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Protein

Retinoic acid receptor RXR-gamma

Gene

RXRG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi136 – 211Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri175 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-5362517 Signaling by Retinoic Acid
SignaLinkiP48443
SIGNORiP48443

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene namesi
Name:RXRG
Synonyms:NR2B3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143171.12
HGNCiHGNC:10479 RXRG
MIMi180247 gene
neXtProtiNX_P48443

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6258
OpenTargetsiENSG00000143171
PharmGKBiPA34892

Chemistry databases

ChEMBLiCHEMBL2004
DrugBankiDB00459 Acitretin
DB00210 Adapalene
DB00523 Alitretinoin
DB00307 Bexarotene
DB00926 Etretinate
DB00755 Tretinoin
GuidetoPHARMACOLOGYi612

Polymorphism and mutation databases

BioMutaiRXRG
DMDMi1350913

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535761 – 463Retinoic acid receptor RXR-gammaAdd BLAST463

Proteomic databases

MaxQBiP48443
PaxDbiP48443
PeptideAtlasiP48443
PRIDEiP48443
ProteomicsDBi55890

PTM databases

iPTMnetiP48443
PhosphoSitePlusiP48443

Expressioni

Gene expression databases

BgeeiENSG00000143171 Expressed in 114 organ(s), highest expression level in caudate nucleus
CleanExiHS_RXRG
ExpressionAtlasiP48443 baseline and differential
GenevisibleiP48443 HS

Organism-specific databases

HPAiCAB002615
HPA012933

Interactioni

Subunit structurei

Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi112170, 29 interactors
DIPiDIP-56220N
IntActiP48443, 18 interactors
MINTiP48443
STRINGi9606.ENSP00000352900

Chemistry databases

BindingDBiP48443

Structurei

Secondary structure

1463
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP48443
SMRiP48443
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48443

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini231 – 459NR LBDPROSITE-ProRule annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 138ModulatingBy similarityAdd BLAST138
Regioni205 – 230HingeAdd BLAST26

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri175 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118948
HOGENOMiHOG000260821
HOVERGENiHBG005606
InParanoidiP48443
KOiK08526
OMAiGGHEDMP
OrthoDBiEOG091G0YX6
PhylomeDBiP48443
TreeFamiTF352097

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR021780 Nuc_recep-AF1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000003 Retinoid-X_rcpt/HNF4
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF11825 Nuc_recep-AF1, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00545 RETINOIDXR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P48443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV
60 70 80 90 100
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL
110 120 130 140 150
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH
160 170 180 190 200
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL
210 220 230 240 250
VMGMKREAVQ EERQRSRERA ESEAECATSG HEDMPVERIL EAELAVEPKT
260 270 280 290 300
ESYGDMNMEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
310 320 330 340 350
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV
360 370 380 390 400
LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT
410 420 430 440 450
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDT
460
FLMEMLETPL QIT
Length:463
Mass (Da):50,871
Last modified:February 1, 1996 - v1
Checksum:iAED5C94BB62A3157
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZ88A0A087WZ88_HUMAN
Retinoic acid receptor RXR-gamma
RXRG
340Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38480 mRNA Translation: AAA80681.1
CR456705 mRNA Translation: CAG32986.1
AL160058 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90745.1
BC012063 mRNA Translation: AAH12063.1
CCDSiCCDS1248.1
RefSeqiNP_001243500.1, NM_001256571.1
NP_008848.1, NM_006917.4
UniGeneiHs.26550

Genome annotation databases

EnsembliENST00000359842; ENSP00000352900; ENSG00000143171
GeneIDi6258
KEGGihsa:6258
UCSCiuc001gda.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38480 mRNA Translation: AAA80681.1
CR456705 mRNA Translation: CAG32986.1
AL160058 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90745.1
BC012063 mRNA Translation: AAH12063.1
CCDSiCCDS1248.1
RefSeqiNP_001243500.1, NM_001256571.1
NP_008848.1, NM_006917.4
UniGeneiHs.26550

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GL8X-ray2.40A/B/C/D227-463[»]
ProteinModelPortaliP48443
SMRiP48443
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112170, 29 interactors
DIPiDIP-56220N
IntActiP48443, 18 interactors
MINTiP48443
STRINGi9606.ENSP00000352900

Chemistry databases

BindingDBiP48443
ChEMBLiCHEMBL2004
DrugBankiDB00459 Acitretin
DB00210 Adapalene
DB00523 Alitretinoin
DB00307 Bexarotene
DB00926 Etretinate
DB00755 Tretinoin
GuidetoPHARMACOLOGYi612

PTM databases

iPTMnetiP48443
PhosphoSitePlusiP48443

Polymorphism and mutation databases

BioMutaiRXRG
DMDMi1350913

Proteomic databases

MaxQBiP48443
PaxDbiP48443
PeptideAtlasiP48443
PRIDEiP48443
ProteomicsDBi55890

Protocols and materials databases

DNASUi6258
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359842; ENSP00000352900; ENSG00000143171
GeneIDi6258
KEGGihsa:6258
UCSCiuc001gda.4 human

Organism-specific databases

CTDi6258
DisGeNETi6258
EuPathDBiHostDB:ENSG00000143171.12
GeneCardsiRXRG
HGNCiHGNC:10479 RXRG
HPAiCAB002615
HPA012933
MIMi180247 gene
neXtProtiNX_P48443
OpenTargetsiENSG00000143171
PharmGKBiPA34892
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118948
HOGENOMiHOG000260821
HOVERGENiHBG005606
InParanoidiP48443
KOiK08526
OMAiGGHEDMP
OrthoDBiEOG091G0YX6
PhylomeDBiP48443
TreeFamiTF352097

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-5362517 Signaling by Retinoic Acid
SignaLinkiP48443
SIGNORiP48443

Miscellaneous databases

ChiTaRSiRXRG human
EvolutionaryTraceiP48443
GeneWikiiRetinoid_X_receptor_gamma
GenomeRNAii6258
PROiPR:P48443
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143171 Expressed in 114 organ(s), highest expression level in caudate nucleus
CleanExiHS_RXRG
ExpressionAtlasiP48443 baseline and differential
GenevisibleiP48443 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR021780 Nuc_recep-AF1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000003 Retinoid-X_rcpt/HNF4
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF11825 Nuc_recep-AF1, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00545 RETINOIDXR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRXRG_HUMAN
AccessioniPrimary (citable) accession number: P48443
Secondary accession number(s): A6NIP1, Q6IBU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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