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Entry version 204 (13 Feb 2019)
Sequence version 2 (17 Oct 2006)
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Protein

Leptin receptor

Gene

LEPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).By similarity1 Publication5 Publications
Isoform A: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3.By similarity
Isoform E: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2586552 Signaling by Leptin

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P48357

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P48357

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leptin receptor
Short name:
LEP-R
Alternative name(s):
HuB219
OB receptor
Short name:
OB-R
CD_antigen: CD295
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LEPR
Synonyms:DB, OBR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000116678.18

Human Gene Nomenclature Database

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HGNCi
HGNC:6554 LEPR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601007 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48357

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 839ExtracellularSequence analysisAdd BLAST818
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei840 – 862HelicalSequence analysisAdd BLAST23
Topological domaini863 – 1165CytoplasmicSequence analysisAdd BLAST303

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leptin receptor deficiency (LEPRD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare disease characterized by normal levels of serum leptin, hyperphagia and severe obesity from an early age. Additional features include alterations in immune function, and delayed puberty due to hypogonadotropic hypogonadism.
See also OMIM:614963
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075723422Y → H in LEPRD; unknown pathological significance. 1 Publication1
Natural variantiVAR_075724604C → G in LEPRD; unknown pathological significance. 1 Publication1
Natural variantiVAR_075725786L → P in LEPRD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1303050393Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi986Y → F: Greatly reduced PTPN11 binding; no PTPN11 phosphorylation; no effect on STAT3 phosphorylation. 1 Publication1
Mutagenesisi1078 – 1079YY → FF: No effect on PTPN11 nor STAT3 phosphorylation. 1 Publication2
Mutagenesisi1141Y → F: No effect on PTPN11 phosphorylation; no STAT3 phosphorylation. 1 Publication1

Keywords - Diseasei

Obesity

Organism-specific databases

DisGeNET

More...
DisGeNETi
3953

MalaCards human disease database

More...
MalaCardsi
LEPR
MIMi614963 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000116678

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
179494 Obesity due to leptin receptor gene deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA229

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5913

Drug and drug target database

More...
DrugBanki
DB05098 Leptin
DB09046 Metreleptin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LEPR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242617

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001090422 – 1165Leptin receptorAdd BLAST1144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi23N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 901 Publication
Glycosylationi41N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi56N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi73N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi81N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi89 ↔ 991 Publication
Glycosylationi98N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi131 ↔ 1421 Publication
Disulfide bondi186 ↔ 1961 Publication
Glycosylationi187N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi188 ↔ 1931 Publication
Glycosylationi206N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi276N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi347N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi352 ↔ 4121 Publication
Glycosylationi397N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi413 ↔ 4181 Publication
Disulfide bondi436 ↔ 4471 Publication
Disulfide bondi473 ↔ 5281 Publication
Disulfide bondi488 ↔ 4981 Publication
Glycosylationi516N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi624N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi659N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi688N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi697N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi728N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi750N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei882PhosphoserineCombined sources1
Modified residuei986Phosphotyrosine; by JAK2By similarity1
Modified residuei1079PhosphotyrosineBy similarity1
Modified residuei1141Phosphotyrosine; by JAK2By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Phosphorylation of Tyr-1079 has a more accessory role.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P48357

MaxQB - The MaxQuant DataBase

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MaxQBi
P48357

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48357

PeptideAtlas

More...
PeptideAtlasi
P48357

PRoteomics IDEntifications database

More...
PRIDEi
P48357

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55876
55877 [P48357-2]
55878 [P48357-3]
55879 [P48357-4]
55880 [P48357-5]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1954

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48357

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48357

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus, but also in skeletal muscle. Detected in fundic and antral epithelial cells of the gastric mucosa (PubMed:19159218). Isoform B and isoform A are expressed by NK cells (at protein level) (PubMed:12504075).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116678 Expressed in 225 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P48357 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA030899

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Present as a mixture of monomers and dimers (Probable). The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity) (PubMed:9600917). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (By similarity).By similarity1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110144, 20 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P48357

Database of interacting proteins

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DIPi
DIP-6117N

Protein interaction database and analysis system

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IntActi
P48357, 11 interactors

Molecular INTeraction database

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MINTi
P48357

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330393

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V6OX-ray1.95A/B428-633[»]
6E2PX-ray2.83C/D863-933[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P48357

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P48357

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini239 – 333Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini331 – 429Ig-likeAdd BLAST99
Domaini539 – 634Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini639 – 732Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini740 – 833Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni467 – 484Leptin-binding1 PublicationAdd BLAST18
Regioni893 – 898Required for JAK2 activationBy similarity6
Regioni898 – 906Required for STAT3 phosphorylationBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi622 – 626WSXWS motif5
Motifi871 – 879Box 1 motif9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKH4 Eukaryota
ENOG4110JZP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111209

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000140

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48357

KEGG Orthology (KO)

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KOi
K05062

Identification of Orthologs from Complete Genome Data

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OMAi
FVSYMPQ

Database of Orthologous Groups

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OrthoDBi
144839at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48357

TreeFam database of animal gene trees

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TreeFami
TF106501

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR003531 Hempt_rcpt_S_F1_CS
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd
IPR015752 Lep_receptor

The PANTHER Classification System

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PANTHERi
PTHR23036:SF109 PTHR23036:SF109, 3 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF06328 Lep_receptor_Ig, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00060 FN3, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B (identifier: P48357-1) [UniParc]FASTAAdd to basket
Also known as: 13.2, OBRb

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MICQKFCVVL LHWEFIYVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP
60 70 80 90 100
AGLSKNTSNS NGHYETAVEP KFNSSGTHFS NLSKTTFHCC FRSEQDRNCS
110 120 130 140 150
LCADNIEGKT FVSTVNSLVF QQIDANWNIQ CWLKGDLKLF ICYVESLFKN
160 170 180 190 200
LFRNYNYKVH LLYVLPEVLE DSPLVPQKGS FQMVHCNCSV HECCECLVPV
210 220 230 240 250
PTAKLNDTLL MCLKITSGGV IFQSPLMSVQ PINMVKPDPP LGLHMEITDD
260 270 280 290 300
GNLKISWSSP PLVPFPLQYQ VKYSENSTTV IREADKIVSA TSLLVDSILP
310 320 330 340 350
GSSYEVQVRG KRLDGPGIWS DWSTPRVFTT QDVIYFPPKI LTSVGSNVSF
360 370 380 390 400
HCIYKKENKI VPSKEIVWWM NLAEKIPQSQ YDVVSDHVSK VTFFNLNETK
410 420 430 440 450
PRGKFTYDAV YCCNEHECHH RYAELYVIDV NINISCETDG YLTKMTCRWS
460 470 480 490 500
TSTIQSLAES TLQLRYHRSS LYCSDIPSIH PISEPKDCYL QSDGFYECIF
510 520 530 540 550
QPIFLLSGYT MWIRINHSLG SLDSPPTCVL PDSVVKPLPP SSVKAEITIN
560 570 580 590 600
IGLLKISWEK PVFPENNLQF QIRYGLSGKE VQWKMYEVYD AKSKSVSLPV
610 620 630 640 650
PDLCAVYAVQ VRCKRLDGLG YWSNWSNPAY TVVMDIKVPM RGPEFWRIIN
660 670 680 690 700
GDTMKKEKNV TLLWKPLMKN DSLCSVQRYV INHHTSCNGT WSEDVGNHTK
710 720 730 740 750
FTFLWTEQAH TVTVLAINSI GASVANFNLT FSWPMSKVNI VQSLSAYPLN
760 770 780 790 800
SSCVIVSWIL SPSDYKLMYF IIEWKNLNED GEIKWLRISS SVKKYYIHDH
810 820 830 840 850
FIPIEKYQFS LYPIFMEGVG KPKIINSFTQ DDIEKHQSDA GLYVIVPVII
860 870 880 890 900
SSSILLLGTL LISHQRMKKL FWEDVPNPKN CSWAQGLNFQ KPETFEHLFI
910 920 930 940 950
KHTASVTCGP LLLEPETISE DISVDTSWKN KDEMMPTTVV SLLSTTDLEK
960 970 980 990 1000
GSVCISDQFN SVNFSEAEGT EVTYEDESQR QPFVKYATLI SNSKPSETGE
1010 1020 1030 1040 1050
EQGLINSSVT KCFSSKNSPL KDSFSNSSWE IEAQAFFILS DQHPNIISPH
1060 1070 1080 1090 1100
LTFSEGLDEL LKLEGNFPEE NNDKKSIYYL GVTSIKKRES GVLLTDKSRV
1110 1120 1130 1140 1150
SCPFPAPCLF TDIRVLQDSC SHFVENNINL GTSSKKTFAS YMPQFQTCST
1160
QTHKIMENKM CDLTV
Length:1,165
Mass (Da):132,494
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCAA03BEAF2602D0A
GO
Isoform A (identifier: P48357-2) [UniParc]FASTAAdd to basket
Also known as: 6.4, HuB219.3

The sequence of this isoform differs from the canonical sequence as follows:
     892-896: PETFE → RTDIL
     897-1165: Missing.

Show »
Length:896
Mass (Da):102,490
Checksum:iD371C7A4186DEEF3
GO
Isoform C (identifier: P48357-3) [UniParc]FASTAAdd to basket
Also known as: 12.1, OBRa

The sequence of this isoform differs from the canonical sequence as follows:
     892-958: PETFEHLFIK...EKGSVCISDQ → MLEGSMFVKS...KSPSVRNTQE
     959-1165: Missing.

Show »
Length:958
Mass (Da):109,393
Checksum:i3F65BC5A187E803A
GO
Isoform D (identifier: P48357-4) [UniParc]FASTAAdd to basket
Also known as: HuB219.2

The sequence of this isoform differs from the canonical sequence as follows:
     892-906: PETFEHLFIKHTASV → KMPGTKELLGGGWLT
     907-1165: Missing.

Show »
Length:906
Mass (Da):103,461
Checksum:i07F4D89DDFDB83CA
GO
Isoform E (identifier: P48357-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     840-1165: Missing.

Show »
Length:839
Mass (Da):96,042
Checksum:i96CA923928EE36FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti85T → A in AAC50509 (PubMed:8616721).Curated1
Sequence conflicti85T → A in AAC50510 (PubMed:8616721).Curated1
Sequence conflicti85T → A in AAC50511 (PubMed:8616721).Curated1
Sequence conflicti976D → A in AAA93015 (PubMed:8548812).Curated1
Sequence conflicti976D → A in AAB09673 (PubMed:9158141).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002703109K → R7 PublicationsCorresponds to variant dbSNP:rs1137100EnsemblClinVar.1
Natural variantiVAR_049167124D → G. Corresponds to variant dbSNP:rs35573508EnsemblClinVar.1
Natural variantiVAR_002704204K → R1 PublicationCorresponds to variant dbSNP:rs146442768Ensembl.1
Natural variantiVAR_002705223Q → R8 PublicationsCorresponds to variant dbSNP:rs1137101EnsemblClinVar.1
Natural variantiVAR_075723422Y → H in LEPRD; unknown pathological significance. 1 Publication1
Natural variantiVAR_028201503I → V. Corresponds to variant dbSNP:rs13306526Ensembl.1
Natural variantiVAR_075724604C → G in LEPRD; unknown pathological significance. 1 Publication1
Natural variantiVAR_002706656K → N4 PublicationsCorresponds to variant dbSNP:rs1805094EnsemblClinVar.1
Natural variantiVAR_002707675S → T1 PublicationCorresponds to variant dbSNP:rs373154589Ensembl.1
Natural variantiVAR_049168699T → M. Corresponds to variant dbSNP:rs34499590EnsemblClinVar.1
Natural variantiVAR_075725786L → P in LEPRD; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1303050393Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001688840 – 1165Missing in isoform E. 1 PublicationAdd BLAST326
Alternative sequenceiVSP_001691892 – 958PETFE…CISDQ → MLEGSMFVKSHHHSLISSTQ GHKHCGRPQGPLHRKTRDLC SLVYLLTLPPLLSYDPAKSP SVRNTQE in isoform C. 2 PublicationsAdd BLAST67
Alternative sequenceiVSP_001693892 – 906PETFE…HTASV → KMPGTKELLGGGWLT in isoform D. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_001689892 – 896PETFE → RTDIL in isoform A. 3 Publications5
Alternative sequenceiVSP_001690897 – 1165Missing in isoform A. 3 PublicationsAdd BLAST269
Alternative sequenceiVSP_001694907 – 1165Missing in isoform D. 1 PublicationAdd BLAST259
Alternative sequenceiVSP_001692959 – 1165Missing in isoform C. 2 PublicationsAdd BLAST207

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U43168 mRNA Translation: AAA93015.1
U66495 mRNA Translation: AAB07495.1
U66496 mRNA Translation: AAB07496.1
U66497 mRNA Translation: AAB07497.1
U52912 mRNA Translation: AAC50509.1
U52913 mRNA Translation: AAC50510.1
U52914 mRNA Translation: AAC50511.1
U59263
, U59248, U59249, U59250, U59252, U59253, U59254, U59255, U59256, U59257, U59258, U59259, U59260, U59261, U59262 Genomic DNA Translation: AAB09673.1
U50748 mRNA Translation: AAC23650.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30740.1 [P48357-2]
CCDS30741.1 [P48357-3]
CCDS55604.1 [P48357-4]
CCDS631.1 [P48357-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001003679.1, NM_001003679.3 [P48357-2]
NP_001003680.1, NM_001003680.3 [P48357-3]
NP_001185616.1, NM_001198687.1 [P48357-3]
NP_001185617.1, NM_001198688.1 [P48357-4]
NP_001185618.1, NM_001198689.1 [P48357-2]
NP_002294.2, NM_002303.5 [P48357-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.23581
Hs.723178

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344610; ENSP00000340884; ENSG00000116678 [P48357-4]
ENST00000349533; ENSP00000330393; ENSG00000116678 [P48357-1]
ENST00000371058; ENSP00000360097; ENSG00000116678 [P48357-4]
ENST00000371059; ENSP00000360098; ENSG00000116678 [P48357-3]
ENST00000371060; ENSP00000360099; ENSG00000116678 [P48357-2]
ENST00000616738; ENSP00000483390; ENSG00000116678 [P48357-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3953

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3953

UCSC genome browser

More...
UCSCi
uc001dcg.4 human [P48357-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43168 mRNA Translation: AAA93015.1
U66495 mRNA Translation: AAB07495.1
U66496 mRNA Translation: AAB07496.1
U66497 mRNA Translation: AAB07497.1
U52912 mRNA Translation: AAC50509.1
U52913 mRNA Translation: AAC50510.1
U52914 mRNA Translation: AAC50511.1
U59263
, U59248, U59249, U59250, U59252, U59253, U59254, U59255, U59256, U59257, U59258, U59259, U59260, U59261, U59262 Genomic DNA Translation: AAB09673.1
U50748 mRNA Translation: AAC23650.1
CCDSiCCDS30740.1 [P48357-2]
CCDS30741.1 [P48357-3]
CCDS55604.1 [P48357-4]
CCDS631.1 [P48357-1]
RefSeqiNP_001003679.1, NM_001003679.3 [P48357-2]
NP_001003680.1, NM_001003680.3 [P48357-3]
NP_001185616.1, NM_001198687.1 [P48357-3]
NP_001185617.1, NM_001198688.1 [P48357-4]
NP_001185618.1, NM_001198689.1 [P48357-2]
NP_002294.2, NM_002303.5 [P48357-1]
UniGeneiHs.23581
Hs.723178

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V6OX-ray1.95A/B428-633[»]
6E2PX-ray2.83C/D863-933[»]
ProteinModelPortaliP48357
SMRiP48357
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110144, 20 interactors
CORUMiP48357
DIPiDIP-6117N
IntActiP48357, 11 interactors
MINTiP48357
STRINGi9606.ENSP00000330393

Chemistry databases

ChEMBLiCHEMBL5913
DrugBankiDB05098 Leptin
DB09046 Metreleptin

PTM databases

GlyConnecti1954
iPTMnetiP48357
PhosphoSitePlusiP48357

Polymorphism and mutation databases

BioMutaiLEPR
DMDMi116242617

Proteomic databases

jPOSTiP48357
MaxQBiP48357
PaxDbiP48357
PeptideAtlasiP48357
PRIDEiP48357
ProteomicsDBi55876
55877 [P48357-2]
55878 [P48357-3]
55879 [P48357-4]
55880 [P48357-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3953
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344610; ENSP00000340884; ENSG00000116678 [P48357-4]
ENST00000349533; ENSP00000330393; ENSG00000116678 [P48357-1]
ENST00000371058; ENSP00000360097; ENSG00000116678 [P48357-4]
ENST00000371059; ENSP00000360098; ENSG00000116678 [P48357-3]
ENST00000371060; ENSP00000360099; ENSG00000116678 [P48357-2]
ENST00000616738; ENSP00000483390; ENSG00000116678 [P48357-2]
GeneIDi3953
KEGGihsa:3953
UCSCiuc001dcg.4 human [P48357-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3953
DisGeNETi3953
EuPathDBiHostDB:ENSG00000116678.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LEPR
HGNCiHGNC:6554 LEPR
HPAiHPA030899
MalaCardsiLEPR
MIMi601007 gene
614963 phenotype
neXtProtiNX_P48357
OpenTargetsiENSG00000116678
Orphaneti179494 Obesity due to leptin receptor gene deficiency
PharmGKBiPA229

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKH4 Eukaryota
ENOG4110JZP LUCA
GeneTreeiENSGT00730000111209
HOVERGENiHBG000140
InParanoidiP48357
KOiK05062
OMAiFVSYMPQ
OrthoDBi144839at2759
PhylomeDBiP48357
TreeFamiTF106501

Enzyme and pathway databases

ReactomeiR-HSA-2586552 Signaling by Leptin
SignaLinkiP48357
SIGNORiP48357

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LEPR human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Leptin_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3953

Protein Ontology

More...
PROi
PR:P48357

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116678 Expressed in 225 organ(s), highest expression level in liver
GenevisibleiP48357 HS

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR003531 Hempt_rcpt_S_F1_CS
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd
IPR015752 Lep_receptor
PANTHERiPTHR23036:SF109 PTHR23036:SF109, 3 hits
PfamiView protein in Pfam
PF06328 Lep_receptor_Ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEPR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48357
Secondary accession number(s): Q13592
, Q13593, Q13594, Q92919, Q92920, Q92921
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 17, 2006
Last modified: February 13, 2019
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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