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UniProtKB - P48563 (MON2_YEAST)
Protein
Protein MON2
Gene
MON2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure.
4 PublicationsMiscellaneous
Present with 2410 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: SGD
GO - Biological processi
- endocytosis Source: SGD
- Golgi to endosome transport Source: HGNC-UCL
- protein targeting to vacuole Source: SGD
- retrograde transport, endosome to Golgi Source: SGD
- trans-Golgi network membrane organization Source: ComplexPortal
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Protein MON2 |
Gene namesi | Name:MON2 Synonyms:YSL2 Ordered Locus Names:YNL297C ORF Names:N0453 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005241, MON2 |
VEuPathDBi | FungiDB:YNL297C |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 3 Publications; Peripheral membrane protein 3 Publications
Note: Late Golgi.
Cytosol
- cytosol Source: GOC
Endosome
- early endosome membrane Source: SGD
- endosome Source: SGD
- endosome membrane Source: ComplexPortal
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
- trans-Golgi network Source: SGD
Other locations
- extrinsic component of membrane Source: SGD
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000203372 | 2 – 1636 | Protein MON2Add BLAST | 1635 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 564 | PhosphoserineCombined sources | 1 | |
Modified residuei | 567 | PhosphoserineCombined sources | 1 | |
Modified residuei | 571 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | P48563 |
PaxDbi | P48563 |
PRIDEi | P48563 |
PTM databases
iPTMneti | P48563 |
Interactioni
Subunit structurei
Homodimer.
Interacts with DOP1, ARL1 and NEO1.
4 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 35541, 449 interactors |
ComplexPortali | CPX-1028, NEO1-MON2-ARL1-DOP1 membrane remodeling complex |
IntActi | P48563, 8 interactors |
MINTi | P48563 |
STRINGi | 4932.YNL297C |
Miscellaneous databases
RNActi | P48563, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 60 – 410 | Golgi membrane targeting and interaction with ARL11 PublicationAdd BLAST | 351 | |
Regioni | 547 – 596 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 1501 – 1636 | Required for function in membrane traffickingAdd BLAST | 136 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 547 – 586 | Polar residuesSequence analysisAdd BLAST | 40 |
Sequence similaritiesi
Belongs to the MON2 family.Curated
Phylogenomic databases
eggNOGi | KOG1848, Eukaryota |
GeneTreei | ENSGT00940000174858 |
HOGENOMi | CLU_001169_1_0_1 |
InParanoidi | P48563 |
OMAi | DETIDCQ |
Family and domain databases
InterProi | View protein in InterPro IPR032629, DCB_dom IPR026829, Mon2-like IPR032817, Mon2_C IPR032691, Sec7_N |
PANTHERi | PTHR10663:SF333, PTHR10663:SF333, 1 hit |
Pfami | View protein in Pfam PF16213, DCB, 1 hit PF16206, Mon2_C, 1 hit PF12783, Sec7_N, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P48563-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMNTGGFDS MQRQLEAELR SLSSESKRRN STIRHASDKS IEILKRVHSF
60 70 80 90 100
EELERHPDFA LPFVLACQSR NAKMTTLAMQ CLQGLSTVPS IPRSRLSEIL
110 120 130 140 150
DAFIEATHLA MEIQLKVLQV VPIFFKTYGK FIYGPLCKKL LLCCSNLLHV
160 170 180 190 200
PNKAPVVVGT ASATLQQLID EIFDRLSIES VVDDKQYEVL ISNSESIKVN
210 220 230 240 250
VYRYDANKLF DNICSLNEIS SNGAVSDEEM LLDIGDIPID YGLEILESIL
260 270 280 290 300
KNSQKNLLEC QDLQYLLRVK AIPLLLRCIS SSRHFSTAVR SCRCLKLLIR
310 320 330 340 350
KEYLSILELE LEVILSLLIH GISVESNLSG WQRVLSLELF KDLSQDPEIV
360 370 380 390 400
NTLYMDYDNY PDKKHVFKYL LKECIVLLNS PEYITFLAPS KVVEKMDSPL
410 420 430 440 450
ITTENSTVKT KFMHLLDKSN APSINITYII SLILTICNHL CEGLNKSALE
460 470 480 490 500
SSPLEKKIED KEREEGTGND STVVKVYSGL FSGLFELNKL FLYSTSLETS
510 520 530 540 550
IFHLVVRAFQ KLAHSAGVLS LKDKLRACMK LFSILITNNV TSSNQYSFND
560 570 580 590 600
TSKSAKNQHT RNISTSSVTT SPVESTKNPS RSIADSAQNK EMKRRLHPRN
610 620 630 640 650
ISSRQVSLLR ALISLSISLG PIFDSESWRY TFLTWQWITY YIYGPSADFK
660 670 680 690 700
ESFYSEDIPP PPILTKSDVT SIESSLTKFF ESTSSYSCST FHLVLTRLIL
710 720 730 740 750
DSKNTLTLEQ TNLNLNNDIG YHPLDAKDEI IPCIYNKAFF VNKIGELATY
760 770 780 790 800
NCKKFLFGKN GKELWSLIST YMIKLISNRE MDNDSLRLYT VRVFTDIIKK
810 820 830 840 850
ATNEVGNSDE QDNKVKQFGT LENLVIDSLM ATINSIKQLD IGKQEIYNGT
860 870 880 890 900
INVESDILFQ LLLTLKEILN EFGELLMNSW TNIFNIINSP FEWTVEDTDF
910 920 930 940 950
SVNEDIDDSS LFEGIVQKHK NMIQVSYDVF KLISDDFLQS LPMSVIKFVI
960 970 980 990 1000
DTLVNFVSQK RNLNISFSSI SQFWLVGDYL RVRFNPETLN LSDEKRRSLS
1010 1020 1030 1040 1050
EKINNQKLIE IITSSSSHDW ELYNGLWIYL LKNLINCTND DRVEVKNGAV
1060 1070 1080 1090 1100
QTFFRIIDSH SVCFPPWDLI FLEVIEPLLT KEWSTEELEN ETDFINVTLQ
1110 1120 1130 1140 1150
GLIKLYPEHF KDFKNNTTCA KEWSMLLDFL KRLLSSTSNN TKNAVILNYQ
1160 1170 1180 1190 1200
TLLKEIITIE DVPSDILKKC CEIFTDYNIT YSDLSTNASS KTEYDCIYEL
1210 1220 1230 1240 1250
ITGFPPLYQL ISKYDAMTDE FVEKVLLLFN SAIKYPLLPE FVQDKTKPSS
1260 1270 1280 1290 1300
MQKAILSGLD IFMTNDSKDT EILILLQLST ISILAFDTRE KITKKLGPKL
1310 1320 1330 1340 1350
PKASLNRLPT FEAISYMSCS NLRNRIAKID QFGISTLKAK HILRILKNLA
1360 1370 1380 1390 1400
EIIKRKSLIT GSESDEIPIW VLASNCFCDL SNKIFKSLQE DAENPLKDNF
1410 1420 1430 1440 1450
CDLFINVIVV TLQRINPELD NLTEIDDLNE YSKYREILLE NRIIDLFNER
1460 1470 1480 1490 1500
QLDTFIYAVW DCSFLYEFDE LENALMQDCG TFSELSQKLS SFDFSCIFGS
1510 1520 1530 1540 1550
TTNPRFQTKY KCSLECLQDL VNFMLNTNEK LRKLTAPYLS ARIALALRRY
1560 1570 1580 1590 1600
ISDEYLIGRA PIPKLRKTEL ATLLNGLCVI LRGVLDQNST LGNKQIGVEN
1610 1620 1630
LQTLSPLILR TIPVSHKMDG LQDKVLELSL GFTKLD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U23084 Genomic DNA Translation: AAC49101.1 Z71573 Genomic DNA Translation: CAA96214.1 BK006947 Genomic DNA Translation: DAA10263.1 |
PIRi | S60403 |
RefSeqi | NP_014102.1, NM_001183135.1 |
Genome annotation databases
EnsemblFungii | YNL297C_mRNA; YNL297C; YNL297C |
GeneIDi | 855420 |
KEGGi | sce:YNL297C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U23084 Genomic DNA Translation: AAC49101.1 Z71573 Genomic DNA Translation: CAA96214.1 BK006947 Genomic DNA Translation: DAA10263.1 |
PIRi | S60403 |
RefSeqi | NP_014102.1, NM_001183135.1 |
3D structure databases
AlphaFoldDBi | P48563 |
SMRi | P48563 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35541, 449 interactors |
ComplexPortali | CPX-1028, NEO1-MON2-ARL1-DOP1 membrane remodeling complex |
IntActi | P48563, 8 interactors |
MINTi | P48563 |
STRINGi | 4932.YNL297C |
PTM databases
iPTMneti | P48563 |
Proteomic databases
MaxQBi | P48563 |
PaxDbi | P48563 |
PRIDEi | P48563 |
Genome annotation databases
EnsemblFungii | YNL297C_mRNA; YNL297C; YNL297C |
GeneIDi | 855420 |
KEGGi | sce:YNL297C |
Organism-specific databases
SGDi | S000005241, MON2 |
VEuPathDBi | FungiDB:YNL297C |
Phylogenomic databases
eggNOGi | KOG1848, Eukaryota |
GeneTreei | ENSGT00940000174858 |
HOGENOMi | CLU_001169_1_0_1 |
InParanoidi | P48563 |
OMAi | DETIDCQ |
Miscellaneous databases
PROi | PR:P48563 |
RNActi | P48563, protein |
Family and domain databases
InterProi | View protein in InterPro IPR032629, DCB_dom IPR026829, Mon2-like IPR032817, Mon2_C IPR032691, Sec7_N |
PANTHERi | PTHR10663:SF333, PTHR10663:SF333, 1 hit |
Pfami | View protein in Pfam PF16213, DCB, 1 hit PF16206, Mon2_C, 1 hit PF12783, Sec7_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MON2_YEAST | |
Accessioni | P48563Primary (citable) accession number: P48563 Secondary accession number(s): D6W0P7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names - SIMILARITY comments
Index of protein domains and families