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Protein

Serpin B10

Gene

SERPINB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei362 – 363Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiI04.015

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B10
Alternative name(s):
Bomapin
Peptidase inhibitor 10
Short name:
PI-10
Gene namesi
Name:SERPINB10
Synonyms:PI10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000242550.5
HGNCiHGNC:8942 SERPINB10
MIMi602058 gene
neXtProtiNX_P48595

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74 – 77KKRK → AAAA: Abolishes nuclear localization. 4
Mutagenesisi395C → S: No effect on cell proliferation. 1 Publication1

Organism-specific databases

DisGeNETi5273
OpenTargetsiENSG00000242550
PharmGKBiPA35510

Polymorphism and mutation databases

BioMutaiSERPINB10
DMDMi1345616

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941141 – 397Serpin B10Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 395Redox-active1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP48595
PaxDbiP48595
PeptideAtlasiP48595
PRIDEiP48595
ProteomicsDBi55912

PTM databases

iPTMnetiP48595
PhosphoSitePlusiP48595
SwissPalmiP48595

Expressioni

Tissue specificityi

Expressed specifically in myeloid cells and the bone marrow.2 Publications

Gene expression databases

BgeeiENSG00000242550 Expressed in 41 organ(s), highest expression level in bone marrow
CleanExiHS_SERPINB10
ExpressionAtlasiP48595 baseline and differential
GenevisibleiP48595 HS

Organism-specific databases

HPAiHPA059582

Interactioni

Protein-protein interaction databases

BioGridi111291, 1 interactor
IntActiP48595, 1 interactor
STRINGi9606.ENSP00000238508

Structurei

3D structure databases

ProteinModelPortaliP48595
SMRiP48595
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi74 – 77Nuclear localization signal4

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP48595
KOiK13963
OMAiADMMELY
OrthoDBiEOG091G0ION
PhylomeDBiP48595
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P48595-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSLATSINQ FALELSKKLA ESAQGKNIFF SSWSISTSLT IVYLGAKGTT
60 70 80 90 100
AAQMAQVLQF NRDQGVKCDP ESEKKRKMEF NLSNSEEIHS DFQTLISEIL
110 120 130 140 150
KPNDDYLLKT ANAIYGEKTY AFHNKYLEDM KTYFGAEPQP VNFVEASDQI
160 170 180 190 200
RKDINSWVER QTEGKIQNLL PDDSVDSTTR MILVNALYFK GIWEHQFLVQ
210 220 230 240 250
NTTEKPFRIN ETTSKPVQMM FMKKKLHIFH IEKPKAVGLQ LYYKSRDLSL
260 270 280 290 300
LILLPEDING LEQLEKAITY EKLNEWTSAD MMELYEVQLH LPKFKLEDSY
310 320 330 340 350
DLKSTLSSMG MSDAFSQSKA DFSGMSSARN LFLSNVFHKA FVEINEQGTE
360 370 380 390
AAAGSGSEID IRIRVPSIEF NANHPFLFFI RHNKTNTILF YGRLCSP
Length:397
Mass (Da):45,403
Last modified:February 1, 1996 - v1
Checksum:i8CE01246867154DF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYS2H7BYS2_HUMAN
Serpin B10
SERPINB10
280Annotation score:
H7C004H7C004_HUMAN
Serpin B10
SERPINB10
253Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0519493S → A. Corresponds to variant dbSNP:rs17072097Ensembl.1
Natural variantiVAR_02435341I → M. Corresponds to variant dbSNP:rs8097425Ensembl.1
Natural variantiVAR_02435499I → T. Corresponds to variant dbSNP:rs724558Ensembl.1
Natural variantiVAR_051950135G → D. Corresponds to variant dbSNP:rs17072146Ensembl.1
Natural variantiVAR_024355140P → S. Corresponds to variant dbSNP:rs9967382Ensembl.1
Natural variantiVAR_022116246R → C. Corresponds to variant dbSNP:rs963075Ensembl.1
Natural variantiVAR_051951360D → N1 PublicationCorresponds to variant dbSNP:rs35453062Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35459 mRNA Translation: AAC50282.1
BC096217 mRNA Translation: AAH96217.1
BC096219 mRNA Translation: AAH96219.1
BC096220 mRNA Translation: AAH96220.1
CCDSiCCDS11990.1
PIRiI39184
RefSeqiNP_005015.1, NM_005024.2
XP_011524329.1, XM_011526027.1
UniGeneiHs.158339

Genome annotation databases

EnsembliENST00000238508; ENSP00000238508; ENSG00000242550
ENST00000619595; ENSP00000479385; ENSG00000242550
GeneIDi5273
KEGGihsa:5273
UCSCiuc010xev.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPB10_HUMAN
AccessioniPrimary (citable) accession number: P48595
Secondary accession number(s): Q4VAX4, Q4VAX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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