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Entry version 169 (18 Sep 2019)
Sequence version 3 (18 May 2010)
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Protein

Protein PRRC2A

Gene

PRRC2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the regulation of pre-mRNA splicing.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Large proline-rich protein BAT2
Proline-rich and coiled-coil-containing protein 2A
Protein G2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRRC2A
Synonyms:BAT2, G2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:13918 PRRC2A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
142580 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48634

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7916

Open Targets

More...
OpenTargetsi
ENSG00000204469

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25263

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRRC2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439424

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000648291 – 2157Protein PRRC2AAdd BLAST2157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei27N6-acetyllysineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei35N6-acetyllysineBy similarity1
Modified residuei146PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei272Asymmetric dimethylarginineCombined sources1
Modified residuei296Omega-N-methylarginineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei363PhosphoserineCombined sources1
Modified residuei380PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei610PhosphothreonineCombined sources1
Modified residuei759PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1
Modified residuei764PhosphoserineCombined sources1
Modified residuei807PhosphothreonineBy similarity1
Modified residuei808PhosphoserineCombined sources1
Modified residuei904Omega-N-methylarginineBy similarity1
Modified residuei908PhosphoserineCombined sources1
Modified residuei932PhosphoserineCombined sources1
Modified residuei997PhosphothreonineBy similarity1
Modified residuei1004PhosphoserineCombined sources1
Modified residuei1066Omega-N-methylarginineBy similarity1
Modified residuei1083PhosphothreonineCombined sources1
Modified residuei1085PhosphoserineCombined sources1
Modified residuei1089PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1
Modified residuei1094PhosphotyrosineCombined sources1
Modified residuei1106PhosphoserineCombined sources1
Modified residuei1110PhosphoserineCombined sources1
Modified residuei1120PhosphoserineCombined sources1
Modified residuei1147PhosphoserineCombined sources1
Modified residuei1196N6-acetyllysineCombined sources1
Modified residuei1219PhosphoserineCombined sources1
Modified residuei1306PhosphoserineCombined sources1
Modified residuei1310PhosphoserineBy similarity1
Modified residuei1323PhosphothreonineBy similarity1
Modified residuei1325PhosphoserineBy similarity1
Modified residuei1328PhosphoserineCombined sources1
Modified residuei1347PhosphothreonineCombined sources1
Modified residuei1353PhosphothreonineCombined sources1
Modified residuei1384PhosphoserineCombined sources1
Modified residuei1386PhosphoserineCombined sources1
Modified residuei1525PhosphoserineCombined sources1
Modified residuei1778PhosphoserineCombined sources1
Modified residuei2036PhosphoserineCombined sources1
Modified residuei2076PhosphothreonineCombined sources1
Modified residuei2082PhosphoserineCombined sources1
Modified residuei2113PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P48634

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P48634

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P48634

MaxQB - The MaxQuant DataBase

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MaxQBi
P48634

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48634

PeptideAtlas

More...
PeptideAtlasi
P48634

PRoteomics IDEntifications database

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PRIDEi
P48634

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55913 [P48634-1]
55914 [P48634-2]
55915 [P48634-3]
55916 [P48634-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48634

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48634

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P48634

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Limited to cell-lines of leukemic origin.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Broadly expressed during the 11th week of gestation, with highest levels in the central nervous system, spinal ganglia, osteoblasts and osteocytes (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204469 Expressed in 226 organ(s), highest expression level in left testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P48634 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P48634 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026383
HPA046791
HPA066501

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113646, 86 interactors

Protein interaction database and analysis system

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IntActi
P48634, 62 interactors

Molecular INTeraction database

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MINTi
P48634

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365201

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P48634

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 951-1Add BLAST55
Repeati98 – 1541-2Add BLAST57
Repeati281 – 3371-3Add BLAST57
Repeati337 – 4302-1Add BLAST94
Repeati488 – 5612-2Add BLAST74
Repeati1757 – 18121-4Add BLAST56
Repeati1916 – 19653-1Add BLAST50
Repeati1982 – 20313-2Add BLAST50
Repeati2057 – 21063-3Add BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 18124 X 57 AA type A repeatsAdd BLAST1772
Regioni337 – 5612 X type B repeatsAdd BLAST225
Regioni1916 – 21063 X 50 AA type C repeatsAdd BLAST191

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi466 – 471Poly-Arg6
Compositional biasi472 – 475Poly-Glu4
Compositional biasi658 – 669Poly-GlnAdd BLAST12
Compositional biasi696 – 700Poly-Pro5
Compositional biasi826 – 833Poly-Pro8
Compositional biasi913 – 916Poly-Pro4
Compositional biasi955 – 958Poly-Pro4
Compositional biasi1139 – 1142Poly-Pro4
Compositional biasi1239 – 1244Poly-Arg6
Compositional biasi1355 – 1360Poly-Gly6
Compositional biasi1413 – 1421Poly-Gly9
Compositional biasi1451 – 1457Poly-Pro7

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4817 Eukaryota
ENOG410XQRI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183161

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48634

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPICPGW

Database of Orthologous Groups

More...
OrthoDBi
17901at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48634

TreeFam database of animal gene trees

More...
TreeFami
TF328738

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009738 BAT2_N
IPR033184 PRRC2

The PANTHER Classification System

More...
PANTHERi
PTHR14038 PTHR14038, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07001 BAT2_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P48634-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV
60 70 80 90 100
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA
110 120 130 140 150
STAQPPESQP LPASQTPASN QPKRPPAAPE NTPLVPSGVK SWAQASVTHG
160 170 180 190 200
AHGDGGRASS LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR
210 220 230 240 250
PQNSTTWRDG GGRGPDELEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM
260 270 280 290 300
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP
310 320 330 340 350
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS
360 370 380 390 400
DEEGAEGHRD SQSASGEERP PEADGKKGNS PNSEPPTPKT AWAETSRPPE
410 420 430 440 450
TEPGPPAPKP PLPPPHRGPA GNWGPPGDYP DRGGPPCKPP APEDEDEAWR
460 470 480 490 500
QRRKQSSSEI SLAVERARRR REEEERRMQE ERRAACAEKL KRLDEKFGAP
510 520 530 540 550
DKRLKAEPAA PPAAPSTPAP PPAVPKELPA PPAPPPASAP TPETEPEEPA
560 570 580 590 600
QAPPAQSTPT PGVAAAPTLV SGGGSTSSTS SGSFEASPVE PQLPSKEGPE
610 620 630 640 650
PPEEVPPPTT PPVPKVEPKG DGIGPTRQPP SQGLGYPKYQ KSLPPRFQRQ
660 670 680 690 700
QQEQLLKQQQ QHQWQQHQQG SAPPTPVPPS PPQPVTLGAV PAPQAPPPPP
710 720 730 740 750
KALYPGALGR PPPMPPMNFD PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP
760 770 780 790 800
SGLVPRERSD SGGSSSEPFD RHAPAMLRER GTPPVDPKLA WVGDVFTATP
810 820 830 840 850
AEPRPLTSPL RQAADEDDKG MRSETPPVPP PPPYLASYPG FPENGAPGPP
860 870 880 890 900
ISRFPLEEPG PRPLPWPPGS DEVAKIQTPP PKKEPPKEET AQLTGPEAGR
910 920 930 940 950
KPARGVGSGG QGPPPPRRES RTETRWGPRP GSSRRGIPPE EPGAPPRRAG
960 970 980 990 1000
PIKKPPPPTK VEELPPKPLE QGDETPKPPK PDPLKITKGK LGGPKETPPN
1010 1020 1030 1040 1050
GNLSPAPRLR RDYSYERVGP TSCRGRGRGE YFARGRGFRG TYGGRGRGAR
1060 1070 1080 1090 1100
SREFRSYREF RGDDGRGGGT GGPNHPPAPR GRTASETRSE GSEYEEIPKR
1110 1120 1130 1140 1150
RRQRGSETGS ETHESDLAPS DKEAPTPKEG TLTQVPLAPP PPGAPPSPAP
1160 1170 1180 1190 1200
ARFTARGGRV FTPRGVPSRR GRGGGRPPPQ VCPGWSPPAK SLAPKKPPTG
1210 1220 1230 1240 1250
PLPPSKEPLK EKLIPGPLSP VARGGSNGGS NVGMEDGERP RRRRHGRAQQ
1260 1270 1280 1290 1300
QDKPPRFRRL KQERENAARG SEGKPSLTLP ASAPGPEEAL TTVTVAPAPR
1310 1320 1330 1340 1350
RAAAKSPDLS NQNSDQANEE WETASESSDF TSERRGDKEA PPPVLLTPKA
1360 1370 1380 1390 1400
VGTPGGGGGG AVPGISAMSR GDLSQRAKDL SKRSFSSQRP GMERQNRRPG
1410 1420 1430 1440 1450
PGGKAGSSGS SSGGGGGGPG GRTGPGRGDK RSWPSPKNRS RPPEERPPGL
1460 1470 1480 1490 1500
PLPPPPPSSS AVFRLDQVIH SNPAGIQQAL AQLSSRQGSV TAPGGHPRHK
1510 1520 1530 1540 1550
PGLPQAPQGP SPRPPTRYEP QRVNSGLSSD PHFEEPGPMV RGVGGTPRDS
1560 1570 1580 1590 1600
AGVSPFPPKR RERPPRKPEL LQEESLPPPH SSGFLGSKPE GPGPQAESRD
1610 1620 1630 1640 1650
TGTEALTPHI WNRLHTATSR KSYRPSSMEP WMEPLSPFED VAGTEMSQSD
1660 1670 1680 1690 1700
SGVDLSGDSQ VSSGPCSQRS SPDGGLKGAA EGPPKRPGGS SPLNAVPCEG
1710 1720 1730 1740 1750
PPGSEPPRRP PPAPHDGDRK ELPREQPLPP GPIGTERSQR TDRGTEPGPI
1760 1770 1780 1790 1800
RPSHRPGPPV QFGTSDKDSD LRLVVGDSLK AEKELTASVT EAIPVSRDWE
1810 1820 1830 1840 1850
LLPSAAASAE PQSKNLDSGH CVPEPSSSGQ RLYPEVFYGS AGPSSSQISG
1860 1870 1880 1890 1900
GAMDSQLHPN SGGFRPGTPS LHPYRSQPLY LPPGPAPPSA LLSGLALKGQ
1910 1920 1930 1940 1950
FLDFSTMQAT ELGKLPAGGV LYPPPSFLYS PAFCPSPLPD TSLLQVRQDL
1960 1970 1980 1990 2000
PSPSDFYSTP LQPGGQSGFL PSGAPAQQML LPMVDSQLPV VNFGSLPPAP
2010 2020 2030 2040 2050
PPAPPPLSLL PVGPALQPPS LAVRPPPAPA TRVLPSPARP FPASLGRAEL
2060 2070 2080 2090 2100
HPVELKPFQD YQKLSSNLGG PGSSRTPPTG RSFSGLNSRL KATPSTYSGV
2110 2120 2130 2140 2150
FRTQRVDLYQ QASPPDALRW IPKPWERTGP PPREGPSRRA EEPGSRGDKE

PGLPPPR
Length:2,157
Mass (Da):228,863
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7353342E72F0D393
GO
Isoform 2 (identifier: P48634-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-424: Missing.
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

Show »
Length:2,144
Mass (Da):227,840
Checksum:i9DF7B60612E16D90
GO
Isoform 3 (identifier: P48634-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1050-1148: RSREFRSYRE...PPPPGAPPSP → QANSAVTESF...PTTRSPTLHR
     1155-1177: ARGGRVFTPRGVPSRRGRGGGRP → CPGVGESSLPEGAISPGPRRREA
     1852-1864: AMDSQLHPNSGGF → SHGLSITSKQWRL

Show »
Length:2,156
Mass (Da):229,064
Checksum:i13C2A71F42213DDC
GO
Isoform 4 (identifier: P48634-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     834-1457: Missing.

Note: No experimental confirmation available.
Show »
Length:1,533
Mass (Da):163,047
Checksum:i0F496D1F2EB629E7
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35585 differs from that shown. Reason: Frameshift at positions 38 and 58.Curated
The sequence AAA35586 differs from that shown. Reason: Frameshift at positions 38 and 58.Curated
The sequence BAE06116 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA78744 differs from that shown. Reason: Frameshift at positions 38 and 58.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57P → A in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti107 – 123ESQPL…SNQPK → NRTTAGFTDACLQPAE in CAA78744 (PubMed:8499947).CuratedAdd BLAST17
Sequence conflicti762G → L in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti762G → L in AAA35586 (PubMed:2156268).Curated1
Sequence conflicti762G → R in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti764S → L in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti764S → L in AAA35586 (PubMed:2156268).Curated1
Sequence conflicti764S → L in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti846A → T in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti902 – 911PARGVGSGGQ → LPASRSGA in AAA35585 (PubMed:2156268).Curated10
Sequence conflicti902 – 911PARGVGSGGQ → LPASRSGA in AAA35586 (PubMed:2156268).Curated10
Sequence conflicti902 – 911PARGVGSGGQ → LPASRSGA in CAA78744 (PubMed:8499947).Curated10
Sequence conflicti934R → G in AAH42295 (PubMed:15489334).Curated1
Sequence conflicti1049A → G in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti1049A → G in AAA35586 (PubMed:2156268).Curated1
Sequence conflicti1300R → P in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti1300R → P in AAA35586 (PubMed:2156268).Curated1
Sequence conflicti1461Missing in CAA78744 (PubMed:8499947).Curated1
Sequence conflicti1626S → T in AAA35585 (PubMed:2156268).Curated1
Sequence conflicti1626S → T in AAA35586 (PubMed:2156268).Curated1
Isoform 3 (identifier: P48634-3)
Sequence conflicti1082M → L in CAA78744 (PubMed:8499947).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02321557P → R1 PublicationCorresponds to variant dbSNP:rs1062968Ensembl.1
Natural variantiVAR_04599282D → V. Corresponds to variant dbSNP:rs6921213Ensembl.1
Natural variantiVAR_023216106P → L2 PublicationsCorresponds to variant dbSNP:rs2280801Ensembl.1
Natural variantiVAR_045993477R → C1 PublicationCorresponds to variant dbSNP:rs17857493Ensembl.1
Natural variantiVAR_023217544T → K7 PublicationsCorresponds to variant dbSNP:rs1046080Ensembl.1
Natural variantiVAR_023218694Q → K1 PublicationCorresponds to variant dbSNP:rs2844469Ensembl.1
Natural variantiVAR_023219742D → E1 PublicationCorresponds to variant dbSNP:rs1046081Ensembl.1
Natural variantiVAR_045994804R → C. Corresponds to variant dbSNP:rs11538262Ensembl.1
Natural variantiVAR_0357961087T → I in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs771808977Ensembl.1
Natural variantiVAR_0357971152R → H in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs151148973Ensembl.1
Natural variantiVAR_0232201285G → A1 PublicationCorresponds to variant dbSNP:rs2736158Ensembl.1
Natural variantiVAR_0459951407S → N. Corresponds to variant dbSNP:rs35464047Ensembl.1
Natural variantiVAR_0232211415G → A1 PublicationCorresponds to variant dbSNP:rs2857703Ensembl.1
Natural variantiVAR_0232221503L → P9 PublicationsCorresponds to variant dbSNP:rs2272593Ensembl.1
Natural variantiVAR_0459961544G → D. Corresponds to variant dbSNP:rs34175432Ensembl.1
Natural variantiVAR_0459971563R → Q. Corresponds to variant dbSNP:rs11538263Ensembl.1
Natural variantiVAR_0232231740R → H3 PublicationsCorresponds to variant dbSNP:rs1046089Ensembl.1
Natural variantiVAR_0232241744G → A1 PublicationCorresponds to variant dbSNP:rs2844491Ensembl.1
Natural variantiVAR_0459981774V → M. Corresponds to variant dbSNP:rs11538264Ensembl.1
Natural variantiVAR_0232251775V → M. Corresponds to variant dbSNP:rs11538264Ensembl.1
Natural variantiVAR_0232261895L → V8 PublicationsCorresponds to variant dbSNP:rs3132453Ensembl.1
Natural variantiVAR_0232272006P → S1 PublicationCorresponds to variant dbSNP:rs10885Ensembl.1
Natural variantiVAR_0567422075R → W. Corresponds to variant dbSNP:rs34137317Ensembl.1
Natural variantiVAR_0232282130P → L1 PublicationCorresponds to variant dbSNP:rs1046756Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015099413 – 424Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_030865834 – 1457Missing in isoform 4. 1 PublicationAdd BLAST624
Alternative sequenceiVSP_0151001050 – 1148RSREF…APPSP → QANSAVTESFEEMMGVEVGQ GDQTTLLLPEAAMPARHGAR VQSMRKSPSGAGSGAQKQAA RPMRVIWLLQTRRLPHPRRE HSPRSSRSPTTRSPTLHR in isoform 2 and isoform 3. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_0151011155 – 1177ARGGR…GGGRP → CPGVGESSLPEGAISPGPRR REA in isoform 2 and isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0151021852 – 1864AMDSQ…NSGGF → SHGLSITSKQWRL in isoform 2 and isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M33509 mRNA Translation: AAA35585.1 Frameshift.
M33518, M33512 Genomic DNA Translation: AAA35586.1 Frameshift.
AB210034 mRNA Translation: BAE06116.1 Different initiation.
AF129756 Genomic DNA Translation: AAD18086.1
CR354443 Genomic DNA No translation available.
BA000025 Genomic DNA Translation: BAB63391.1
AL662801 Genomic DNA No translation available.
AL662847 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR753892 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03452.1
BC030127 mRNA Translation: AAH30127.1
BC032134 mRNA Translation: AAH32134.1
BC042295 mRNA Translation: AAH42295.1
BC060668 mRNA Translation: AAH60668.1
Z15025 Genomic DNA Translation: CAA78744.1 Frameshift.
CR749245 mRNA Translation: CAH18101.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4708.1 [P48634-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
B35098
S37671

NCBI Reference Sequences

More...
RefSeqi
NP_004629.3, NM_004638.3 [P48634-1]
NP_542417.2, NM_080686.2 [P48634-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376007; ENSP00000365175; ENSG00000204469 [P48634-1]
ENST00000376033; ENSP00000365201; ENSG00000204469 [P48634-1]
ENST00000383455; ENSP00000372947; ENSG00000206427
ENST00000383464; ENSP00000372956; ENSG00000206427
ENST00000414956; ENSP00000404619; ENSG00000226618
ENST00000416335; ENSP00000415182; ENSG00000231370
ENST00000422962; ENSP00000415363; ENSG00000231825
ENST00000428775; ENSP00000387910; ENSG00000225164
ENST00000430737; ENSP00000413977; ENSG00000231825
ENST00000432252; ENSP00000408226; ENSG00000225748
ENST00000435971; ENSP00000409444; ENSG00000225164
ENST00000439762; ENSP00000400540; ENSG00000231370
ENST00000454306; ENSP00000387477; ENSG00000225748
ENST00000458561; ENSP00000396812; ENSG00000226618

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7916

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7916

UCSC genome browser

More...
UCSCi
uc003nvb.5 human [P48634-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33509 mRNA Translation: AAA35585.1 Frameshift.
M33518, M33512 Genomic DNA Translation: AAA35586.1 Frameshift.
AB210034 mRNA Translation: BAE06116.1 Different initiation.
AF129756 Genomic DNA Translation: AAD18086.1
CR354443 Genomic DNA No translation available.
BA000025 Genomic DNA Translation: BAB63391.1
AL662801 Genomic DNA No translation available.
AL662847 Genomic DNA No translation available.
AL805934 Genomic DNA No translation available.
BX511262 Genomic DNA No translation available.
CR753892 Genomic DNA No translation available.
CR759761 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03452.1
BC030127 mRNA Translation: AAH30127.1
BC032134 mRNA Translation: AAH32134.1
BC042295 mRNA Translation: AAH42295.1
BC060668 mRNA Translation: AAH60668.1
Z15025 Genomic DNA Translation: CAA78744.1 Frameshift.
CR749245 mRNA Translation: CAH18101.1
CCDSiCCDS4708.1 [P48634-1]
PIRiB35098
S37671
RefSeqiNP_004629.3, NM_004638.3 [P48634-1]
NP_542417.2, NM_080686.2 [P48634-1]

3D structure databases

SMRiP48634
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113646, 86 interactors
IntActiP48634, 62 interactors
MINTiP48634
STRINGi9606.ENSP00000365201

PTM databases

iPTMnetiP48634
PhosphoSitePlusiP48634
SwissPalmiP48634

Polymorphism and mutation databases

BioMutaiPRRC2A
DMDMi296439424

Proteomic databases

EPDiP48634
jPOSTiP48634
MassIVEiP48634
MaxQBiP48634
PaxDbiP48634
PeptideAtlasiP48634
PRIDEiP48634
ProteomicsDBi55913 [P48634-1]
55914 [P48634-2]
55915 [P48634-3]
55916 [P48634-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376007; ENSP00000365175; ENSG00000204469 [P48634-1]
ENST00000376033; ENSP00000365201; ENSG00000204469 [P48634-1]
ENST00000383455; ENSP00000372947; ENSG00000206427
ENST00000383464; ENSP00000372956; ENSG00000206427
ENST00000414956; ENSP00000404619; ENSG00000226618
ENST00000416335; ENSP00000415182; ENSG00000231370
ENST00000422962; ENSP00000415363; ENSG00000231825
ENST00000428775; ENSP00000387910; ENSG00000225164
ENST00000430737; ENSP00000413977; ENSG00000231825
ENST00000432252; ENSP00000408226; ENSG00000225748
ENST00000435971; ENSP00000409444; ENSG00000225164
ENST00000439762; ENSP00000400540; ENSG00000231370
ENST00000454306; ENSP00000387477; ENSG00000225748
ENST00000458561; ENSP00000396812; ENSG00000226618
GeneIDi7916
KEGGihsa:7916
UCSCiuc003nvb.5 human [P48634-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7916
DisGeNETi7916

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRRC2A
HGNCiHGNC:13918 PRRC2A
HPAiCAB026383
HPA046791
HPA066501
MIMi142580 gene
neXtProtiNX_P48634
OpenTargetsiENSG00000204469
PharmGKBiPA25263

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4817 Eukaryota
ENOG410XQRI LUCA
GeneTreeiENSGT00950000183161
InParanoidiP48634
OMAiPPICPGW
OrthoDBi17901at2759
PhylomeDBiP48634
TreeFamiTF328738

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PRRC2A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BAT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7916

Pharos

More...
Pharosi
P48634

Protein Ontology

More...
PROi
PR:P48634

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204469 Expressed in 226 organ(s), highest expression level in left testis
ExpressionAtlasiP48634 baseline and differential
GenevisibleiP48634 HS

Family and domain databases

InterProiView protein in InterPro
IPR009738 BAT2_N
IPR033184 PRRC2
PANTHERiPTHR14038 PTHR14038, 1 hit
PfamiView protein in Pfam
PF07001 BAT2_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRC2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48634
Secondary accession number(s): B0UX77
, B0UZE9, B0UZL3, O95875, Q05BK4, Q4LE37, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q8MGQ9, Q96QC6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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