IFNAR2

Functionⁱ

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).7 Publications

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 7759950
type I interferon binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 7759950
type I interferon receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7665574
- 7759950

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8798579
defense response to virus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26424569
JAK-STAT cascade
Source: ProtInc
Traceable author statementⁱ
- 7588638
regulation of type I interferon-mediated signaling pathway Source: Reactome
response to interferon-alpha
Source: UniProtKB
Inferred from direct assayⁱ
- 7759950
response to interferon-beta
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26424569
response to virus
Source: ProtInc
Traceable author statementⁱ
- 7588638
type I interferon signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 7665574

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-909733 Interferon alpha/beta signaling R-HSA-912694 Regulation of IFNA signaling
SignaLinkⁱ	P48551
SIGNORⁱ	P48551

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon alpha/beta receptor 2 Short name: IFN-R-2 Short name: IFN-alpha binding protein Short name: IFN-alpha/beta receptor 2 Alternative name(s): Interferon alpha binding protein Type I interferon receptor 2
Gene namesⁱ	Name:IFNAR2 Synonyms:IFNABR, IFNARB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000159110.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5433 IFNAR2
MIMⁱ	602376 gene
neXtProtⁱ	NX_P48551

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 243	ExtracellularSequence analysisAdd BLAST	217
Transmembraneⁱ	244 – 264	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	265 – 515	CytoplasmicSequence analysisAdd BLAST	251

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency 45 (IMD45)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	269	Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318 and F-337. 2 Publications	1
Mutagenesisⁱ	306	Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318 and F-337. 2 Publications	1
Mutagenesisⁱ	316	Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318 and F-337. 2 Publications	1
Mutagenesisⁱ	318	Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337. 2 Publications	1
Mutagenesisⁱ	337	Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-318. 2 Publications	1
Mutagenesisⁱ	411	Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. 2 Publications	1
Mutagenesisⁱ	512	Y → F: Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-411. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-411. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-411. 2 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3455
MalaCards human disease database More...MalaCardsⁱ	IFNAR2
MIMⁱ	610424 phenotype 616669 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000159110
PharmGKBⁱ	PA29671

Chemistry databases

ChEMBLⁱ	CHEMBL2364170
Drug and drug target database More...DrugBankⁱ	DB00011 Interferon alfa-n1 DB00018 Interferon alfa-n3 DB00069 Interferon alfacon-1 DB00060 Interferon beta-1a DB00068 Interferon beta-1b DB05472 omega interferon DB00008 Peginterferon alfa-2a DB00022 Peginterferon alfa-2b

Polymorphism and mutation databases

BioMutaⁱ	IFNAR2
DMDMⁱ	1352466

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Add BLAST		26
ChainⁱPRO_0000011006	27 – 515	Interferon alpha/beta receptor 2Add BLAST		489

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	39 ↔ 122	Combined sources4 Publications
Glycosylationⁱ	58	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	85 ↔ 93	Combined sources4 Publications
Glycosylationⁱ	87	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	116	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	188	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	192	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	207 ↔ 227	Combined sources4 Publications
Modified residueⁱ	337	Phosphotyrosine2 Publications	1
Modified residueⁱ	400	PhosphoserineCombined sources	1
Modified residueⁱ	467	PhosphoserineBy similarity	1
Modified residueⁱ	512	Phosphotyrosine2 Publications	1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.3 Publications

Glycosylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P48551
PaxDbⁱ	P48551
PeptideAtlas More...PeptideAtlasⁱ	P48551
PRIDEⁱ	P48551
ProteomicsDBⁱ	55905 55906 [P48551-2] 55907 [P48551-3]

PTM databases

iPTMnetⁱ	P48551
PhosphoSitePlusⁱ	P48551

Miscellaneous databases

PMAP-CutDBⁱ	Q6FHD7

PMAP-CutDBⁱ

Q6FHD7

Expressionⁱ

Tissue specificityⁱ

Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000159110 Expressed in 227 organ(s), highest expression level in blood
CleanExⁱ	HS_IFNAR2
ExpressionAtlasⁱ	P48551 baseline and differential
Genevisibleⁱ	P48551 HS

Interactionⁱ

Subunit structureⁱ

Heterodimer with IFNAR1 (PubMed:8181059, PubMed:7665574, PubMed:10049744, PubMed:24075985, PubMed:21854986). Isoform 1 interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453). Interacts with JAK1 (PubMed:8181059, PubMed:7759950).9 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CREBBP	Q92793	4	EBI-958408,EBI-81215
IRF9	Q00978	6	EBI-958408,EBI-626526
JAK1	P23458	3	EBI-958408,EBI-1383438
RACK1	P63244	4	EBI-958408,EBI-296739
STAT1	P42224	2	EBI-958408,EBI-1057697
STAT2	P52630	4	EBI-958408,EBI-1546963
USP18	Q9UMW8	4	EBI-958408,EBI-356206

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 7759950
type I interferon binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 7759950

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109677, 12 interactors
CORUMⁱ	P48551
Database of interacting proteins More...DIPⁱ	DIP-945N
IntActⁱ	P48551, 14 interactors
Molecular INTeraction database More...MINTⁱ	P48551
STRINGⁱ	9606.ENSP00000343957

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	40 – 46	Combined sources	7
Beta strandⁱ	49 – 55	Combined sources	7
Beta strandⁱ	59 – 61	Combined sources	3
Beta strandⁱ	65 – 75	Combined sources	11
Helixⁱ	83 – 85	Combined sources	3
Beta strandⁱ	86 – 89	Combined sources	4
Beta strandⁱ	91 – 94	Combined sources	4
Turnⁱ	96 – 98	Combined sources	3
Beta strandⁱ	102 – 104	Combined sources	3
Beta strandⁱ	106 – 113	Combined sources	8
Beta strandⁱ	119 – 126	Combined sources	8
Helixⁱ	128 – 131	Combined sources	4
Beta strandⁱ	138 – 143	Combined sources	6
Beta strandⁱ	148 – 153	Combined sources	6
Helixⁱ	159 – 161	Combined sources	3
Beta strandⁱ	167 – 174	Combined sources	8
Beta strandⁱ	177 – 181	Combined sources	5
Beta strandⁱ	186 – 188	Combined sources	3
Beta strandⁱ	191 – 197	Combined sources	7
Beta strandⁱ	205 – 213	Combined sources	9
Beta strandⁱ	226 – 229	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P48551
SMRⁱ	P48551
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P48551

EvolutionaryTraceⁱ

P48551

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the type II cytokine receptor family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHB9 Eukaryota ENOG410YTXY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000049322
HOGENOMⁱ	HOG000013219
HOVERGENⁱ	HBG053907
InParanoidⁱ	P48551
KEGG Orthology (KO) More...KOⁱ	K05131
OMAⁱ	KVWDYNY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09YY
PhylomeDBⁱ	P48551
TreeFamⁱ	TF335897

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR015373 Interferon/interleukin_rcp_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09294 Interfer-bind, 1 hit PF01108 Tissue_fac, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P48551-1) [UniParc]FASTA Add to basket

Also known as: Long form beta1 Publication, IFNaR2-2, IFNaR2-1b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS 
        60         70         80         90        100
ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR 
       110        120        130        140        150
STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV 
       160        170        180        190        200
MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL 
       210        220        230        240        250
IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV 
       260        270        280        290        300
FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD 
       310        320        330        340        350
MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA 
       360        370        380        390        400
SATSTESQLI DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS 
       410        420        430        440        450
PLQDPFPEED YSSTEGSGGR ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS 
       460        470        480        490        500
SHLEEMVDPE DPDNVQSNHL LASGEGTQPT FPSPSSEGLW SEDAPSDQSD 
       510 
TSESDVDLGD GYIMR

Length:515

Mass (Da):57,759

Last modified:February 1, 1996 - v1

Checksum:ⁱ4D7730D93AA739F4

GO

Isoform 2 (identifier: P48551-2) [UniParc]FASTA Add to basket

Also known as: Short form beta1 Publication, IFNaR2-1, IFNaR2-1a

The sequence of this isoform differs from the canonical sequence as follows:
281-331: NFHNFLAWPF...SDSDTEAAPR → RQGLAKGWNA...YKRASLCPSD
332-515: Missing.

« Hide

        10         20         30         40         50
MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS 
        60         70         80         90        100
ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR 
       110        120        130        140        150
STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV 
       160        170        180        190        200
MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL 
       210        220        230        240        250
IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV 
       260        270        280        290        300
FLIALVLTST IVTLKWIGYI CLRNSLPKVL RQGLAKGWNA VAIHRCSHNA 
       310        320        330 
LQSETPELKQ SSCLSFPSSW DYKRASLCPS D

Show »

Length:331

Mass (Da):37,393

Checksum:ⁱ6F6A2FD6E7A7449B

GO

Isoform 3 (identifier: P48551-3) [UniParc]FASTA Add to basket

Also known as: IFNaR2-3, IFNaR2-2a, P401 Publication

The sequence of this isoform differs from the canonical sequence as follows:
238-239: SA → FS
240-515: Missing.

« Hide

        10         20         30         40         50
MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS 
        60         70         80         90        100
ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR 
       110        120        130        140        150
STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV 
       160        170        180        190        200
MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL 
       210        220        230 
IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESEFS

Note: Soluble receptor.

Show »

Length:239

Mass (Da):27,384

Checksum:ⁱ705E887E728A4FB6

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
C9JCU0	C9JCU0_HUMAN	Interferon alpha/beta receptor 2 Interferon alpha/beta receptor 2	IFNAR2	229	Annotation score:
C9JM33	C9JM33_HUMAN	Interferon alpha/beta receptor 2 Interferon alpha/beta receptor 2	IFNAR2	204	Annotation score:
F8WDE1	F8WDE1_HUMAN	Interferon alpha/beta receptor 2 Interferon alpha/beta receptor 2	IFNAR2	197	Annotation score:
C9K067	C9K067_HUMAN	Interferon alpha/beta receptor 2 Interferon alpha/beta receptor 2	IFNAR2	167	Annotation score:
H7C176	H7C176_HUMAN	Interferon alpha/beta receptor 2 Interferon alpha/beta receptor 2	IFNAR2	54	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	151	M → V in AAC50202 (PubMed:7665574).Curated		1

Polymorphismⁱ

Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIMⁱ:610424].

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_020521	8	F → S Associated with susceptibility to HVB infection; lower cell surface levels; lower induction of MHC class 1 expression by INF-alpha. 2 PublicationsCorresponds to variant dbSNP:rs2229207EnsemblClinVar.	1
Natural variantⁱVAR_020522	10	F → V5 PublicationsCorresponds to variant dbSNP:rs1051393Ensembl.	1
Natural variantⁱVAR_020523	196	I → V1 PublicationCorresponds to variant dbSNP:rs17860223Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_001736	238 – 239	SA → FS in isoform 3. 2 Publications	2
Alternative sequenceⁱVSP_001737	240 – 515	Missing in isoform 3. 2 PublicationsAdd BLAST	276
Alternative sequenceⁱVSP_001738	281 – 331	NFHNF…EAAPR → RQGLAKGWNAVAIHRCSHNA LQSETPELKQSSCLSFPSSW DYKRASLCPSD in isoform 2. 3 PublicationsAdd BLAST	51
Alternative sequenceⁱVSP_001739	332 – 515	Missing in isoform 2. 3 PublicationsAdd BLAST	184

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X77722 mRNA Translation: CAA54785.1 L42243 L42242 Genomic DNA Translation: AAB46417.1 L42243 L42241 Genomic DNA Translation: AAB46418.1 L42243 L42242 Genomic DNA Translation: AAB46419.1 L41942 mRNA Translation: AAB46413.1 L41943 mRNA Translation: AAB46414.1 L41944 mRNA Translation: AAB46415.1 U29584 mRNA Translation: AAC50202.1 X89814 mRNA Translation: CAA61940.1 X89772 mRNA Translation: CAA61914.1 AY740397 Genomic DNA Translation: AAU21038.1 AK293059 mRNA Translation: BAF85748.1 CR541817 mRNA Translation: CAG46616.1 AP000292 Genomic DNA No translation available. AP000293 Genomic DNA No translation available. AP000294 Genomic DNA No translation available. AP000295 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09842.1 CH471079 Genomic DNA Translation: EAX09843.1 CH471079 Genomic DNA Translation: EAX09844.1 CH471079 Genomic DNA Translation: EAX09846.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13621.1 [P48551-1] CCDS13622.1 [P48551-2] CCDS74782.1 [P48551-3]
PIRⁱ	I39073 S59501
NCBI Reference Sequences More...RefSeqⁱ	NP_000865.2, NM_000874.4 [P48551-2] NP_001276054.1, NM_001289125.1 [P48551-1] NP_001276055.1, NM_001289126.1 [P48551-3] NP_001276057.1, NM_001289128.1 [P48551-3] NP_997467.1, NM_207584.2 [P48551-2] NP_997468.1, NM_207585.2 [P48551-1]
UniGeneⁱ	Hs.708195

Genome annotation databases

Ensemblⁱ	ENST00000342101; ENSP00000343289; ENSG00000159110 [P48551-3] ENST00000342136; ENSP00000343957; ENSG00000159110 [P48551-1] ENST00000382264; ENSP00000371699; ENSG00000159110 [P48551-2] ENST00000404220; ENSP00000384309; ENSG00000159110 [P48551-2]
GeneIDⁱ	3455
KEGGⁱ	hsa:3455
UCSC genome browser More...UCSCⁱ	uc002yrb.5 human [P48551-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P48551	Interferon alpha/beta receptor 2 (Fragment)		HUMAN		229	UniRef100_P48551
UPI0002236ACA		HUMAN		199
P48551-3	Interferon alpha/beta receptor 2		HUMAN		167	UniRef100_C9K067
UPI00001B2994		HUMAN		212

Protein	Similar proteins		Species	Score	Length	Source
P48551	Interferon alpha/beta receptor 2 (Fragment)		HUMAN		229	UniRef90_P48551
Uncharacterized protein		PANPA		519
Interferon alpha and beta receptor subunit 2		PANTR		519
Uncharacterized protein		GORGO		519
Interferon alpha/beta receptor 2 isoform a		MACMU		516
+19
P48551-2	Uncharacterized protein		PANTR		334	UniRef90_P48551-2
Uncharacterized protein		GORGO		334
Uncharacterized protein		MACFA		331
Interferon (Alpha, beta and omega) receptor 2		HUMAN		331
Uncharacterized protein		PANPA		331
+6
P48551-3	Interferon alpha and beta receptor subunit 2		PANTR		239	UniRef90_A0A2I3T9T1
Uncharacterized protein		PANPA		239
Interferon (Alpha, beta and omega) receptor 2 (Fragment)		HUMAN		248
Uncharacterized protein		MACNE		239
Interferon alpha/beta receptor 2 precursor		PAPAN		239
+20

Protein	Similar proteins		Species	Score	Length	Source
P48551	Interferon alpha/beta receptor 2 (Fragment)		HUMAN		229	UniRef50_P48551
Uncharacterized protein		PANPA		519
Uncharacterized protein		GORGO		519
Interferon alpha and beta receptor subunit 2		PANTR		519
Uncharacterized protein		COLAP		516
+21
P48551-2	Uncharacterized protein		GORGO		334	UniRef50_P48551-2
Uncharacterized protein		PANTR		334
Uncharacterized protein		MACFA		331
Uncharacterized protein		PANPA		331
Interferon (Alpha, beta and omega) receptor 2		HUMAN		331
+6
P48551-3	Interferon alpha and beta receptor subunit 2		PANTR		239	UniRef50_A0A2I3T9T1
Uncharacterized protein		PANPA		239
Interferon (Alpha, beta and omega) receptor 2 (Fragment)		HUMAN		248
Interferon alpha/beta receptor 2 precursor		PAPAN		239
Uncharacterized protein		MACNE		239
+41

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X77722 mRNA Translation: CAA54785.1 L42243 L42242 Genomic DNA Translation: AAB46417.1 L42243 L42241 Genomic DNA Translation: AAB46418.1 L42243 L42242 Genomic DNA Translation: AAB46419.1 L41942 mRNA Translation: AAB46413.1 L41943 mRNA Translation: AAB46414.1 L41944 mRNA Translation: AAB46415.1 U29584 mRNA Translation: AAC50202.1 X89814 mRNA Translation: CAA61940.1 X89772 mRNA Translation: CAA61914.1 AY740397 Genomic DNA Translation: AAU21038.1 AK293059 mRNA Translation: BAF85748.1 CR541817 mRNA Translation: CAG46616.1 AP000292 Genomic DNA No translation available. AP000293 Genomic DNA No translation available. AP000294 Genomic DNA No translation available. AP000295 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09842.1 CH471079 Genomic DNA Translation: EAX09843.1 CH471079 Genomic DNA Translation: EAX09844.1 CH471079 Genomic DNA Translation: EAX09846.1
CCDSⁱ	CCDS13621.1 [P48551-1] CCDS13622.1 [P48551-2] CCDS74782.1 [P48551-3]
PIRⁱ	I39073 S59501
RefSeqⁱ	NP_000865.2, NM_000874.4 [P48551-2] NP_001276054.1, NM_001289125.1 [P48551-1] NP_001276055.1, NM_001289126.1 [P48551-3] NP_001276057.1, NM_001289128.1 [P48551-3] NP_997467.1, NM_207584.2 [P48551-2] NP_997468.1, NM_207585.2 [P48551-1]
UniGeneⁱ	Hs.708195

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1N6U	NMR	-	A	28-237	[»]
	1N6V	NMR	-	A	28-237	[»]
	2HYM	NMR	-	A	28-237	[»]
	2KZ1	NMR	-	B	28-237	[»]
	2LAG	NMR	-	B	28-237	[»]
	3S8W	X-ray	2.60	A/B/C	131-232	[»]
	3S9D	X-ray	2.00	B/D	37-232	[»]
	3SE3	X-ray	4.00	C	34-232	[»]
	3SE4	X-ray	3.50	C	34-232	[»]
ProteinModelPortalⁱ	P48551
SMRⁱ	P48551
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109677, 12 interactors
CORUMⁱ	P48551
DIPⁱ	DIP-945N
IntActⁱ	P48551, 14 interactors
MINTⁱ	P48551
STRINGⁱ	9606.ENSP00000343957

Chemistry databases

ChEMBLⁱ	CHEMBL2364170
DrugBankⁱ	DB00011 Interferon alfa-n1 DB00018 Interferon alfa-n3 DB00069 Interferon alfacon-1 DB00060 Interferon beta-1a DB00068 Interferon beta-1b DB05472 omega interferon DB00008 Peginterferon alfa-2a DB00022 Peginterferon alfa-2b

PTM databases

iPTMnetⁱ	P48551
PhosphoSitePlusⁱ	P48551

Polymorphism and mutation databases

BioMutaⁱ	IFNAR2
DMDMⁱ	1352466

Proteomic databases

MaxQBⁱ	P48551
PaxDbⁱ	P48551
PeptideAtlasⁱ	P48551
PRIDEⁱ	P48551
ProteomicsDBⁱ	55905 55906 [P48551-2] 55907 [P48551-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3455
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000342101; ENSP00000343289; ENSG00000159110 [P48551-3] ENST00000342136; ENSP00000343957; ENSG00000159110 [P48551-1] ENST00000382264; ENSP00000371699; ENSG00000159110 [P48551-2] ENST00000404220; ENSP00000384309; ENSG00000159110 [P48551-2]
GeneIDⁱ	3455
KEGGⁱ	hsa:3455
UCSCⁱ	uc002yrb.5 human [P48551-1]

Organism-specific databases

CTDⁱ	3455
DisGeNETⁱ	3455
EuPathDBⁱ	HostDB:ENSG00000159110.19
GeneCardsⁱ	IFNAR2
HGNCⁱ	HGNC:5433 IFNAR2
MalaCardsⁱ	IFNAR2
MIMⁱ	602376 gene 610424 phenotype 616669 phenotype
neXtProtⁱ	NX_P48551
OpenTargetsⁱ	ENSG00000159110
PharmGKBⁱ	PA29671
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHB9 Eukaryota ENOG410YTXY LUCA
GeneTreeⁱ	ENSGT00510000049322
HOGENOMⁱ	HOG000013219
HOVERGENⁱ	HBG053907
InParanoidⁱ	P48551
KOⁱ	K05131
OMAⁱ	KVWDYNY
OrthoDBⁱ	EOG091G09YY
PhylomeDBⁱ	P48551
TreeFamⁱ	TF335897

Enzyme and pathway databases

Reactomeⁱ	R-HSA-909733 Interferon alpha/beta signaling R-HSA-912694 Regulation of IFNA signaling
SignaLinkⁱ	P48551
SIGNORⁱ	P48551

Miscellaneous databases

ChiTaRSⁱ	IFNAR2 human
EvolutionaryTraceⁱ	P48551
GeneWikiⁱ	IFNAR2
GenomeRNAiⁱ	3455
PMAP-CutDBⁱ	Q6FHD7
Protein Ontology More...PROⁱ	PR:P48551
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000159110 Expressed in 227 organ(s), highest expression level in blood
CleanExⁱ	HS_IFNAR2
ExpressionAtlasⁱ	P48551 baseline and differential
Genevisibleⁱ	P48551 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR015373 Interferon/interleukin_rcp_dom
Pfamⁱ	View protein in Pfam PF09294 Interfer-bind, 1 hit PF01108 Tissue_fac, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	INAR2_HUMAN
Accessionⁱ	P48551Primary (citable) accession number: P48551 Secondary accession number(s): A8KAJ4 , D3DSE8, D3DSE9, Q15467, Q6FHD7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	September 12, 2018
	This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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Supporting data

UniProtKB - P48551 (INAR2_HUMAN)

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Interferon alpha/beta receptor 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma membrane

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ