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Protein

Prelamin-A/C

Gene

Lmna

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone. Required for cardiac homeostasis (PubMed:26436652). Isoform C2 may have a role in determining the organization of nuclear and chromosomal structures during spermatogenesis.7 Publications
Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence (By similarity).By similarity

Miscellaneous

The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei266Heptad change of phase1
Sitei325StutterBy similarity1
Sitei330Heptad change of phase1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-352238 Breakdown of the nuclear lamina
R-MMU-4419969 Depolymerisation of the Nuclear Lamina

Names & Taxonomyi

Protein namesi
Recommended name:
Prelamin-A/C
Cleaved into the following chain:
Gene namesi
Name:Lmna
Synonyms:Lmn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:96794 Lmna

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant mice survive postnatally for 6-8 weeks and show skeletal and cardiac myopathy, sarcopenia, osteopenia, decreased bone formation, neuropathy, abnormal neuromuscular junctions, decreased skeletal muscle growth and decreased muscle satellite cell proliferation. They develop ventricular dilation and cardiac dysfunction. Within 2-3 weeks they show a reduction in their growth rate and by week 4 their growth ceases with their mean body weight being half of that of the wild-type or the heterozygous littermates. Simultaneous knockout of LMNA and LAP2 results in partial rescue of the phenotype, with a 30% increase in survival rate and a 25-50% increase in body weight. Double knockouts for MLIP and LMNA die sooner than single LMNA knockout. They develop much more severe ventricular dilation and cardiac dysfunction (PubMed:26436652).7 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi201K → L: Decreased sumoylation; aberrant localization with decreased nuclear rim staining and formation of intranuclear foci; associated with increased cell death. 1 Publication1
Mutagenesisi203E → G or K: Decreased sumoylation; aberrant localization with decreased nuclear rim staining and formation of intranuclear foci; associated with increased cell death. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003988371 – 662Prelamin-A/CAdd BLAST662
ChainiPRO_00000638111 – 647Lamin-A/CAdd BLAST647
PropeptideiPRO_0000398838648 – 662Removed in Lamin-A/C formAdd BLAST15
PropeptideiPRO_0000403443663 – 665Removed in Prelamin-A/C form and in Lamin-A/C form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei3PhosphothreonineBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei18PhosphoserineBy similarity1
Modified residuei19PhosphothreonineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei32N6-acetyllysine; alternateCombined sources1
Modified residuei32N6-succinyllysine; alternateCombined sources1
Cross-linki32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei51PhosphoserineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei71PhosphoserineBy similarity1
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei107PhosphoserineBy similarity1
Modified residuei108N6-acetyllysineBy similarity1
Modified residuei123N6-acetyllysineCombined sources1
Modified residuei135N6-acetyllysineCombined sources1
Modified residuei155N6-acetyllysineCombined sources1
Modified residuei171N6-acetyllysine; alternateCombined sources1
Modified residuei171N6-succinyllysine; alternateCombined sources1
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei201N6-acetyllysine; alternateCombined sources1
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei212PhosphoserineBy similarity1
Cross-linki219Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei260N6-acetyllysine; alternateCombined sources1
Cross-linki260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei270N6-acetyllysine; alternateCombined sources1
Cross-linki270Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei277PhosphoserineBy similarity1
Modified residuei301PhosphoserineCombined sources1
Modified residuei307PhosphoserineBy similarity1
Modified residuei311N6-acetyllysine; alternateCombined sources1
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki378Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei390PhosphoserineCombined sources1
Modified residuei392Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei395PhosphoserineBy similarity1
Modified residuei398PhosphoserineBy similarity1
Modified residuei403PhosphoserineBy similarity1
Modified residuei404PhosphoserineBy similarity1
Modified residuei407Phosphoserine1 Publication1
Modified residuei409Phosphoserine1 Publication1
Modified residuei414PhosphoserineBy similarity1
Cross-linki417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki420Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei429PhosphoserineBy similarity1
Modified residuei431PhosphoserineBy similarity1
Modified residuei450N6-acetyllysine; alternateCombined sources1
Cross-linki450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei457N6-acetyllysineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei463PhosphoserineBy similarity1
Cross-linki486Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei496PhosphothreonineBy similarity1
Modified residuei500PhosphoserineBy similarity1
Modified residuei505PhosphothreonineBy similarity1
Modified residuei510PhosphothreonineBy similarity1
Modified residuei533PhosphoserineBy similarity1
Modified residuei546PhosphoserineCombined sources1
Modified residuei548PhosphothreonineCombined sources1
Modified residuei570PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Cross-linki599Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki599Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei613PhosphoserineBy similarity1
Modified residuei614PhosphoserineBy similarity1
Modified residuei617PhosphoserineCombined sources1
Modified residuei620PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei662Cysteine methyl esterBy similarity1
Lipidationi662S-farnesyl cysteineBy similarity1
Isoform C (identifier: P48678-2)
Modified residuei392PhosphoserineCombined sources1 Publication1
Modified residuei407PhosphoserineCombined sources1 Publication1
Modified residuei409PhosphoserineCombined sources1 Publication1
Modified residuei572PhosphoserineCombined sources1 Publication1
Isoform C2 (identifier: P48678-3)
Modified residuei460PhosphoserineCombined sources1

Post-translational modificationi

Proteolytic cleavage of the C-terminal of 18 residues of prelamin-A/C results in the production of lamin-A/C. The prelamin-A/C maturation pathway includes farnesylation of CAAX motif, ZMPSTE24/FACE1 mediated cleavage of the last three amino acids, methylation of the C-terminal cysteine and endoproteolytic removal of the last 15 C-terminal amino acids. Proteolytic cleavage requires prior farnesylation and methylation, and absence of these blocks cleavage (By similarity).By similarity
Sumoylation is necessary for the localization to the nuclear envelope.By similarity
Farnesylation of prelamin-A/C facilitates nuclear envelope targeting.By similarity
Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
Isoform C is phosphorylated on Ser-392, Ser-407 and Ser-409 at interphase.1 Publication
The N-terminus is blocked.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei647 – 648Cleavage; by endoproteaseBy similarity2

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Methylation, Phosphoprotein, Prenylation, Ubl conjugation

Proteomic databases

EPDiP48678
MaxQBiP48678
PaxDbiP48678
PeptideAtlasiP48678
PRIDEiP48678
TopDownProteomicsiP48678-2 [P48678-2]

2D gel databases

REPRODUCTION-2DPAGEiIPI00400300
IPI00620256

PTM databases

iPTMnetiP48678
PhosphoSitePlusiP48678
SwissPalmiP48678

Expressioni

Tissue specificityi

Expressed in liver and in bone marrow (at protein level). Isoform C2 is specifically expressed in germ cells. Expressed in cardiomyocytes (PubMed:26436652).3 Publications

Gene expression databases

BgeeiENSMUSG00000028063 Expressed in 291 organ(s), highest expression level in ascending aorta
CleanExiMM_LMNA
ExpressionAtlasiP48678 baseline and differential
GenevisibleiP48678 MM

Interactioni

Subunit structurei

Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1 and with emerin. Proteolytically processed isoform A interacts with NARF (By similarity). Interacts with SREBF1, SREBF2, SUN1, SUN2 and TMEM43. Interacts with TMEM201. Prelamin-A/C interacts with EMD. Interacts with DMPK; may regulate nuclear envelope stability (By similarity). Interacts with MLIP (PubMed:26436652, PubMed:21498514). Interacts with SUV39H1; the interaction increases stability of SUV39H1.By similarity10 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201176, 69 interactors
DIPiDIP-31384N
IntActiP48678, 25 interactors
MINTiP48678
STRINGi10090.ENSMUSP00000029699

Structurei

Secondary structure

1665
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP48678
SMRiP48678
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48678

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 387IF rodPROSITE-ProRule annotationAdd BLAST357
Domaini428 – 545LTDPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 130Interaction with MLIPBy similarityAdd BLAST130
Regioni1 – 33HeadAdd BLAST33
Regioni34 – 70Coil 1AAdd BLAST37
Regioni71 – 80Linker 110
Regioni81 – 218Coil 1BAdd BLAST138
Regioni219 – 242Linker 2Add BLAST24
Regioni243 – 383Coil 2Add BLAST141
Regioni384 – 665TailAdd BLAST282

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi417 – 422Nuclear localization signalSequence analysis6

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0977 Eukaryota
ENOG410Y2H6 LUCA
GeneTreeiENSGT00910000143989
HOGENOMiHOG000007711
HOVERGENiHBG013015
InParanoidiP48678
KOiK12641
OMAiSHVSRHR
OrthoDBiEOG091G063B
PhylomeDBiP48678
TreeFamiTF101181

Family and domain databases

Gene3Di2.60.40.1260, 1 hit
InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR001322 Lamin_tail_dom
IPR036415 Lamin_tail_dom_sf
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF00932 LTD, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
SUPFAMiSSF74853 SSF74853, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
PS51841 LTD, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoform A and isoform C are present in equal amounts in the lamina of mammals.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A (identifier: P48678-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR
60 70 80 90 100
SLETENAGLR LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA
110 120 130 140 150
RLQLELSKVR EEFKELKARN TKKEGDLLAA QARLKDLEAL LNSKEAALST
160 170 180 190 200
ALSEKRTLEG ELHDLRGQVA KLEAALGEAK KQLQDEMLRR VDAENRLQTL
210 220 230 240 250
KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR LADALQELRA
260 270 280 290 300
QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID
310 320 330 340 350
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA
360 370 380 390 400
RMQQQLDEYQ ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG
410 420 430 440 450
RASSHSSQSQ GGGSVTKKRK LESSESRSSF SQHARTSGRV AVEEVDEEGK
460 470 480 490 500
FVRLRNKSNE DQSMGNWQIR RQNGDDPLMT YRFPPKFTLK AGQVVTIWAS
510 520 530 540 550
GAGATHSPPT DLVWKAQNTW GCGSSLRTAL INSTGEEVAM RKLVRSLTMV
560 570 580 590 600
EDNEDDDEDG EELLHHHRGS HCSGSGDPAE YNLRSRTVLC GTCGQPADKA
610 620 630 640 650
AGGAGAQVGG SISSGSSASS VTVTRSFRSV GGSGGGSFGD NLVTRSYLLG
660
NSSPRSQSSQ NCSIM
Length:665
Mass (Da):74,238
Last modified:January 24, 2006 - v2
Checksum:i5434F574803FCB15
GO
Isoform C (identifier: P48678-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-574: GSHCSG → VSGSRR
     575-665: Missing.

Show »
Length:574
Mass (Da):65,446
Checksum:iA736DF1CCEDB65BE
GO
Isoform C2 (identifier: P48678-3) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     113-118: FKELKA → MGNAEG
     569-574: GSHCSG → VSGSRR
     575-665: Missing.

Show »
Length:462
Mass (Da):52,652
Checksum:i4A12573CECAA93AA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUF7D3YUF7_MOUSE
Prelamin-A/C
Lmna
117Annotation score:

Sequence cautioni

The sequence BAE31539 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4P → S in BAE31384 (PubMed:16141072).Curated1
Sequence conflicti4P → S in BAE29519 (PubMed:16141072).Curated1
Sequence conflicti118 – 119AR → VC in CAA32372 (PubMed:2719959).Curated2
Sequence conflicti118A → D in BAE39876 (PubMed:16141072).Curated1
Sequence conflicti340E → G in BAE29614 (PubMed:16141072).Curated1
Sequence conflicti401R → P in CAA32372 (PubMed:2719959).Curated1
Sequence conflicti439 – 440RV → WL in CAA32372 (PubMed:2719959).Curated2
Sequence conflicti450K → E in BAE31384 (PubMed:16141072).Curated1
Sequence conflicti453R → L in BAE36246 (PubMed:16141072).Curated1
Sequence conflicti612I → V in BAB23415 (PubMed:16141072).Curated1
Sequence conflicti617S → Y in BAB23415 (PubMed:16141072).Curated1
Sequence conflicti623V → A in BAA02476 (PubMed:7916626).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0024711 – 112Missing in isoform C2. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_002472113 – 118FKELKA → MGNAEG in isoform C2. 1 Publication6
Alternative sequenceiVSP_017064569 – 574GSHCSG → VSGSRR in isoform C and isoform C2. 4 Publications6
Alternative sequenceiVSP_017065575 – 665Missing in isoform C and isoform C2. 4 PublicationsAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49733 Genomic DNA Translation: BAA08569.1
D49733 Genomic DNA Translation: BAA08570.1
D49733 Genomic DNA Translation: BAA08571.1
X14170 mRNA Translation: CAA32372.1
D14850 mRNA Translation: BAA03578.1
DQ832702 mRNA Translation: ABI16251.1
DQ832703 mRNA Translation: ABI16252.1
AK004619 mRNA Translation: BAB23415.1
AK147150 mRNA Translation: BAE27717.1
AK149998 mRNA Translation: BAE29226.1
AK150391 mRNA Translation: BAE29519.1
AK150501 mRNA Translation: BAE29614.1
AK150624 mRNA Translation: BAE29714.1
AK152539 mRNA Translation: BAE31294.1
AK152646 mRNA Translation: BAE31384.1
AK152846 mRNA Translation: BAE31539.1 Different initiation.
AK161221 mRNA Translation: BAE36246.1
AK167858 mRNA Translation: BAE39876.1
CH466547 Genomic DNA Translation: EDL15275.1
BC015302 mRNA Translation: AAH15302.1
BC094020 mRNA Translation: AAH94020.1
D13181 mRNA Translation: BAA02476.1
CCDSiCCDS38482.1 [P48678-1]
CCDS38483.1 [P48678-3]
CCDS50951.1 [P48678-2]
PIRiI53414
S04333
S18324
S28182
RefSeqiNP_001002011.2, NM_001002011.3 [P48678-1]
NP_001104572.1, NM_001111102.2 [P48678-2]
NP_062263.1, NM_019390.3 [P48678-3]
XP_006501136.1, XM_006501073.1 [P48678-1]
UniGeneiMm.243014
Mm.471227

Genome annotation databases

EnsembliENSMUST00000029699; ENSMUSP00000029699; ENSMUSG00000028063 [P48678-1]
ENSMUST00000036252; ENSMUSP00000040265; ENSMUSG00000028063 [P48678-3]
ENSMUST00000120377; ENSMUSP00000113093; ENSMUSG00000028063 [P48678-2]
GeneIDi16905
KEGGimmu:16905
UCSCiuc008pvj.3 mouse [P48678-1]
uc008pvk.3 mouse [P48678-3]
uc008pvl.3 mouse [P48678-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49733 Genomic DNA Translation: BAA08569.1
D49733 Genomic DNA Translation: BAA08570.1
D49733 Genomic DNA Translation: BAA08571.1
X14170 mRNA Translation: CAA32372.1
D14850 mRNA Translation: BAA03578.1
DQ832702 mRNA Translation: ABI16251.1
DQ832703 mRNA Translation: ABI16252.1
AK004619 mRNA Translation: BAB23415.1
AK147150 mRNA Translation: BAE27717.1
AK149998 mRNA Translation: BAE29226.1
AK150391 mRNA Translation: BAE29519.1
AK150501 mRNA Translation: BAE29614.1
AK150624 mRNA Translation: BAE29714.1
AK152539 mRNA Translation: BAE31294.1
AK152646 mRNA Translation: BAE31384.1
AK152846 mRNA Translation: BAE31539.1 Different initiation.
AK161221 mRNA Translation: BAE36246.1
AK167858 mRNA Translation: BAE39876.1
CH466547 Genomic DNA Translation: EDL15275.1
BC015302 mRNA Translation: AAH15302.1
BC094020 mRNA Translation: AAH94020.1
D13181 mRNA Translation: BAA02476.1
CCDSiCCDS38482.1 [P48678-1]
CCDS38483.1 [P48678-3]
CCDS50951.1 [P48678-2]
PIRiI53414
S04333
S18324
S28182
RefSeqiNP_001002011.2, NM_001002011.3 [P48678-1]
NP_001104572.1, NM_001111102.2 [P48678-2]
NP_062263.1, NM_019390.3 [P48678-3]
XP_006501136.1, XM_006501073.1 [P48678-1]
UniGeneiMm.243014
Mm.471227

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFGNMR-A408-545[»]
ProteinModelPortaliP48678
SMRiP48678
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201176, 69 interactors
DIPiDIP-31384N
IntActiP48678, 25 interactors
MINTiP48678
STRINGi10090.ENSMUSP00000029699

PTM databases

iPTMnetiP48678
PhosphoSitePlusiP48678
SwissPalmiP48678

2D gel databases

REPRODUCTION-2DPAGEiIPI00400300
IPI00620256

Proteomic databases

EPDiP48678
MaxQBiP48678
PaxDbiP48678
PeptideAtlasiP48678
PRIDEiP48678
TopDownProteomicsiP48678-2 [P48678-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029699; ENSMUSP00000029699; ENSMUSG00000028063 [P48678-1]
ENSMUST00000036252; ENSMUSP00000040265; ENSMUSG00000028063 [P48678-3]
ENSMUST00000120377; ENSMUSP00000113093; ENSMUSG00000028063 [P48678-2]
GeneIDi16905
KEGGimmu:16905
UCSCiuc008pvj.3 mouse [P48678-1]
uc008pvk.3 mouse [P48678-3]
uc008pvl.3 mouse [P48678-2]

Organism-specific databases

CTDi4000
MGIiMGI:96794 Lmna

Phylogenomic databases

eggNOGiKOG0977 Eukaryota
ENOG410Y2H6 LUCA
GeneTreeiENSGT00910000143989
HOGENOMiHOG000007711
HOVERGENiHBG013015
InParanoidiP48678
KOiK12641
OMAiSHVSRHR
OrthoDBiEOG091G063B
PhylomeDBiP48678
TreeFamiTF101181

Enzyme and pathway databases

ReactomeiR-MMU-352238 Breakdown of the nuclear lamina
R-MMU-4419969 Depolymerisation of the Nuclear Lamina

Miscellaneous databases

ChiTaRSiLmna mouse
EvolutionaryTraceiP48678
PROiPR:P48678
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028063 Expressed in 291 organ(s), highest expression level in ascending aorta
CleanExiMM_LMNA
ExpressionAtlasiP48678 baseline and differential
GenevisibleiP48678 MM

Family and domain databases

Gene3Di2.60.40.1260, 1 hit
InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR001322 Lamin_tail_dom
IPR036415 Lamin_tail_dom_sf
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF00932 LTD, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
SUPFAMiSSF74853 SSF74853, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
PS51841 LTD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLMNA_MOUSE
AccessioniPrimary (citable) accession number: P48678
Secondary accession number(s): B3RH23
, B3RH24, P11516, P97859, Q3TIH0, Q3TTS8, Q3U733, Q3U7I5, Q3UCA0, Q3UCJ8, Q3UCU3, Q91WF2, Q9DC21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 24, 2006
Last modified: September 12, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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