SOX2

Functionⁱ

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	41 – 109	HMG boxPROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18027866
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
miRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18710938
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 20713518
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18407919
transcription regulatory region sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenohypophysis development Source: Ensembl
cell cycle arrest
Source: UniProtKB
Inferred from direct assayⁱ
- 18268498
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell fate commitment
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chromatin organization
Source: UniProtKB
Non-traceable author statementⁱ
- 7849401
cytokine-mediated signaling pathway Source: Reactome
endodermal cell fate specification
Source: MGI
Inferred from direct assayⁱ
- 21245162
eye development
Source: UniProtKB
Inferred from expression patternⁱ
- 18285410
forebrain development
Source: UniProtKB
Inferred from expression patternⁱ
- 18285410
glial cell fate commitment
Source: UniProtKB
Non-traceable author statementⁱ
- 17291498
inner ear development
Source: UniProtKB
Inferred from expression patternⁱ
- 18407919
negative regulation of canonical Wnt signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 18285410
negative regulation of epithelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 18268498
negative regulation of neuron differentiation Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: UniProtKB
neuronal stem cell population maintenance Source: UniProtKB
osteoblast differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 18187129
pituitary gland development
Source: UniProtKB
Inferred from expression patternⁱ
- 18285410
positive regulation of cell-cell adhesion Source: Ensembl
positive regulation of cell differentiation Source: Ensembl
positive regulation of MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 18187129
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 18407919
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 18027866
regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 18268498
regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18388306
regulation of transcription, DNA-templated
Source: HGNC
Inferred from direct assayⁱ
- 16153702
response to growth factor
Source: UniProtKB
Inferred from direct assayⁱ
- 18187129
response to wounding
Source: UniProtKB
Inferred from expression patternⁱ
- 17982423
somatic stem cell population maintenance
Source: UniProtKB
Inferred from direct assayⁱ
- 19409607
tissue regeneration Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-3769402 Deactivation of the beta-catenin transactivating complex R-HSA-452723 Transcriptional regulation of pluripotent stem cells R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P48431
SIGNORⁱ	P48431

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor SOX-2
Gene namesⁱ	Name:SOX2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000181449.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11195 SOX2
MIMⁱ	184429 gene
neXtProtⁱ	NX_P48431

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Microphthalmia, syndromic, 3 (MCOPS3)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.

Biotechnological useⁱ

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication

Keywords - Diseaseⁱ

Disease mutation, Microphthalmia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6657
GeneReviewsⁱ	SOX2
MalaCards human disease database More...MalaCardsⁱ	SOX2
MIMⁱ	206900 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000181449
Orphanetⁱ	77298 Anophthalmia/microphthalmia-esophageal atresia syndrome 2542 Isolated anophthalmia-microphthalmia syndrome 3157 Septo-optic dysplasia spectrum
PharmGKBⁱ	PA36032

Polymorphism and mutation databases

BioMutaⁱ	SOX2
DMDMⁱ	1351091

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048715	1 – 317	Transcription factor SOX-2Add BLAST		317

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	245	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residueⁱ	251	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P48431
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P48431
PaxDbⁱ	P48431
PeptideAtlas More...PeptideAtlasⁱ	P48431
PRIDEⁱ	P48431
ProteomicsDBⁱ	55888

PTM databases

iPTMnetⁱ	P48431
PhosphoSitePlusⁱ	P48431

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000181449 Expressed in 150 organ(s), highest expression level in cerebral cortex
CleanExⁱ	HS_SOX2
ExpressionAtlasⁱ	P48431 baseline and differential
Genevisibleⁱ	P48431 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010648 HPA045725 HPA071379

HPAⁱ

CAB010648
HPA045725
HPA071379

Interactionⁱ

Subunit structureⁱ

Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
MBD3	O95983	3	EBI-6124081,EBI-1783068
PRKCI	P41743	2	EBI-6124081,EBI-286199
SUMO1	P63165	3	EBI-6124081,EBI-80140
VRK1	Q99986	14	EBI-6124081,EBI-1769146

Protein-protein interaction databases

BioGridⁱ	112540, 352 interactors
CORUMⁱ	P48431
Database of interacting proteins More...DIPⁱ	DIP-59913N
IntActⁱ	P48431, 9 interactors
Molecular INTeraction database More...MINTⁱ	P48431
STRINGⁱ	9606.ENSP00000323588

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	47 – 62	Combined sources	16
Helixⁱ	68 – 79	Combined sources	12
Helixⁱ	84 – 104	Combined sources	21

Show more details

3D structure databases

ProteinModelPortalⁱ	P48431
SMRⁱ	P48431
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P48431

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	19 – 23	Poly-Gly		5
Compositional biasⁱ	27 – 30	Poly-Ala		4

Phylogenomic databases

eggNOGⁱ	ENOG410IPZI Eukaryota ENOG411009V LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231647
HOVERGENⁱ	HBG105663
InParanoidⁱ	P48431
KEGG Orthology (KO) More...KOⁱ	K16796
OMAⁱ	MQSMHRY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F15
PhylomeDBⁱ	P48431
TreeFamⁱ	TF351735

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR032643 SOX-2 IPR022097 SOX_fam
PANTHERⁱ	PTHR10270:SF231 PTHR10270:SF231, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit PF12336 SOXp, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P48431-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV 
        60         70         80         90        100
WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL 
       110        120        130        140        150
HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG 
       160        170        180        190        200
AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY 
       210        220        230        240        250
DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS 
       260        270        280        290        300
SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS 
       310 
GPVPGTAING TLPLSHM

Length:317

Mass (Da):34,310

Last modified:February 1, 1996 - v1

Checksum:ⁱEFCCAFE3E3A2B67B

GO

Sequence cautionⁱ

The sequence AAA35997 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAA83435 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_075627	51	W → R in MCOPS3; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_075628	74	R → P in MCOPS3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104893805EnsemblClinVar.	1
Natural variantⁱVAR_075629	79	W → S in MCOPS3; unknown pathological significance. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z31560 mRNA Translation: CAA83435.1 Different initiation. L07335 mRNA Translation: AAA35997.1 Different initiation. BC013923 mRNA Translation: AAH13923.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3239.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003097.1, NM_003106.3
UniGeneⁱ	Hs.518438 Hs.732963

Genome annotation databases

Ensemblⁱ	ENST00000325404; ENSP00000323588; ENSG00000181449
GeneIDⁱ	6657
KEGGⁱ	hsa:6657
UCSC genome browser More...UCSCⁱ	uc003fkx.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P48431	SRY (Sex determining region Y)-box 2		HUMAN		317	UniRef100_P48431

Protein	Similar proteins		Species	Score	Length	Source
P48431	Transcription factor SOX-2	)	MOUSE		319	UniRef90_P48432
Transcription factor SOX-2		SHEEP		320
transcription factor SOX-2		Yangtze finless porpoise		327
transcription factor SOX-2		TARSY		325
SRY-box 2		AILME		325
+71

Protein	Similar proteins		Species	Score	Length	Source
P48431	Transcription factor SOX-2	)	MOUSE		319	UniRef50_P48432
Transcription factor SOX-2		SHEEP		320
Transcription factor Sox-2		DANRE		315
Transcription factor Sox-3-A		XENLA		309
Transcription factor Sox-3		XENTR		307
+370

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Sox2 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z31560 mRNA Translation: CAA83435.1 Different initiation. L07335 mRNA Translation: AAA35997.1 Different initiation. BC013923 mRNA Translation: AAH13923.1
CCDSⁱ	CCDS3239.1
RefSeqⁱ	NP_003097.1, NM_003106.3
UniGeneⁱ	Hs.518438 Hs.732963

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1O4X	NMR	-	B	39-121	[»]
	2LE4	NMR	-	A	39-118	[»]
ProteinModelPortalⁱ	P48431
SMRⁱ	P48431
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112540, 352 interactors
CORUMⁱ	P48431
DIPⁱ	DIP-59913N
IntActⁱ	P48431, 9 interactors
MINTⁱ	P48431
STRINGⁱ	9606.ENSP00000323588

PTM databases

iPTMnetⁱ	P48431
PhosphoSitePlusⁱ	P48431

Polymorphism and mutation databases

BioMutaⁱ	SOX2
DMDMⁱ	1351091

Proteomic databases

EPDⁱ	P48431
MaxQBⁱ	P48431
PaxDbⁱ	P48431
PeptideAtlasⁱ	P48431
PRIDEⁱ	P48431
ProteomicsDBⁱ	55888

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6657
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000325404; ENSP00000323588; ENSG00000181449
GeneIDⁱ	6657
KEGGⁱ	hsa:6657
UCSCⁱ	uc003fkx.4 human

Organism-specific databases

CTDⁱ	6657
DisGeNETⁱ	6657
EuPathDBⁱ	HostDB:ENSG00000181449.3
GeneCardsⁱ	SOX2
GeneReviewsⁱ	SOX2
HGNCⁱ	HGNC:11195 SOX2
HPAⁱ	CAB010648 HPA045725 HPA071379
MalaCardsⁱ	SOX2
MIMⁱ	184429 gene 206900 phenotype
neXtProtⁱ	NX_P48431
OpenTargetsⁱ	ENSG00000181449
Orphanetⁱ	77298 Anophthalmia/microphthalmia-esophageal atresia syndrome 2542 Isolated anophthalmia-microphthalmia syndrome 3157 Septo-optic dysplasia spectrum
PharmGKBⁱ	PA36032
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IPZI Eukaryota ENOG411009V LUCA
GeneTreeⁱ	ENSGT00760000118988
HOGENOMⁱ	HOG000231647
HOVERGENⁱ	HBG105663
InParanoidⁱ	P48431
KOⁱ	K16796
OMAⁱ	MQSMHRY
OrthoDBⁱ	EOG091G0F15
PhylomeDBⁱ	P48431
TreeFamⁱ	TF351735

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation R-HSA-3769402 Deactivation of the beta-catenin transactivating complex R-HSA-452723 Transcriptional regulation of pluripotent stem cells R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P48431
SIGNORⁱ	P48431

Miscellaneous databases

EvolutionaryTraceⁱ	P48431
GeneWikiⁱ	SOX2
GenomeRNAiⁱ	6657
Protein Ontology More...PROⁱ	PR:P48431
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000181449 Expressed in 150 organ(s), highest expression level in cerebral cortex
CleanExⁱ	HS_SOX2
ExpressionAtlasⁱ	P48431 baseline and differential
Genevisibleⁱ	P48431 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 1 hit
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR032643 SOX-2 IPR022097 SOX_fam
PANTHERⁱ	PTHR10270:SF231 PTHR10270:SF231, 1 hit
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit PF12336 SOXp, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 1 hit
SUPFAMⁱ	SSF47095 SSF47095, 1 hit
PROSITEⁱ	View protein in PROSITE PS50118 HMG_BOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SOX2_HUMAN
Accessionⁱ	P48431Primary (citable) accession number: P48431 Secondary accession number(s): Q14537
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P48431 (SOX2_HUMAN)

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Transcription factor SOX-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Biotechnological useⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ