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Protein

Tubulin-specific chaperone A

Gene

Tbca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tubulin-folding protein; involved in the early step of the tubulin folding pathway.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin-specific chaperone A
Alternative name(s):
TCP1-chaperonin cofactor A
Tubulin-folding cofactor A
Short name:
CFA
Gene namesi
Name:Tbca
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:107549 Tbca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000800402 – 108Tubulin-specific chaperone AAdd BLAST107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP48428
PaxDbiP48428
PeptideAtlasiP48428
PRIDEiP48428

2D gel databases

REPRODUCTION-2DPAGEiP48428

PTM databases

iPTMnetiP48428
PhosphoSitePlusiP48428

Expressioni

Tissue specificityi

Widely expressed, but is most abundant in the testis.

Gene expression databases

BgeeiENSMUSG00000042043 Expressed in 267 organ(s), highest expression level in Ammon's horn
CleanExiMM_TBCA
ExpressionAtlasiP48428 baseline and differential
GenevisibleiP48428 MM

Interactioni

Subunit structurei

Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP48428, 1 interactor
MINTiP48428
STRINGi10090.ENSMUSP00000038781

Structurei

3D structure databases

ProteinModelPortaliP48428
SMRiP48428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TBCA family.Curated

Phylogenomic databases

eggNOGiKOG3470 Eukaryota
ENOG4111Y9A LUCA
GeneTreeiENSGT00390000009710
HOGENOMiHOG000213817
HOVERGENiHBG004499
InParanoidiP48428
KOiK17292
OMAiIMMVPDS
OrthoDBiEOG091G1809
PhylomeDBiP48428
TreeFamiTF313971

Family and domain databases

InterProiView protein in InterPro
IPR004226 TBCA
IPR036126 TBCA_sf
PANTHERiPTHR21500 PTHR21500, 1 hit
PfamiView protein in Pfam
PF02970 TBCA, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010430 CofA_tubulin_bd, 1 hit
SUPFAMiSSF46988 SSF46988, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P48428-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPRVRQIK IKTGVVRRLV KERVMYEKEA KQQEEKIEKM KAEDGENYAI
60 70 80 90 100
KKQAEILQES RMMIPDCQRR LEAAYTDLQQ ILESEKDLEE AEEYKEARVV

LDSVKLEA
Length:108
Mass (Da):12,758
Last modified:January 23, 2007 - v3
Checksum:i93D4E497F256C48E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJ48A0A1Y7VJ48_MOUSE
Tubulin-specific chaperone A
Tbca
84Annotation score:
A0A1Y7VLW1A0A1Y7VLW1_MOUSE
Tubulin-specific chaperone A
Tbca
36Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05333 mRNA Translation: AAA83250.1
BC034267 mRNA Translation: AAH34267.1
BC051475 mRNA Translation: AAH51475.1
BC055749 mRNA Translation: AAH55749.1
CCDSiCCDS26694.1
PIRiI48930
RefSeqiNP_033347.1, NM_009321.2
UniGeneiMm.379025

Genome annotation databases

EnsembliENSMUST00000046644; ENSMUSP00000038781; ENSMUSG00000042043
GeneIDi21371
KEGGimmu:21371
UCSCiuc007rlx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05333 mRNA Translation: AAA83250.1
BC034267 mRNA Translation: AAH34267.1
BC051475 mRNA Translation: AAH51475.1
BC055749 mRNA Translation: AAH55749.1
CCDSiCCDS26694.1
PIRiI48930
RefSeqiNP_033347.1, NM_009321.2
UniGeneiMm.379025

3D structure databases

ProteinModelPortaliP48428
SMRiP48428
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP48428, 1 interactor
MINTiP48428
STRINGi10090.ENSMUSP00000038781

PTM databases

iPTMnetiP48428
PhosphoSitePlusiP48428

2D gel databases

REPRODUCTION-2DPAGEiP48428

Proteomic databases

EPDiP48428
PaxDbiP48428
PeptideAtlasiP48428
PRIDEiP48428

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046644; ENSMUSP00000038781; ENSMUSG00000042043
GeneIDi21371
KEGGimmu:21371
UCSCiuc007rlx.1 mouse

Organism-specific databases

CTDi6902
MGIiMGI:107549 Tbca

Phylogenomic databases

eggNOGiKOG3470 Eukaryota
ENOG4111Y9A LUCA
GeneTreeiENSGT00390000009710
HOGENOMiHOG000213817
HOVERGENiHBG004499
InParanoidiP48428
KOiK17292
OMAiIMMVPDS
OrthoDBiEOG091G1809
PhylomeDBiP48428
TreeFamiTF313971

Miscellaneous databases

PROiPR:P48428
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042043 Expressed in 267 organ(s), highest expression level in Ammon's horn
CleanExiMM_TBCA
ExpressionAtlasiP48428 baseline and differential
GenevisibleiP48428 MM

Family and domain databases

InterProiView protein in InterPro
IPR004226 TBCA
IPR036126 TBCA_sf
PANTHERiPTHR21500 PTHR21500, 1 hit
PfamiView protein in Pfam
PF02970 TBCA, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010430 CofA_tubulin_bd, 1 hit
SUPFAMiSSF46988 SSF46988, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBCA_MOUSE
AccessioniPrimary (citable) accession number: P48428
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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