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Protein

Interferon alpha/beta receptor 2

Gene

IFNAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).7 Publications

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • type I interferon binding Source: UniProtKB
  • type I interferon receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
SignaLinkiP48551
SIGNORiP48551

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha/beta receptor 2
Short name:
IFN-R-2
Short name:
IFN-alpha binding protein
Short name:
IFN-alpha/beta receptor 2
Alternative name(s):
Interferon alpha binding protein
Type I interferon receptor 2
Gene namesi
Name:IFNAR2
Synonyms:IFNABR, IFNARB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000159110.19
HGNCiHGNC:5433 IFNAR2
MIMi602376 gene
neXtProtiNX_P48551

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 243ExtracellularSequence analysisAdd BLAST217
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 515CytoplasmicSequence analysisAdd BLAST251

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 45 (IMD45)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination.
See also OMIM:616669

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi269Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318 and F-337. 2 Publications1
Mutagenesisi306Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318 and F-337. 2 Publications1
Mutagenesisi316Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318 and F-337. 2 Publications1
Mutagenesisi318Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337. 2 Publications1
Mutagenesisi337Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-318. 2 Publications1
Mutagenesisi411Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. 2 Publications1
Mutagenesisi512Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-411. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-411. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-411. 2 Publications1

Organism-specific databases

DisGeNETi3455
MalaCardsiIFNAR2
MIMi610424 phenotype
616669 phenotype
OpenTargetsiENSG00000159110
PharmGKBiPA29671

Chemistry databases

ChEMBLiCHEMBL2364170
DrugBankiDB00011 Interferon alfa-n1
DB00018 Interferon alfa-n3
DB00069 Interferon alfacon-1
DB00060 Interferon beta-1a
DB00068 Interferon beta-1b
DB05472 omega interferon
DB00008 Peginterferon alfa-2a
DB00022 Peginterferon alfa-2b

Polymorphism and mutation databases

BioMutaiIFNAR2
DMDMi1352466

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001100627 – 515Interferon alpha/beta receptor 2Add BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 122Combined sources4 Publications
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi85 ↔ 93Combined sources4 Publications
Glycosylationi87N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi207 ↔ 227Combined sources4 Publications
Modified residuei337Phosphotyrosine2 Publications1
Modified residuei400PhosphoserineCombined sources1
Modified residuei467PhosphoserineBy similarity1
Modified residuei512Phosphotyrosine2 Publications1

Post-translational modificationi

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.3 Publications
Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP48551
PaxDbiP48551
PeptideAtlasiP48551
PRIDEiP48551
ProteomicsDBi55905
55906 [P48551-2]
55907 [P48551-3]

PTM databases

iPTMnetiP48551
PhosphoSitePlusiP48551

Miscellaneous databases

PMAP-CutDBiQ6FHD7

Expressioni

Tissue specificityi

Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.3 Publications

Gene expression databases

BgeeiENSG00000159110 Expressed in 227 organ(s), highest expression level in blood
CleanExiHS_IFNAR2
ExpressionAtlasiP48551 baseline and differential
GenevisibleiP48551 HS

Interactioni

Subunit structurei

Heterodimer with IFNAR1 (PubMed:8181059, PubMed:7665574, PubMed:10049744, PubMed:24075985, PubMed:21854986). Isoform 1 interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453). Interacts with JAK1 (PubMed:8181059, PubMed:7759950).9 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109677, 12 interactors
CORUMiP48551
DIPiDIP-945N
IntActiP48551, 14 interactors
MINTiP48551
STRINGi9606.ENSP00000343957

Structurei

Secondary structure

1515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP48551
SMRiP48551
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48551

Family & Domainsi

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHB9 Eukaryota
ENOG410YTXY LUCA
GeneTreeiENSGT00510000049322
HOGENOMiHOG000013219
HOVERGENiHBG053907
InParanoidiP48551
KOiK05131
OMAiKVWDYNY
OrthoDBiEOG091G09YY
PhylomeDBiP48551
TreeFamiTF335897

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P48551-1) [UniParc]FASTAAdd to basket
Also known as: Long form beta1 Publication, IFNaR2-2, IFNaR2-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS
60 70 80 90 100
ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR
110 120 130 140 150
STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV
160 170 180 190 200
MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL
210 220 230 240 250
IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV
260 270 280 290 300
FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD
310 320 330 340 350
MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA
360 370 380 390 400
SATSTESQLI DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS
410 420 430 440 450
PLQDPFPEED YSSTEGSGGR ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS
460 470 480 490 500
SHLEEMVDPE DPDNVQSNHL LASGEGTQPT FPSPSSEGLW SEDAPSDQSD
510
TSESDVDLGD GYIMR
Length:515
Mass (Da):57,759
Last modified:February 1, 1996 - v1
Checksum:i4D7730D93AA739F4
GO
Isoform 2 (identifier: P48551-2) [UniParc]FASTAAdd to basket
Also known as: Short form beta1 Publication, IFNaR2-1, IFNaR2-1a

The sequence of this isoform differs from the canonical sequence as follows:
     281-331: NFHNFLAWPF...SDSDTEAAPR → RQGLAKGWNA...YKRASLCPSD
     332-515: Missing.

Show »
Length:331
Mass (Da):37,393
Checksum:i6F6A2FD6E7A7449B
GO
Isoform 3 (identifier: P48551-3) [UniParc]FASTAAdd to basket
Also known as: IFNaR2-3, IFNaR2-2a, P401 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     238-239: SA → FS
     240-515: Missing.

Note: Soluble receptor.
Show »
Length:239
Mass (Da):27,384
Checksum:i705E887E728A4FB6
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JCU0C9JCU0_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
229Annotation score:
C9JM33C9JM33_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
204Annotation score:
F8WDE1F8WDE1_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
197Annotation score:
C9K067C9K067_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
167Annotation score:
H7C176H7C176_HUMAN
Interferon alpha/beta receptor 2
IFNAR2
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151M → V in AAC50202 (PubMed:7665574).Curated1

Polymorphismi

Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIMi:610424].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0205218F → S Associated with susceptibility to HVB infection; lower cell surface levels; lower induction of MHC class 1 expression by INF-alpha. 2 PublicationsCorresponds to variant dbSNP:rs2229207EnsemblClinVar.1
Natural variantiVAR_02052210F → V5 PublicationsCorresponds to variant dbSNP:rs1051393Ensembl.1
Natural variantiVAR_020523196I → V1 PublicationCorresponds to variant dbSNP:rs17860223Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001736238 – 239SA → FS in isoform 3. 2 Publications2
Alternative sequenceiVSP_001737240 – 515Missing in isoform 3. 2 PublicationsAdd BLAST276
Alternative sequenceiVSP_001738281 – 331NFHNF…EAAPR → RQGLAKGWNAVAIHRCSHNA LQSETPELKQSSCLSFPSSW DYKRASLCPSD in isoform 2. 3 PublicationsAdd BLAST51
Alternative sequenceiVSP_001739332 – 515Missing in isoform 2. 3 PublicationsAdd BLAST184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77722 mRNA Translation: CAA54785.1
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46417.1
L42243
, L42238, L42239, L42240, L42323, L42241 Genomic DNA Translation: AAB46418.1
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46419.1
L41942 mRNA Translation: AAB46413.1
L41943 mRNA Translation: AAB46414.1
L41944 mRNA Translation: AAB46415.1
U29584 mRNA Translation: AAC50202.1
X89814 mRNA Translation: CAA61940.1
X89772 mRNA Translation: CAA61914.1
AY740397 Genomic DNA Translation: AAU21038.1
AK293059 mRNA Translation: BAF85748.1
CR541817 mRNA Translation: CAG46616.1
AP000292 Genomic DNA No translation available.
AP000293 Genomic DNA No translation available.
AP000294 Genomic DNA No translation available.
AP000295 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09842.1
CH471079 Genomic DNA Translation: EAX09843.1
CH471079 Genomic DNA Translation: EAX09844.1
CH471079 Genomic DNA Translation: EAX09846.1
CCDSiCCDS13621.1 [P48551-1]
CCDS13622.1 [P48551-2]
CCDS74782.1 [P48551-3]
PIRiI39073
S59501
RefSeqiNP_000865.2, NM_000874.4 [P48551-2]
NP_001276054.1, NM_001289125.1 [P48551-1]
NP_001276055.1, NM_001289126.1 [P48551-3]
NP_001276057.1, NM_001289128.1 [P48551-3]
NP_997467.1, NM_207584.2 [P48551-2]
NP_997468.1, NM_207585.2 [P48551-1]
UniGeneiHs.708195

Genome annotation databases

EnsembliENST00000342101; ENSP00000343289; ENSG00000159110 [P48551-3]
ENST00000342136; ENSP00000343957; ENSG00000159110 [P48551-1]
ENST00000382264; ENSP00000371699; ENSG00000159110 [P48551-2]
ENST00000404220; ENSP00000384309; ENSG00000159110 [P48551-2]
GeneIDi3455
KEGGihsa:3455
UCSCiuc002yrb.5 human [P48551-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77722 mRNA Translation: CAA54785.1
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46417.1
L42243
, L42238, L42239, L42240, L42323, L42241 Genomic DNA Translation: AAB46418.1
L42243
, L42238, L42239, L42240, L42323, L42241, L42242 Genomic DNA Translation: AAB46419.1
L41942 mRNA Translation: AAB46413.1
L41943 mRNA Translation: AAB46414.1
L41944 mRNA Translation: AAB46415.1
U29584 mRNA Translation: AAC50202.1
X89814 mRNA Translation: CAA61940.1
X89772 mRNA Translation: CAA61914.1
AY740397 Genomic DNA Translation: AAU21038.1
AK293059 mRNA Translation: BAF85748.1
CR541817 mRNA Translation: CAG46616.1
AP000292 Genomic DNA No translation available.
AP000293 Genomic DNA No translation available.
AP000294 Genomic DNA No translation available.
AP000295 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09842.1
CH471079 Genomic DNA Translation: EAX09843.1
CH471079 Genomic DNA Translation: EAX09844.1
CH471079 Genomic DNA Translation: EAX09846.1
CCDSiCCDS13621.1 [P48551-1]
CCDS13622.1 [P48551-2]
CCDS74782.1 [P48551-3]
PIRiI39073
S59501
RefSeqiNP_000865.2, NM_000874.4 [P48551-2]
NP_001276054.1, NM_001289125.1 [P48551-1]
NP_001276055.1, NM_001289126.1 [P48551-3]
NP_001276057.1, NM_001289128.1 [P48551-3]
NP_997467.1, NM_207584.2 [P48551-2]
NP_997468.1, NM_207585.2 [P48551-1]
UniGeneiHs.708195

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6UNMR-A28-237[»]
1N6VNMR-A28-237[»]
2HYMNMR-A28-237[»]
2KZ1NMR-B28-237[»]
2LAGNMR-B28-237[»]
3S8WX-ray2.60A/B/C131-232[»]
3S9DX-ray2.00B/D37-232[»]
3SE3X-ray4.00C34-232[»]
3SE4X-ray3.50C34-232[»]
ProteinModelPortaliP48551
SMRiP48551
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109677, 12 interactors
CORUMiP48551
DIPiDIP-945N
IntActiP48551, 14 interactors
MINTiP48551
STRINGi9606.ENSP00000343957

Chemistry databases

ChEMBLiCHEMBL2364170
DrugBankiDB00011 Interferon alfa-n1
DB00018 Interferon alfa-n3
DB00069 Interferon alfacon-1
DB00060 Interferon beta-1a
DB00068 Interferon beta-1b
DB05472 omega interferon
DB00008 Peginterferon alfa-2a
DB00022 Peginterferon alfa-2b

PTM databases

iPTMnetiP48551
PhosphoSitePlusiP48551

Polymorphism and mutation databases

BioMutaiIFNAR2
DMDMi1352466

Proteomic databases

MaxQBiP48551
PaxDbiP48551
PeptideAtlasiP48551
PRIDEiP48551
ProteomicsDBi55905
55906 [P48551-2]
55907 [P48551-3]

Protocols and materials databases

DNASUi3455
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342101; ENSP00000343289; ENSG00000159110 [P48551-3]
ENST00000342136; ENSP00000343957; ENSG00000159110 [P48551-1]
ENST00000382264; ENSP00000371699; ENSG00000159110 [P48551-2]
ENST00000404220; ENSP00000384309; ENSG00000159110 [P48551-2]
GeneIDi3455
KEGGihsa:3455
UCSCiuc002yrb.5 human [P48551-1]

Organism-specific databases

CTDi3455
DisGeNETi3455
EuPathDBiHostDB:ENSG00000159110.19
GeneCardsiIFNAR2
HGNCiHGNC:5433 IFNAR2
MalaCardsiIFNAR2
MIMi602376 gene
610424 phenotype
616669 phenotype
neXtProtiNX_P48551
OpenTargetsiENSG00000159110
PharmGKBiPA29671
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHB9 Eukaryota
ENOG410YTXY LUCA
GeneTreeiENSGT00510000049322
HOGENOMiHOG000013219
HOVERGENiHBG053907
InParanoidiP48551
KOiK05131
OMAiKVWDYNY
OrthoDBiEOG091G09YY
PhylomeDBiP48551
TreeFamiTF335897

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
SignaLinkiP48551
SIGNORiP48551

Miscellaneous databases

ChiTaRSiIFNAR2 human
EvolutionaryTraceiP48551
GeneWikiiIFNAR2
GenomeRNAii3455
PMAP-CutDBiQ6FHD7
PROiPR:P48551
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159110 Expressed in 227 organ(s), highest expression level in blood
CleanExiHS_IFNAR2
ExpressionAtlasiP48551 baseline and differential
GenevisibleiP48551 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
PfamiView protein in Pfam
PF09294 Interfer-bind, 1 hit
PF01108 Tissue_fac, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiINAR2_HUMAN
AccessioniPrimary (citable) accession number: P48551
Secondary accession number(s): A8KAJ4
, D3DSE8, D3DSE9, Q15467, Q6FHD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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