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Protein

Trafficking protein particle complex subunit 10

Gene

TRAPPC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functioni

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • early endosome to Golgi transport Source: GO_Central
  • intra-Golgi vesicle-mediated transport Source: GO_Central
  • protein complex oligomerization Source: UniProtKB

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 10
Alternative name(s):
Epilepsy holoprosencephaly candidate 1 protein
Short name:
EHOC-1
Protein GT334
Trafficking protein particle complex subunit TMEM1
Transport protein particle subunit TMEM1
Short name:
TRAPP subunit TMEM1
Gene namesi
Name:TRAPPC10
Synonyms:EHOC1, TMEM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160218.12
HGNCiHGNC:11868 TRAPPC10
MIMi602103 gene
neXtProtiNX_P48553

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7109
OpenTargetsiENSG00000160218
PharmGKBiPA162406870

Polymorphism and mutation databases

BioMutaiTRAPPC10
DMDMi12644285

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935091 – 1259Trafficking protein particle complex subunit 10Add BLAST1259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei708PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP48553
MaxQBiP48553
PaxDbiP48553
PeptideAtlasiP48553
PRIDEiP48553
ProteomicsDBi55909

PTM databases

iPTMnetiP48553
PhosphoSitePlusiP48553

Expressioni

Tissue specificityi

Expressed in all tissues examined.

Gene expression databases

BgeeiENSG00000160218 Expressed in 142 organ(s), highest expression level in corpus callosum
CleanExiHS_TRAPPC10
ExpressionAtlasiP48553 baseline and differential
GenevisibleiP48553 HS

Organism-specific databases

HPAiHPA050423

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RAB3IPQ96QF07EBI-6160572,EBI-747844

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112964, 42 interactors
CORUMiP48553
DIPiDIP-48281N
IntActiP48553, 7 interactors
MINTiP48553
STRINGi9606.ENSP00000291574

Structurei

3D structure databases

ProteinModelPortaliP48553
SMRiP48553
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM1 family.Curated

Phylogenomic databases

eggNOGiKOG1931 Eukaryota
ENOG410XNVF LUCA
GeneTreeiENSGT00390000003873
HOGENOMiHOG000046007
HOVERGENiHBG067402
InParanoidiP48553
KOiK20307
OMAiFQVENFF
OrthoDBiEOG091G02NV
PhylomeDBiP48553
TreeFamiTF320954

Family and domain databases

InterProiView protein in InterPro
IPR022233 TRAPP_II_complex_TRAPPC10
PfamiView protein in Pfam
PF12584 TRAPPC10, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P48553-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDASEEPLPP VIYTMENKPI VTCAGDQNLF TSVYPTLSQQ LPREPMEWRR
60 70 80 90 100
SYGRAPKMIH LESNFVQFKE ELLPKEGNKA LLTFPFLHIY WTECCDTEVY
110 120 130 140 150
KATVKDDLTK WQNVLKAHSS VDWLIVIVEN DAKKKNKTNI LPRTSIVDKI
160 170 180 190 200
RNDFCNKQSD RCVVLSDPLK DSSRTQESWN AFLTKLRTLL LMSFTKNLGK
210 220 230 240 250
FEDDMRTLRE KRTEPGWSFC EYFMVQEELA FVFEMLQQFE DALVQYDELD
260 270 280 290 300
ALFSQYVVNF GAGDGANWLT FFCQPVKSWN GLILRKPIDM EKRESIQRRE
310 320 330 340 350
ATLLDLRSYL FSRQCTLLLF LQRPWEVAQR ALELLHNCVQ ELKLLEVSVP
360 370 380 390 400
PGALDCWVFL SCLEVLQRIE GCCDRAQIDS NIAHTVGLWS YATEKLKSLG
410 420 430 440 450
YLCGLVSEKG PNSEDLNRTV DLLAGLGAER PETANTAQSP YKKLKEALSS
460 470 480 490 500
VEAFEKHYLD LSHATIEMYT SIGRIRSAKF VGKDLAEFYM RKKAPQKAEI
510 520 530 540 550
YLQGALKNYL AEGWALPITH TRKQLAECQK HLGQIENYLQ TSSLLASDHH
560 570 580 590 600
LTEEERKHFC QEILDFASQP SDSPGHKIVL PMHSFAQLRD LHFDPSNAVV
610 620 630 640 650
HVGGVLCVEI TMYSQMPVPV HVEQIVVNVH FSIEKNSYRK TAEWLTKHKT
660 670 680 690 700
SNGIINFPPE TAPFPVSQNS LPALELYEMF ERSPSDNSLN TTGIICRNVH
710 720 730 740 750
MLLRRQESSS SLEMPSGVAL EEGAHVLRCS HVTLEPGANQ ITFRTQAKEP
760 770 780 790 800
GTYTLRQLCA SVGSVWFVLP HIYPIVQYDV YSQEPQLHVE PLADSLLAGI
810 820 830 840 850
PQRVKFTVTT GHYTIKNGDS LQLSNAEAML ILCQAESRAV VYSNTREQSS
860 870 880 890 900
EAALRIQSSD KVTSISLPVA PAYHVIEFEL EVLSLPSAPA LGGESDMLGM
910 920 930 940 950
AEPHRKHKDK QRTGRCMVTT DHKVSIDCPW SIYSTVIALT FSVPFRTTHS
960 970 980 990 1000
LLSSGTRKYV QVCVQNLSEL DFQLSDSYLV DTGDSTDLQL VPLNTQSQQP
1010 1020 1030 1040 1050
IYSKQSVFFV WELKWTEEPP PSLHCRFSVG FSPASEEQLS ISLKPYTYEF
1060 1070 1080 1090 1100
KVENFFTLYN VKAEIFPPSG MEYCRTGSLC SLEVLITRLS DLLEVDKDEA
1110 1120 1130 1140 1150
LTESDEHFST KLMYEVVDNS SNWAVCGKSC GVISMPVAAR ATHRVHMEVM
1160 1170 1180 1190 1200
PLFAGYLPLP DVRLFKYLPH HSAHSSQLDA DSWIENDSLS VDKHGDDQPD
1210 1220 1230 1240 1250
SSSLKSRGSV HSACSSEHKG LPMPRLQALP AGQVFNSSSG TQVLVIPSQD

DHVLEVSVT
Length:1,259
Mass (Da):142,189
Last modified:December 1, 2000 - v2
Checksum:iE8AB6847C9C6FE0C
GO
Isoform 2 (identifier: P48553-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-276: DGANWLTFFCQPV → GIKCPFHNSVACW
     277-1259: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):32,173
Checksum:i33730891ECCDACE7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WE24F8WE24_HUMAN
Trafficking protein particle comple...
TRAPPC10
265Annotation score:

Sequence cautioni

The sequence AAC50134 differs from that shown. Reason: Frameshift at position 1187.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114V → A in AAB58468 (PubMed:9370297).Curated1
Sequence conflicti121V → A in AAB58468 (PubMed:9370297).Curated1
Sequence conflicti813Y → D in AAC50134 (PubMed:7633421).Curated1
Sequence conflicti910K → Q in AAC51826 (PubMed:9370297).Curated1
Sequence conflicti910K → Q in AAB58468 (PubMed:9370297).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009514257V → E1 Publication1
Natural variantiVAR_009515633I → M1 PublicationCorresponds to variant dbSNP:rs915877Ensembl.1
Natural variantiVAR_009516726V → M Common polymorphism. 1 PublicationCorresponds to variant dbSNP:rs2071152Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056589264 – 276DGANW…FCQPV → GIKCPFHNSVACW in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_056590277 – 1259Missing in isoform 2. 1 PublicationAdd BLAST983

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19252 mRNA Translation: AAC50134.1 Frameshift.
AB001523 Genomic DNA Translation: BAA21099.1
U61500 mRNA Translation: AAC51826.1
U61520
, U61501, U61502, U61503, U61504, U61505, U61506, U61507, U61508, U61509, U61510, U61511, U61512, U61513, U61514, U61515, U61516, U61517, U61518, U61519 Genomic DNA Translation: AAB58468.1
AB001517 Genomic DNA No translation available.
BC046241 mRNA Translation: AAH46241.1
BC052247 mRNA Translation: AAH52247.1
BC094823 mRNA Translation: AAH94823.1
BC101728 mRNA Translation: AAI01729.1
CCDSiCCDS13704.1 [P48553-1]
PIRiJC5523
RefSeqiNP_003265.3, NM_003274.4 [P48553-1]
XP_016855323.1, XM_016999834.1
UniGeneiHs.126221

Genome annotation databases

EnsembliENST00000291574; ENSP00000291574; ENSG00000160218 [P48553-1]
ENST00000380221; ENSP00000369570; ENSG00000160218 [P48553-2]
GeneIDi7109
KEGGihsa:7109
UCSCiuc002zdz.4 human [P48553-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19252 mRNA Translation: AAC50134.1 Frameshift.
AB001523 Genomic DNA Translation: BAA21099.1
U61500 mRNA Translation: AAC51826.1
U61520
, U61501, U61502, U61503, U61504, U61505, U61506, U61507, U61508, U61509, U61510, U61511, U61512, U61513, U61514, U61515, U61516, U61517, U61518, U61519 Genomic DNA Translation: AAB58468.1
AB001517 Genomic DNA No translation available.
BC046241 mRNA Translation: AAH46241.1
BC052247 mRNA Translation: AAH52247.1
BC094823 mRNA Translation: AAH94823.1
BC101728 mRNA Translation: AAI01729.1
CCDSiCCDS13704.1 [P48553-1]
PIRiJC5523
RefSeqiNP_003265.3, NM_003274.4 [P48553-1]
XP_016855323.1, XM_016999834.1
UniGeneiHs.126221

3D structure databases

ProteinModelPortaliP48553
SMRiP48553
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112964, 42 interactors
CORUMiP48553
DIPiDIP-48281N
IntActiP48553, 7 interactors
MINTiP48553
STRINGi9606.ENSP00000291574

PTM databases

iPTMnetiP48553
PhosphoSitePlusiP48553

Polymorphism and mutation databases

BioMutaiTRAPPC10
DMDMi12644285

Proteomic databases

EPDiP48553
MaxQBiP48553
PaxDbiP48553
PeptideAtlasiP48553
PRIDEiP48553
ProteomicsDBi55909

Protocols and materials databases

DNASUi7109
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291574; ENSP00000291574; ENSG00000160218 [P48553-1]
ENST00000380221; ENSP00000369570; ENSG00000160218 [P48553-2]
GeneIDi7109
KEGGihsa:7109
UCSCiuc002zdz.4 human [P48553-1]

Organism-specific databases

CTDi7109
DisGeNETi7109
EuPathDBiHostDB:ENSG00000160218.12
GeneCardsiTRAPPC10
HGNCiHGNC:11868 TRAPPC10
HPAiHPA050423
MIMi602103 gene
neXtProtiNX_P48553
OpenTargetsiENSG00000160218
PharmGKBiPA162406870
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1931 Eukaryota
ENOG410XNVF LUCA
GeneTreeiENSGT00390000003873
HOGENOMiHOG000046007
HOVERGENiHBG067402
InParanoidiP48553
KOiK20307
OMAiFQVENFF
OrthoDBiEOG091G02NV
PhylomeDBiP48553
TreeFamiTF320954

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTRAPPC10 human
GeneWikiiTMEM1
GenomeRNAii7109
PROiPR:P48553
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160218 Expressed in 142 organ(s), highest expression level in corpus callosum
CleanExiHS_TRAPPC10
ExpressionAtlasiP48553 baseline and differential
GenevisibleiP48553 HS

Family and domain databases

InterProiView protein in InterPro
IPR022233 TRAPP_II_complex_TRAPPC10
PfamiView protein in Pfam
PF12584 TRAPPC10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPC10_HUMAN
AccessioniPrimary (citable) accession number: P48553
Secondary accession number(s): Q3MIR2
, Q86SI7, Q9UMD4, Q9Y4L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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