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Entry version 159 (29 Sep 2021)
Sequence version 2 (09 May 2003)
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Protein

Calcium-binding protein E63-1

Gene

Eip63F-1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi48 – 591PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi140 – 1512PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi176 – 1873PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • enzyme regulator activity Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-111932, CaMK IV-mediated phosphorylation of CREB
R-DME-111933, Calmodulin induced events
R-DME-111957, Cam-PDE 1 activation
R-DME-114608, Platelet degranulation
R-DME-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DME-163615, PKA activation
R-DME-1855204, Synthesis of IP3 and IP4 in the cytosol
R-DME-2025928, Calcineurin activates NFAT
R-DME-203615, eNOS activation
R-DME-2514859, Inactivation, recovery and regulation of the phototransduction cascade
R-DME-2871809, FCERI mediated Ca+2 mobilization
R-DME-4086398, Ca2+ pathway
R-DME-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-DME-442729, CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-DME-451308, Activation of Ca-permeable Kainate Receptor
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-5578775, Ion homeostasis
R-DME-5607763, CLEC7A (Dectin-1) induces NFAT activation
R-DME-5673000, RAF activation
R-DME-6798695, Neutrophil degranulation
R-DME-70221, Glycogen breakdown (glycogenolysis)
R-DME-8876725, Protein methylation
R-DME-9009391, Extra-nuclear estrogen signaling
R-DME-936837, Ion transport by P-type ATPases
R-DME-9619229, Activation of RAC1 downstream of NMDARs
R-DME-9648002, RAS processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium-binding protein E63-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eip63F-1
Synonyms:E63-1
ORF Names:CG15855
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004910, Eip63F-1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0004910

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000738621 – 193Calcium-binding protein E63-1Add BLAST193

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48593

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By ecdysone.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004910, Expressed in saliva-secreting gland and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P48593, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
71025, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-21826N

Protein interaction database and analysis system

More...
IntActi
P48593, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073031

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P48593

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 70EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini71 – 106EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini127 – 162EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini163 – 193EF-hand 4PROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0027, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48593

Identification of Orthologs from Complete Genome Data

More...
OMAi
QHEDNAS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48593

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499, EF-hand_7, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 3 hits
PS50222, EF_HAND_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P48593-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPMSGLRQQ LKMLGTALLG KRATKSVKKK PFTEVEIKDL RTAFDLLDRN
60 70 80 90 100
RDGRVTANEL QFMLKNLGIN VSDELIHDLI REASHSGNGL INEAEFLQWV
110 120 130 140 150
GRIQALRDEQ HSHEDSKDSK PVDEADDVTE DLIAAFRVFD RDGNGFITRD
160 170 180 190
ELQTAMEMIG EPLNEQQLEQ LLVIADLDQD GRINYEEFTR LLL
Length:193
Mass (Da):21,995
Last modified:May 9, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98C117B944727578
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9MRP5M9MRP5_DROME
Ecdysone-induced protein 63F 1, iso...
Eip63F-1 63F-1, Ca[2+] binding protein, CBP12, Dmel\CG15855, E63-1
181Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MS04M9MS04_DROME
Ecdysone-induced protein 63F 1, iso...
Eip63F-1 63F-1, Ca[2+] binding protein, CBP12, Dmel\CG15855, E63-1
166Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9MSK2M9MSK2_DROME
Ecdysone-induced protein 63F 1, iso...
Eip63F-1 63F-1, Ca[2+] binding protein, CBP12, Dmel\CG15855, E63-1
161Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171L → M in AAB61120 (PubMed:7671827).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U25882 mRNA Translation: AAB61120.1
AE014296 Genomic DNA Translation: AAG22243.1

NCBI Reference Sequences

More...
RefSeqi
NP_524902.2, NM_080163.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073174; FBpp0073031; FBgn0004910

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
47878

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG15855

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25882 mRNA Translation: AAB61120.1
AE014296 Genomic DNA Translation: AAG22243.1
RefSeqiNP_524902.2, NM_080163.4

3D structure databases

SMRiP48593
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi71025, 5 interactors
DIPiDIP-21826N
IntActiP48593, 3 interactors
STRINGi7227.FBpp0073031

Proteomic databases

PaxDbiP48593

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
47878

Genome annotation databases

EnsemblMetazoaiFBtr0073174; FBpp0073031; FBgn0004910
GeneIDi47878
KEGGidme:Dmel_CG15855

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
47878
FlyBaseiFBgn0004910, Eip63F-1
VEuPathDBiVectorBase:FBgn0004910

Phylogenomic databases

eggNOGiKOG0027, Eukaryota
InParanoidiP48593
OMAiQHEDNAS
PhylomeDBiP48593

Enzyme and pathway databases

ReactomeiR-DME-111932, CaMK IV-mediated phosphorylation of CREB
R-DME-111933, Calmodulin induced events
R-DME-111957, Cam-PDE 1 activation
R-DME-114608, Platelet degranulation
R-DME-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-DME-163615, PKA activation
R-DME-1855204, Synthesis of IP3 and IP4 in the cytosol
R-DME-2025928, Calcineurin activates NFAT
R-DME-203615, eNOS activation
R-DME-2514859, Inactivation, recovery and regulation of the phototransduction cascade
R-DME-2871809, FCERI mediated Ca+2 mobilization
R-DME-4086398, Ca2+ pathway
R-DME-438066, Unblocking of NMDA receptors, glutamate binding and activation
R-DME-442729, CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
R-DME-451308, Activation of Ca-permeable Kainate Receptor
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-5578775, Ion homeostasis
R-DME-5607763, CLEC7A (Dectin-1) induces NFAT activation
R-DME-5673000, RAF activation
R-DME-6798695, Neutrophil degranulation
R-DME-70221, Glycogen breakdown (glycogenolysis)
R-DME-8876725, Protein methylation
R-DME-9009391, Extra-nuclear estrogen signaling
R-DME-936837, Ion transport by P-type ATPases
R-DME-9619229, Activation of RAC1 downstream of NMDARs
R-DME-9648002, RAS processing

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
47878, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
47878

Protein Ontology

More...
PROi
PR:P48593

Gene expression databases

BgeeiFBgn0004910, Expressed in saliva-secreting gland and 37 other tissues
ExpressionAtlasiP48593, baseline and differential

Family and domain databases

CDDicd00051, EFh, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
PfamiView protein in Pfam
PF13499, EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054, EFh, 4 hits
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 3 hits
PS50222, EF_HAND_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE631_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48593
Secondary accession number(s): Q9I7T4, Q9VZL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 9, 2003
Last modified: September 29, 2021
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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