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Protein

Heat shock 70 kDa protein 13

Gene

HSPA13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has peptide-independent ATPase activity.

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 13
Alternative name(s):
Microsomal stress-70 protein ATPase core
Stress-70 protein chaperone microsome-associated 60 kDa protein
Gene namesi
Name:HSPA13
Synonyms:STCH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000155304.5
HGNCiHGNC:11375 HSPA13
MIMi601100 gene
neXtProtiNX_P48723

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi6782
OpenTargetsiENSG00000155304
PharmGKBiPA162391697

Polymorphism and mutation databases

BioMutaiHSPA13
DMDMi1351125

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001355823 – 471Heat shock 70 kDa protein 13Add BLAST449

Proteomic databases

EPDiP48723
MaxQBiP48723
PaxDbiP48723
PeptideAtlasiP48723
PRIDEiP48723
ProteomicsDBi55924
TopDownProteomicsiP48723

2D gel databases

REPRODUCTION-2DPAGEiIPI00299299

PTM databases

iPTMnetiP48723
PhosphoSitePlusiP48723

Expressioni

Tissue specificityi

Constitutively expressed in all tissues.

Gene expression databases

BgeeiENSG00000155304 Expressed in 233 organ(s), highest expression level in caudate nucleus
CleanExiHS_HSPA13
ExpressionAtlasiP48723 baseline and differential
GenevisibleiP48723 HS

Organism-specific databases

HPAiHPA014797

Interactioni

Subunit structurei

Binds UBQLN2.

Binary interactionsi

Protein-protein interaction databases

BioGridi112659, 15 interactors
IntActiP48723, 12 interactors
MINTiP48723
STRINGi9606.ENSP00000285667

Structurei

3D structure databases

ProteinModelPortaliP48723
SMRiP48723
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00890000139503
HOGENOMiHOG000228135
HOVERGENiHBG098979
InParanoidiP48723
KOiK09491
OMAiTRAMSGN
OrthoDBiEOG091G06OD
PhylomeDBiP48723
TreeFamiTF105047

Family and domain databases

InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48723-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAREMTILGS AVLTLLLAGY LAQQYLPLPT PKVIGIDLGT TYCSVGVFFP
60 70 80 90 100
GTGKVKVIPD ENGHISIPSM VSFTDNDVYV GYESVELADS NPQNTIYDAK
110 120 130 140 150
RFIGKIFTAE ELEAEIGRYP FKVLNKNGMV EFSVTSNETI TVSPEYVGSR
160 170 180 190 200
LLLKLKEMAE AYLGMPVANA VISVPAEFDL KQRNSTIEAA NLAGLKILRV
210 220 230 240 250
INEPTAAAMA YGLHKADVFH VLVIDLGGGT LDVSLLNKQG GMFLTRAMSG
260 270 280 290 300
NNKLGGQDFN QRLLQYLYKQ IYQTYGFVPS RKEEIHRLRQ AVEMVKLNLT
310 320 330 340 350
LHQSAQLSVL LTVEEQDRKE PHSSDTELPK DKLSSADDHR VNSGFGRGLS
360 370 380 390 400
DKKSGESQVL FETEISRKLF DTLNEDLFQK ILVPIQQVLK EGHLEKTEID
410 420 430 440 450
EVVLVGGSTR IPRIRQVIQE FFGKDPNTSV DPDLAVVTGV AIQAGIDGGS
460 470
WPLQVSALEI PNKHLQKTNF N
Length:471
Mass (Da):51,927
Last modified:February 1, 1996 - v1
Checksum:iC78028E7CB0D03F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti450S → F in AAH36370 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04735 mRNA Translation: AAA16954.1
AF130249 Genomic DNA Translation: AAD21091.1
AK312396 mRNA Translation: BAG35313.1
AL163206 Genomic DNA Translation: CAB90390.1
CH471079 Genomic DNA Translation: EAX10056.1
BC036370 mRNA Translation: AAH36370.1
CCDSiCCDS13567.1
PIRiS42631
RefSeqiNP_008879.3, NM_006948.4
UniGeneiHs.352341

Genome annotation databases

EnsembliENST00000285667; ENSP00000285667; ENSG00000155304
GeneIDi6782
KEGGihsa:6782
UCSCiuc002yjt.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04735 mRNA Translation: AAA16954.1
AF130249 Genomic DNA Translation: AAD21091.1
AK312396 mRNA Translation: BAG35313.1
AL163206 Genomic DNA Translation: CAB90390.1
CH471079 Genomic DNA Translation: EAX10056.1
BC036370 mRNA Translation: AAH36370.1
CCDSiCCDS13567.1
PIRiS42631
RefSeqiNP_008879.3, NM_006948.4
UniGeneiHs.352341

3D structure databases

ProteinModelPortaliP48723
SMRiP48723
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112659, 15 interactors
IntActiP48723, 12 interactors
MINTiP48723
STRINGi9606.ENSP00000285667

PTM databases

iPTMnetiP48723
PhosphoSitePlusiP48723

Polymorphism and mutation databases

BioMutaiHSPA13
DMDMi1351125

2D gel databases

REPRODUCTION-2DPAGEiIPI00299299

Proteomic databases

EPDiP48723
MaxQBiP48723
PaxDbiP48723
PeptideAtlasiP48723
PRIDEiP48723
ProteomicsDBi55924
TopDownProteomicsiP48723

Protocols and materials databases

DNASUi6782
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285667; ENSP00000285667; ENSG00000155304
GeneIDi6782
KEGGihsa:6782
UCSCiuc002yjt.4 human

Organism-specific databases

CTDi6782
DisGeNETi6782
EuPathDBiHostDB:ENSG00000155304.5
GeneCardsiHSPA13
HGNCiHGNC:11375 HSPA13
HPAiHPA014797
MIMi601100 gene
neXtProtiNX_P48723
OpenTargetsiENSG00000155304
PharmGKBiPA162391697
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00890000139503
HOGENOMiHOG000228135
HOVERGENiHBG098979
InParanoidiP48723
KOiK09491
OMAiTRAMSGN
OrthoDBiEOG091G06OD
PhylomeDBiP48723
TreeFamiTF105047

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

ChiTaRSiHSPA13 human
GeneWikiiSTCH
GenomeRNAii6782
PROiPR:P48723
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155304 Expressed in 233 organ(s), highest expression level in caudate nucleus
CleanExiHS_HSPA13
ExpressionAtlasiP48723 baseline and differential
GenevisibleiP48723 HS

Family and domain databases

InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 2 hits
PRINTSiPR00301 HEATSHOCK70
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHSP13_HUMAN
AccessioniPrimary (citable) accession number: P48723
Secondary accession number(s): B2R616, Q8NE40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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