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Protein

Transcription factor SOX-2

Gene

SOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi41 – 109HMG boxPROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-8986944 Transcriptional Regulation by MECP2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P48431

SIGNOR Signaling Network Open Resource

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SIGNORi
P48431

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor SOX-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SOX2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000181449.3

Human Gene Nomenclature Database

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HGNCi
HGNC:11195 SOX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
184429 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48431

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microphthalmia, syndromic, 3 (MCOPS3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
See also OMIM:206900
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07562751W → R in MCOPS3; unknown pathological significance. 1 Publication1
Natural variantiVAR_07562874R → P in MCOPS3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104893805EnsemblClinVar.1
Natural variantiVAR_07562979W → S in MCOPS3; unknown pathological significance. 1 Publication1

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication

Keywords - Diseasei

Disease mutation, Microphthalmia

Organism-specific databases

DisGeNET

More...
DisGeNETi
6657

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
SOX2

MalaCards human disease database

More...
MalaCardsi
SOX2
MIMi206900 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000181449

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
77298 Anophthalmia/microphthalmia-esophageal atresia syndrome
2542 Isolated microphthalmia-anophthalmia-coloboma
3157 Septo-optic dysplasia spectrum

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36032

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SOX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1351091

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000487151 – 317Transcription factor SOX-2Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei251PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P48431

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P48431

MaxQB - The MaxQuant DataBase

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MaxQBi
P48431

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P48431

PeptideAtlas

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PeptideAtlasi
P48431

PRoteomics IDEntifications database

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PRIDEi
P48431

ProteomicsDB human proteome resource

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ProteomicsDBi
55888

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P48431

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P48431

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000181449 Expressed in 150 organ(s), highest expression level in cerebral cortex

CleanEx database of gene expression profiles

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CleanExi
HS_SOX2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P48431 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P48431 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB010648
HPA045725
HPA071379

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112540, 352 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P48431

Database of interacting proteins

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DIPi
DIP-59913N

Protein interaction database and analysis system

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IntActi
P48431, 9 interactors

Molecular INTeraction database

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MINTi
P48431

STRING: functional protein association networks

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STRINGi
9606.ENSP00000323588

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O4XNMR-B39-121[»]
2LE4NMR-A39-118[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P48431

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P48431

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P48431

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 23Poly-Gly5
Compositional biasi27 – 30Poly-Ala4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IPZI Eukaryota
ENOG411009V LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231647

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG105663

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P48431

KEGG Orthology (KO)

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KOi
K16796

Identification of Orthologs from Complete Genome Data

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OMAi
MQSMHRY

Database of Orthologous Groups

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OrthoDBi
1161594at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P48431

TreeFam database of animal gene trees

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TreeFami
TF351735

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR032643 SOX-2
IPR022097 SOX_fam

The PANTHER Classification System

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PANTHERi
PTHR10270:SF231 PTHR10270:SF231, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P48431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV
60 70 80 90 100
WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL
110 120 130 140 150
HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG
160 170 180 190 200
AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY
210 220 230 240 250
DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS
260 270 280 290 300
SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS
310
GPVPGTAING TLPLSHM
Length:317
Mass (Da):34,310
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFCCAFE3E3A2B67B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35997 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA83435 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07562751W → R in MCOPS3; unknown pathological significance. 1 Publication1
Natural variantiVAR_07562874R → P in MCOPS3; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs104893805EnsemblClinVar.1
Natural variantiVAR_07562979W → S in MCOPS3; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z31560 mRNA Translation: CAA83435.1 Different initiation.
L07335 mRNA Translation: AAA35997.1 Different initiation.
BC013923 mRNA Translation: AAH13923.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3239.1

NCBI Reference Sequences

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RefSeqi
NP_003097.1, NM_003106.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.518438
Hs.732963

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000325404; ENSP00000323588; ENSG00000181449

Database of genes from NCBI RefSeq genomes

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GeneIDi
6657

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6657

UCSC genome browser

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UCSCi
uc003fkx.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Sox2 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z31560 mRNA Translation: CAA83435.1 Different initiation.
L07335 mRNA Translation: AAA35997.1 Different initiation.
BC013923 mRNA Translation: AAH13923.1
CCDSiCCDS3239.1
RefSeqiNP_003097.1, NM_003106.3
UniGeneiHs.518438
Hs.732963

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O4XNMR-B39-121[»]
2LE4NMR-A39-118[»]
ProteinModelPortaliP48431
SMRiP48431
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112540, 352 interactors
CORUMiP48431
DIPiDIP-59913N
IntActiP48431, 9 interactors
MINTiP48431
STRINGi9606.ENSP00000323588

PTM databases

iPTMnetiP48431
PhosphoSitePlusiP48431

Polymorphism and mutation databases

BioMutaiSOX2
DMDMi1351091

Proteomic databases

EPDiP48431
jPOSTiP48431
MaxQBiP48431
PaxDbiP48431
PeptideAtlasiP48431
PRIDEiP48431
ProteomicsDBi55888

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6657
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325404; ENSP00000323588; ENSG00000181449
GeneIDi6657
KEGGihsa:6657
UCSCiuc003fkx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6657
DisGeNETi6657
EuPathDBiHostDB:ENSG00000181449.3

GeneCards: human genes, protein and diseases

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GeneCardsi
SOX2
GeneReviewsiSOX2
HGNCiHGNC:11195 SOX2
HPAiCAB010648
HPA045725
HPA071379
MalaCardsiSOX2
MIMi184429 gene
206900 phenotype
neXtProtiNX_P48431
OpenTargetsiENSG00000181449
Orphaneti77298 Anophthalmia/microphthalmia-esophageal atresia syndrome
2542 Isolated microphthalmia-anophthalmia-coloboma
3157 Septo-optic dysplasia spectrum
PharmGKBiPA36032

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IPZI Eukaryota
ENOG411009V LUCA
GeneTreeiENSGT00940000160614
HOGENOMiHOG000231647
HOVERGENiHBG105663
InParanoidiP48431
KOiK16796
OMAiMQSMHRY
OrthoDBi1161594at2759
PhylomeDBiP48431
TreeFamiTF351735

Enzyme and pathway databases

ReactomeiR-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-8986944 Transcriptional Regulation by MECP2
SignaLinkiP48431
SIGNORiP48431

Miscellaneous databases

EvolutionaryTraceiP48431

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SOX2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6657

Protein Ontology

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PROi
PR:P48431

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000181449 Expressed in 150 organ(s), highest expression level in cerebral cortex
CleanExiHS_SOX2
ExpressionAtlasiP48431 baseline and differential
GenevisibleiP48431 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR032643 SOX-2
IPR022097 SOX_fam
PANTHERiPTHR10270:SF231 PTHR10270:SF231, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48431
Secondary accession number(s): Q14537
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 16, 2019
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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