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Protein

Ras-related protein Rac2

Gene

Rac2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW
  • protein kinase binding Source: FlyBase

GO - Biological processi

  • actin cytoskeleton reorganization Source: FlyBase
  • actin filament bundle assembly Source: FlyBase
  • adherens junction maintenance Source: FlyBase
  • aggressive behavior Source: FlyBase
  • cell morphogenesis Source: FlyBase
  • defense response to bacterium Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • dorsal closure Source: FlyBase
  • dorsal closure, elongation of leading edge cells Source: FlyBase
  • encapsulation of foreign target Source: FlyBase
  • feeding behavior Source: FlyBase
  • germ-band shortening Source: FlyBase
  • head involution Source: FlyBase
  • hemocyte migration Source: FlyBase
  • immune response-regulating cell surface receptor signaling pathway involved in phagocytosis Source: FlyBase
  • JNK cascade Source: FlyBase
  • lamellipodium assembly Source: FlyBase
  • mating behavior Source: FlyBase
  • melanotic encapsulation of foreign target Source: FlyBase
  • morphogenesis of an epithelium Source: FlyBase
  • muscle attachment Source: FlyBase
  • myoblast fusion Source: FlyBase
  • open tracheal system development Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of wound healing Source: FlyBase
  • regulation of axonogenesis Source: FlyBase
  • regulation of lipid storage Source: FlyBase
  • Rho protein signal transduction Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • tracheal outgrowth, open tracheal system Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein
Biological processPhagocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-114604 GPVI-mediated activation cascade
R-DME-1433557 Signaling by SCF-KIT
R-DME-193648 NRAGE signals death through JNK
R-DME-194840 Rho GTPase cycle
R-DME-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DME-376172 DSCAM interactions
R-DME-389359 CD28 dependent Vav1 pathway
R-DME-3928662 EPHB-mediated forward signaling
R-DME-3928664 Ephrin signaling
R-DME-3928665 EPH-ephrin mediated repulsion of cells
R-DME-4086400 PCP/CE pathway
R-DME-416482 G alpha (12/13) signalling events
R-DME-418885 DCC mediated attractive signaling
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-445144 Signal transduction by L1
R-DME-5218920 VEGFR2 mediated vascular permeability
R-DME-5625740 RHO GTPases activate PKNs
R-DME-5625900 RHO GTPases activate CIT
R-DME-5627123 RHO GTPases activate PAKs
R-DME-5663213 RHO GTPases Activate WASPs and WAVEs
R-DME-5687128 MAPK6/MAPK4 signaling
R-DME-6798695 Neutrophil degranulation
R-DME-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-DME-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rac2
Gene namesi
Name:Rac2
Synonyms:RacB
ORF Names:CG8556
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0014011 Rac2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988941 – 189Ras-related protein Rac2Add BLAST189
PropeptideiPRO_0000281245190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei189Cysteine methyl esterBy similarity1
Lipidationi189S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP48554
PRIDEiP48554

Expressioni

Gene expression databases

BgeeiFBgn0014011
ExpressionAtlasiP48554 baseline and differential
GenevisibleiP48554 DM

Interactioni

Subunit structurei

Interacts with Pkn (via N-terminus).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PakQ242133EBI-74869,EBI-74826

GO - Molecular functioni

  • protein kinase binding Source: FlyBase

Protein-protein interaction databases

BioGridi64269, 21 interactors
DIPiDIP-18225N
IntActiP48554, 7 interactors
STRINGi7227.FBpp0305023

Structurei

3D structure databases

ProteinModelPortaliP48554
SMRiP48554
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
InParanoidiP48554
KOiK04392
OMAiKAKWFPE
OrthoDBiEOG091G0KCM
PhylomeDBiP48554

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDAKP
60 70 80 90 100
INLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVNPASF ENVRAKWFPE
110 120 130 140 150
VRHHCPSVPI ILVGTKLDLR DDKQTIEKLK DKKLTPITYP QGLAMAKEIA
160 170 180 190
AVKYLECSAL TQKGLKTVFD EAIRSVLCPV VRGPKRHKCA LL
Length:192
Mass (Da):21,359
Last modified:February 1, 1996 - v1
Checksum:i06AE11CC18019982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38310 mRNA Translation: AAA67041.1
Z35643 mRNA Translation: CAA84710.1
AE014296 Genomic DNA Translation: AAF50559.1
AY118845 mRNA Translation: AAM50705.1
PIRiS54296
RefSeqiNP_001261517.1, NM_001274588.2
NP_648121.1, NM_139864.3
UniGeneiDm.3545

Genome annotation databases

EnsemblMetazoaiFBtr0076867; FBpp0076577; FBgn0014011
FBtr0332800; FBpp0305023; FBgn0014011
GeneIDi38831
KEGGidme:Dmel_CG8556

Similar proteinsi

Entry informationi

Entry nameiRAC2_DROME
AccessioniPrimary (citable) accession number: P48554
Secondary accession number(s): Q540X5, Q9VS69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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