConnecti | 1294, 5 N-Linked glycans (2 sites) |
GlyGeni | P48723, 2 sites |
iPTMneti | P48723 |
PhosphoSitePlusi | P48723 |
Genetic variation databases
BioMutai | HSPA13 |
DMDMi | 1351125 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00299299 |
Proteomic databases
EPDi | P48723 |
jPOSTi | P48723 |
MassIVEi | P48723 |
MaxQBi | P48723 |
PaxDbi | P48723 |
PeptideAtlasi | P48723 |
PRIDEi | P48723 |
ProteomicsDBi | 55924 |
TopDownProteomicsi | P48723 |
Protocols and materials databases
Antibodypediai | 2522, 189 antibodies |
DNASUi | 6782 |
Genome annotation databases
Ensembli | ENST00000285667; ENSP00000285667; ENSG00000155304 |
GeneIDi | 6782 |
KEGGi | hsa:6782 |
UCSCi | uc002yjt.4, human |
Organism-specific databases
CTDi | 6782 |
DisGeNETi | 6782 |
GeneCardsi | HSPA13 |
HGNCi | HGNC:11375, HSPA13 |
HPAi | ENSG00000155304, Low tissue specificity |
MIMi | 601100, gene |
neXtProti | NX_P48723 |
OpenTargetsi | ENSG00000155304 |
PharmGKBi | PA162391697 |
VEuPathDBi | HostDB:ENSG00000155304.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0101, Eukaryota |
GeneTreei | ENSGT00890000139503 |
HOGENOMi | CLU_005965_0_3_1 |
InParanoidi | P48723 |
OMAi | LRKTNFN |
OrthoDBi | 288077at2759 |
PhylomeDBi | P48723 |
TreeFami | TF105047 |
Enzyme and pathway databases
PathwayCommonsi | P48723 |
Reactomei | R-HSA-3371453, Regulation of HSF1-mediated heat shock response |
Miscellaneous databases
BioGRID-ORCSi | 6782, 110 hits in 997 CRISPR screens |
ChiTaRSi | HSPA13, human |
GeneWikii | STCH |
GenomeRNAii | 6782 |
Pharosi | P48723, Tbio |
PROi | PR:P48723 |
RNActi | P48723, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000155304, Expressed in ventricular zone and 243 other tissues |
ExpressionAtlasi | P48723, baseline and differential |
Genevisiblei | P48723, HS |
Family and domain databases
CDDi | cd10237, HSPA13-like_NBD, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018181, Heat_shock_70_CS IPR013126, Hsp_70_fam IPR042048, HSPA13 |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 2 hits |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HSP13_HUMAN | |
Accessioni | P48723Primary (citable) accession number: P48723 Secondary accession number(s): B2R616, Q8NE40 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families