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Entry version 175 (02 Jun 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Excitatory amino acid transporter 4

Gene

SLC1A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878).

Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion. Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (By similarity).

Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable).

By similarityCurated1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi419Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi421Sodium 2; via carbonyl oxygenBy similarity1
Metal bindingi423Sodium 1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei427AspartateBy similarity1
Binding sitei501AspartateBy similarity1
Metal bindingi508Sodium 1; via carbonyl oxygenBy similarity1
Binding sitei508AspartateBy similarity1
Metal bindingi512Sodium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Symport, Transport
LigandChloride, Metal-binding, Potassium, Sodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P48664

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-425393, Transport of inorganic cations/anions and amino acids/oligopeptides

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.23.2.8, the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Excitatory amino acid transporter 4
Alternative name(s):
Sodium-dependent glutamate/aspartate transporter
Solute carrier family 1 member 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC1A6
Synonyms:EAAT4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10944, SLC1A6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600637, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48664

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000105143.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 55CytoplasmicSequence analysisAdd BLAST55
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Transmembranei262 – 285Helical; Name=4By similarityAdd BLAST24
Transmembranei295 – 322Helical; Name=5By similarityAdd BLAST28
Transmembranei344 – 365Helical; Name=6By similarityAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei371 – 401Discontinuously helicalBy similarityAdd BLAST31
Transmembranei411 – 437Helical; Name=7By similarityAdd BLAST27
Intramembranei451 – 484Discontinuously helicalBy similarityAdd BLAST34
Transmembranei498 – 519Helical; Name=8By similarityAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6511

Open Targets

More...
OpenTargetsi
ENSG00000105143

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35831

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P48664, Tchem

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00142, Glutamic acid

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
871

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC1A6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1352333

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002020701 – 564Excitatory amino acid transporter 4Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P48664

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P48664

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48664

PeptideAtlas

More...
PeptideAtlasi
P48664

PRoteomics IDEntifications database

More...
PRIDEi
P48664

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55921 [P48664-1]
72264

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P48664, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48664

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48664

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain. Expressed densely and selectively in cell bodies of Purkinje cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105143, Expressed in cerebellum and 98 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P48664, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P48664, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105143, Group enriched (brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.

Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
112402, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P48664, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000221742

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P48664, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni388 – 390Aspartate bindingBy similarity3
Regioni468 – 472Aspartate bindingBy similarity5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3787, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019375_3_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48664

Identification of Orthologs from Complete Genome Data

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OMAi
AQIYGIP

Database of Orthologous Groups

More...
OrthoDBi
1184392at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48664

TreeFam database of animal gene trees

More...
TreeFami
TF315206

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3860.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001991, Na-dicarboxylate_symporter
IPR018107, Na-dicarboxylate_symporter_CS
IPR036458, Na:dicarbo_symporter_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00375, SDF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118215, SSF118215, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00713, NA_DICARBOXYL_SYMP_1, 1 hit
PS00714, NA_DICARBOXYL_SYMP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P48664-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSHGNSLFL RESGQRLGRV GWLQRLQESL QQRALRTRLR LQTMTLEHVL
60 70 80 90 100
RFLRRNAFIL LTVSAVVIGV SLAFALRPYQ LTYRQIKYFS FPGELLMRML
110 120 130 140 150
QMLVLPLIVS SLVTGMASLD NKATGRMGMR AAVYYMVTTI IAVFIGILMV
160 170 180 190 200
TIIHPGKGSK EGLHREGRIE TIPTADAFMD LIRNMFPPNL VEACFKQFKT
210 220 230 240 250
QYSTRVVTRT MVRTENGSEP GASMPPPFSV ENGTSFLENV TRALGTLQEM
260 270 280 290 300
LSFEETVPVP GSANGINALG LVVFSVAFGL VIGGMKHKGR VLRDFFDSLN
310 320 330 340 350
EAIMRLVGII IWYAPVGILF LIAGKILEME DMAVLGGQLG MYTLTVIVGL
360 370 380 390 400
FLHAGIVLPL IYFLVTHRNP FPFIGGMLQA LITAMGTSSS SATLPITFRC
410 420 430 440 450
LEEGLGVDRR ITRFVLPVGA TVNMDGTALY EALAAIFIAQ VNNYELNLGQ
460 470 480 490 500
ITTISITATA ASVGAAGIPQ AGLVTMVIVL TSVGLPTEDI TLIIAVDWFL
510 520 530 540 550
DRLRTMTNVL GDSIGAAVIE HLSQRELELQ EAELTLPSLG KPYKSLMAQE
560
KGASRGRGGN ESAM
Length:564
Mass (Da):61,565
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB6700D6EAEC2B20
GO
Isoform 2 (identifier: P48664-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-564: Missing.

Show »
Length:312
Mass (Da):34,846
Checksum:i0C06E0DEC9A864C6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EV13E7EV13_HUMAN
Amino acid transporter
SLC1A6
500Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R063M0R063_HUMAN
Amino acid transporter
SLC1A6
486Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R106M0R106_HUMAN
Amino acid transporter
SLC1A6
160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY32M0QY32_HUMAN
Excitatory amino acid transporter 4
SLC1A6
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2V7M0R2V7_HUMAN
Excitatory amino acid transporter 4
SLC1A6
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0B5M0R0B5_HUMAN
Excitatory amino acid transporter 4
SLC1A6
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1V3M0R1V3_HUMAN
Excitatory amino acid transporter 4
SLC1A6
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055130313 – 564Missing in isoform 2. 1 PublicationAdd BLAST252

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U18244 mRNA Translation: AAA75314.1
AC004659 Genomic DNA Translation: AAC15754.1
AC104528 Genomic DNA No translation available.
BC028721 mRNA Translation: AAH28721.1
BC040604 mRNA Translation: AAH40604.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12321.1 [P48664-1]
CCDS62578.1 [P48664-2]

Protein sequence database of the Protein Information Resource

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PIRi
S58398

NCBI Reference Sequences

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RefSeqi
NP_001259016.1, NM_001272087.1 [P48664-2]
NP_001259017.1, NM_001272088.1 [P48664-2]
NP_005062.1, NM_005071.2 [P48664-1]
XP_006722905.1, XM_006722842.1
XP_006722907.1, XM_006722844.1
XP_016882641.1, XM_017027152.1 [P48664-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000221742; ENSP00000221742; ENSG00000105143 [P48664-1]
ENST00000544886; ENSP00000446175; ENSG00000105143 [P48664-2]
ENST00000598504; ENSP00000471781; ENSG00000105143 [P48664-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6511

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6511

UCSC genome browser

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UCSCi
uc002naa.3, human [P48664-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18244 mRNA Translation: AAA75314.1
AC004659 Genomic DNA Translation: AAC15754.1
AC104528 Genomic DNA No translation available.
BC028721 mRNA Translation: AAH28721.1
BC040604 mRNA Translation: AAH40604.1
CCDSiCCDS12321.1 [P48664-1]
CCDS62578.1 [P48664-2]
PIRiS58398
RefSeqiNP_001259016.1, NM_001272087.1 [P48664-2]
NP_001259017.1, NM_001272088.1 [P48664-2]
NP_005062.1, NM_005071.2 [P48664-1]
XP_006722905.1, XM_006722842.1
XP_006722907.1, XM_006722844.1
XP_016882641.1, XM_017027152.1 [P48664-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi112402, 1 interactor
IntActiP48664, 1 interactor
STRINGi9606.ENSP00000221742

Chemistry databases

DrugBankiDB00142, Glutamic acid
GuidetoPHARMACOLOGYi871

Protein family/group databases

TCDBi2.A.23.2.8, the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

PTM databases

GlyGeniP48664, 3 sites
iPTMnetiP48664
PhosphoSitePlusiP48664

Genetic variation databases

BioMutaiSLC1A6
DMDMi1352333

Proteomic databases

MassIVEiP48664
MaxQBiP48664
PaxDbiP48664
PeptideAtlasiP48664
PRIDEiP48664
ProteomicsDBi55921 [P48664-1]
72264

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
26923, 180 antibodies

The DNASU plasmid repository

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DNASUi
6511

Genome annotation databases

EnsembliENST00000221742; ENSP00000221742; ENSG00000105143 [P48664-1]
ENST00000544886; ENSP00000446175; ENSG00000105143 [P48664-2]
ENST00000598504; ENSP00000471781; ENSG00000105143 [P48664-2]
GeneIDi6511
KEGGihsa:6511
UCSCiuc002naa.3, human [P48664-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6511
DisGeNETi6511

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC1A6
HGNCiHGNC:10944, SLC1A6
HPAiENSG00000105143, Group enriched (brain, testis)
MIMi600637, gene
neXtProtiNX_P48664
OpenTargetsiENSG00000105143
PharmGKBiPA35831
VEuPathDBiHostDB:ENSG00000105143.12

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3787, Eukaryota
GeneTreeiENSGT00940000159972
HOGENOMiCLU_019375_3_2_1
InParanoidiP48664
OMAiAQIYGIP
OrthoDBi1184392at2759
PhylomeDBiP48664
TreeFamiTF315206

Enzyme and pathway databases

PathwayCommonsiP48664
ReactomeiR-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-425393, Transport of inorganic cations/anions and amino acids/oligopeptides

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6511, 8 hits in 987 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC1A6, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Excitatory_amino-acid_transporter_4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6511
PharosiP48664, Tchem

Protein Ontology

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PROi
PR:P48664
RNActiP48664, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105143, Expressed in cerebellum and 98 other tissues
ExpressionAtlasiP48664, baseline and differential
GenevisibleiP48664, HS

Family and domain databases

Gene3Di1.10.3860.10, 2 hits
InterProiView protein in InterPro
IPR001991, Na-dicarboxylate_symporter
IPR018107, Na-dicarboxylate_symporter_CS
IPR036458, Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375, SDF, 1 hit
SUPFAMiSSF118215, SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713, NA_DICARBOXYL_SYMP_1, 1 hit
PS00714, NA_DICARBOXYL_SYMP_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEAA4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48664
Secondary accession number(s): Q8N753
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 2, 2021
This is version 175 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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