F-actin-capping protein subunit beta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• actin filament binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels."
    Amandio A.R., Gaspar P., Whited J.L., Janody F.
    PLoS One 9:e96326-e96326(2014) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• actin cytoskeleton organization Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration."
    Delalle I., Pfleger C.M., Buff E., Lueras P., Hariharan I.K.
    Genetics 171:1757-1765(2005) [PubMed] [Europe PMC] [Abstract]
• actin filament organization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis."
    Gates J., Nowotarski S.H., Yin H., Mahaffey J.P., Bridges T., Herrera C., Homem C.C., Janody F., Montell D.J., Peifer M.
    Dev Biol 333:90-107(2009) [PubMed] [Europe PMC] [Abstract]
• barbed-end actin filament capping Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Actin organization, bristle morphology, and viability are affected by actin capping protein mutations in Drosophila."
    Hopmann R., Cooper J.A., Miller K.G.
    J. Cell Biol. 133:1293-1305(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
• border follicle cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis."
    Gates J., Nowotarski S.H., Yin H., Mahaffey J.P., Bridges T., Herrera C., Homem C.C., Janody F., Montell D.J., Peifer M.
    Dev Biol 333:90-107(2009) [PubMed] [Europe PMC] [Abstract]
  • "The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells."
    Lucas E.P., Khanal I., Gaspar P., Fletcher G.C., Polesello C., Tapon N., Thompson B.J.
    J Cell Biol 201:875-885(2013) [PubMed] [Europe PMC] [Abstract]
• cell morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis."
    D'Ambrosio M.V., Vale R.D.
    J Cell Biol 191:471-478(2010) [PubMed] [Europe PMC] [Abstract]
• cytoplasmic transport, nurse cell to oocyte Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis."
    Gates J., Nowotarski S.H., Yin H., Mahaffey J.P., Bridges T., Herrera C., Homem C.C., Janody F., Montell D.J., Peifer M.
    Dev Biol 333:90-107(2009) [PubMed] [Europe PMC] [Abstract]
• microtubule-based movement Source: FlyBase <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1."
    Eckley D.M., Schroer T.A.
    Mol Biol Cell 14:2645-2654(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of filopodium assembly Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model."
    Goncalves-Pimentel C., Gombos R., Mihaly J., Sanchez-Soriano N., Prokop A.
    PLoS One 6:e18340-e18340(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of JNK cascade Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene."
    Fernandez B.G., Jezowska B., Janody F.
    Oncogene 33:2027-2039(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synaptic growth at neuromuscular junction Source: FlyBaseInferred from mutant phenotypeⁱ
  • "miR-8 controls synapse structure by repression of the actin regulator enabled."
    Loya C.M., McNeill E.M., Bao H., Zhang B., Van Vactor D.
    Development 141:1864-1874(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of actin filament length Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Molecular requirements for actin-based lamella formation in Drosophila S2 cells."
    Rogers S.L., Wiedemann U., Stuurman N., Vale R.D.
    J. Cell Biol. 162:1079-1088(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of lamellipodium assembly Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly."
    Iwasa J.H., Mullins R.D.
    Curr Biol 17:395-406(2007) [PubMed] [Europe PMC] [Abstract]
• wing disc development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium."
    Janody F., Treisman J.E.
    Development 133:3349-3357(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• actin filament binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: FlyBaseInferred from physical interactionⁱ
  • "Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels."
    Amandio A.R., Gaspar P., Whited J.L., Janody F.
    PLoS One 9:e96326-e96326(2014) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSEMQMDCAL DLMRRLPPQQ IEKNLIDLID LAPDLCEDLL SSVDQPLKIA 
        60         70         80         90        100
KDKEHGKDYL LCDYNRDGDS YRSPWSNSYY PPLEDGQMPS ERLRKLEIEA 
       110        120        130        140        150
NYAFDQYREM YYEGGVSSVY LWDLDHGFAA VILIKKAGDG SKMIRGCWDS 
       160        170        180        190        200
IHVVEVQEKT TGRTAHYKLT STAMLWLQTN KQGSGTMNLG GSLTRQQEQD 
       210        220        230        240        250
ANVSESSPHI ANIGKMVEEM ENKIRNTLNE IYFGKTKDIV NGLRSTQSLA 
       260        270 
DQRQQAAMKQ DLAAAILRRN VKPESN                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. SIMILARITY comments
   Index of protein domains and families