UniProtKB - P48605 (TCPG_DROME)
Protein
T-complex protein 1 subunit gamma
Gene
CCT3
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.
GO - Molecular functioni
- ATPase activity Source: FlyBase
- ATP binding Source: UniProtKB-KW
- unfolded protein binding Source: GO_Central
GO - Biological processi
- lumen formation, open tracheal system Source: FlyBase
- protein folding Source: FlyBase
- terminal branching, open tracheal system Source: FlyBase
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DME-390471, Association of TriC/CCT with target proteins during biosynthesis R-DME-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Names & Taxonomyi
Protein namesi | Recommended name: T-complex protein 1 subunit gammaShort name: TCP-1-gamma Alternative name(s): CCT-gamma1 Publication Chaperonin containing TCP1 subunit 3Imported |
Gene namesi | ORF Names:CG8977Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0015019, CCT3 |
Subcellular locationi
Cytoplasm and Cytosol
Cytosol
- chaperonin-containing T-complex Source: FlyBase
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000128327 | 1 – 544 | T-complex protein 1 subunit gammaAdd BLAST | 544 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 368 ↔ 374 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P48605 |
PRIDEi | P48605 |
Expressioni
Gene expression databases
Bgeei | FBgn0015019, Expressed in egg cell and 63 other tissues |
ExpressionAtlasi | P48605, baseline and differential |
Genevisiblei | P48605, DM |
Interactioni
Subunit structurei
Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
GO - Molecular functioni
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 67074, 93 interactors |
DIPi | DIP-20434N |
IntActi | P48605, 16 interactors |
MINTi | P48605 |
STRINGi | 7227.FBpp0082787 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TCP-1 chaperonin family.Curated
Phylogenomic databases
eggNOGi | KOG0364, Eukaryota |
GeneTreei | ENSGT00570000079224 |
HOGENOMi | CLU_008891_7_3_1 |
InParanoidi | P48605 |
OMAi | HFLLKAG |
OrthoDBi | 391677at2759 |
PhylomeDBi | P48605 |
Family and domain databases
CDDi | cd03337, TCP1_gamma, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012719, Chap_CCT_gamma IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02344, chap_CCT_gamma, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P48605-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFGGQQPILV LSQNTKRESG RKVQLENIQA GKAIADVIRT CLGPQAMLKM
60 70 80 90 100
LMDPMGGIVM TNDGNAILRE ITVQHPAAKS MIEIARTQDE EVGDGTTSVI
110 120 130 140 150
VLAGEMLAAA EPFLQQQIHP TVIIRAYREA LEDIVGHLQS QLSIQLDVKD
160 170 180 190 200
KAKMADVVKA CVGTKFIGKW SDLAVKIALD AVETVTLSEN GRLEVDIKRY
210 220 230 240 250
AKVEKIPGGA IEESCVLKGV MINKDVTHPK MRRLIENPRI VLLDCSLEYK
260 270 280 290 300
KGESQTNVEI IGEQDFTRML QIEEEFVQRI CADIIAVKPD LVFTEKGVSD
310 320 330 340 350
LAQHYLLKAG ITAIRRLRKT DNLRIARACG ATIVNRTEEL TEKDVGTGAG
360 370 380 390 400
LFEVKKIGDE YFTFVTECKE PKACTILLRG ASKDILNETE RNLQDALHVA
410 420 430 440 450
RNLVLEPRLV AGGGAVEMAA SQLLTRKQVK GPYTAVAHAL EIIPRTLAQN
460 470 480 490 500
CGANTIRALT ALRAKHASHT GDGVCAWGID GESGEIVDMN VKNIWEPLAV
510 520 530 540
KLQTYKTAVE TAILLLRIDD IVSGSKKRGG NEPTNPAAMA QGQE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA4V303 | A4V303_DROME | T-complex protein 1 subunit gamma | CCT3 Cct-gamma, cct-gamma, Cct3, Cctg, cctg | 544 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | S → SD in CAA64860 (PubMed:8666276).Curated | 1 | |
Sequence conflicti | 35 – 47 | Missing in AAA84416 (PubMed:7667301).CuratedAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31961 Genomic DNA Translation: AAA84416.1 X95602 Genomic DNA Translation: CAA64860.1 AE014297 Genomic DNA Translation: AAF55350.1 AY089543 mRNA Translation: AAL90281.1 |
RefSeqi | NP_001189236.1, NM_001202307.2 NP_001189237.1, NM_001202308.2 NP_650572.2, NM_142315.4 NP_732167.1, NM_169727.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0083337; FBpp0082787; FBgn0015019 FBtr0083338; FBpp0082788; FBgn0015019 FBtr0302370; FBpp0291565; FBgn0015019 FBtr0302371; FBpp0291566; FBgn0015019 |
GeneIDi | 42029 |
KEGGi | dme:Dmel_CG8977 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31961 Genomic DNA Translation: AAA84416.1 X95602 Genomic DNA Translation: CAA64860.1 AE014297 Genomic DNA Translation: AAF55350.1 AY089543 mRNA Translation: AAL90281.1 |
RefSeqi | NP_001189236.1, NM_001202307.2 NP_001189237.1, NM_001202308.2 NP_650572.2, NM_142315.4 NP_732167.1, NM_169727.2 |
3D structure databases
SMRi | P48605 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 67074, 93 interactors |
DIPi | DIP-20434N |
IntActi | P48605, 16 interactors |
MINTi | P48605 |
STRINGi | 7227.FBpp0082787 |
Proteomic databases
PaxDbi | P48605 |
PRIDEi | P48605 |
Genome annotation databases
EnsemblMetazoai | FBtr0083337; FBpp0082787; FBgn0015019 FBtr0083338; FBpp0082788; FBgn0015019 FBtr0302370; FBpp0291565; FBgn0015019 FBtr0302371; FBpp0291566; FBgn0015019 |
GeneIDi | 42029 |
KEGGi | dme:Dmel_CG8977 |
Organism-specific databases
CTDi | 7203 |
FlyBasei | FBgn0015019, CCT3 |
Phylogenomic databases
eggNOGi | KOG0364, Eukaryota |
GeneTreei | ENSGT00570000079224 |
HOGENOMi | CLU_008891_7_3_1 |
InParanoidi | P48605 |
OMAi | HFLLKAG |
OrthoDBi | 391677at2759 |
PhylomeDBi | P48605 |
Enzyme and pathway databases
Reactomei | R-DME-390471, Association of TriC/CCT with target proteins during biosynthesis R-DME-6814122, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
Miscellaneous databases
BioGRID-ORCSi | 42029, 1 hit in 1 CRISPR screen |
GenomeRNAii | 42029 |
PROi | PR:P48605 |
Gene expression databases
Bgeei | FBgn0015019, Expressed in egg cell and 63 other tissues |
ExpressionAtlasi | P48605, baseline and differential |
Genevisiblei | P48605, DM |
Family and domain databases
CDDi | cd03337, TCP1_gamma, 1 hit |
Gene3Di | 1.10.560.10, 1 hit 3.30.260.10, 1 hit 3.50.7.10, 1 hit |
InterProi | View protein in InterPro IPR012719, Chap_CCT_gamma IPR017998, Chaperone_TCP-1 IPR002194, Chaperonin_TCP-1_CS IPR002423, Cpn60/TCP-1 IPR027409, GroEL-like_apical_dom_sf IPR027413, GROEL-like_equatorial_sf IPR027410, TCP-1-like_intermed_sf |
Pfami | View protein in Pfam PF00118, Cpn60_TCP1, 1 hit |
PRINTSi | PR00304, TCOMPLEXTCP1 |
SUPFAMi | SSF48592, SSF48592, 1 hit SSF52029, SSF52029, 1 hit SSF54849, SSF54849, 1 hit |
TIGRFAMsi | TIGR02344, chap_CCT_gamma, 1 hit |
PROSITEi | View protein in PROSITE PS00750, TCP1_1, 1 hit PS00751, TCP1_2, 1 hit PS00995, TCP1_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCPG_DROME | |
Accessioni | P48605Primary (citable) accession number: P48605 Secondary accession number(s): Q9VER9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families