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Entry version 178 (26 Feb 2020)
Sequence version 1 (01 Feb 1996)
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Protein

Eukaryotic translation initiation factor 4E1

Gene

eIF4E1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:8663200). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition (PubMed:28875934).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-110523 TOR signaling pathway
R-DME-1169408 ISG15 antiviral mechanism
R-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-159227 Transport of the SLBP independent Mature mRNA
R-DME-159230 Transport of the SLBP Dependant Mature mRNA
R-DME-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-166208 mTORC1-mediated signalling
R-DME-429947 Deadenylation of mRNA
R-DME-72649 Translation initiation complex formation
R-DME-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-DME-72702 Ribosomal scanning and start codon recognition

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E1
Alternative name(s):
eIF-4F 25 kDa subunit
mRNA cap-binding protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eIF4E1Imported
Synonyms:eIF-4E1 Publication, Eif4e1 Publication
ORF Names:CG4035Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0015218 eIF4E1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi107I → A: Abolishes interaction with cup and mxt; when associated with A-123. 1 Publication1
Mutagenesisi117W → A: Disrupts interaction with cup, eIF4G and mxt. 2 Publications1
Mutagenesisi121 – 122NH → EE: Abolishes interaction with mxt, reduces binding to Thor and 4E-T, and does not affect interaction with cup. 1 Publication2
Mutagenesisi123I → A: Abolishes interaction with cup and mxt; when associated with A-107. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001936421 – 259Eukaryotic translation initiation factor 4E1Add BLAST259

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48598

PRoteomics IDEntifications database

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PRIDEi
P48598

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48598

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferential expression in the pole cells, at different developmental stages.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

High levels of expression in early embryos, with levels decreasing slightly over the first 5 hours of embryogenesis (at protein level) (PubMed:28875934). Throughout development (PubMed:7742371, PubMed:9065696).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0015218 Expressed in egg chamber and 46 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P48598 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P48598 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1. eIF4E1 is also known to interact with other partners (By similarity). Recruited by cup in oocytes and in early embryos, preventing the interaction with eIF4G. The interaction with cup therefore prevents the translation of key transcripts such as oskar (osk) and nanos (nos) in some regions in the early embryo (PubMed:14691132, PubMed:14723848, PubMed:14685270, PubMed:26294658).

Interacts with mxt (PubMed:23716590, PubMed:26294658).

Interacts with 4E-T and Thor (PubMed:26294658).

Forms a RNP containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
69740, 49 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3177 eIF4E-cup complex

Database of interacting proteins

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DIPi
DIP-17448N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P48598

Protein interaction database and analysis system

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IntActi
P48598, 11 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0076215

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1259
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P48598

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni100 – 1017-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni146 – 1477-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni199 – 2047-methylguanosine-containing mRNA cap bindingBy similarity6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1670 Eukaryota
COG5053 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000167792

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P48598

KEGG Orthology (KO)

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KOi
K03259

Identification of Orthologs from Complete Genome Data

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OMAi
NDIRPEW

Database for complete collections of gene phylogenies

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PhylomeDBi
P48598

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.760.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS

The PANTHER Classification System

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PANTHERi
PTHR11960 PTHR11960, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01652 IF4E, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55418 SSF55418, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00813 IF4E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform I1 Publication (identifier: P48598-1) [UniParc]FASTAAdd to basket
Also known as: A, B, D, E, F, G

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSDFHRMKN FANPKSMFKT SAPSTEQGRP EPPTSAAAPA EAKDVKPKED
60 70 80 90 100
PQETGEPAGN TATTTAPAGD DAVRTEHLYK HPLMNVWTLW YLENDRSKSW
110 120 130 140 150
EDMQNEITSF DTVEDFWSLY NHIKPPSEIK LGSDYSLFKK NIRPMWEDAA
160 170 180 190 200
NKQGGRWVIT LNKSSKTDLD NLWLDVLLCL IGEAFDHSDQ ICGAVINIRG
210 220 230 240 250
KSNKISIWTA DGNNEEAALE IGHKLRDALR LGRNNSLQYQ LHKDTMVKQG

SNVKSIYTL
Length:259
Mass (Da):29,224
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB844B2DD5738758E
GO
Isoform II1 Publication (identifier: P48598-2) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MQSDFHRMKNFANPKSMF → MVVLETE

Show »
Length:248
Mass (Da):27,827
Checksum:i10513B026B676BC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PBZ9M9PBZ9_DROME
Eukaryotic translation initiation f...
eIF4E1 0260, 0587, 0589, 09, 0919
259Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL25509 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0014371 – 18MQSDF…PKSMF → MVVLETE in isoform II. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U16139 mRNA Translation: AAC46603.1
U54469 Genomic DNA Translation: AAC03525.1
U54469 Genomic DNA Translation: AAC03524.1
U63033 Genomic DNA Translation: AAC47480.1
U63033 Genomic DNA Translation: AAC47479.1
AE014296 Genomic DNA Translation: AAF50281.1
AE014296 Genomic DNA Translation: AAF50282.1
AE014296 Genomic DNA Translation: AAF50283.1
AE014296 Genomic DNA Translation: AAN11963.1
AE014296 Genomic DNA Translation: AAN11964.1
AE014296 Genomic DNA Translation: AAN11965.1
AE014296 Genomic DNA Translation: AAN11966.1
AY060470 mRNA Translation: AAL25509.1 Frameshift.
BT012467 mRNA Translation: AAS93738.1
BT044219 mRNA Translation: ACH92284.1

Protein sequence database of the Protein Information Resource

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PIRi
S55936

NCBI Reference Sequences

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RefSeqi
NP_001261626.1, NM_001274697.1 [P48598-1]
NP_001261627.1, NM_001274698.1 [P48598-1]
NP_524829.1, NM_080090.3 [P48598-1]
NP_729480.1, NM_168333.2 [P48598-2]
NP_729481.1, NM_168334.1 [P48598-1]
NP_729482.1, NM_168335.2 [P48598-1]
NP_729483.1, NM_168336.2 [P48598-1]
NP_729484.1, NM_168337.2 [P48598-1]
NP_729485.1, NM_168338.2 [P48598-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0076487; FBpp0076215; FBgn0015218 [P48598-1]
FBtr0076488; FBpp0076216; FBgn0015218 [P48598-2]
FBtr0076489; FBpp0076217; FBgn0015218 [P48598-1]
FBtr0076490; FBpp0076218; FBgn0015218 [P48598-1]
FBtr0076491; FBpp0076219; FBgn0015218 [P48598-1]
FBtr0076492; FBpp0076220; FBgn0015218 [P48598-1]
FBtr0076493; FBpp0076221; FBgn0015218 [P48598-1]
FBtr0333884; FBpp0306016; FBgn0015218 [P48598-1]
FBtr0333885; FBpp0306017; FBgn0015218 [P48598-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
45525

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4035

UCSC genome browser

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UCSCi
CG4035-RB d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16139 mRNA Translation: AAC46603.1
U54469 Genomic DNA Translation: AAC03525.1
U54469 Genomic DNA Translation: AAC03524.1
U63033 Genomic DNA Translation: AAC47480.1
U63033 Genomic DNA Translation: AAC47479.1
AE014296 Genomic DNA Translation: AAF50281.1
AE014296 Genomic DNA Translation: AAF50282.1
AE014296 Genomic DNA Translation: AAF50283.1
AE014296 Genomic DNA Translation: AAN11963.1
AE014296 Genomic DNA Translation: AAN11964.1
AE014296 Genomic DNA Translation: AAN11965.1
AE014296 Genomic DNA Translation: AAN11966.1
AY060470 mRNA Translation: AAL25509.1 Frameshift.
BT012467 mRNA Translation: AAS93738.1
BT044219 mRNA Translation: ACH92284.1
PIRiS55936
RefSeqiNP_001261626.1, NM_001274697.1 [P48598-1]
NP_001261627.1, NM_001274698.1 [P48598-1]
NP_524829.1, NM_080090.3 [P48598-1]
NP_729480.1, NM_168333.2 [P48598-2]
NP_729481.1, NM_168334.1 [P48598-1]
NP_729482.1, NM_168335.2 [P48598-1]
NP_729483.1, NM_168336.2 [P48598-1]
NP_729484.1, NM_168337.2 [P48598-1]
NP_729485.1, NM_168338.2 [P48598-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AXGX-ray2.80A/B19-259[»]
4UE8X-ray1.10A80-259[»]
4UE9X-ray2.15A80-259[»]
4UEAX-ray2.62A/C/E80-259[»]
4UEBX-ray2.52A/C/E80-259[»]
4UECX-ray2.40A/C80-259[»]
5ABUX-ray2.16A80-259[»]
5ABVX-ray2.13A/C/E/G80-259[»]
5T47X-ray2.20A/C80-259[»]
5T48X-ray2.19A80-259[»]
SMRiP48598
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi69740, 49 interactors
ComplexPortaliCPX-3177 eIF4E-cup complex
DIPiDIP-17448N
ELMiP48598
IntActiP48598, 11 interactors
STRINGi7227.FBpp0076215

PTM databases

iPTMnetiP48598

Proteomic databases

PaxDbiP48598
PRIDEiP48598

Genome annotation databases

EnsemblMetazoaiFBtr0076487; FBpp0076215; FBgn0015218 [P48598-1]
FBtr0076488; FBpp0076216; FBgn0015218 [P48598-2]
FBtr0076489; FBpp0076217; FBgn0015218 [P48598-1]
FBtr0076490; FBpp0076218; FBgn0015218 [P48598-1]
FBtr0076491; FBpp0076219; FBgn0015218 [P48598-1]
FBtr0076492; FBpp0076220; FBgn0015218 [P48598-1]
FBtr0076493; FBpp0076221; FBgn0015218 [P48598-1]
FBtr0333884; FBpp0306016; FBgn0015218 [P48598-1]
FBtr0333885; FBpp0306017; FBgn0015218 [P48598-1]
GeneIDi45525
KEGGidme:Dmel_CG4035
UCSCiCG4035-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
45525
FlyBaseiFBgn0015218 eIF4E1

Phylogenomic databases

eggNOGiKOG1670 Eukaryota
COG5053 LUCA
GeneTreeiENSGT00940000167792
InParanoidiP48598
KOiK03259
OMAiNDIRPEW
PhylomeDBiP48598

Enzyme and pathway databases

ReactomeiR-DME-110523 TOR signaling pathway
R-DME-1169408 ISG15 antiviral mechanism
R-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-159227 Transport of the SLBP independent Mature mRNA
R-DME-159230 Transport of the SLBP Dependant Mature mRNA
R-DME-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-166208 mTORC1-mediated signalling
R-DME-429947 Deadenylation of mRNA
R-DME-72649 Translation initiation complex formation
R-DME-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-DME-72702 Ribosomal scanning and start codon recognition

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
eIF-4E fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
45525

Protein Ontology

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PROi
PR:P48598

Gene expression databases

BgeeiFBgn0015218 Expressed in egg chamber and 46 other tissues
ExpressionAtlasiP48598 baseline and differential
GenevisibleiP48598 DM

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813 IF4E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4E_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48598
Secondary accession number(s): A4V1Q6
, Q95SV3, Q9VSX8, Q9VSX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 26, 2020
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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