UniProtKB - P48603 (CAPZB_DROME)
Protein
F-actin-capping protein subunit beta
Gene
cpb
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.1 Publication
GO - Molecular functioni
- actin filament binding Source: GO_Central
- protein heterodimerization activity Source: FlyBase
GO - Biological processi
- actin cytoskeleton organization Source: FlyBase
- actin filament organization Source: FlyBase
- barbed-end actin filament capping Source: FlyBase
- border follicle cell migration Source: FlyBase
- cell morphogenesis Source: FlyBase
- cytoplasmic transport, nurse cell to oocyte Source: FlyBase
- microtubule-based movement Source: FlyBase
- negative regulation of filopodium assembly Source: FlyBase
- negative regulation of JNK cascade Source: FlyBase
- positive regulation of synaptic growth at neuromuscular junction Source: FlyBase
- regulation of actin filament length Source: FlyBase
- regulation of lamellipodium assembly Source: FlyBase
- wing disc development Source: FlyBase
Keywordsi
Molecular function | Actin capping, Actin-binding |
Enzyme and pathway databases
Reactomei | R-DME-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-6807878, COPI-mediated anterograde transport R-DME-6811436, COPI-independent Golgi-to-ER retrograde traffic R-DME-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: F-actin-capping protein subunit beta |
Gene namesi | Name:cpb Synonyms:ANCP-BETA ORF Names:CG17158 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0011570, cpb |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- dynactin complex Source: FlyBase
- F-actin capping protein complex Source: FlyBase
Cytosol
- cytosol Source: GOC
Other locations
- WASH complex Source: FlyBase
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204639 | 1 – 276 | F-actin-capping protein subunit betaAdd BLAST | 276 |
Proteomic databases
PaxDbi | P48603 |
PRIDEi | P48603 |
Expressioni
Gene expression databases
Bgeei | FBgn0011570, Expressed in embryonic/larval hemocyte (Drosophila) and 49 other tissues |
ExpressionAtlasi | P48603, baseline and differential |
Genevisiblei | P48603, DM |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit.
GO - Molecular functioni
- actin filament binding Source: GO_Central
- protein heterodimerization activity Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 59586, 56 interactors |
DIPi | DIP-17681N |
IntActi | P48603, 23 interactors |
STRINGi | 7227.FBpp0077549 |
Family & Domainsi
Sequence similaritiesi
Belongs to the F-actin-capping protein beta subunit family.Curated
Phylogenomic databases
eggNOGi | KOG3174, Eukaryota |
GeneTreei | ENSGT00390000017957 |
HOGENOMi | CLU_045864_1_1_1 |
InParanoidi | P48603 |
OMAi | GRQAHYK |
OrthoDBi | 1076134at2759 |
PhylomeDBi | P48603 |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 2.40.160.80, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P48603-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEMQMDCAL DLMRRLPPQQ IEKNLIDLID LAPDLCEDLL SSVDQPLKIA
60 70 80 90 100
KDKEHGKDYL LCDYNRDGDS YRSPWSNSYY PPLEDGQMPS ERLRKLEIEA
110 120 130 140 150
NYAFDQYREM YYEGGVSSVY LWDLDHGFAA VILIKKAGDG SKMIRGCWDS
160 170 180 190 200
IHVVEVQEKT TGRTAHYKLT STAMLWLQTN KQGSGTMNLG GSLTRQQEQD
210 220 230 240 250
ANVSESSPHI ANIGKMVEEM ENKIRNTLNE IYFGKTKDIV NGLRSTQSLA
260 270
DQRQQAAMKQ DLAAAILRRN VKPESN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9PBN7 | M9PBN7_DROME | F-actin-capping protein subunit bet... | cpb bnd, Cap2, CAPB_DROME, CapZ, CapZbeta | 276 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35240 mRNA Translation: AAB38521.1 AE014134 Genomic DNA Translation: AAF51349.1 AY069829 mRNA Translation: AAL39974.1 |
RefSeqi | NP_001259877.1, NM_001272948.1 NP_477005.1, NM_057657.5 |
Genome annotation databases
EnsemblMetazoai | FBtr0077881; FBpp0077549; FBgn0011570 FBtr0331630; FBpp0304020; FBgn0011570 |
GeneIDi | 33346 |
KEGGi | dme:Dmel_CG17158 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U35240 mRNA Translation: AAB38521.1 AE014134 Genomic DNA Translation: AAF51349.1 AY069829 mRNA Translation: AAL39974.1 |
RefSeqi | NP_001259877.1, NM_001272948.1 NP_477005.1, NM_057657.5 |
3D structure databases
SMRi | P48603 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 59586, 56 interactors |
DIPi | DIP-17681N |
IntActi | P48603, 23 interactors |
STRINGi | 7227.FBpp0077549 |
Proteomic databases
PaxDbi | P48603 |
PRIDEi | P48603 |
Genome annotation databases
EnsemblMetazoai | FBtr0077881; FBpp0077549; FBgn0011570 FBtr0331630; FBpp0304020; FBgn0011570 |
GeneIDi | 33346 |
KEGGi | dme:Dmel_CG17158 |
Organism-specific databases
CTDi | 33346 |
FlyBasei | FBgn0011570, cpb |
Phylogenomic databases
eggNOGi | KOG3174, Eukaryota |
GeneTreei | ENSGT00390000017957 |
HOGENOMi | CLU_045864_1_1_1 |
InParanoidi | P48603 |
OMAi | GRQAHYK |
OrthoDBi | 1076134at2759 |
PhylomeDBi | P48603 |
Enzyme and pathway databases
Reactomei | R-DME-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-DME-6807878, COPI-mediated anterograde transport R-DME-6811436, COPI-independent Golgi-to-ER retrograde traffic R-DME-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
BioGRID-ORCSi | 33346, 0 hits in 1 CRISPR screen |
GenomeRNAii | 33346 |
PROi | PR:P48603 |
Gene expression databases
Bgeei | FBgn0011570, Expressed in embryonic/larval hemocyte (Drosophila) and 49 other tissues |
ExpressionAtlasi | P48603, baseline and differential |
Genevisiblei | P48603, DM |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 2.40.160.80, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAPZB_DROME | |
Accessioni | P48603Primary (citable) accession number: P48603 Secondary accession number(s): Q9VQ33 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families