UniProtKB - P48551 (INAR2_HUMAN)
Protein
Interferon alpha/beta receptor 2
Gene
IFNAR2
Organism
Homo sapiens (Human)
Status
Functioni
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569, PubMed:32972995). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).8 Publications
GO - Molecular functioni
- cytokine receptor activity Source: GO_Central
- protein kinase binding Source: UniProtKB
- type I interferon binding Source: UniProtKB
- type I interferon receptor activity Source: UniProtKB
GO - Biological processi
- cell surface receptor signaling pathway Source: ProtInc
- cytokine-mediated signaling pathway Source: GO_Central
- defense response to virus Source: UniProtKB
- receptor signaling pathway via JAK-STAT Source: ProtInc
- regulation of type I interferon-mediated signaling pathway Source: Reactome
- response to interferon-alpha Source: UniProtKB
- response to interferon-beta Source: UniProtKB
- response to virus Source: ProtInc
- type I interferon signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | P48551 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling [P48551-2] R-HSA-912694, Regulation of IFNA signaling [P48551-2] R-HSA-9679191, Potential therapeutics for SARS [P48551-2] |
SignaLinki | P48551 |
SIGNORi | P48551 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon alpha/beta receptor 2Short name: IFN-R-2 Short name: IFN-alpha binding protein Short name: IFN-alpha/beta receptor 2 Alternative name(s): Interferon alpha binding protein Type I interferon receptor 2 |
Gene namesi | Name:IFNAR2 Synonyms:IFNABR, IFNARB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5433, IFNAR2 |
MIMi | 602376, gene |
neXtProti | NX_P48551 |
VEuPathDBi | HostDB:ENSG00000159110.19 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Plasma membrane
- Cell membrane 3 Publications; Single-pass type I membrane protein 1 Publication
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: ProtInc
- extracellular space Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 243 | ExtracellularSequence analysisAdd BLAST | 217 | |
Transmembranei | 244 – 264 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 265 – 515 | CytoplasmicSequence analysisAdd BLAST | 251 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Immunodeficiency 45 (IMD45)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination.
Related information in OMIMMutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 269 | Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318 and F-337. 2 Publications | 1 | |
Mutagenesisi | 306 | Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318 and F-337. 2 Publications | 1 | |
Mutagenesisi | 316 | Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318 and F-337. 2 Publications | 1 | |
Mutagenesisi | 318 | Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337. 2 Publications | 1 | |
Mutagenesisi | 337 | Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-318. 2 Publications | 1 | |
Mutagenesisi | 411 | Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. 2 Publications | 1 | |
Mutagenesisi | 512 | Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-411. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-411. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-411. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 3455 |
MalaCardsi | IFNAR2 |
MIMi | 610424, phenotype 616669, phenotype |
OpenTargetsi | ENSG00000159110 |
Orphaneti | 431166, Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection |
PharmGKBi | PA29671 |
Miscellaneous databases
Pharosi | P48551, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2364170 |
DrugBanki | DB00034, Interferon alfa-2a, Recombinant DB00105, Interferon alfa-2b DB00011, Interferon alfa-n1 DB00018, Interferon alfa-n3 DB00069, Interferon alfacon-1 DB00060, Interferon beta-1a DB00068, Interferon beta-1b DB06152, Nylidrin DB05472, omega interferon DB00008, Peginterferon alfa-2a DB00022, Peginterferon alfa-2b |
DrugCentrali | P48551 |
Genetic variation databases
BioMutai | IFNAR2 |
DMDMi | 1352466 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Add BLAST | 26 | |
ChainiPRO_0000011006 | 27 – 515 | Interferon alpha/beta receptor 2Add BLAST | 489 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 39 ↔ 122 | Combined sources4 Publications | ||
Glycosylationi | 58 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 85 ↔ 93 | Combined sources4 Publications | ||
Glycosylationi | 87 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 192 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 207 ↔ 227 | Combined sources4 Publications | ||
Modified residuei | 337 | Phosphotyrosine2 Publications | 1 | |
Modified residuei | 400 | PhosphoserineCombined sources | 1 | |
Modified residuei | 467 | PhosphoserineBy similarity | 1 | |
Modified residuei | 512 | Phosphotyrosine2 Publications | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.3 Publications
Glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P48551 |
MassIVEi | P48551 |
MaxQBi | P48551 |
PaxDbi | P48551 |
PeptideAtlasi | P48551 |
PRIDEi | P48551 |
ProteomicsDBi | 55905 [P48551-1] 55906 [P48551-2] 55907 [P48551-3] |
PTM databases
GlyConnecti | 2051, 4 N-Linked glycans (1 site) |
GlyGeni | P48551, 6 sites, 4 N-linked glycans (1 site) |
iPTMneti | P48551 |
PhosphoSitePlusi | P48551 |
Expressioni
Tissue specificityi
Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.3 Publications
Gene expression databases
Bgeei | ENSG00000159110, Expressed in blood and 241 other tissues |
ExpressionAtlasi | P48551, baseline and differential |
Genevisiblei | P48551, HS |
Organism-specific databases
HPAi | ENSG00000159110, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP48551
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- type I interferon binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109677, 13 interactors |
ComplexPortali | CPX-5995, Interferon alpha receptor-ligand complex, IFNA2 variant CPX-5996, Interferon alpha receptor-ligand complex, IFNA1 variant CPX-5997, Interferon alpha receptor-ligand complex, IFNA7 variant CPX-5998, Interferon alpha receptor-ligand complex, IFNA4 variant CPX-5999, Interferon alpha receptor-ligand complex, IFNA5 variant CPX-6000, Interferon alpha receptor-ligand complex, IFNA6 variant CPX-6001, Interferon alpha receptor-ligand complex, IFNA8 variant CPX-6002, Interferon alpha receptor-ligand complex, IFNA10 variant CPX-6003, Interferon alpha receptor-ligand complex, IFNA14 variant CPX-6004, Interferon alpha receptor-ligand complex, IFNA16 variant CPX-6005, Interferon alpha receptor-ligand complex, IFNA17 variant CPX-6006, Interferon alpha receptor-ligand complex, IFNA21 variant CPX-6007, Interferon beta receptor-ligand complex CPX-6008, Interferon epsilon receptor-ligand complex CPX-6009, Interferon kappa receptor-ligand complex CPX-6010, Interferon omega receptor-ligand complex |
CORUMi | P48551 |
DIPi | DIP-945N |
IntActi | P48551, 16 interactors |
MINTi | P48551 |
STRINGi | 9606.ENSP00000343957 |
Miscellaneous databases
RNActi | P48551, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P48551 |
SMRi | P48551 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P48551 |
Family & Domainsi
Sequence similaritiesi
Belongs to the type II cytokine receptor family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S60E, Eukaryota |
GeneTreei | ENSGT00510000049322 |
HOGENOMi | CLU_072607_0_0_1 |
InParanoidi | P48551 |
OMAi | TGDGYIM |
OrthoDBi | 680035at2759 |
PhylomeDBi | P48551 |
TreeFami | TF335897 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR015373, Interferon/interleukin_rcp_dom |
Pfami | View protein in Pfam PF09294, Interfer-bind, 1 hit PF01108, Tissue_fac, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P48551-1) [UniParc]FASTAAdd to basket
Also known as: Long form beta1 Publication, IFNaR2-2, IFNaR2-1b
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS
60 70 80 90 100
ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR
110 120 130 140 150
STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV
160 170 180 190 200
MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL
210 220 230 240 250
IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV
260 270 280 290 300
FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD
310 320 330 340 350
MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA
360 370 380 390 400
SATSTESQLI DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS
410 420 430 440 450
PLQDPFPEED YSSTEGSGGR ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS
460 470 480 490 500
SHLEEMVDPE DPDNVQSNHL LASGEGTQPT FPSPSSEGLW SEDAPSDQSD
510
TSESDVDLGD GYIMR
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JCU0 | C9JCU0_HUMAN | Interferon alpha/beta receptor 2 | IFNAR2 | 229 | Annotation score: | ||
C9JM33 | C9JM33_HUMAN | Interferon alpha/beta receptor 2 | IFNAR2 | 204 | Annotation score: | ||
F8WDE1 | F8WDE1_HUMAN | Interferon alpha/beta receptor 2 | IFNAR2 | 197 | Annotation score: | ||
C9K067 | C9K067_HUMAN | Interferon alpha/beta receptor 2 | IFNAR2 | 167 | Annotation score: | ||
H7C176 | H7C176_HUMAN | Interferon alpha/beta receptor 2 | IFNAR2 | 54 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 151 | M → V in AAC50202 (PubMed:7665574).Curated | 1 |
Polymorphismi
Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020521 | 8 | F → S Associated with susceptibility to HVB infection; lower cell surface levels; lower induction of MHC class 1 expression by INF-alpha. 2 PublicationsCorresponds to variant dbSNP:rs2229207EnsemblClinVar. | 1 | |
Natural variantiVAR_020522 | 10 | F → V5 PublicationsCorresponds to variant dbSNP:rs1051393Ensembl. | 1 | |
Natural variantiVAR_084099 | 37 | E → Q No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084100 | 73 | M → V No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084101 | 138 | E → V No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_020523 | 196 | I → V1 PublicationCorresponds to variant dbSNP:rs17860223Ensembl. | 1 | |
Natural variantiVAR_084102 | 215 | S → G No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084103 | 283 | H → R No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084104 | 295 | P → L No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084105 | 318 | Y → C No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084106 | 324 | S → N No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084107 | 346 | P → S No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084108 | 362 | P → S No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084109 | 385 | P → L No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 | |
Natural variantiVAR_084110 | 450 | S → L No effect on activation of STAT1 upon IFNA2 or IFNG binding. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001736 | 238 – 239 | SA → FS in isoform 3. 2 Publications | 2 | |
Alternative sequenceiVSP_001737 | 240 – 515 | Missing in isoform 3. 2 PublicationsAdd BLAST | 276 | |
Alternative sequenceiVSP_001738 | 281 – 331 | NFHNF…EAAPR → RQGLAKGWNAVAIHRCSHNA LQSETPELKQSSCLSFPSSW DYKRASLCPSD in isoform 2. 3 PublicationsAdd BLAST | 51 | |
Alternative sequenceiVSP_001739 | 332 – 515 | Missing in isoform 2. 3 PublicationsAdd BLAST | 184 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77722 mRNA Translation: CAA54785.1 L42243 , L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46417.1 L42243 , L42238, L42239, L42240, L42323, L42241 Genomic DNA Translation: AAB46418.1 L42243 , L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46419.1 L41942 mRNA Translation: AAB46413.1 L41943 mRNA Translation: AAB46414.1 L41944 mRNA Translation: AAB46415.1 U29584 mRNA Translation: AAC50202.1 X89814 mRNA Translation: CAA61940.1 X89772 mRNA Translation: CAA61914.1 AY740397 Genomic DNA Translation: AAU21038.1 AK293059 mRNA Translation: BAF85748.1 CR541817 mRNA Translation: CAG46616.1 AP000292 Genomic DNA No translation available. AP000293 Genomic DNA No translation available. AP000294 Genomic DNA No translation available. AP000295 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09842.1 CH471079 Genomic DNA Translation: EAX09843.1 CH471079 Genomic DNA Translation: EAX09844.1 CH471079 Genomic DNA Translation: EAX09846.1 |
CCDSi | CCDS13621.1 [P48551-1] CCDS13622.1 [P48551-2] CCDS74782.1 [P48551-3] |
PIRi | I39073 S59501 |
RefSeqi | NP_000865.2, NM_000874.4 [P48551-2] NP_001276054.1, NM_001289125.1 [P48551-1] NP_001276055.1, NM_001289126.1 [P48551-3] NP_001276057.1, NM_001289128.1 [P48551-3] NP_997467.1, NM_207584.2 [P48551-2] NP_997468.1, NM_207585.2 [P48551-1] |
Genome annotation databases
Ensembli | ENST00000342101; ENSP00000343289; ENSG00000159110 [P48551-3] ENST00000342136; ENSP00000343957; ENSG00000159110 [P48551-1] ENST00000382264; ENSP00000371699; ENSG00000159110 [P48551-2] ENST00000404220; ENSP00000384309; ENSG00000159110 [P48551-2] |
GeneIDi | 3455 |
KEGGi | hsa:3455 |
UCSCi | uc002yrb.5, human [P48551-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77722 mRNA Translation: CAA54785.1 L42243 , L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46417.1 L42243 , L42238, L42239, L42240, L42323, L42241 Genomic DNA Translation: AAB46418.1 L42243 , L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46419.1 L41942 mRNA Translation: AAB46413.1 L41943 mRNA Translation: AAB46414.1 L41944 mRNA Translation: AAB46415.1 U29584 mRNA Translation: AAC50202.1 X89814 mRNA Translation: CAA61940.1 X89772 mRNA Translation: CAA61914.1 AY740397 Genomic DNA Translation: AAU21038.1 AK293059 mRNA Translation: BAF85748.1 CR541817 mRNA Translation: CAG46616.1 AP000292 Genomic DNA No translation available. AP000293 Genomic DNA No translation available. AP000294 Genomic DNA No translation available. AP000295 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09842.1 CH471079 Genomic DNA Translation: EAX09843.1 CH471079 Genomic DNA Translation: EAX09844.1 CH471079 Genomic DNA Translation: EAX09846.1 |
CCDSi | CCDS13621.1 [P48551-1] CCDS13622.1 [P48551-2] CCDS74782.1 [P48551-3] |
PIRi | I39073 S59501 |
RefSeqi | NP_000865.2, NM_000874.4 [P48551-2] NP_001276054.1, NM_001289125.1 [P48551-1] NP_001276055.1, NM_001289126.1 [P48551-3] NP_001276057.1, NM_001289128.1 [P48551-3] NP_997467.1, NM_207584.2 [P48551-2] NP_997468.1, NM_207585.2 [P48551-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N6U | NMR | - | A | 28-237 | [»] | |
1N6V | NMR | - | A | 28-237 | [»] | |
2HYM | NMR | - | A | 28-237 | [»] | |
2KZ1 | NMR | - | B | 28-237 | [»] | |
2LAG | NMR | - | B | 28-237 | [»] | |
3S8W | X-ray | 2.60 | A/B/C | 131-232 | [»] | |
3S9D | X-ray | 2.00 | B/D | 37-232 | [»] | |
3SE3 | X-ray | 4.00 | C | 34-232 | [»] | |
3SE4 | X-ray | 3.50 | C | 34-232 | [»] | |
BMRBi | P48551 | |||||
SMRi | P48551 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109677, 13 interactors |
ComplexPortali | CPX-5995, Interferon alpha receptor-ligand complex, IFNA2 variant CPX-5996, Interferon alpha receptor-ligand complex, IFNA1 variant CPX-5997, Interferon alpha receptor-ligand complex, IFNA7 variant CPX-5998, Interferon alpha receptor-ligand complex, IFNA4 variant CPX-5999, Interferon alpha receptor-ligand complex, IFNA5 variant CPX-6000, Interferon alpha receptor-ligand complex, IFNA6 variant CPX-6001, Interferon alpha receptor-ligand complex, IFNA8 variant CPX-6002, Interferon alpha receptor-ligand complex, IFNA10 variant CPX-6003, Interferon alpha receptor-ligand complex, IFNA14 variant CPX-6004, Interferon alpha receptor-ligand complex, IFNA16 variant CPX-6005, Interferon alpha receptor-ligand complex, IFNA17 variant CPX-6006, Interferon alpha receptor-ligand complex, IFNA21 variant CPX-6007, Interferon beta receptor-ligand complex CPX-6008, Interferon epsilon receptor-ligand complex CPX-6009, Interferon kappa receptor-ligand complex CPX-6010, Interferon omega receptor-ligand complex |
CORUMi | P48551 |
DIPi | DIP-945N |
IntActi | P48551, 16 interactors |
MINTi | P48551 |
STRINGi | 9606.ENSP00000343957 |
Chemistry databases
ChEMBLi | CHEMBL2364170 |
DrugBanki | DB00034, Interferon alfa-2a, Recombinant DB00105, Interferon alfa-2b DB00011, Interferon alfa-n1 DB00018, Interferon alfa-n3 DB00069, Interferon alfacon-1 DB00060, Interferon beta-1a DB00068, Interferon beta-1b DB06152, Nylidrin DB05472, omega interferon DB00008, Peginterferon alfa-2a DB00022, Peginterferon alfa-2b |
DrugCentrali | P48551 |
PTM databases
GlyConnecti | 2051, 4 N-Linked glycans (1 site) |
GlyGeni | P48551, 6 sites, 4 N-linked glycans (1 site) |
iPTMneti | P48551 |
PhosphoSitePlusi | P48551 |
Genetic variation databases
BioMutai | IFNAR2 |
DMDMi | 1352466 |
Proteomic databases
jPOSTi | P48551 |
MassIVEi | P48551 |
MaxQBi | P48551 |
PaxDbi | P48551 |
PeptideAtlasi | P48551 |
PRIDEi | P48551 |
ProteomicsDBi | 55905 [P48551-1] 55906 [P48551-2] 55907 [P48551-3] |
Protocols and materials databases
Antibodypediai | 34938, 419 antibodies |
DNASUi | 3455 |
Genome annotation databases
Ensembli | ENST00000342101; ENSP00000343289; ENSG00000159110 [P48551-3] ENST00000342136; ENSP00000343957; ENSG00000159110 [P48551-1] ENST00000382264; ENSP00000371699; ENSG00000159110 [P48551-2] ENST00000404220; ENSP00000384309; ENSG00000159110 [P48551-2] |
GeneIDi | 3455 |
KEGGi | hsa:3455 |
UCSCi | uc002yrb.5, human [P48551-1] |
Organism-specific databases
CTDi | 3455 |
DisGeNETi | 3455 |
GeneCardsi | IFNAR2 |
HGNCi | HGNC:5433, IFNAR2 |
HPAi | ENSG00000159110, Low tissue specificity |
MalaCardsi | IFNAR2 |
MIMi | 602376, gene 610424, phenotype 616669, phenotype |
neXtProti | NX_P48551 |
OpenTargetsi | ENSG00000159110 |
Orphaneti | 431166, Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection |
PharmGKBi | PA29671 |
VEuPathDBi | HostDB:ENSG00000159110.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S60E, Eukaryota |
GeneTreei | ENSGT00510000049322 |
HOGENOMi | CLU_072607_0_0_1 |
InParanoidi | P48551 |
OMAi | TGDGYIM |
OrthoDBi | 680035at2759 |
PhylomeDBi | P48551 |
TreeFami | TF335897 |
Enzyme and pathway databases
PathwayCommonsi | P48551 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling [P48551-2] R-HSA-912694, Regulation of IFNA signaling [P48551-2] R-HSA-9679191, Potential therapeutics for SARS [P48551-2] |
SignaLinki | P48551 |
SIGNORi | P48551 |
Miscellaneous databases
BioGRID-ORCSi | 3455, 8 hits in 876 CRISPR screens |
ChiTaRSi | IFNAR2, human |
EvolutionaryTracei | P48551 |
GeneWikii | IFNAR2 |
GenomeRNAii | 3455 |
Pharosi | P48551, Tclin |
PROi | PR:P48551 |
RNActi | P48551, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159110, Expressed in blood and 241 other tissues |
ExpressionAtlasi | P48551, baseline and differential |
Genevisiblei | P48551, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR015373, Interferon/interleukin_rcp_dom |
Pfami | View protein in Pfam PF09294, Interfer-bind, 1 hit PF01108, Tissue_fac, 1 hit |
SUPFAMi | SSF49265, SSF49265, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INAR2_HUMAN | |
Accessioni | P48551Primary (citable) accession number: P48551 Secondary accession number(s): A8KAJ4 Q6FHD7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 200 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants