UniProtKB - P48363 (PFD3_YEAST)
Protein
Prefoldin subunit 3
Gene
PAC10
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Miscellaneous
Present with 6550 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- tubulin binding Source: SGD
GO - Biological processi
- microtubule-based process Source: GO_Central
- protein folding Source: InterPro
- tubulin complex assembly Source: SGD
Keywordsi
Molecular function | Chaperone |
Names & Taxonomyi
Protein namesi | Recommended name: Prefoldin subunit 3Alternative name(s): Genes involved in microtubule biogenesis protein 2 Gim complex subunit 2 Short name: GimC subunit 2 |
Gene namesi | Name:PAC10 Synonyms:GIM2, PFD3 Ordered Locus Names:YGR078C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YGR078C |
SGDi | S000003310, PAC10 |
Subcellular locationi
Other locations
- cytoplasm Source: SGD
- polysome Source: SGD
- prefoldin complex Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153659 | 1 – 199 | Prefoldin subunit 3Add BLAST | 199 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
MaxQBi | P48363 |
PaxDbi | P48363 |
PRIDEi | P48363 |
PTM databases
iPTMneti | P48363 |
Interactioni
Subunit structurei
Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.
1 PublicationBinary interactionsi
Hide detailsP48363
With | #Exp. | IntAct |
---|---|---|
GIM3 [P53900] | 3 | EBI-13239,EBI-13246 |
GIM5 [Q04493] | 5 | EBI-13239,EBI-13253 |
YKE2 [P52553] | 5 | EBI-13239,EBI-13260 |
GO - Molecular functioni
- tubulin binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 33320, 642 interactors |
ComplexPortali | CPX-1671, Prefoldin complex |
DIPi | DIP-6837N |
IntActi | P48363, 10 interactors |
MINTi | P48363 |
STRINGi | 4932.YGR078C |
Miscellaneous databases
RNActi | P48363, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the prefoldin subunit alpha family.Curated
Phylogenomic databases
eggNOGi | KOG3313, Eukaryota |
GeneTreei | ENSGT00390000018904 |
HOGENOMi | CLU_083737_0_0_1 |
InParanoidi | P48363 |
OMAi | EPMETHF |
Family and domain databases
InterProi | View protein in InterPro IPR016655, PFD3 IPR004127, Prefoldin_subunit_alpha |
PANTHERi | PTHR12409, PTHR12409, 1 hit |
Pfami | View protein in Pfam PF02996, Prefoldin, 1 hit |
PIRSFi | PIRSF016396, Prefoldin_subunit_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P48363-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTLFNSTEK NARGIPQAPF IENVNEIIKD PSDFELCFNK FQERLSKYKF
60 70 80 90 100
MQESKLATIK QLKTRIPDLE NTLKICQSLR NHSDEGDESD EPILLHYQLN
110 120 130 140 150
DTLYTKAQVD IPEDRADLKV GLWLGADVML EYPIDEAIEL LKKKLADSEQ
160 170 180 190
SLTVSTEDVE FLRENITTME VNCARLYNWD VQRRQDLKQA QEGTKNLKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29137 Genomic DNA Translation: AAA70038.1 Z72863 Genomic DNA Translation: CAA97080.1 AY557774 Genomic DNA Translation: AAS56100.1 BK006941 Genomic DNA Translation: DAA08171.1 |
PIRi | S59741 |
RefSeqi | NP_011592.3, NM_001181207.3 |
Genome annotation databases
EnsemblFungii | YGR078C_mRNA; YGR078C; YGR078C |
GeneIDi | 852969 |
KEGGi | sce:YGR078C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U29137 Genomic DNA Translation: AAA70038.1 Z72863 Genomic DNA Translation: CAA97080.1 AY557774 Genomic DNA Translation: AAS56100.1 BK006941 Genomic DNA Translation: DAA08171.1 |
PIRi | S59741 |
RefSeqi | NP_011592.3, NM_001181207.3 |
3D structure databases
SMRi | P48363 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33320, 642 interactors |
ComplexPortali | CPX-1671, Prefoldin complex |
DIPi | DIP-6837N |
IntActi | P48363, 10 interactors |
MINTi | P48363 |
STRINGi | 4932.YGR078C |
PTM databases
iPTMneti | P48363 |
Proteomic databases
MaxQBi | P48363 |
PaxDbi | P48363 |
PRIDEi | P48363 |
Genome annotation databases
EnsemblFungii | YGR078C_mRNA; YGR078C; YGR078C |
GeneIDi | 852969 |
KEGGi | sce:YGR078C |
Organism-specific databases
EuPathDBi | FungiDB:YGR078C |
SGDi | S000003310, PAC10 |
Phylogenomic databases
eggNOGi | KOG3313, Eukaryota |
GeneTreei | ENSGT00390000018904 |
HOGENOMi | CLU_083737_0_0_1 |
InParanoidi | P48363 |
OMAi | EPMETHF |
Miscellaneous databases
PROi | PR:P48363 |
RNActi | P48363, protein |
Family and domain databases
InterProi | View protein in InterPro IPR016655, PFD3 IPR004127, Prefoldin_subunit_alpha |
PANTHERi | PTHR12409, PTHR12409, 1 hit |
Pfami | View protein in Pfam PF02996, Prefoldin, 1 hit |
PIRSFi | PIRSF016396, Prefoldin_subunit_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PFD3_YEAST | |
Accessioni | P48363Primary (citable) accession number: P48363 Secondary accession number(s): D6VUL0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | October 7, 2020 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names