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Protein

GrpE protein homolog, mitochondrial

Gene

Roe1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog, mitochondrial
Alternative name(s):
dRoe1
Gene namesi
Name:Roe1
ORF Names:CG6155
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0014877 Roe1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000013048? – 213GrpE protein homolog, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiP48604
PRIDEiP48604

Expressioni

Gene expression databases

BgeeiFBgn0014877
ExpressionAtlasiP48604 baseline and differential
GenevisibleiP48604 DM

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, Roe1, TIM44, blp/TIM16 and TIM14.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi62264, 3 interactors
IntActiP48604, 6 interactors
STRINGi7227.FBpp0086795

Structurei

3D structure databases

ProteinModelPortaliP48604
SMRiP48604
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003 Eukaryota
COG0576 LUCA
GeneTreeiENSGT00390000005589
InParanoidiP48604
KOiK03687
OMAiYAYEKIA
OrthoDBiEOG091G0O5D
PhylomeDBiP48604

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKAALPLQ MFGRRLVHLR SSVTSQNMSA LRLYSTEKQP EEATEQKATE
60 70 80 90 100
SSPEVEKLTK ELAAAKEQNA ELMDKYKRSL ADSENMRNRL NKQISDAKIF
110 120 130 140 150
GIQSFCKDLL EVADTLGHAT QAVPKDKLSG NADLKNLYEG LTMTRASLLQ
160 170 180 190 200
VFKRHGLEPL DPINQKFDPN QHEALFQKED KTVEPNTVVE VTKLGYKLHE
210
RCIRPALVGV SKC
Length:213
Mass (Da):23,926
Last modified:September 27, 2004 - v2
Checksum:i3418F8A23F31528D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55V → L in AAA79044 (Ref. 1) Curated1
Sequence conflicti132A → T in AAA79044 (Ref. 1) Curated1
Sequence conflicti158E → K in AAM11242 (PubMed:12537569).Curated1
Sequence conflicti159P → S in AAA79044 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34903 mRNA Translation: AAA79044.1
AE013599 Genomic DNA Translation: AAF58354.1
AY094889 mRNA Translation: AAM11242.1
RefSeqiNP_610886.2, NM_137042.4
UniGeneiDm.4119

Genome annotation databases

EnsemblMetazoaiFBtr0087675; FBpp0086795; FBgn0014877
GeneIDi36508
KEGGidme:Dmel_CG6155
UCSCiCG6155-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiGRPE_DROME
AccessioniPrimary (citable) accession number: P48604
Secondary accession number(s): Q8SX27, Q9V6R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 27, 2004
Last modified: July 18, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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