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Protein

Leptin receptor

Gene

Lepr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:25383904, PubMed:11923481, PubMed:11861497). In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043, PubMed:12594516). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25383904, PubMed:11923481). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873).1 Publication7 Publications
Isoform A: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:17620316, PubMed:20223942). Does not induce phosphorylation of and activate STAT3 (PubMed:11923481, PubMed:20223942).3 Publications
Isoform E: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine binding Source: GO_Central
  • cytokine receptor activity Source: GO_Central
  • identical protein binding Source: MGI
  • leptin receptor activity Source: UniProtKB
  • peptide hormone binding Source: MGI
  • protein-hormone receptor activity Source: MGI
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leptin receptor
Short name:
LEP-R
Alternative name(s):
B219
OB receptor
Short name:
OB-R
CD_antigen: CD295
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lepr
Synonyms:Db, Obr
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104993 Lepr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 839ExtracellularSequence analysisAdd BLAST818
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei840 – 860HelicalSequence analysisAdd BLAST21
Topological domaini861 – 1162CytoplasmicSequence analysisAdd BLAST302

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants are hyperphagic, obese, infertile, diabetic and have impaired growth (PubMed:12594516). Have wet brain weight significantly lower than controls. Brain uptake of leptin is also reduced (PubMed:11861497). Animals have an increased bone formation leading to high bone mass (PubMed:10660043). Have impaired T-cell immunity, Th2 responses are favoured in mutants (PubMed:9732873). Conditional knockout in parabrachial nucleus CCK-expressing neurons, treated with 2-deoxyglucose, have increased levels of glucagon, corticosterone and epinephrin concentrations compared to wild-types (PubMed:25383904).5 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi891E → A: No effect on STAT3 phosphorylation. 1 Publication1
Mutagenesisi894E → A: No effect on STAT3 phosphorylation. 1 Publication1
Mutagenesisi896 – 897LF → AA: Abrogates STAT3 phosphorylation. 1 Publication2
Mutagenesisi899 – 900KH → AA: No effect on STAT3 phosphorylation. 1 Publication2
Mutagenesisi902E → A: No effect on STAT3 phosphorylation. 1 Publication1
Mutagenesisi908P → A: No effect on STAT3 phosphorylation. 1 Publication1
Mutagenesisi985Y → L: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with S-1138. No phosphorylation; when associated with both S-1138 and F-1077. No change in STAT3 activation. No PTPN11 binding. No SOCS3 binding nor inhibition of signaling. Greatly reduced ERK/FOS activation. Mutants are hyperphagic, obese and hyperglycaemic, females show a defect in lactation. 3 Publications1
Mutagenesisi1077Y → F: No effect on EPO-induced tyrosine phosphorylation. 1 Publication1
Mutagenesisi1138Y → S: No change in EPO-induced JAK2 activation and EPO-induced tyrosine phosphorylation. No phosphorylation; when associated with L-985. No phosphorylation; when associated with L-985 and F-1077. No STAT3 activation. No change in SOCS3 binding nor signaling inhibition. No effect on ERK/FOS activation. 2 Publications1

Keywords - Diseasei

Obesity

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1712

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001090622 – 1162Leptin receptorAdd BLAST1141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi37 ↔ 90By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 99By similarity
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 142By similarity
Disulfide bondi186 ↔ 195By similarity
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi188 ↔ 193By similarity
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi350 ↔ 410By similarity
Disulfide bondi411 ↔ 416By similarity
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi434 ↔ 445By similarity
Disulfide bondi471 ↔ 526By similarity
Disulfide bondi486 ↔ 496By similarity
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi622N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi657N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi668N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi695N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi698N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei880PhosphoserineCombined sources1
Modified residuei985Phosphotyrosine; by JAK22 Publications1
Modified residuei1077Phosphotyrosine1 Publication1
Modified residuei1138Phosphotyrosine; by JAK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. Phosphorylation of Tyr-1077 has a more accessory role.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P48356

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48356

PeptideAtlas

More...
PeptideAtlasi
P48356

PRoteomics IDEntifications database

More...
PRIDEi
P48356

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48356

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48356

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform A: highest level of expression in lung and kidney, also present in heart, brain, spleen, liver, muscle, choroid plexus and hypothalamus. Isoform B: highest levels of expression in hypothalamus and lower levels in brain, testes and adipose tissue. Expressed by neurons of the parabrachial nucleus (PubMed:25383904). Expressed by peripheral blood mononuclear cells and CD4+ T-cells (PubMed:9732873). Isoform E: expressed in adipose tissue, liver, hypothalamus, cerebral microvessels, heart, and testes (PubMed:17620316).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057722 Expressed in 191 organ(s), highest expression level in placenta labyrinth

CleanEx database of gene expression profiles

More...
CleanExi
MM_LEPR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P48356 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P48356 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Present as a mixture of monomers and dimers (Probable). The phosphorylated receptor binds a number of SH2 domain-containing proteins such as JAK2, STAT3, PTPN11, and SOCS3 (By similarity) (PubMed:11018044, PubMed:11923481). Interaction with SOCS3 inhibits JAK/STAT signaling and MAPK cascade (PubMed:11018044).By similarity1 Publication2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201139, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P48356

Database of interacting proteins

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DIPi
DIP-42763N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P48356

Protein interaction database and analysis system

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IntActi
P48356, 13 interactors

Molecular INTeraction database

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MINTi
P48356

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000037385

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P48356

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini238 – 331Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini329 – 427Ig-likeAdd BLAST99
Domaini537 – 632Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini637 – 729Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST93
Domaini738 – 832Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni465 – 482Leptin-bindingBy similarityAdd BLAST18
Regioni891 – 896Required for JAK2 activation1 Publication6
Regioni896 – 904Required for STAT3 phosphorylation1 Publication9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi620 – 624WSXWS motif5
Motifi869 – 877Box 1 motif9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.1 Publication
The box 1 motif is required for JAK interaction and/or activation.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKH4 Eukaryota
ENOG4110JZP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000111209

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000140

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P48356

KEGG Orthology (KO)

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KOi
K05062

Identification of Orthologs from Complete Genome Data

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OMAi
FVSYMPQ

Database of Orthologous Groups

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OrthoDBi
EOG091G00QX

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48356

TreeFam database of animal gene trees

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TreeFami
TF106501

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 6 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR003531 Hempt_rcpt_S_F1_CS
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd
IPR015752 Lep_receptor

The PANTHER Classification System

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PANTHERi
PTHR23036:SF109 PTHR23036:SF109, 3 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF06328 Lep_receptor_Ig, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00060 FN3, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform B (identifier: P48356-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMCQKFYVVL LHWEFLYVIA ALNLAYPISP WKFKLFCGPP NTTDDSFLSP
60 70 80 90 100
AGAPNNASAL KGASEAIVEA KFNSSGIYVP ELSKTVFHCC FGNEQGQNCS
110 120 130 140 150
ALTDNTEGKT LASVVKASVF RQLGVNWDIE CWMKGDLTLF ICHMEPLPKN
160 170 180 190 200
PFKNYDSKVH LLYDLPEVID DSPLPPLKDS FQTVQCNCSL RGCECHVPVP
210 220 230 240 250
RAKLNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL GLHMEVTDDG
260 270 280 290 300
NLKISWDSQT MAPFPLQYQV KYLENSTIVR EAAEIVSATS LLVDSVLPGS
310 320 330 340 350
SYEVQVRSKR LDGSGVWSDW SSPQVFTTQD VVYFPPKILT SVGSNASFHC
360 370 380 390 400
IYKNENQIIS SKQIVWWRNL AEKIPEIQYS IVSDRVSKVT FSNLKATRPR
410 420 430 440 450
GKFTYDAVYC CNEQACHHRY AELYVIDVNI NISCETDGYL TKMTCRWSPS
460 470 480 490 500
TIQSLVGSTV QLRYHRRSLY CPDSPSIHPT SEPKNCVLQR DGFYECVFQP
510 520 530 540 550
IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN VKAEITVNTG
560 570 580 590 600
LLKVSWEKPV FPENNLQFQI RYGLSGKEIQ WKTHEVFDAK SKSASLLVSD
610 620 630 640 650
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRKMDGD
660 670 680 690 700
VTKKERNVTL LWKPLTKNDS LCSVRRYVVK HRTAHNGTWS EDVGNRTNLT
710 720 730 740 750
FLWTEPAHTV TVLAVNSLGA SLVNFNLTFS WPMSKVSAVE SLSAYPLSSS
760 770 780 790 800
CVILSWTLSP DDYSLLYLVI EWKILNEDDG MKWLRIPSNV KKFYIHDNFI
810 820 830 840 850
PIEKYQFSLY PVFMEGVGKP KIINGFTKDA IDKQQNDAGL YVIVPIIISS
860 870 880 890 900
CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKP ETFEHLFTKH
910 920 930 940 950
AESVIFGPLL LEPEPISEEI SVDTAWKNKD EMVPAAMVSL LLTTPDPESS
960 970 980 990 1000
SICISDQCNS ANFSGSQSTQ VTCEDECQRQ PSVKYATLVS NDKLVETDEE
1010 1020 1030 1040 1050
QGFIHSPVSN CISSNHSPLR QSFSSSSWET EAQTFFLLSD QQPTMISPQL
1060 1070 1080 1090 1100
SFSGLDELLE LEGSFPEENH REKSVCYLGV TSVNRRESGV LLTGEAGILC
1110 1120 1130 1140 1150
TFPAQCLFSD IRILQERCSH FVENNLSLGT SGENFVPYMP QFQTCSTHSH
1160
KIMENKMCDL TV
Length:1,162
Mass (Da):130,789
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E1E75B076BA60A2
GO
Isoform A (identifier: P48356-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-894: PETFE → RTDTL
     895-1162: Missing.

Show »
Length:894
Mass (Da):101,058
Checksum:iDF9A7A0E5AC75A53
GO
Isoform C (identifier: P48356-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-892: PET → VTV
     893-1162: Missing.

Show »
Length:892
Mass (Da):100,771
Checksum:i726E5C075A53C9F3
GO
Isoform D (identifier: P48356-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-900: PETFEHLFTKH → DISFHEVFIFR
     901-1162: Missing.

Show »
Length:900
Mass (Da):101,863
Checksum:i7370A3C7BB5E7942
GO
Isoform E (identifier: P48356-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-805: DNFIPIEKY → GMCTVLFMD
     806-1162: Missing.

Show »
Length:805
Mass (Da):90,887
Checksum:i591B5DE008BDB898
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AV66A2AV66_MOUSE
Leptin receptor
Lepr
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140F → I in AAC52705 (PubMed:8692797).Curated1
Sequence conflicti140F → I in AAC52706 (PubMed:8692797).Curated1
Sequence conflicti140F → I in AAC52707 (PubMed:8692797).Curated1
Sequence conflicti720A → T in CAA71343 (PubMed:9322935).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti541V → I in strain: NZO. 1
Natural varianti600D → N in strain: KK Obese. 1 Publication1
Natural varianti651V → I in strain: NZO. 1
Natural varianti1044T → I in strain: NZO. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001703797 – 805DNFIPIEKY → GMCTVLFMD in isoform E. 1 Publication9
Alternative sequenceiVSP_001704806 – 1162Missing in isoform E. 1 PublicationAdd BLAST357
Alternative sequenceiVSP_001701890 – 900PETFEHLFTKH → DISFHEVFIFR in isoform D. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_001697890 – 894PETFE → RTDTL in isoform A. 3 Publications5
Alternative sequenceiVSP_001699890 – 892PET → VTV in isoform C. 2 Publications3
Alternative sequenceiVSP_001700893 – 1162Missing in isoform C. 2 PublicationsAdd BLAST270
Alternative sequenceiVSP_001698895 – 1162Missing in isoform A. 3 PublicationsAdd BLAST268
Alternative sequenceiVSP_001702901 – 1162Missing in isoform D. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U42467 mRNA Translation: AAA93014.1
U46135 mRNA Translation: AAC52408.1
U49106 mRNA Translation: AAC52420.1
U49107 mRNA Translation: AAC52421.1
U49108 mRNA Translation: AAC52422.1
U49109 mRNA Translation: AAC52423.1
U49110 mRNA Translation: AAC52424.1
U52915 mRNA Translation: AAC52599.1
U58861 mRNA Translation: AAC52705.1
U58862 mRNA Translation: AAC52706.1
U58863 mRNA Translation: AAC52707.1
Y10298 mRNA Translation: CAA71343.1
AF039456
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455 Genomic DNA Translation: AAB95334.1
AF039461
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA Translation: AAB95333.1 Different termination.
AF039459
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458 Genomic DNA Translation: AAB95335.1
AF039460
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA Translation: AAB95332.1
Y10296 mRNA Translation: CAA71342.1
AF098792 Genomic DNA Translation: AAD13218.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS18397.1 [P48356-3]
CCDS51239.1 [P48356-2]
CCDS51240.1 [P48356-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S68437
S68438
S68439
S68440
S68441

NCBI Reference Sequences

More...
RefSeqi
NP_001116371.1, NM_001122899.1 [P48356-2]
NP_034834.1, NM_010704.2 [P48356-3]
NP_666258.2, NM_146146.2 [P48356-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.259282

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037552; ENSMUSP00000037385; ENSMUSG00000057722 [P48356-1]
ENSMUST00000102777; ENSMUSP00000099838; ENSMUSG00000057722 [P48356-3]
ENSMUST00000106921; ENSMUSP00000102534; ENSMUSG00000057722 [P48356-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16847

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16847

UCSC genome browser

More...
UCSCi
uc008tvx.2 mouse [P48356-1]
uc008twa.1 mouse [P48356-5]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42467 mRNA Translation: AAA93014.1
U46135 mRNA Translation: AAC52408.1
U49106 mRNA Translation: AAC52420.1
U49107 mRNA Translation: AAC52421.1
U49108 mRNA Translation: AAC52422.1
U49109 mRNA Translation: AAC52423.1
U49110 mRNA Translation: AAC52424.1
U52915 mRNA Translation: AAC52599.1
U58861 mRNA Translation: AAC52705.1
U58862 mRNA Translation: AAC52706.1
U58863 mRNA Translation: AAC52707.1
Y10298 mRNA Translation: CAA71343.1
AF039456
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455 Genomic DNA Translation: AAB95334.1
AF039461
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA Translation: AAB95333.1 Different termination.
AF039459
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458 Genomic DNA Translation: AAB95335.1
AF039460
, AF039443, AF039444, AF039445, AF039446, AF039447, AF039448, AF039449, AF039450, AF039451, AF039452, AF039453, AF039454, AF039455, AF039456, AF039457, AF039458, AF039459 Genomic DNA Translation: AAB95332.1
Y10296 mRNA Translation: CAA71342.1
AF098792 Genomic DNA Translation: AAD13218.1
CCDSiCCDS18397.1 [P48356-3]
CCDS51239.1 [P48356-2]
CCDS51240.1 [P48356-1]
PIRiS68437
S68438
S68439
S68440
S68441
RefSeqiNP_001116371.1, NM_001122899.1 [P48356-2]
NP_034834.1, NM_010704.2 [P48356-3]
NP_666258.2, NM_146146.2 [P48356-1]
UniGeneiMm.259282

3D structure databases

ProteinModelPortaliP48356
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201139, 3 interactors
CORUMiP48356
DIPiDIP-42763N
ELMiP48356
IntActiP48356, 13 interactors
MINTiP48356
STRINGi10090.ENSMUSP00000037385

Chemistry databases

GuidetoPHARMACOLOGYi1712

PTM databases

iPTMnetiP48356
PhosphoSitePlusiP48356

Proteomic databases

MaxQBiP48356
PaxDbiP48356
PeptideAtlasiP48356
PRIDEiP48356

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037552; ENSMUSP00000037385; ENSMUSG00000057722 [P48356-1]
ENSMUST00000102777; ENSMUSP00000099838; ENSMUSG00000057722 [P48356-3]
ENSMUST00000106921; ENSMUSP00000102534; ENSMUSG00000057722 [P48356-2]
GeneIDi16847
KEGGimmu:16847
UCSCiuc008tvx.2 mouse [P48356-1]
uc008twa.1 mouse [P48356-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3953
MGIiMGI:104993 Lepr

Phylogenomic databases

eggNOGiENOG410IKH4 Eukaryota
ENOG4110JZP LUCA
GeneTreeiENSGT00730000111209
HOVERGENiHBG000140
InParanoidiP48356
KOiK05062
OMAiFVSYMPQ
OrthoDBiEOG091G00QX
PhylomeDBiP48356
TreeFamiTF106501

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P48356

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057722 Expressed in 191 organ(s), highest expression level in placenta labyrinth
CleanExiMM_LEPR
ExpressionAtlasiP48356 baseline and differential
GenevisibleiP48356 MM

Family and domain databases

CDDicd00063 FN3, 3 hits
Gene3Di2.60.40.10, 6 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003529 Hematopoietin_rcpt_Gp130_CS
IPR003531 Hempt_rcpt_S_F1_CS
IPR007110 Ig-like_dom
IPR013783 Ig-like_fold
IPR010457 IgC2-like_lig-bd
IPR015752 Lep_receptor
PANTHERiPTHR23036:SF109 PTHR23036:SF109, 3 hits
PfamiView protein in Pfam
PF06328 Lep_receptor_Ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS01353 HEMATOPO_REC_L_F2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEPR_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48356
Secondary accession number(s): O35686
, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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