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Protein

Omega-3 fatty acid desaturase, endoplasmic reticulum

Gene

FAD3

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ER (microsomal) omega-3 fatty acid desaturase introduces the third double bond in the biosynthesis of 18:3 fatty acids, important constituents of plant membranes. It is thought to use cytochrome b5 as an electron donor and to act on fatty acids esterified to phosphatidylcholine and, possibly, other phospholipids.

Pathwayi: polyunsaturated fatty acid biosynthesis

This protein is involved in the pathway polyunsaturated fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway polyunsaturated fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayi
UPA00658

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-3 fatty acid desaturase, endoplasmic reticulum (EC:1.14.19.-)
Gene namesi
Name:FAD3
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
Proteomesi
  • UP000084051 Componenti: Genome assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854151 – 379Omega-3 fatty acid desaturase, endoplasmic reticulumAdd BLAST379

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 101Histidine box-15
Motifi133 – 137Histidine box-25
Motifi300 – 304Histidine box-35

Domaini

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK10257

Family and domain databases

InterProiView protein in InterPro
IPR005804 FA_desaturase_dom
IPR021863 FAS_N
PfamiView protein in Pfam
PF11960 DUF3474, 1 hit
PF00487 FA_desaturase, 1 hit

Sequencei

Sequence statusi: Complete.

P48626-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLGISEIY DKNSFNEMEF EFDPSAPPPF RLAEIRNVIP KHCWVKDPLR
60 70 80 90 100
SLSYVVRDVI FVATLIGIAI HLDSWLFYPL YWAIQGTMFW AIFVLGHDCG
110 120 130 140 150
HGSFSDSQLL NNVVGHILHS AILVPYHGWR ISHKTHHQNH GNVETDESWV
160 170 180 190 200
PMPEKLYNKV GYSTKFLRYK IPFPLLAYPM YLMKRSPGKS GSHFNPYSDL
210 220 230 240 250
FQPHERKYVV TSTLCWTVMA ALLLYLCTAF GSLQMFKIYG APYLIFVMWL
260 270 280 290 300
DFVTYLHHHG YEKKLPWYRG KEWSYLRGGL TTVDRDYGLF NNIHHDIGTH
310 320 330 340 350
VIHHLFPQIP HYHLREATKA AKPVLGKYYR EPKKSGPIPF HLVKDLTRSM
360 370
KQDHYVSDSG EIVFYQTDPH IFRSAPKDE
Length:379
Mass (Da):44,149
Last modified:February 1, 1996 - v1
Checksum:i87221A21AB02E1B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26509 mRNA Translation: BAA05515.1
PIRiJC2555
RefSeqiNP_001311727.1, NM_001324798.1
UniGeneiNta.22314

Genome annotation databases

GeneIDi107763446
KEGGinta:107763446

Similar proteinsi

Entry informationi

Entry nameiFAD3E_TOBAC
AccessioniPrimary (citable) accession number: P48626
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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