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Protein

Arginine kinase

Gene

Argk

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei185ATPPROSITE-ProRule annotation1
Binding sitei225SubstrateBy similarity1
Binding sitei229ATPPROSITE-ProRule annotation1
Binding sitei271SubstrateBy similarity1
Binding sitei314SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi122 – 126ATPPROSITE-ProRule annotation5
Nucleotide bindingi280 – 284ATPPROSITE-ProRule annotation5
Nucleotide bindingi309 – 314ATPPROSITE-ProRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-71288 Creatine metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine kinase (EC:2.7.3.3)
Short name:
AK
Gene namesi
Name:Argk
ORF Names:CG32031
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000116 Argk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002119921 – 356Arginine kinaseAdd BLAST356

Proteomic databases

PaxDbiP48610
PRIDEiP48610

Expressioni

Gene expression databases

BgeeiFBgn0000116
ExpressionAtlasiP48610 baseline and differential
GenevisibleiP48610 DM

Interactioni

Protein-protein interaction databases

BioGridi64445, 60 interactors
IntActiP48610, 20 interactors
STRINGi7227.FBpp0076270

Structurei

3D structure databases

ProteinModelPortaliP48610
SMRiP48610
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 91Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST86
Domaini119 – 356Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 68Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3581 Eukaryota
COG3869 LUCA
GeneTreeiENSGT00550000074561
InParanoidiP48610
KOiK00934
OrthoDBiEOG091G0HZ0
PhylomeDBiP48610

Family and domain databases

Gene3Di1.10.135.10, 1 hit
InterProiView protein in InterPro
IPR000749 ATP-guanido_PTrfase
IPR022415 ATP-guanido_PTrfase_AS
IPR022414 ATP-guanido_PTrfase_cat
IPR022413 ATP-guanido_PTrfase_N
IPR036802 ATP-guanido_PTrfase_N_sf
IPR014746 Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11547 PTHR11547, 1 hit
PfamiView protein in Pfam
PF00217 ATP-gua_Ptrans, 1 hit
PF02807 ATP-gua_PtransN, 1 hit
SUPFAMiSSF48034 SSF48034, 1 hit
SSF55931 SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00112 PHOSPHAGEN_KINASE, 1 hit
PS51510 PHOSPHAGEN_KINASE_C, 1 hit
PS51509 PHOSPHAGEN_KINASE_N, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform D (identifier: P48610-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVDAAVLAKL EEGYAKLAAS DSKSLLKKYL TKEVFDNLKN KVTPTFKSTL
60 70 80 90 100
LDVIQSGLEN HDSGVGIYAP DAEAYTVFAD LFDPIIEDYH GGFKKTDKHP
110 120 130 140 150
ASNFGDVSTF GNVDPTNEYV ISTRVRCGRS MQGYPFNPCL TEAQYKEMES
160 170 180 190 200
KVSSTLSGLE GELKGKFYPL TGMEKAVQQQ LIDDHFLFKE GDRFLQAANA
210 220 230 240 250
CRFWPSGRGI YHNDAKTFLV WCNEEDHLRI ISMQQGGDLG QIYKRLVTAV
260 270 280 290 300
NEIEKRVPFS HDDRLGFLTF CPTNLGTTIR ASVHIKVPKL ASNKAKLEEV
310 320 330 340 350
AAKYNLQVRG TRGEHTEAEG GVYDISNKRR MGLTEFEAVK EMYDGITELI

KLEKSL
Length:356
Mass (Da):39,866
Last modified:May 24, 2005 - v2
Checksum:i9AD0E80D2CE4F446
GO
Isoform A (identifier: P48610-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MFALWYLTFA...QLGERKQDTM

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):61,264
Checksum:iD05E15973650E0B7
GO
Isoform B (identifier: P48610-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPIPLPKSLT...QLGERKQDTM

Note: No experimental confirmation available.
Show »
Length:432
Mass (Da):47,889
Checksum:iD3CC748B41704E59
GO
Isoform C (identifier: P48610-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGLCASKDKKEKVIEGEVANGEPNGTATAAGAGGDGKQDTM

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):43,754
Checksum:iAD60FC4C81C1E9C4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 90Missing in AAA68173 (Ref. 1) CuratedAdd BLAST90
Sequence conflicti42 – 51VTPTFKSTLL → GHAHLQVDPA in AAA68172 (Ref. 1) Curated10
Sequence conflicti64 – 66GVG → ASA in AAA68172 (Ref. 1) Curated3
Sequence conflicti85I → F in AAA68172 (Ref. 1) Curated1
Sequence conflicti280R → L in AAA68172 (Ref. 1) Curated1
Sequence conflicti291A → P in AAA68172 (Ref. 1) Curated1
Sequence conflicti309 – 313RGTRG → ANPR in AAA68172 (Ref. 1) Curated5
Sequence conflicti322V → S in AAA68172 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0138071M → MFALWYLTFAVDEIRKRLAW LFSSNKPAAPALDNKPANPA PAKESAPAPAPAPTPKPAVV PPAPKPDPPKPAPAVAKPTP VPVPATAPAPPKEEPAPKPK PEPVPSPVVAPPKPTPPPAK PSSPPKQADKMPIPLPKSLT EANTNGQNGNAANGGNVDEL VFGGQQAEKVLPAAKEASND FIKGETNAFIQSIKEAQQLG ERKQDTM in isoform A. 1 Publication1
Alternative sequenceiVSP_0138081M → MPIPLPKSLTEANTNGQNGN AANGGNVDELVFGGQQAEKV LPAAKEASNDFIKGETNAFI QSIKEAQQLGERKQDTM in isoform B. Curated1
Alternative sequenceiVSP_0138091M → MGLCASKDKKEKVIEGEVAN GEPNGTATAAGAGGDGKQDT M in isoform C. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26939 Genomic DNA Translation: AAA68172.1
U26940 mRNA Translation: AAA68173.1
AE014296 Genomic DNA Translation: AAF50325.2
AE014296 Genomic DNA Translation: AAF50326.2
AE014296 Genomic DNA Translation: AAN11982.1
AE014296 Genomic DNA Translation: AAN11983.1
AY069099 mRNA Translation: AAL39244.1
RefSeqiNP_001097556.2, NM_001104086.2 [P48610-1]
NP_001286989.1, NM_001300060.1 [P48610-1]
NP_523988.2, NM_079264.3 [P48610-1]
NP_729446.1, NM_168311.3 [P48610-2]
NP_729447.1, NM_168312.3 [P48610-3]
NP_729448.1, NM_168313.4 [P48610-4]
UniGeneiDm.902

Genome annotation databases

EnsemblMetazoaiFBtr0076543; FBpp0076270; FBgn0000116 [P48610-2]
FBtr0076544; FBpp0076271; FBgn0000116 [P48610-3]
FBtr0076545; FBpp0076272; FBgn0000116 [P48610-1]
FBtr0076546; FBpp0076273; FBgn0000116 [P48610-4]
FBtr0331550; FBpp0303940; FBgn0000116 [P48610-1]
FBtr0345030; FBpp0311280; FBgn0000116 [P48610-1]
GeneIDi39041
KEGGidme:Dmel_CG32031

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKARG_DROME
AccessioniPrimary (citable) accession number: P48610
Secondary accession number(s): Q8IQB9
, Q8IQC0, Q8T0S2, Q9VST5, Q9VST6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 24, 2005
Last modified: July 18, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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