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UniProtKB - P48510 (DSK2_YEAST)
Protein
Ubiquitin domain-containing protein DSK2
Gene
DSK2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved, with RAD23 in spindle pole body duplication. Involved in the ubiquitin-proteasome proteolytic pathway.
Miscellaneous
Present with 3930 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- polyubiquitin modification-dependent protein binding Source: GO_Central
- protein-macromolecule adaptor activity Source: SGD
GO - Biological processi
- protein localization to vacuole Source: SGD
- spindle pole body duplication Source: SGD
- ubiquitin-dependent ERAD pathway Source: SGD
- ubiquitin-dependent protein catabolic process Source: GO_Central
Enzyme and pathway databases
Reactomei | R-SCE-8856825, Cargo recognition for clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin domain-containing protein DSK2 |
Gene namesi | Name:DSK2 Synonyms:SHE4 Ordered Locus Names:YMR276W ORF Names:YM8021.02 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000004889, DSK2 |
VEuPathDBi | FungiDB:YMR276W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114900 | 1 – 373 | Ubiquitin domain-containing protein DSK2Add BLAST | 373 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 13 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Cross-linki | 76 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | P48510 |
PaxDbi | P48510 |
PRIDEi | P48510 |
PTM databases
iPTMneti | P48510 |
Interactioni
Binary interactionsi
P48510
GO - Molecular functioni
- polyubiquitin modification-dependent protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 35455, 138 interactors |
DIPi | DIP-4398N |
IntActi | P48510, 25 interactors |
MINTi | P48510 |
STRINGi | 4932.YMR276W |
Miscellaneous databases
RNActi | P48510, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P48510 |
SMRi | P48510 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P48510 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 76 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 327 – 371 | UBAPROSITE-ProRule annotationAdd BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 221 – 270 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 245 – 270 | Polar residuesSequence analysisAdd BLAST | 26 |
Phylogenomic databases
eggNOGi | KOG0010, Eukaryota |
GeneTreei | ENSGT00940000175001 |
HOGENOMi | CLU_024293_0_1_1 |
InParanoidi | P48510 |
OMAi | GMDMFGP |
Family and domain databases
InterProi | View protein in InterPro IPR006636, STI1_HS-bd IPR015940, UBA IPR009060, UBA-like_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00727, STI1, 2 hits SM00165, UBA, 1 hit SM00213, UBQ, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50030, UBA, 1 hit PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P48510-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLNIHIKSG QDKWEVNVAP ESTVLQFKEA INKANGIPVA NQRLIYSGKI
60 70 80 90 100
LKDDQTVESY HIQDGHSVHL VKSQPKPQTA SAAGANNATA TGAAAGTGAT
110 120 130 140 150
PNMSSGQSAG FNPLADLTSA RYAGYLNMPS ADMFGPDGGA LNNDSNNQDE
160 170 180 190 200
LLRMMENPIF QSQMNEMLSN PQMLDFMIQS NPQLQAMGPQ ARQMLQSPMF
210 220 230 240 250
RQMLTNPDMI RQSMQFARMM DPNAGMGSAG GAASAFPAPG GDAPEEGSNT
260 270 280 290 300
NTTSSSNTGN NAGTNAGTNA GANTAANPFA SLLNPALNPF ANAGNAASTG
310 320 330 340 350
MPAFDPALLA SMFQPPVQAS QAEDTRPPEE RYEHQLRQLN DMGFFDFDRN
360 370
VAALRRSGGS VQGALDSLLN GDV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 | A → R in AAB07267 (PubMed:8682868).Curated | 1 | |
Sequence conflicti | 296 | A → R in AAB07267 (PubMed:8682868).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L40587 Genomic DNA Translation: AAB07267.1 Z49704 Genomic DNA Translation: CAA89774.1 BK006946 Genomic DNA Translation: DAA10177.1 |
PIRi | S54583 |
RefSeqi | NP_014003.1, NM_001182783.1 |
Genome annotation databases
EnsemblFungii | YMR276W_mRNA; YMR276W; YMR276W |
GeneIDi | 855319 |
KEGGi | sce:YMR276W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L40587 Genomic DNA Translation: AAB07267.1 Z49704 Genomic DNA Translation: CAA89774.1 BK006946 Genomic DNA Translation: DAA10177.1 |
PIRi | S54583 |
RefSeqi | NP_014003.1, NM_001182783.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WR1 | NMR | - | B | 328-373 | [»] | |
2BWB | X-ray | 2.30 | A/B/C/D/E/F/G/H/I | 328-371 | [»] | |
2BWE | X-ray | 3.10 | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R | 328-373 | [»] | |
S/T/U | 1-75 | [»] | ||||
2BWF | X-ray | 1.15 | A/B | 1-75 | [»] | |
3M63 | X-ray | 2.40 | B | 1-75 | [»] | |
4UN2 | X-ray | 1.51 | B | 328-373 | [»] | |
BMRBi | P48510 | |||||
SMRi | P48510 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 35455, 138 interactors |
DIPi | DIP-4398N |
IntActi | P48510, 25 interactors |
MINTi | P48510 |
STRINGi | 4932.YMR276W |
PTM databases
iPTMneti | P48510 |
Proteomic databases
MaxQBi | P48510 |
PaxDbi | P48510 |
PRIDEi | P48510 |
Genome annotation databases
EnsemblFungii | YMR276W_mRNA; YMR276W; YMR276W |
GeneIDi | 855319 |
KEGGi | sce:YMR276W |
Organism-specific databases
SGDi | S000004889, DSK2 |
VEuPathDBi | FungiDB:YMR276W |
Phylogenomic databases
eggNOGi | KOG0010, Eukaryota |
GeneTreei | ENSGT00940000175001 |
HOGENOMi | CLU_024293_0_1_1 |
InParanoidi | P48510 |
OMAi | GMDMFGP |
Enzyme and pathway databases
Reactomei | R-SCE-8856825, Cargo recognition for clathrin-mediated endocytosis |
Miscellaneous databases
EvolutionaryTracei | P48510 |
PROi | PR:P48510 |
RNActi | P48510, protein |
Family and domain databases
InterProi | View protein in InterPro IPR006636, STI1_HS-bd IPR015940, UBA IPR009060, UBA-like_sf IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS |
Pfami | View protein in Pfam PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00727, STI1, 2 hits SM00165, UBA, 1 hit SM00213, UBQ, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50030, UBA, 1 hit PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DSK2_YEAST | |
Accessioni | P48510Primary (citable) accession number: P48510 Secondary accession number(s): D6W0A3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | October 5, 2010 | |
Last modified: | February 23, 2022 | |
This is version 185 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIII
Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references