UniProtKB - P48346 (IL15_MOUSE)
Interleukin-15
Il15
Functioni
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha (By similarity).
In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity).
By similarityGO - Molecular functioni
- cytokine activity Source: MGI
- cytokine receptor binding Source: InterPro
GO - Biological processi
- aging Source: Ensembl
- cell maturation Source: MGI
- cellular response to vitamin D Source: Ensembl
- extrathymic T cell selection Source: MGI
- hyaluronan metabolic process Source: MGI
- immune response Source: InterPro
- inflammatory response Source: Ensembl
- interleukin-15-mediated signaling pathway Source: UniProtKB
- lymph node development Source: MGI
- macrophage differentiation Source: MGI
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- negative regulation of smooth muscle cell proliferation Source: MGI
- neutrophil activation Source: UniProtKB
- NK T cell proliferation Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cytokine production Source: GO_Central
- positive regulation of immune response Source: MGI
- positive regulation of interleukin-17 production Source: MGI
- positive regulation of natural killer cell differentiation Source: MGI
- positive regulation of natural killer cell proliferation Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
- positive regulation of phagocytosis Source: UniProtKB
- positive regulation of protein O-linked glycosylation Source: MGI
- positive regulation of T cell proliferation Source: MGI
- positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
- regulation of defense response to virus by host Source: MGI
- regulation of T cell differentiation Source: MGI
- skeletal muscle atrophy Source: Ensembl
- tyrosine phosphorylation of STAT protein Source: MGI
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
Reactomei | R-MMU-8983432, Interleukin-15 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-15Short name: IL-15 |
Gene namesi | Name:Il15 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103014, Il15 |
VEuPathDBi | HostDB:ENSMUSG00000031712 |
Subcellular locationi
Extracellular region or secreted
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: MGI
Nucleus
- nuclear speck Source: MGI
- nucleoplasm Source: MGI
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
PropeptideiPRO_0000015399 | 30 – 48 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000015400 | 49 – 162 | Interleukin-15Add BLAST | 114 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 83 ↔ 133 | 1 Publication | ||
Disulfide bondi | 90 ↔ 136 | 1 Publication | ||
Glycosylationi | 104 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 108 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P48346 |
PRIDEi | P48346 |
ProteomicsDBi | 267121 |
PTM databases
GlyGeni | P48346, 3 sites |
PhosphoSitePlusi | P48346 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031712, Expressed in granulocyte and 180 other tissues |
ExpressionAtlasi | P48346, baseline and differential |
Genevisiblei | P48346, MM |
Interactioni
GO - Molecular functioni
- cytokine activity Source: MGI
- cytokine receptor binding Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034148 |
Miscellaneous databases
RNActi | P48346, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P48346 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P48346 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SCMF, Eukaryota |
GeneTreei | ENSGT00390000016264 |
HOGENOMi | CLU_135111_0_0_1 |
InParanoidi | P48346 |
OMAi | ANWQDVI |
OrthoDBi | 1521691at2759 |
PhylomeDBi | P48346 |
TreeFami | TF336199 |
Family and domain databases
Gene3Di | 1.20.1250.70, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR020466, IL-15_mml |
PANTHERi | PTHR14356, PTHR14356, 1 hit |
Pfami | View protein in Pfam PF02372, IL15, 1 hit |
PRINTSi | PR01947, INTLKN15MAML PR01930, INTRLEUKIN15 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MKILKPYMRN TSISCYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW
60 70 80 90 100
IDVRYDLEKI ESLIQSIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH
110 120 130 140 150
EYSNMTLNET VRNVLYLANS TLSSNKNVAE SGCKECEELE EKTFTEFLQS
160
FIRIVQMFIN TS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GQZ2 | A0A1B0GQZ2_MOUSE | Interleukin-15 | Il15 | 48 | Annotation score: | ||
A0A1B0GQZ8 | A0A1B0GQZ8_MOUSE | Interleukin-15 | Il15 | 61 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14332 mRNA Translation: AAA75377.1 BC023698 mRNA Translation: AAH23698.1 |
CCDSi | CCDS40401.1 |
PIRi | I49124 |
RefSeqi | NP_001241676.1, NM_001254747.1 NP_032383.1, NM_008357.2 XP_006530768.1, XM_006530705.3 XP_006530769.1, XM_006530706.3 XP_006530770.1, XM_006530707.3 XP_006530771.1, XM_006530708.3 XP_006530772.1, XM_006530709.2 XP_006530773.1, XM_006530710.2 XP_006530774.1, XM_006530711.3 XP_006530775.1, XM_006530712.3 XP_006530776.1, XM_006530713.3 XP_011246614.1, XM_011248312.2 XP_011246615.1, XM_011248313.2 XP_011246616.1, XM_011248314.2 |
Genome annotation databases
Ensembli | ENSMUST00000034148; ENSMUSP00000034148; ENSMUSG00000031712 ENSMUST00000209363; ENSMUSP00000147848; ENSMUSG00000031712 ENSMUST00000209573; ENSMUSP00000148256; ENSMUSG00000031712 |
GeneIDi | 16168 |
KEGGi | mmu:16168 |
UCSCi | uc009mjk.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U14332 mRNA Translation: AAA75377.1 BC023698 mRNA Translation: AAH23698.1 |
CCDSi | CCDS40401.1 |
PIRi | I49124 |
RefSeqi | NP_001241676.1, NM_001254747.1 NP_032383.1, NM_008357.2 XP_006530768.1, XM_006530705.3 XP_006530769.1, XM_006530706.3 XP_006530770.1, XM_006530707.3 XP_006530771.1, XM_006530708.3 XP_006530772.1, XM_006530709.2 XP_006530773.1, XM_006530710.2 XP_006530774.1, XM_006530711.3 XP_006530775.1, XM_006530712.3 XP_006530776.1, XM_006530713.3 XP_011246614.1, XM_011248312.2 XP_011246615.1, XM_011248313.2 XP_011246616.1, XM_011248314.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2PSM | X-ray | 2.19 | A/B | 49-162 | [»] | |
SMRi | P48346 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034148 |
PTM databases
GlyGeni | P48346, 3 sites |
PhosphoSitePlusi | P48346 |
Proteomic databases
PaxDbi | P48346 |
PRIDEi | P48346 |
ProteomicsDBi | 267121 |
Protocols and materials databases
Antibodypediai | 3844, 1125 antibodies from 43 providers |
DNASUi | 16168 |
Genome annotation databases
Ensembli | ENSMUST00000034148; ENSMUSP00000034148; ENSMUSG00000031712 ENSMUST00000209363; ENSMUSP00000147848; ENSMUSG00000031712 ENSMUST00000209573; ENSMUSP00000148256; ENSMUSG00000031712 |
GeneIDi | 16168 |
KEGGi | mmu:16168 |
UCSCi | uc009mjk.2, mouse |
Organism-specific databases
CTDi | 3600 |
MGIi | MGI:103014, Il15 |
VEuPathDBi | HostDB:ENSMUSG00000031712 |
Phylogenomic databases
eggNOGi | ENOG502SCMF, Eukaryota |
GeneTreei | ENSGT00390000016264 |
HOGENOMi | CLU_135111_0_0_1 |
InParanoidi | P48346 |
OMAi | ANWQDVI |
OrthoDBi | 1521691at2759 |
PhylomeDBi | P48346 |
TreeFami | TF336199 |
Enzyme and pathway databases
Reactomei | R-MMU-8983432, Interleukin-15 signaling |
Miscellaneous databases
BioGRID-ORCSi | 16168, 0 hits in 64 CRISPR screens |
ChiTaRSi | Il15, mouse |
EvolutionaryTracei | P48346 |
PROi | PR:P48346 |
RNActi | P48346, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031712, Expressed in granulocyte and 180 other tissues |
ExpressionAtlasi | P48346, baseline and differential |
Genevisiblei | P48346, MM |
Family and domain databases
Gene3Di | 1.20.1250.70, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR020439, IL-15 IPR003443, IL-15/IL-21_fam IPR020466, IL-15_mml |
PANTHERi | PTHR14356, PTHR14356, 1 hit |
Pfami | View protein in Pfam PF02372, IL15, 1 hit |
PRINTSi | PR01947, INTLKN15MAML PR01930, INTRLEUKIN15 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL15_MOUSE | |
Accessioni | P48346Primary (citable) accession number: P48346 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families