Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serpin B4

Gene

SERPINB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a protease inhibitor to modulate the host immune response against tumor cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei354 – 355Reactive bond2

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protease binding Source: UniProtKB
  • serine-type endopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  • negative regulation of endopeptidase activity Source: GO_Central
  • negative regulation of peptidase activity Source: UniProtKB
  • protection from natural killer cell mediated cytotoxicity Source: UniProtKB
  • regulation of proteolysis Source: UniProtKB

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.009

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B4
Alternative name(s):
Leupin
Peptidase inhibitor 11
Short name:
PI-11
Squamous cell carcinoma antigen 2
Short name:
SCCA-2
Gene namesi
Name:SERPINB4
Synonyms:PI11, SCCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000206073.10
HGNCiHGNC:10570 SERPINB4
MIMi600518 gene
neXtProtiNX_P48594

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6318
OpenTargetsiENSG00000206073
PharmGKBiPA35539

Polymorphism and mutation databases

BioMutaiSERPINB4
DMDMi1710877

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941041 – 390Serpin B4Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP48594
MaxQBiP48594
PaxDbiP48594
PeptideAtlasiP48594
PRIDEiP48594
ProteomicsDBi55911

2D gel databases

UCD-2DPAGEiP48594

PTM databases

iPTMnetiP48594
PhosphoSitePlusiP48594
SwissPalmiP48594

Expressioni

Tissue specificityi

Squamous cells.

Gene expression databases

BgeeiENSG00000206073 Expressed in 48 organ(s), highest expression level in ectocervix
CleanExiHS_SERPINB4
ExpressionAtlasiP48594 baseline and differential
GenevisibleiP48594 HS

Organism-specific databases

HPAiHPA048341
HPA049988
HPA055992

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112224, 63 interactors
IntActiP48594, 7 interactors
STRINGi9606.ENSP00000343445

Structurei

3D structure databases

ProteinModelPortaliP48594
SMRiP48594
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP48594
KOiK13963
OMAiTNAYELK
OrthoDBiEOG091G0ION
PhylomeDBiP48594
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P48594-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA
60 70 80 90 100
QQISKVLHFD QVTENTTEKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE
110 120 130 140 150
LKIANKLFGE KTYQFLQEYL DAIKKFYQTS VESTDFANAP EESRKKINSW
160 170 180 190 200
VESQTNEKIK NLFPDGTIGN DTTLVLVNAI YFKGQWENKF KKENTKEEKF
210 220 230 240 250
WPNKNTYKSV QMMRQYNSFN FALLEDVQAK VLEIPYKGKD LSMIVLLPNE
260 270 280 290 300
IDGLQKLEEK LTAEKLMEWT SLQNMRETCV DLHLPRFKME ESYDLKDTLR
310 320 330 340 350
TMGMVNIFNG DADLSGMTWS HGLSVSKVLH KAFVEVTEEG VEAAAATAVV
360 370 380 390
VVELSSPSTN EEFCCNHPFL FFIRQNKTNS ILFYGRFSSP
Length:390
Mass (Da):44,854
Last modified:October 1, 1996 - v2
Checksum:i04E213CD892587D5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JZ65C9JZ65_HUMAN
Serpin B4
SERPINB4
211Annotation score:
H0Y5H9H0Y5H9_HUMAN
Serpin B4
SERPINB4
371Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353E → K in BAF84901 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89015 mRNA Translation: CAA61420.1
U19557 mRNA Translation: AAA97553.1
U19576
, U19570, U19571, U19572, U19574, U19575 Genomic DNA Translation: AAA92602.1
AB035089 Genomic DNA Translation: BAB21525.1
AK292212 mRNA Translation: BAF84901.1
BC017401 mRNA Translation: AAH17401.1
CCDSiCCDS11986.1
PIRiI38202
RefSeqiNP_002965.1, NM_002974.3
NP_778206.1, NM_175041.1
XP_011524440.1, XM_011526138.1
UniGeneiHs.123035

Genome annotation databases

EnsembliENST00000341074; ENSP00000343445; ENSG00000206073
GeneIDi6318
KEGGihsa:6318
UCSCiuc002ljf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89015 mRNA Translation: CAA61420.1
U19557 mRNA Translation: AAA97553.1
U19576
, U19570, U19571, U19572, U19574, U19575 Genomic DNA Translation: AAA92602.1
AB035089 Genomic DNA Translation: BAB21525.1
AK292212 mRNA Translation: BAF84901.1
BC017401 mRNA Translation: AAH17401.1
CCDSiCCDS11986.1
PIRiI38202
RefSeqiNP_002965.1, NM_002974.3
NP_778206.1, NM_175041.1
XP_011524440.1, XM_011526138.1
UniGeneiHs.123035

3D structure databases

ProteinModelPortaliP48594
SMRiP48594
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112224, 63 interactors
IntActiP48594, 7 interactors
STRINGi9606.ENSP00000343445

Protein family/group databases

MEROPSiI04.009

PTM databases

iPTMnetiP48594
PhosphoSitePlusiP48594
SwissPalmiP48594

Polymorphism and mutation databases

BioMutaiSERPINB4
DMDMi1710877

2D gel databases

UCD-2DPAGEiP48594

Proteomic databases

EPDiP48594
MaxQBiP48594
PaxDbiP48594
PeptideAtlasiP48594
PRIDEiP48594
ProteomicsDBi55911

Protocols and materials databases

DNASUi6318
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341074; ENSP00000343445; ENSG00000206073
GeneIDi6318
KEGGihsa:6318
UCSCiuc002ljf.4 human

Organism-specific databases

CTDi6318
DisGeNETi6318
EuPathDBiHostDB:ENSG00000206073.10
GeneCardsiSERPINB4
HGNCiHGNC:10570 SERPINB4
HPAiHPA048341
HPA049988
HPA055992
MIMi600518 gene
neXtProtiNX_P48594
OpenTargetsiENSG00000206073
PharmGKBiPA35539
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP48594
KOiK13963
OMAiTNAYELK
OrthoDBiEOG091G0ION
PhylomeDBiP48594
TreeFamiTF352619

Miscellaneous databases

ChiTaRSiSERPINB4 human
GeneWikiiSERPINB4
GenomeRNAii6318
PROiPR:P48594
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206073 Expressed in 48 organ(s), highest expression level in ectocervix
CleanExiHS_SERPINB4
ExpressionAtlasiP48594 baseline and differential
GenevisibleiP48594 HS

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPB4_HUMAN
AccessioniPrimary (citable) accession number: P48594
Secondary accession number(s): A8K847
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again