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Entry version 169 (13 Feb 2019)
Sequence version 2 (01 Dec 2000)
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Protein

Nuclear receptor-interacting protein 1

Gene

NRIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • estrogen receptor binding Source: UniProtKB
  • glucocorticoid receptor binding Source: UniProtKB
  • histone deacetylase binding Source: Ensembl
  • nuclear hormone receptor binding Source: UniProtKB
  • retinoid X receptor binding Source: GO_Central
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400253 Circadian Clock
R-HSA-9018519 Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P48552

SIGNOR Signaling Network Open Resource

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SIGNORi
P48552

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor-interacting protein 1
Alternative name(s):
Nuclear factor RIP140
Receptor-interacting protein 140
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRIP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000180530.9

Human Gene Nomenclature Database

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HGNCi
HGNC:8001 NRIP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602490 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48552

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi440 – 443PIDL → AAAA: Abolishes interaction with CTBP1. 1 Publication4
Mutagenesisi440 – 442PID → AIA: Abolishes interaction with CTBP1 and attenuates nuclear hormone receptor-dependent transcription repression. 3
Mutagenesisi442 – 443DL → AA: Reduces, but does not completely abolish, interaction with CTBP. Reduces transcriptional repression. 2 Publications2
Mutagenesisi442 – 443DL → AS: Disrupts interaction with CTBP1, and CTBP2 to a lesser extent. Disrupts transcriptional repression; when associated with 567-AS-568. 2 Publications2
Mutagenesisi446K → Q: Disrupts interaction with CTBP1. Decreases lysine acetylation. Disrupts nuclear hormone receptor-dependent transcription repression. 1 Publication1
Mutagenesisi446K → R: Does not disrupt nuclear hormone receptor-dependent transcription repression. 1 Publication1
Mutagenesisi567 – 568NL → AA: Disrupts transcriptional repression. 2 Publications2
Mutagenesisi567 – 568NL → AS: Disrupts interaction with CTBP1 and CTBP2. Disrupts transcriptional repression; when associated with 442-AS-443. 2 Publications2
Mutagenesisi599 – 603SMDLT → PIAAS: Does not further disrupt transcriptional repression; when associated with 442-AA-443 and 567-AA-568. 5
Mutagenesisi948 – 949DL → AA: Abolishes CTBP binding but retains transcriptional repressor activity. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
8204

Open Targets

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OpenTargetsi
ENSG00000180530

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31780

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB06884 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NRIP1

Domain mapping of disease mutations (DMDM)

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DMDMi
9988061

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000579511 – 1158Nuclear receptor-interacting protein 1Add BLAST1158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104PhosphoserineBy similarity1
Modified residuei111N6-acetyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei158N6-acetyllysineBy similarity1
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei207PhosphothreonineBy similarity1
Modified residuei218PhosphoserineCombined sources1
Modified residuei286N6-acetyllysineBy similarity1
Modified residuei310N6-acetyllysineBy similarity1
Modified residuei356PhosphoserineBy similarity1
Cross-linki372Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei378PhosphoserineBy similarity1
Modified residuei446N6-acetyllysine1 Publication1
Modified residuei481N6-acetyllysineBy similarity1
Modified residuei487PhosphoserineBy similarity1
Cross-linki508Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei518PhosphoserineBy similarity1
Modified residuei528N6-acetyllysineBy similarity1
Modified residuei542PhosphoserineBy similarity1
Modified residuei564PhosphoserineCombined sources1
Modified residuei606N6-acetyllysineBy similarity1
Modified residuei671PhosphoserineCombined sources1
Cross-linki756Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki802Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei807PhosphoserineCombined sources1
Cross-linki850Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki901Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei931N6-acetyllysine; alternateBy similarity1
Cross-linki931Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1001PhosphoserineBy similarity1
Cross-linki1105Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation regulates its nuclear translocation and corepressive activity (By similarity). Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH.By similarity1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P48552

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P48552

MaxQB - The MaxQuant DataBase

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MaxQBi
P48552

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P48552

PeptideAtlas

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PeptideAtlasi
P48552

PRoteomics IDEntifications database

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PRIDEi
P48552

ProteomicsDB human proteome resource

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ProteomicsDBi
55908

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P48552

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P48552

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expressed in a circadian manner in the liver (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180530 Expressed in 242 organ(s), highest expression level in uterine cervix

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P48552 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P48552 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046571
HPA060036

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1 (By similarity). Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366. Interacts with RORA.By similarity14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113843, 59 interactors

Database of interacting proteins

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DIPi
DIP-5964N

Protein interaction database and analysis system

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IntActi
P48552, 26 interactors

Molecular INTeraction database

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MINTi
P48552

STRING: functional protein association networks

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STRINGi
9606.ENSP00000327213

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GPOX-ray1.95C366-390[»]
2GPPX-ray2.60C/D366-390[»]
4S14X-ray3.54C499-510[»]
4S15X-ray1.90C/D499-510[»]
5NTIX-ray2.40P/Q/R/S493-512[»]
5NTNX-ray1.90P/Q/R/S493-512[»]
5NTWX-ray1.64P/Q/R/S493-512[»]
5NU1X-ray1.85P/Q493-512[»]
6FZUX-ray1.80P/Q493-512[»]
6G05X-ray1.90P/Q493-512[»]
6G07X-ray1.66P/Q/R/S493-512[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P48552

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P48552

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P48552

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 415Interaction with ZNF3661 PublicationAdd BLAST415
Regioni78 – 333Repression domain 1Add BLAST256
Regioni410 – 700Repression domain 2Add BLAST291
Regioni431 – 472Required for targeting to small nuclear fociAdd BLAST42
Regioni735 – 885Repression domain 3Add BLAST151
Regioni753 – 1158Interaction with ZNF3661 PublicationAdd BLAST406
Regioni1118 – 1158Repression domain 4Add BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi21 – 25LXXLL motif 15
Motifi133 – 137LXXLL motif 25
Motifi185 – 189LXXLL motif 35
Motifi266 – 270LXXLL motif 45
Motifi380 – 384LXXLL motif 55
Motifi440 – 446CTBP-binding; principal site7
Motifi500 – 504LXXLL motif 65
Motifi565 – 569CTBP-binding5
Motifi599 – 603CTBP-bindingSequence analysis5
Motifi713 – 717LXXLL motif 75
Motifi819 – 823LXXLL motif 85
Motifi936 – 940LXXLL motif 95
Motifi946 – 950CTBP-binding5
Motifi1061 – 1074Ligand-dependent nuclear receptor bindingBy similarityAdd BLAST14

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFW7 Eukaryota
ENOG410XPVS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007999

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000236277

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052667

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P48552

KEGG Orthology (KO)

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KOi
K17965

Identification of Orthologs from Complete Genome Data

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OMAi
CDDLHIH

Database of Orthologous Groups

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OrthoDBi
345693at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P48552

TreeFam database of animal gene trees

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TreeFami
TF332210

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026649 NRIP1
IPR031405 NRIP1_RD1
IPR031406 NRIP1_RD2
IPR031407 NRIP1_RD3
IPR031408 NRIP1_RD4

The PANTHER Classification System

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PANTHERi
PTHR15088 PTHR15088, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15687 NRIP1_repr_1, 1 hit
PF15688 NRIP1_repr_2, 1 hit
PF15689 NRIP1_repr_3, 1 hit
PF15690 NRIP1_repr_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P48552-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHGEELGSD VHQDSIVLTY LEGLLMHQAA GGSGTAVDKK SAGHNEEDQN
60 70 80 90 100
FNISGSAFPT CQSNGPVLNT HTYQGSGMLH LKKARLLQSS EDWNAAKRKR
110 120 130 140 150
LSDSIMNLNV KKEALLAGMV DSVPKGKQDS TLLASLLQSF SSRLQTVALS
160 170 180 190 200
QQIRQSLKEQ GYALSHDSLK VEKDLRCYGV ASSHLKTLLK KSKVKDQKPD
210 220 230 240 250
TNLPDVTKNL IRDRFAESPH HVGQSGTKVM SEPLSCAARL QAVASMVEKR
260 270 280 290 300
ASPATSPKPS VACSQLALLL SSEAHLQQYS REHALKTQNA NQAASERLAA
310 320 330 340 350
MARLQENGQK DVGSYQLPKG MSSHLNGQAR TSSSKLMASK SSATVFQNPM
360 370 380 390 400
GIIPSSPKNA GYKNSLERNN IKQAANNSLL LHLLKSQTIP KPMNGHSHSE
410 420 430 440 450
RGSIFEESST PTTIDEYSDN NPSFTDDSSG DESSYSNCVP IDLSCKHRTE
460 470 480 490 500
KSESDQPVSL DNFTQSLLNT WDPKVPDVDI KEDQDTSKNS KLNSHQKVTL
510 520 530 540 550
LQLLLGHKNE ENVEKNTSPQ GVHNDVSKFN TQNYARTSVI ESPSTNRTTP
560 570 580 590 600
VSTPPLLTSS KAGSPINLSQ HSLVIKWNSP PYVCSTQSEK LTNTASNHSM
610 620 630 640 650
DLTKSKDPPG EKPAQNEGAQ NSATFSASKL LQNLAQCGMQ SSMSVEEQRP
660 670 680 690 700
SKQLLTGNTD KPIGMIDRLN SPLLSNKTNA VEENKAFSSQ PTGPEPGLSG
710 720 730 740 750
SEIENLLERR TVLQLLLGNP NKGKSEKKEK TPLRDESTQE HSERALSEQI
760 770 780 790 800
LMVKIKSEPC DDLQIPNTNV HLSHDAKSAP FLGMAPAVQR SAPALPVSED
810 820 830 840 850
FKSEPVSPQD FSFSKNGLLS RLLRQNQDSY LADDSDRSHR NNEMALLESK
860 870 880 890 900
NLCMVPKKRK LYTEPLENPF KKMKNNIVDA ANNHSAPEVL YGSLLNQEEL
910 920 930 940 950
KFSRNDLEFK YPAGHGSASE SEHRSWARES KSFNVLKQLL LSENCVRDLS
960 970 980 990 1000
PHRSNSVADS KKKGHKNNVT NSKPEFSISS LNGLMYSSTQ PSSCMDNRTF
1010 1020 1030 1040 1050
SYPGVVKTPV SPTFPEHLGC AGSRPESGLL NGCSMPSEKG PIKWVITDAE
1060 1070 1080 1090 1100
KNEYEKDSPR LTKTNPILYY MLQKGGNSVT SRETQDKDIW REASSAESVS
1110 1120 1130 1140 1150
QVTAKEELLP TAETKASFFN LRSPYNSHMG NNASRPHSAN GEVYGLLGSV

LTIKKESE
Length:1,158
Mass (Da):126,942
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81FC424968E9A5F6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J130C9J130_HUMAN
Nuclear receptor-interacting protei...
NRIP1
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUG9A0A1B0GUG9_HUMAN
Nuclear receptor-interacting protei...
NRIP1
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124P → R in CAA59108 (PubMed:7641693).Curated1
Sequence conflicti721 – 726NKGKSE → TKGRVK in CAA59108 (PubMed:7641693).Curated6
Sequence conflicti954S → I in AAH40361 (PubMed:15489334).Curated1
Sequence conflicti1080T → A in CAA59108 (PubMed:7641693).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05124137V → I. Corresponds to variant dbSNP:rs9941840Ensembl.1
Natural variantiVAR_023706221H → R1 PublicationCorresponds to variant dbSNP:rs139263261Ensembl.1
Natural variantiVAR_034142315Y → F. Corresponds to variant dbSNP:rs2228507Ensembl.1
Natural variantiVAR_023707441I → V1 PublicationCorresponds to variant dbSNP:rs150468995Ensembl.1
Natural variantiVAR_023708448R → G Common polymorphism. 2 PublicationsCorresponds to variant dbSNP:rs2229742Ensembl.1
Natural variantiVAR_051242567N → S. Corresponds to variant dbSNP:rs9975169Ensembl.1
Natural variantiVAR_023709803S → L1 PublicationCorresponds to variant dbSNP:rs61750208Ensembl.1
Natural variantiVAR_0237101079V → F1 PublicationCorresponds to variant dbSNP:rs140803495Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X84373 mRNA Translation: CAA59108.1
AF248484 Genomic DNA Translation: AAF62185.1
AF127577 Genomic DNA Translation: AAF35255.1
AL163207 Genomic DNA Translation: CAB90396.1
BC040361 mRNA Translation: AAH40361.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13568.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S57348

NCBI Reference Sequences

More...
RefSeqi
NP_003480.2, NM_003489.3
XP_005261120.1, XM_005261063.3
XP_005261122.1, XM_005261065.3
XP_011528049.1, XM_011529747.1
XP_011528050.1, XM_011529748.2
XP_011528051.1, XM_011529749.2
XP_011528053.1, XM_011529751.2
XP_011528054.1, XM_011529752.1
XP_016883962.1, XM_017028473.1
XP_016883963.1, XM_017028474.1
XP_016883964.1, XM_017028475.1
XP_016883965.1, XM_017028476.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.155017

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318948; ENSP00000327213; ENSG00000180530
ENST00000400199; ENSP00000383060; ENSG00000180530
ENST00000400202; ENSP00000383063; ENSG00000180530

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8204

UCSC genome browser

More...
UCSCi
uc002yjx.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84373 mRNA Translation: CAA59108.1
AF248484 Genomic DNA Translation: AAF62185.1
AF127577 Genomic DNA Translation: AAF35255.1
AL163207 Genomic DNA Translation: CAB90396.1
BC040361 mRNA Translation: AAH40361.1
CCDSiCCDS13568.1
PIRiS57348
RefSeqiNP_003480.2, NM_003489.3
XP_005261120.1, XM_005261063.3
XP_005261122.1, XM_005261065.3
XP_011528049.1, XM_011529747.1
XP_011528050.1, XM_011529748.2
XP_011528051.1, XM_011529749.2
XP_011528053.1, XM_011529751.2
XP_011528054.1, XM_011529752.1
XP_016883962.1, XM_017028473.1
XP_016883963.1, XM_017028474.1
XP_016883964.1, XM_017028475.1
XP_016883965.1, XM_017028476.1
UniGeneiHs.155017

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GPOX-ray1.95C366-390[»]
2GPPX-ray2.60C/D366-390[»]
4S14X-ray3.54C499-510[»]
4S15X-ray1.90C/D499-510[»]
5NTIX-ray2.40P/Q/R/S493-512[»]
5NTNX-ray1.90P/Q/R/S493-512[»]
5NTWX-ray1.64P/Q/R/S493-512[»]
5NU1X-ray1.85P/Q493-512[»]
6FZUX-ray1.80P/Q493-512[»]
6G05X-ray1.90P/Q493-512[»]
6G07X-ray1.66P/Q/R/S493-512[»]
ProteinModelPortaliP48552
SMRiP48552
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113843, 59 interactors
DIPiDIP-5964N
IntActiP48552, 26 interactors
MINTiP48552
STRINGi9606.ENSP00000327213

Chemistry databases

DrugBankiDB06884 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE

PTM databases

iPTMnetiP48552
PhosphoSitePlusiP48552

Polymorphism and mutation databases

BioMutaiNRIP1
DMDMi9988061

Proteomic databases

EPDiP48552
jPOSTiP48552
MaxQBiP48552
PaxDbiP48552
PeptideAtlasiP48552
PRIDEiP48552
ProteomicsDBi55908

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8204
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318948; ENSP00000327213; ENSG00000180530
ENST00000400199; ENSP00000383060; ENSG00000180530
ENST00000400202; ENSP00000383063; ENSG00000180530
GeneIDi8204
KEGGihsa:8204
UCSCiuc002yjx.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8204
DisGeNETi8204
EuPathDBiHostDB:ENSG00000180530.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NRIP1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0027827
HGNCiHGNC:8001 NRIP1
HPAiHPA046571
HPA060036
MIMi602490 gene
neXtProtiNX_P48552
OpenTargetsiENSG00000180530
PharmGKBiPA31780

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFW7 Eukaryota
ENOG410XPVS LUCA
GeneTreeiENSGT00390000007999
HOGENOMiHOG000236277
HOVERGENiHBG052667
InParanoidiP48552
KOiK17965
OMAiCDDLHIH
OrthoDBi345693at2759
PhylomeDBiP48552
TreeFamiTF332210

Enzyme and pathway databases

ReactomeiR-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-400253 Circadian Clock
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiP48552
SIGNORiP48552

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NRIP1 human
EvolutionaryTraceiP48552

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NRIP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8204

Protein Ontology

More...
PROi
PR:P48552

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000180530 Expressed in 242 organ(s), highest expression level in uterine cervix
ExpressionAtlasiP48552 baseline and differential
GenevisibleiP48552 HS

Family and domain databases

InterProiView protein in InterPro
IPR026649 NRIP1
IPR031405 NRIP1_RD1
IPR031406 NRIP1_RD2
IPR031407 NRIP1_RD3
IPR031408 NRIP1_RD4
PANTHERiPTHR15088 PTHR15088, 1 hit
PfamiView protein in Pfam
PF15687 NRIP1_repr_1, 1 hit
PF15688 NRIP1_repr_2, 1 hit
PF15689 NRIP1_repr_3, 1 hit
PF15690 NRIP1_repr_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRIP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48552
Secondary accession number(s): Q8IWE8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: February 13, 2019
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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