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Protein

Protein Wnt-10b

Gene

Wnt10b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.1 Publication

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: MGI

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • bone trabecula formation Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cell-cell signaling Source: MGI
  • cell cycle arrest Source: MGI
  • cell fate commitment Source: GO_Central
  • cellular response to cAMP Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • cellular response to organic substance Source: MGI
  • cellular response to parathyroid hormone stimulus Source: MGI
  • chondrocyte differentiation Source: Ensembl
  • fungiform papilla development Source: MGI
  • G2/M transition of mitotic cell cycle Source: MGI
  • hematopoietic stem cell proliferation Source: MGI
  • lipid metabolic process Source: MGI
  • myoblast differentiation involved in skeletal muscle regeneration Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of fat cell differentiation Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neuron differentiation Source: GO_Central
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of DNA binding transcription factor activity Source: MGI
  • positive regulation of epithelial cell differentiation Source: MGI
  • positive regulation of G2/M transition of mitotic cell cycle Source: MGI
  • positive regulation of ossification Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: MGI
  • positive regulation of timing of anagen Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • protein stabilization Source: MGI
  • regulation of fat cell differentiation Source: MGI
  • regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
  • regulation of protein metabolic process Source: MGI
  • regulation of skeletal muscle tissue development Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • sensory perception of taste Source: MGI
  • signal transduction Source: MGI
  • skeletal muscle fiber development Source: MGI
  • skeletal muscle tissue regeneration Source: MGI
  • smoothened signaling pathway Source: MGI
  • Wnt signaling pathway Source: MGI

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-3238698 WNT ligand biogenesis and trafficking

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-10b
Alternative name(s):
Protein Wnt-12
Gene namesi
Name:Wnt10b
Synonyms:Wnt-10b, Wnt10, Wnt12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:108061 Wnt10b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000004146429 – 389Protein Wnt-10bAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphothreonineBy similarity1
Disulfide bondi83 ↔ 94By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 144By similarity
Disulfide bondi146 ↔ 199By similarity
Disulfide bondi247 ↔ 261By similarity
Disulfide bondi249 ↔ 256By similarity
Lipidationi253O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi334 ↔ 349By similarity
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi364 ↔ 379By similarity
Disulfide bondi366 ↔ 376By similarity
Disulfide bondi371 ↔ 372By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Phosphoprotein

Proteomic databases

PaxDbiP48614
PRIDEiP48614

PTM databases

iPTMnetiP48614
PhosphoSitePlusiP48614

Expressioni

Tissue specificityi

Expressed in embryos and in the mammary gland of non-pregnant mice.

Gene expression databases

BgeeiENSMUSG00000022996
CleanExiMM_WNT10B
ExpressionAtlasiP48614 baseline and differential
GenevisibleiP48614 MM

Interactioni

Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids.By similarity

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023732

Structurei

3D structure databases

ProteinModelPortaliP48614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00690000101857
HOGENOMiHOG000039528
HOVERGENiHBG001595
InParanoidiP48614
KOiK01357
OMAiQIVTDNM
OrthoDBiEOG091G0OFF
PhylomeDBiP48614
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013302 Wnt10
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01893 WNT10PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P48614-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEEPRSRPP PLGLAGLLFL ALFSRALSNE ILGLKLPGEP PLTANTVCLT
60 70 80 90 100
LSGLSKRQLG LCLRSPDVTA SALQGLHIAV HECQHQLRDQ RWNCSALEGG
110 120 130 140 150
GRLPHHSAIL KRGFRESAFS FSMLAAGVMH AVATACSLGK LVSCGCGWKG
160 170 180 190 200
SGEQDRLRAK LLQLQALSRG KTFPISQPSP VPGSVPSPGP QDTWEWGGCN
210 220 230 240 250
HDMDFGEKFS RDFLDSREAP RDIQARMRIH NNRVGRQVVT ENLKRKCKCH
260 270 280 290 300
GTSGSCQFKT CWRAAPEFRA IGAALRERLS RAIFIDTHNR NSGAFQPRLR
310 320 330 340 350
PRRLSGELVY FEKSPDFCER DPTLGSPGTR GRACNKTSRL LDGCGSLCCG
360 370 380
RGHNVLRQTR VERCHCRFHW CCYVLCDECK VTEWVNVCK
Length:389
Mass (Da):43,119
Last modified:February 1, 1996 - v1
Checksum:iF990AB33B7C84633
GO
Isoform Short (identifier: P48614-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-238: Missing.

Show »
Length:293
Mass (Da):32,400
Checksum:iE2BB87BC40C40240
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006796143 – 238Missing in isoform Short. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20658 mRNA Translation: AAA80110.1
U30464 mRNA Translation: AAA84399.1
U61970 mRNA Translation: AAB08086.1
U61971 mRNA Translation: AAB08087.1
CCDSiCCDS27806.1 [P48614-1]
PIRiA59393 A59392
I49263
RefSeqiNP_035848.1, NM_011718.2 [P48614-1]
XP_006520954.1, XM_006520891.3 [P48614-1]
XP_006520955.1, XM_006520892.3 [P48614-2]
UniGeneiMm.4709

Genome annotation databases

EnsembliENSMUST00000023732; ENSMUSP00000023732; ENSMUSG00000022996 [P48614-1]
ENSMUST00000166022; ENSMUSP00000131056; ENSMUSG00000022996 [P48614-1]
ENSMUST00000226610; ENSMUSP00000153817; ENSMUSG00000022996 [P48614-1]
ENSMUST00000226846; ENSMUSP00000154513; ENSMUSG00000022996 [P48614-2]
ENSMUST00000228594; ENSMUSP00000153930; ENSMUSG00000022996 [P48614-1]
GeneIDi22410
KEGGimmu:22410
UCSCiuc007xns.2 mouse [P48614-2]
uc007xnt.2 mouse [P48614-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiWN10B_MOUSE
AccessioniPrimary (citable) accession number: P48614
Secondary accession number(s): P70702
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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