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UniProtKB - P48563 (MON2_YEAST)

Entry version 165 (07 Apr 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Protein MON2

Gene

MON2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure.4 Publications

Miscellaneous

Present with 2410 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: SGD
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MON2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MON2
Synonyms:YSL2
Ordered Locus Names:YNL297C
ORF Names:N0453
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000005241, MON2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YNL297C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002033722 – 1636Protein MON2Add BLAST1635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei564PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P48563

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P48563

PRoteomics IDEntifications database

More...PRIDEi		P48563

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P48563

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with DOP1, ARL1 and NEO1.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		35541, 448 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1028, NEO1-MON2-ARL1-DOP1 membrane remodeling complex

Protein interaction database and analysis system

More...IntActi		P48563, 8 interactors

Molecular INTeraction database

More...MINTi		P48563

STRING: functional protein association networks

More...STRINGi		4932.YNL297C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P48563, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P48563

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni60 – 410Golgi membrane targeting and interaction with ARL11 PublicationAdd BLAST351
Regioni1501 – 1636Required for function in membrane traffickingAdd BLAST136

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MON2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1848, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000174858

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001169_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P48563

Identification of Orthologs from Complete Genome Data

More...OMAi		YIPSQAF

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032629, DCB_dom
IPR026829, Mon2-like
IPR032817, Mon2_C
IPR032691, Sec7_N

The PANTHER Classification System

More...PANTHERi		PTHR10663:SF333, PTHR10663:SF333, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16213, DCB, 1 hit
PF16206, Mon2_C, 1 hit
PF12783, Sec7_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P48563-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMNTGGFDS MQRQLEAELR SLSSESKRRN STIRHASDKS IEILKRVHSF 
        60         70         80         90        100
EELERHPDFA LPFVLACQSR NAKMTTLAMQ CLQGLSTVPS IPRSRLSEIL 
       110        120        130        140        150
DAFIEATHLA MEIQLKVLQV VPIFFKTYGK FIYGPLCKKL LLCCSNLLHV 
       160        170        180        190        200
PNKAPVVVGT ASATLQQLID EIFDRLSIES VVDDKQYEVL ISNSESIKVN 
       210        220        230        240        250
VYRYDANKLF DNICSLNEIS SNGAVSDEEM LLDIGDIPID YGLEILESIL 
       260        270        280        290        300
KNSQKNLLEC QDLQYLLRVK AIPLLLRCIS SSRHFSTAVR SCRCLKLLIR 
       310        320        330        340        350
KEYLSILELE LEVILSLLIH GISVESNLSG WQRVLSLELF KDLSQDPEIV 
       360        370        380        390        400
NTLYMDYDNY PDKKHVFKYL LKECIVLLNS PEYITFLAPS KVVEKMDSPL 
       410        420        430        440        450
ITTENSTVKT KFMHLLDKSN APSINITYII SLILTICNHL CEGLNKSALE 
       460        470        480        490        500
SSPLEKKIED KEREEGTGND STVVKVYSGL FSGLFELNKL FLYSTSLETS 
       510        520        530        540        550
IFHLVVRAFQ KLAHSAGVLS LKDKLRACMK LFSILITNNV TSSNQYSFND 
       560        570        580        590        600
TSKSAKNQHT RNISTSSVTT SPVESTKNPS RSIADSAQNK EMKRRLHPRN 
       610        620        630        640        650
ISSRQVSLLR ALISLSISLG PIFDSESWRY TFLTWQWITY YIYGPSADFK 
       660        670        680        690        700
ESFYSEDIPP PPILTKSDVT SIESSLTKFF ESTSSYSCST FHLVLTRLIL 
       710        720        730        740        750
DSKNTLTLEQ TNLNLNNDIG YHPLDAKDEI IPCIYNKAFF VNKIGELATY 
       760        770        780        790        800
NCKKFLFGKN GKELWSLIST YMIKLISNRE MDNDSLRLYT VRVFTDIIKK 
       810        820        830        840        850
ATNEVGNSDE QDNKVKQFGT LENLVIDSLM ATINSIKQLD IGKQEIYNGT 
       860        870        880        890        900
INVESDILFQ LLLTLKEILN EFGELLMNSW TNIFNIINSP FEWTVEDTDF 
       910        920        930        940        950
SVNEDIDDSS LFEGIVQKHK NMIQVSYDVF KLISDDFLQS LPMSVIKFVI 
       960        970        980        990       1000
DTLVNFVSQK RNLNISFSSI SQFWLVGDYL RVRFNPETLN LSDEKRRSLS 
      1010       1020       1030       1040       1050
EKINNQKLIE IITSSSSHDW ELYNGLWIYL LKNLINCTND DRVEVKNGAV 
      1060       1070       1080       1090       1100
QTFFRIIDSH SVCFPPWDLI FLEVIEPLLT KEWSTEELEN ETDFINVTLQ 
      1110       1120       1130       1140       1150
GLIKLYPEHF KDFKNNTTCA KEWSMLLDFL KRLLSSTSNN TKNAVILNYQ 
      1160       1170       1180       1190       1200
TLLKEIITIE DVPSDILKKC CEIFTDYNIT YSDLSTNASS KTEYDCIYEL 
      1210       1220       1230       1240       1250
ITGFPPLYQL ISKYDAMTDE FVEKVLLLFN SAIKYPLLPE FVQDKTKPSS 
      1260       1270       1280       1290       1300
MQKAILSGLD IFMTNDSKDT EILILLQLST ISILAFDTRE KITKKLGPKL 
      1310       1320       1330       1340       1350
PKASLNRLPT FEAISYMSCS NLRNRIAKID QFGISTLKAK HILRILKNLA 
      1360       1370       1380       1390       1400
EIIKRKSLIT GSESDEIPIW VLASNCFCDL SNKIFKSLQE DAENPLKDNF 
      1410       1420       1430       1440       1450
CDLFINVIVV TLQRINPELD NLTEIDDLNE YSKYREILLE NRIIDLFNER 
      1460       1470       1480       1490       1500
QLDTFIYAVW DCSFLYEFDE LENALMQDCG TFSELSQKLS SFDFSCIFGS 
      1510       1520       1530       1540       1550
TTNPRFQTKY KCSLECLQDL VNFMLNTNEK LRKLTAPYLS ARIALALRRY 
      1560       1570       1580       1590       1600
ISDEYLIGRA PIPKLRKTEL ATLLNGLCVI LRGVLDQNST LGNKQIGVEN 
      1610       1620       1630 
LQTLSPLILR TIPVSHKMDG LQDKVLELSL GFTKLD
Length:1,636
Mass (Da):186,836
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0B3D8E6B0D994D6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U23084 Genomic DNA Translation: AAC49101.1
Z71573 Genomic DNA Translation: CAA96214.1
BK006947 Genomic DNA Translation: DAA10263.1

Protein sequence database of the Protein Information Resource

More...PIRi		S60403

NCBI Reference Sequences

More...RefSeqi		NP_014102.1, NM_001183135.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YNL297C_mRNA; YNL297C; YNL297C

Database of genes from NCBI RefSeq genomes

More...GeneIDi		855420

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YNL297C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23084 Genomic DNA Translation: AAC49101.1
Z71573 Genomic DNA Translation: CAA96214.1
BK006947 Genomic DNA Translation: DAA10263.1
PIRiS60403
RefSeqiNP_014102.1, NM_001183135.1

3D structure databases

SMRiP48563
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35541, 448 interactors
ComplexPortaliCPX-1028, NEO1-MON2-ARL1-DOP1 membrane remodeling complex
IntActiP48563, 8 interactors
MINTiP48563
STRINGi4932.YNL297C

PTM databases

iPTMnetiP48563

Proteomic databases

MaxQBiP48563
PaxDbiP48563
PRIDEiP48563

Genome annotation databases

EnsemblFungiiYNL297C_mRNA; YNL297C; YNL297C
GeneIDi855420
KEGGisce:YNL297C

Organism-specific databases

SGDiS000005241, MON2
VEuPathDBiFungiDB:YNL297C

Phylogenomic databases

eggNOGiKOG1848, Eukaryota
GeneTreeiENSGT00940000174858
HOGENOMiCLU_001169_1_0_1
InParanoidiP48563
OMAiYIPSQAF

Miscellaneous databases

Protein Ontology

More...PROi		PR:P48563
RNActiP48563, protein

Family and domain databases

InterProiView protein in InterPro
IPR032629, DCB_dom
IPR026829, Mon2-like
IPR032817, Mon2_C
IPR032691, Sec7_N
PANTHERiPTHR10663:SF333, PTHR10663:SF333, 1 hit
PfamiView protein in Pfam
PF16213, DCB, 1 hit
PF16206, Mon2_C, 1 hit
PF12783, Sec7_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMON2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48563
Secondary accession number(s): D6W0P7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 7, 2021
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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