UniProtKB - P48443 (RXRG_HUMAN)
Protein
Retinoic acid receptor RXR-gamma
Gene
RXRG
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 136 – 211 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 139 – 159 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 175 – 199 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- nuclear receptor activity Source: GO_Central
- retinoic acid-responsive element binding Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- anatomical structure development Source: GO_Central
- cell differentiation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to retinoic acid Source: GO_Central
- retinoic acid receptor signaling pathway Source: GO_Central
- transcription initiation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P48443 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-5362517, Signaling by Retinoic Acid |
SignaLinki | P48443 |
SIGNORi | P48443 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoic acid receptor RXR-gammaAlternative name(s): Nuclear receptor subfamily 2 group B member 3 Retinoid X receptor gamma |
Gene namesi | Name:RXRG Synonyms:NR2B3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10479, RXRG |
MIMi | 180247, gene |
neXtProti | NX_P48443 |
VEuPathDBi | HostDB:ENSG00000143171.12 |
Subcellular locationi
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: Reactome
Other locations
- cytoplasm Source: UniProtKB-SubCell
- RNA polymerase II transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6258 |
OpenTargetsi | ENSG00000143171 |
PharmGKBi | PA34892 |
Miscellaneous databases
Pharosi | P48443, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2004 |
DrugBanki | DB00459, Acitretin DB00210, Adapalene DB00523, Alitretinoin DB00307, Bexarotene DB01393, Bezafibrate DB03756, Doconexent DB00926, Etretinate DB02746, Phthalic Acid DB00412, Rosiglitazone DB00755, Tretinoin |
DrugCentrali | P48443 |
GuidetoPHARMACOLOGYi | 612 |
Genetic variation databases
BioMutai | RXRG |
DMDMi | 1350913 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053576 | 1 – 463 | Retinoic acid receptor RXR-gammaAdd BLAST | 463 |
Post-translational modificationi
Acetylated by EP300.1 Publication
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | P48443 |
MassIVEi | P48443 |
MaxQBi | P48443 |
PaxDbi | P48443 |
PeptideAtlasi | P48443 |
PRIDEi | P48443 |
ProteomicsDBi | 55890 |
PTM databases
iPTMneti | P48443 |
PhosphoSitePlusi | P48443 |
Expressioni
Tissue specificityi
Expressed in aortic endothelial cells (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000143171, Expressed in caudate nucleus and 133 other tissues |
ExpressionAtlasi | P48443, baseline and differential |
Genevisiblei | P48443, HS |
Organism-specific databases
HPAi | ENSG00000143171, Group enriched (brain, pituitary gland, retina, skeletal muscle) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP48443
Protein-protein interaction databases
BioGRIDi | 112170, 32 interactors |
DIPi | DIP-56220N |
IntActi | P48443, 29 interactors |
MINTi | P48443 |
STRINGi | 9606.ENSP00000352900 |
Chemistry databases
BindingDBi | P48443 |
Miscellaneous databases
RNActi | P48443, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P48443 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P48443 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 231 – 459 | NR LBDPROSITE-ProRule annotationAdd BLAST | 229 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 138 | ModulatingBy similarityAdd BLAST | 138 | |
Regioni | 205 – 230 | HingeAdd BLAST | 26 |
Domaini
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 139 – 159 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 175 – 199 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000161269 |
HOGENOMi | CLU_007368_5_4_1 |
InParanoidi | P48443 |
OMAi | YGNYPHF |
OrthoDBi | 912470at2759 |
PhylomeDBi | P48443 |
TreeFami | TF352097 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P48443-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV
60 70 80 90 100
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL
110 120 130 140 150
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH
160 170 180 190 200
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL
210 220 230 240 250
VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL EAELAVEPKT
260 270 280 290 300
ESYGDMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
310 320 330 340 350
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV
360 370 380 390 400
LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT
410 420 430 440 450
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT
460
FLMEMLETPL QIT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZ88 | A0A087WZ88_HUMAN | Retinoic acid receptor RXR-gamma | RXRG | 340 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38480 mRNA Translation: AAA80681.1 CR456705 mRNA Translation: CAG32986.1 AL160058 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90745.1 BC012063 mRNA Translation: AAH12063.1 |
CCDSi | CCDS1248.1 |
RefSeqi | NP_001243500.1, NM_001256571.1 NP_008848.1, NM_006917.4 |
Genome annotation databases
Ensembli | ENST00000359842; ENSP00000352900; ENSG00000143171 |
GeneIDi | 6258 |
KEGGi | hsa:6258 |
UCSCi | uc001gda.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U38480 mRNA Translation: AAA80681.1 CR456705 mRNA Translation: CAG32986.1 AL160058 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW90745.1 BC012063 mRNA Translation: AAH12063.1 |
CCDSi | CCDS1248.1 |
RefSeqi | NP_001243500.1, NM_001256571.1 NP_008848.1, NM_006917.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GL8 | X-ray | 2.40 | A/B/C/D | 227-463 | [»] | |
7A79 | X-ray | 2.05 | A/B | 233-463 | [»] | |
SMRi | P48443 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112170, 32 interactors |
DIPi | DIP-56220N |
IntActi | P48443, 29 interactors |
MINTi | P48443 |
STRINGi | 9606.ENSP00000352900 |
Chemistry databases
BindingDBi | P48443 |
ChEMBLi | CHEMBL2004 |
DrugBanki | DB00459, Acitretin DB00210, Adapalene DB00523, Alitretinoin DB00307, Bexarotene DB01393, Bezafibrate DB03756, Doconexent DB00926, Etretinate DB02746, Phthalic Acid DB00412, Rosiglitazone DB00755, Tretinoin |
DrugCentrali | P48443 |
GuidetoPHARMACOLOGYi | 612 |
PTM databases
iPTMneti | P48443 |
PhosphoSitePlusi | P48443 |
Genetic variation databases
BioMutai | RXRG |
DMDMi | 1350913 |
Proteomic databases
jPOSTi | P48443 |
MassIVEi | P48443 |
MaxQBi | P48443 |
PaxDbi | P48443 |
PeptideAtlasi | P48443 |
PRIDEi | P48443 |
ProteomicsDBi | 55890 |
Protocols and materials databases
Antibodypediai | 3620, 389 antibodies |
DNASUi | 6258 |
Genome annotation databases
Ensembli | ENST00000359842; ENSP00000352900; ENSG00000143171 |
GeneIDi | 6258 |
KEGGi | hsa:6258 |
UCSCi | uc001gda.4, human |
Organism-specific databases
CTDi | 6258 |
DisGeNETi | 6258 |
GeneCardsi | RXRG |
HGNCi | HGNC:10479, RXRG |
HPAi | ENSG00000143171, Group enriched (brain, pituitary gland, retina, skeletal muscle) |
MIMi | 180247, gene |
neXtProti | NX_P48443 |
OpenTargetsi | ENSG00000143171 |
PharmGKBi | PA34892 |
VEuPathDBi | HostDB:ENSG00000143171.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000161269 |
HOGENOMi | CLU_007368_5_4_1 |
InParanoidi | P48443 |
OMAi | YGNYPHF |
OrthoDBi | 912470at2759 |
PhylomeDBi | P48443 |
TreeFami | TF352097 |
Enzyme and pathway databases
PathwayCommonsi | P48443 |
Reactomei | R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-5362517, Signaling by Retinoic Acid |
SignaLinki | P48443 |
SIGNORi | P48443 |
Miscellaneous databases
BioGRID-ORCSi | 6258, 5 hits in 896 CRISPR screens |
ChiTaRSi | RXRG, human |
EvolutionaryTracei | P48443 |
GeneWikii | Retinoid_X_receptor_gamma |
GenomeRNAii | 6258 |
Pharosi | P48443, Tclin |
PROi | PR:P48443 |
RNActi | P48443, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143171, Expressed in caudate nucleus and 133 other tissues |
ExpressionAtlasi | P48443, baseline and differential |
Genevisiblei | P48443, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RXRG_HUMAN | |
Accessioni | P48443Primary (citable) accession number: P48443 Secondary accession number(s): A6NIP1, Q6IBU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 203 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families