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Entry version 171 (03 Jul 2019)
Sequence version 2 (01 Dec 2000)
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Protein

Trafficking protein particle complex subunit 10

Gene

TRAPPC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 10
Alternative name(s):
Epilepsy holoprosencephaly candidate 1 protein
Short name:
EHOC-1
Protein GT334
Trafficking protein particle complex subunit TMEM1
Transport protein particle subunit TMEM1
Short name:
TRAPP subunit TMEM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC10
Synonyms:EHOC1, TMEM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11868 TRAPPC10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602103 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48553

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7109

Open Targets

More...
OpenTargetsi
ENSG00000160218

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162406870

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAPPC10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12644285

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001935091 – 1259Trafficking protein particle complex subunit 10Add BLAST1259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei708PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P48553

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P48553

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P48553

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48553

PeptideAtlas

More...
PeptideAtlasi
P48553

PRoteomics IDEntifications database

More...
PRIDEi
P48553

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55909

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48553

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48553

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160218 Expressed in 142 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P48553 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P48553 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050423

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RAB3IPQ96QF07EBI-6160572,EBI-747844

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112964, 56 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P48553

Database of interacting proteins

More...
DIPi
DIP-48281N

Protein interaction database and analysis system

More...
IntActi
P48553, 10 interactors

Molecular INTeraction database

More...
MINTi
P48553

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291574

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P48553

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1931 Eukaryota
ENOG410XNVF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003873

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046007

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48553

KEGG Orthology (KO)

More...
KOi
K20307

Identification of Orthologs from Complete Genome Data

More...
OMAi
FFMQEDL

Database of Orthologous Groups

More...
OrthoDBi
537782at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48553

TreeFam database of animal gene trees

More...
TreeFami
TF320954

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022233 TRAPP_II_complex_TRAPPC10

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12584 TRAPPC10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P48553-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDASEEPLPP VIYTMENKPI VTCAGDQNLF TSVYPTLSQQ LPREPMEWRR
60 70 80 90 100
SYGRAPKMIH LESNFVQFKE ELLPKEGNKA LLTFPFLHIY WTECCDTEVY
110 120 130 140 150
KATVKDDLTK WQNVLKAHSS VDWLIVIVEN DAKKKNKTNI LPRTSIVDKI
160 170 180 190 200
RNDFCNKQSD RCVVLSDPLK DSSRTQESWN AFLTKLRTLL LMSFTKNLGK
210 220 230 240 250
FEDDMRTLRE KRTEPGWSFC EYFMVQEELA FVFEMLQQFE DALVQYDELD
260 270 280 290 300
ALFSQYVVNF GAGDGANWLT FFCQPVKSWN GLILRKPIDM EKRESIQRRE
310 320 330 340 350
ATLLDLRSYL FSRQCTLLLF LQRPWEVAQR ALELLHNCVQ ELKLLEVSVP
360 370 380 390 400
PGALDCWVFL SCLEVLQRIE GCCDRAQIDS NIAHTVGLWS YATEKLKSLG
410 420 430 440 450
YLCGLVSEKG PNSEDLNRTV DLLAGLGAER PETANTAQSP YKKLKEALSS
460 470 480 490 500
VEAFEKHYLD LSHATIEMYT SIGRIRSAKF VGKDLAEFYM RKKAPQKAEI
510 520 530 540 550
YLQGALKNYL AEGWALPITH TRKQLAECQK HLGQIENYLQ TSSLLASDHH
560 570 580 590 600
LTEEERKHFC QEILDFASQP SDSPGHKIVL PMHSFAQLRD LHFDPSNAVV
610 620 630 640 650
HVGGVLCVEI TMYSQMPVPV HVEQIVVNVH FSIEKNSYRK TAEWLTKHKT
660 670 680 690 700
SNGIINFPPE TAPFPVSQNS LPALELYEMF ERSPSDNSLN TTGIICRNVH
710 720 730 740 750
MLLRRQESSS SLEMPSGVAL EEGAHVLRCS HVTLEPGANQ ITFRTQAKEP
760 770 780 790 800
GTYTLRQLCA SVGSVWFVLP HIYPIVQYDV YSQEPQLHVE PLADSLLAGI
810 820 830 840 850
PQRVKFTVTT GHYTIKNGDS LQLSNAEAML ILCQAESRAV VYSNTREQSS
860 870 880 890 900
EAALRIQSSD KVTSISLPVA PAYHVIEFEL EVLSLPSAPA LGGESDMLGM
910 920 930 940 950
AEPHRKHKDK QRTGRCMVTT DHKVSIDCPW SIYSTVIALT FSVPFRTTHS
960 970 980 990 1000
LLSSGTRKYV QVCVQNLSEL DFQLSDSYLV DTGDSTDLQL VPLNTQSQQP
1010 1020 1030 1040 1050
IYSKQSVFFV WELKWTEEPP PSLHCRFSVG FSPASEEQLS ISLKPYTYEF
1060 1070 1080 1090 1100
KVENFFTLYN VKAEIFPPSG MEYCRTGSLC SLEVLITRLS DLLEVDKDEA
1110 1120 1130 1140 1150
LTESDEHFST KLMYEVVDNS SNWAVCGKSC GVISMPVAAR ATHRVHMEVM
1160 1170 1180 1190 1200
PLFAGYLPLP DVRLFKYLPH HSAHSSQLDA DSWIENDSLS VDKHGDDQPD
1210 1220 1230 1240 1250
SSSLKSRGSV HSACSSEHKG LPMPRLQALP AGQVFNSSSG TQVLVIPSQD

DHVLEVSVT
Length:1,259
Mass (Da):142,189
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8AB6847C9C6FE0C
GO
Isoform 2 (identifier: P48553-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-276: DGANWLTFFCQPV → GIKCPFHNSVACW
     277-1259: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):32,173
Checksum:i33730891ECCDACE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WE24F8WE24_HUMAN
Trafficking protein particle comple...
TRAPPC10
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50134 differs from that shown. Reason: Frameshift at position 1187.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114V → A in AAB58468 (PubMed:9370297).Curated1
Sequence conflicti121V → A in AAB58468 (PubMed:9370297).Curated1
Sequence conflicti813Y → D in AAC50134 (PubMed:7633421).Curated1
Sequence conflicti910K → Q in AAC51826 (PubMed:9370297).Curated1
Sequence conflicti910K → Q in AAB58468 (PubMed:9370297).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_009514257V → E1 Publication1
Natural variantiVAR_009515633I → M1 PublicationCorresponds to variant dbSNP:rs915877Ensembl.1
Natural variantiVAR_009516726V → M Common polymorphism. 1 PublicationCorresponds to variant dbSNP:rs2071152Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056589264 – 276DGANW…FCQPV → GIKCPFHNSVACW in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_056590277 – 1259Missing in isoform 2. 1 PublicationAdd BLAST983

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U19252 mRNA Translation: AAC50134.1 Frameshift.
AB001523 Genomic DNA Translation: BAA21099.1
U61500 mRNA Translation: AAC51826.1
U61520
, U61501, U61502, U61503, U61504, U61505, U61506, U61507, U61508, U61509, U61510, U61511, U61512, U61513, U61514, U61515, U61516, U61517, U61518, U61519 Genomic DNA Translation: AAB58468.1
AB001517 Genomic DNA No translation available.
BC046241 mRNA Translation: AAH46241.1
BC052247 mRNA Translation: AAH52247.1
BC094823 mRNA Translation: AAH94823.1
BC101728 mRNA Translation: AAI01729.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13704.1 [P48553-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5523

NCBI Reference Sequences

More...
RefSeqi
NP_003265.3, NM_003274.4 [P48553-1]
XP_016855323.1, XM_016999834.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291574; ENSP00000291574; ENSG00000160218 [P48553-1]
ENST00000380221; ENSP00000369570; ENSG00000160218 [P48553-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7109

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7109

UCSC genome browser

More...
UCSCi
uc002zdz.4 human [P48553-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19252 mRNA Translation: AAC50134.1 Frameshift.
AB001523 Genomic DNA Translation: BAA21099.1
U61500 mRNA Translation: AAC51826.1
U61520
, U61501, U61502, U61503, U61504, U61505, U61506, U61507, U61508, U61509, U61510, U61511, U61512, U61513, U61514, U61515, U61516, U61517, U61518, U61519 Genomic DNA Translation: AAB58468.1
AB001517 Genomic DNA No translation available.
BC046241 mRNA Translation: AAH46241.1
BC052247 mRNA Translation: AAH52247.1
BC094823 mRNA Translation: AAH94823.1
BC101728 mRNA Translation: AAI01729.1
CCDSiCCDS13704.1 [P48553-1]
PIRiJC5523
RefSeqiNP_003265.3, NM_003274.4 [P48553-1]
XP_016855323.1, XM_016999834.1

3D structure databases

SMRiP48553
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112964, 56 interactors
CORUMiP48553
DIPiDIP-48281N
IntActiP48553, 10 interactors
MINTiP48553
STRINGi9606.ENSP00000291574

PTM databases

iPTMnetiP48553
PhosphoSitePlusiP48553

Polymorphism and mutation databases

BioMutaiTRAPPC10
DMDMi12644285

Proteomic databases

EPDiP48553
jPOSTiP48553
MaxQBiP48553
PaxDbiP48553
PeptideAtlasiP48553
PRIDEiP48553
ProteomicsDBi55909

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7109
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291574; ENSP00000291574; ENSG00000160218 [P48553-1]
ENST00000380221; ENSP00000369570; ENSG00000160218 [P48553-2]
GeneIDi7109
KEGGihsa:7109
UCSCiuc002zdz.4 human [P48553-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7109
DisGeNETi7109

GeneCards: human genes, protein and diseases

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GeneCardsi
TRAPPC10
HGNCiHGNC:11868 TRAPPC10
HPAiHPA050423
MIMi602103 gene
neXtProtiNX_P48553
OpenTargetsiENSG00000160218
PharmGKBiPA162406870

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1931 Eukaryota
ENOG410XNVF LUCA
GeneTreeiENSGT00390000003873
HOGENOMiHOG000046007
InParanoidiP48553
KOiK20307
OMAiFFMQEDL
OrthoDBi537782at2759
PhylomeDBiP48553
TreeFamiTF320954

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRAPPC10 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TMEM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7109

Protein Ontology

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PROi
PR:P48553

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000160218 Expressed in 142 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP48553 baseline and differential
GenevisibleiP48553 HS

Family and domain databases

InterProiView protein in InterPro
IPR022233 TRAPP_II_complex_TRAPPC10
PfamiView protein in Pfam
PF12584 TRAPPC10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPC10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48553
Secondary accession number(s): Q3MIR2
, Q86SI7, Q9UMD4, Q9Y4L3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: July 3, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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