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Protein

CD151 antigen

Gene

CD151

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.1 Publication
(Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.1 Publication

GO - Molecular functioni

  • integrin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionBlood group antigen

Enzyme and pathway databases

ReactomeiR-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-446107 Type I hemidesmosome assembly
SIGNORiP48509

Protein family/group databases

TCDBi8.A.40.1.15 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
CD151 antigen
Alternative name(s):
GP27
Membrane glycoprotein SFA-1
Platelet-endothelial tetraspan antigen 3
Short name:
PETA-3
Tetraspanin-24
Short name:
Tspan-24
CD_antigen: CD151
Gene namesi
Name:CD151
Synonyms:TSPAN24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000177697.17
HGNCiHGNC:1630 CD151
MIMi602243 gene
neXtProtiNX_P48509

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 57ExtracellularSequence analysisAdd BLAST18
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 91CytoplasmicSequence analysisAdd BLAST13
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 221ExtracellularSequence analysisAdd BLAST109
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 253CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Nephropathy with pretibial epidermolysis bullosa and deafness (NPEBD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the association of hereditary nephritis, epidermolysis bullosa, deafness, and beta-thalassemia minor.
See also OMIM:609057

Keywords - Diseasei

Deafness, Epidermolysis bullosa

Organism-specific databases

DisGeNETi977
MalaCardsiCD151
MIMi179620 phenotype
609057 phenotype
OpenTargetsiENSG00000177697
Orphaneti300333 Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome
PharmGKBiPA26189

Polymorphism and mutation databases

BioMutaiCD151
DMDMi85687560

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192301 – 253CD151 antigenAdd BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi11S-palmitoyl cysteine1 Publication1
Lipidationi15S-palmitoyl cysteine1 Publication1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi242S-palmitoyl cysteine1 Publication1
Lipidationi243S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

EPDiP48509
MaxQBiP48509
PaxDbiP48509
PeptideAtlasiP48509
PRIDEiP48509
ProteomicsDBi55898

PTM databases

iPTMnetiP48509
PhosphoSitePlusiP48509
SwissPalmiP48509

Expressioni

Tissue specificityi

Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.1 Publication

Inductioni

By HTLV-1.

Gene expression databases

BgeeiENSG00000177697 Expressed in 218 organ(s), highest expression level in descending thoracic aorta
CleanExiHS_CD151
ExpressionAtlasiP48509 baseline and differential
GenevisibleiP48509 HS

Organism-specific databases

HPAiCAB002428
HPA011906

Interactioni

Subunit structurei

Interacts with integrins ITGA3:ITGB1, ITGA5:ITGB1, ITGA3:ITGB1 and ITGA6:ITGB4 and with CD9 and CD181 (PubMed:11907260). Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (PubMed:27993971).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GRAMD1CQ8IYS08EBI-10210332,EBI-7054335

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107415, 12 interactors
CORUMiP48509
IntActiP48509, 7 interactors
STRINGi9606.ENSP00000324101

Structurei

3D structure databases

ProteinModelPortaliP48509
SMRiP48509
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230651
HOVERGENiHBG107306
InParanoidiP48509
KOiK06537
OMAiCKTVVAG
OrthoDBiEOG091G0CQO
PhylomeDBiP48509
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.iShow all

P48509-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS
60 70 80 90 100
LLASGTYLAT AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII
110 120 130 140 150
FLLEIIAGIL AYAYYQQLNT ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ
160 170 180 190 200
QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV PDSCCKTVVA LCGQRDHASN
210 220 230 240 250
IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF TCCLYRSLKL

EHY
Length:253
Mass (Da):28,295
Last modified:January 24, 2006 - v3
Checksum:i0C8FE4CF2C3C286D
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLZ6E9PLZ6_HUMAN
Tetraspanin
CD151
176Annotation score:
E9PRJ3E9PRJ3_HUMAN
Tetraspanin
CD151
178Annotation score:
E9PJC8E9PJC8_HUMAN
Tetraspanin
CD151
170Annotation score:
K4DIB7K4DIB7_HUMAN
Tetraspanin
CD151
180Annotation score:
K4DIA7K4DIA7_HUMAN
Tetraspanin
CD151
230Annotation score:
E9PMR4E9PMR4_HUMAN
Tetraspanin
CD151
251Annotation score:
E9PJE8E9PJE8_HUMAN
CD151 antigen
CD151
90Annotation score:
E9PSA1E9PSA1_HUMAN
CD151 antigen
CD151
82Annotation score:
E9PK37E9PK37_HUMAN
CD151 antigen
CD151
79Annotation score:
E9PP93E9PP93_HUMAN
CD151 antigen
CD151
64Annotation score:

Polymorphismi

CD151 defines the MER2=RAPH1 antigen of the RAPH blood group system. 92% of Caucasians are MER2-positive and 8% are apparently MER2-negative.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025098120T → M1 PublicationCorresponds to variant dbSNP:rs34215390Ensembl.1
Natural variantiVAR_012490132K → R2 Publications1
Natural variantiVAR_012491137P → S2 Publications1
Natural variantiVAR_021153178R → H1 PublicationCorresponds to variant dbSNP:rs779114765Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14650 mRNA Translation: AAA87064.1
D29963 mRNA Translation: BAA06229.1
AF315942 Genomic DNA Translation: AAK14179.1
BT007397 mRNA Translation: AAP36061.1
BT020132 mRNA Translation: AAV38934.1
CR456826 mRNA Translation: CAG33107.1
CR542098 mRNA Translation: CAG46895.1
AK293073 mRNA Translation: BAF85762.1
DQ074789 Genomic DNA Translation: AAY68211.1
AP006621 Genomic DNA No translation available.
AP006623 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02400.1
BC001374 mRNA Translation: AAH01374.1
BC013302 mRNA Translation: AAH13302.1
CCDSiCCDS7719.1
RefSeqiNP_001034579.1, NM_001039490.1
NP_004348.2, NM_004357.4
NP_620598.1, NM_139029.1
NP_620599.1, NM_139030.3
UniGeneiHs.654379

Genome annotation databases

EnsembliENST00000322008; ENSP00000324101; ENSG00000177697
ENST00000397420; ENSP00000380565; ENSG00000177697
ENST00000397421; ENSP00000380566; ENSG00000177697
ENST00000530726; ENSP00000432385; ENSG00000177697
GeneIDi977
KEGGihsa:977
UCSCiuc001lry.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14650 mRNA Translation: AAA87064.1
D29963 mRNA Translation: BAA06229.1
AF315942 Genomic DNA Translation: AAK14179.1
BT007397 mRNA Translation: AAP36061.1
BT020132 mRNA Translation: AAV38934.1
CR456826 mRNA Translation: CAG33107.1
CR542098 mRNA Translation: CAG46895.1
AK293073 mRNA Translation: BAF85762.1
DQ074789 Genomic DNA Translation: AAY68211.1
AP006621 Genomic DNA No translation available.
AP006623 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02400.1
BC001374 mRNA Translation: AAH01374.1
BC013302 mRNA Translation: AAH13302.1
CCDSiCCDS7719.1
RefSeqiNP_001034579.1, NM_001039490.1
NP_004348.2, NM_004357.4
NP_620598.1, NM_139029.1
NP_620599.1, NM_139030.3
UniGeneiHs.654379

3D structure databases

ProteinModelPortaliP48509
SMRiP48509
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107415, 12 interactors
CORUMiP48509
IntActiP48509, 7 interactors
STRINGi9606.ENSP00000324101

Protein family/group databases

TCDBi8.A.40.1.15 the tetraspanin (tetraspanin) family

PTM databases

iPTMnetiP48509
PhosphoSitePlusiP48509
SwissPalmiP48509

Polymorphism and mutation databases

BioMutaiCD151
DMDMi85687560

Proteomic databases

EPDiP48509
MaxQBiP48509
PaxDbiP48509
PeptideAtlasiP48509
PRIDEiP48509
ProteomicsDBi55898

Protocols and materials databases

DNASUi977
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322008; ENSP00000324101; ENSG00000177697
ENST00000397420; ENSP00000380565; ENSG00000177697
ENST00000397421; ENSP00000380566; ENSG00000177697
ENST00000530726; ENSP00000432385; ENSG00000177697
GeneIDi977
KEGGihsa:977
UCSCiuc001lry.4 human

Organism-specific databases

CTDi977
DisGeNETi977
EuPathDBiHostDB:ENSG00000177697.17
GeneCardsiCD151
HGNCiHGNC:1630 CD151
HPAiCAB002428
HPA011906
MalaCardsiCD151
MIMi179620 phenotype
602243 gene
609057 phenotype
neXtProtiNX_P48509
OpenTargetsiENSG00000177697
Orphaneti300333 Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome
PharmGKBiPA26189
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230651
HOVERGENiHBG107306
InParanoidiP48509
KOiK06537
OMAiCKTVVAG
OrthoDBiEOG091G0CQO
PhylomeDBiP48509
TreeFamiTF352892

Enzyme and pathway databases

ReactomeiR-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-446107 Type I hemidesmosome assembly
SIGNORiP48509

Miscellaneous databases

GeneWikiiCD151
GenomeRNAii977
PROiPR:P48509
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177697 Expressed in 218 organ(s), highest expression level in descending thoracic aorta
CleanExiHS_CD151
ExpressionAtlasiP48509 baseline and differential
GenevisibleiP48509 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD151_HUMAN
AccessioniPrimary (citable) accession number: P48509
Secondary accession number(s): A8KAK8
, E9PI15, Q14826, Q86U54, Q96TE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 24, 2006
Last modified: September 12, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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